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Volumn 68, Issue 2, 2018, Pages 230-237

Preclinical models of non-alcoholic fatty liver disease

Author keywords

Fibrosis; Mouse models; NAFLD activity score; Non alcoholic fatty liver disease; Non alcoholic steatohepatitis; Preclinical models; Transcriptome

Indexed keywords

CHOLESTEROL; CHOLIC ACID; CHOLINE; FRUCTOSE; LEPTIN; LEPTIN RECEPTOR; METHIONINE; STREPTOZOCIN;

EID: 85038928790     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2017.10.031     Document Type: Review
Times cited : (281)

References (73)
  • 1
    • 84952683464 scopus 로고    scopus 로고
    • End points must be clinically meaningful for drug development in nonalcoholic fatty liver disease
    • Sanyal, A.J., Neuschwander-Tetri, B.A., Tonascia, J., End points must be clinically meaningful for drug development in nonalcoholic fatty liver disease. Gastroenterology 150 (2016), 11–13.
    • (2016) Gastroenterology , vol.150 , pp. 11-13
    • Sanyal, A.J.1    Neuschwander-Tetri, B.A.2    Tonascia, J.3
  • 2
    • 84867152637 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease (NAFLD): Is it really a serious condition?
    • Wattacheril, J., Chalasani, N., Non-alcoholic fatty liver disease (NAFLD): Is it really a serious condition?. Hepatology 56 (2012), 1580–1584.
    • (2012) Hepatology , vol.56 , pp. 1580-1584
    • Wattacheril, J.1    Chalasani, N.2
  • 3
    • 84976479130 scopus 로고    scopus 로고
    • Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes
    • Younossi, Z.M., Koenig, A.B., Abdelatif, D., Fazel, Y., Henry, L., Wymer, M., Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology 64 (2016), 73–84.
    • (2016) Hepatology , vol.64 , pp. 73-84
    • Younossi, Z.M.1    Koenig, A.B.2    Abdelatif, D.3    Fazel, Y.4    Henry, L.5    Wymer, M.6
  • 4
    • 84937524539 scopus 로고    scopus 로고
    • Nonalcoholic Fatty liver disease and risk of diabetes and cardiovascular disease: what is important for primary care physicians?
    • Ahmed, M.H., Husain, N.E., Almobarak, A.O., Nonalcoholic Fatty liver disease and risk of diabetes and cardiovascular disease: what is important for primary care physicians?. J Family Med Prim Care 4 (2015), 45–52.
    • (2015) J Family Med Prim Care , vol.4 , pp. 45-52
    • Ahmed, M.H.1    Husain, N.E.2    Almobarak, A.O.3
  • 5
    • 84927712360 scopus 로고    scopus 로고
    • You are what you eat, or are you? The challenges of translating high-fat-fed rodents to human obesity and diabetes
    • Lai, M., Chandrasekera, P.C., Barnard, N.D., You are what you eat, or are you? The challenges of translating high-fat-fed rodents to human obesity and diabetes. Nutr Diabetes, 8, 2014, e135.
    • (2014) Nutr Diabetes , vol.8 , pp. e135
    • Lai, M.1    Chandrasekera, P.C.2    Barnard, N.D.3
  • 6
    • 84875810895 scopus 로고    scopus 로고
    • Mouse models for liver cancer
    • Bakiri, L., Wagner, E.F., Mouse models for liver cancer. Mol Oncol 7 (2013), 206–223.
    • (2013) Mol Oncol , vol.7 , pp. 206-223
    • Bakiri, L.1    Wagner, E.F.2
  • 7
    • 84977567249 scopus 로고    scopus 로고
    • A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer
    • Asgharpour, A., Cazanave, S.C., Pacana, T., Seneshaw, M., Vincent, R., Banini, B.A., et al. A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer. J Hepatol 65 (2016), 579–588.
    • (2016) J Hepatol , vol.65 , pp. 579-588
    • Asgharpour, A.1    Cazanave, S.C.2    Pacana, T.3    Seneshaw, M.4    Vincent, R.5    Banini, B.A.6
  • 8
    • 85021999399 scopus 로고    scopus 로고
    • Animal models of alcoholic liver disease: pathogenesis and clinical relevance
    • Gao, B., Xu, M.J., Bertola, A., Wang, H., Zhou, Z., Liangpunsakul, S., Animal models of alcoholic liver disease: pathogenesis and clinical relevance. Gene Exp 17 (2017), 173–186.
    • (2017) Gene Exp , vol.17 , pp. 173-186
    • Gao, B.1    Xu, M.J.2    Bertola, A.3    Wang, H.4    Zhou, Z.5    Liangpunsakul, S.6
  • 9
    • 34547882082 scopus 로고    scopus 로고
    • Comparative review of diets for the metabolic syndrome: implications for nonalcoholic fatty liver disease
    • Zivkovic, A.M., German, J.B., Sanyal, A.J., Comparative review of diets for the metabolic syndrome: implications for nonalcoholic fatty liver disease. Am J Clin Nutr 86 (2007), 285–300.
    • (2007) Am J Clin Nutr , vol.86 , pp. 285-300
    • Zivkovic, A.M.1    German, J.B.2    Sanyal, A.J.3
  • 10
    • 84884947798 scopus 로고    scopus 로고
    • Diet-induced mouse model of fatty liver disease and nonalcoholic steatohepatitis reflecting clinical disease progression and methods of assessment
    • Clapper, J.R., Hendricks, M.D., Gu, G., Wittmer, C., Dolman, C.S., Herich, J., et al. Diet-induced mouse model of fatty liver disease and nonalcoholic steatohepatitis reflecting clinical disease progression and methods of assessment. Am J Physiol Gastrointest Liver Physiol 305 (2013), G483–G495.
    • (2013) Am J Physiol Gastrointest Liver Physiol , vol.305 , pp. G483-G495
    • Clapper, J.R.1    Hendricks, M.D.2    Gu, G.3    Wittmer, C.4    Dolman, C.S.5    Herich, J.6
  • 11
    • 84949508612 scopus 로고    scopus 로고
    • Animal models of nonalcoholic steatohepatitis: eat, delete, and inflame
    • Ibrahim, S.H., Hirsova, P., Malhi, H., Gores, G.J., Animal models of nonalcoholic steatohepatitis: eat, delete, and inflame. Dig Dis Sci 61 (2016), 1325–1336.
    • (2016) Dig Dis Sci , vol.61 , pp. 1325-1336
    • Ibrahim, S.H.1    Hirsova, P.2    Malhi, H.3    Gores, G.J.4
  • 12
    • 84897632457 scopus 로고    scopus 로고
    • Role of diet and nutritional management in non-alcoholic fatty liver disease
    • Fan, J.G., Cao, H.X., Role of diet and nutritional management in non-alcoholic fatty liver disease. J Gastroenterol Hepatol 28 (2013), 81–87.
    • (2013) J Gastroenterol Hepatol , vol.28 , pp. 81-87
    • Fan, J.G.1    Cao, H.X.2
  • 13
    • 3042550624 scopus 로고    scopus 로고
    • Upregulation of osteopontin expression is involved in the development of nonalcoholic steatohepatitis in a dietary murine model
    • Sahai, A., Malladi, P., Melin-Aldana, H., Green, R.M., Whitington, P.F., Upregulation of osteopontin expression is involved in the development of nonalcoholic steatohepatitis in a dietary murine model. Am J Physiol Gastrointest Liver Physiol 287 (2004), G264–G273.
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.287 , pp. G264-G273
    • Sahai, A.1    Malladi, P.2    Melin-Aldana, H.3    Green, R.M.4    Whitington, P.F.5
  • 14
    • 0029829455 scopus 로고    scopus 로고
    • Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation
    • Weltman, M.D., Farrell, G.C., Liddle, C., Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation. Gastroenterology 111 (1996), 1645–1653.
    • (1996) Gastroenterology , vol.111 , pp. 1645-1653
    • Weltman, M.D.1    Farrell, G.C.2    Liddle, C.3
  • 15
    • 84959315041 scopus 로고    scopus 로고
    • Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease
    • Machado, M.V., Michelotti, G.A., Xie, G., Almeida Pereira, T., Boursier, J., Bohnic, B., et al. Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease. PLoS One, 10, 2015, e0127991.
    • (2015) PLoS One , vol.10 , pp. e0127991
    • Machado, M.V.1    Michelotti, G.A.2    Xie, G.3    Almeida Pereira, T.4    Boursier, J.5    Bohnic, B.6
  • 16
    • 0346689994 scopus 로고    scopus 로고
    • The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance
    • Rinella, M.E., Green, R.M., The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance. J Hepatol 40 (2004), 47–51.
    • (2004) J Hepatol , vol.40 , pp. 47-51
    • Rinella, M.E.1    Green, R.M.2
  • 17
    • 50049097587 scopus 로고    scopus 로고
    • Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet
    • Rinella, M.E., Elias, M.S., Smolak, R.R., Fu, T., Borensztajn, J., Green, R.M., Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet. J Lipid Res 49 (2008), 1068–1076.
    • (2008) J Lipid Res , vol.49 , pp. 1068-1076
    • Rinella, M.E.1    Elias, M.S.2    Smolak, R.R.3    Fu, T.4    Borensztajn, J.5    Green, R.M.6
  • 18
    • 84932623164 scopus 로고    scopus 로고
    • Differential hepatotoxicity of dietary and DNL-derived palmitate in the methionine-choline-deficient model of steatohepatitis
    • Pierce, A.A., Pickens, M.K., Siao, K., Grenert, J.P., Maher, J.J., Differential hepatotoxicity of dietary and DNL-derived palmitate in the methionine-choline-deficient model of steatohepatitis. BMC Gastroenterol, 24, 2015, 72.
    • (2015) BMC Gastroenterol , vol.24 , pp. 72
    • Pierce, A.A.1    Pickens, M.K.2    Siao, K.3    Grenert, J.P.4    Maher, J.J.5
  • 19
    • 0025252448 scopus 로고
    • Production of both 8-hydroxydeoxyguanosine in liver DNA and gamma-glutamyltransferase-positive hepatocellular lesions in rats given a choline-deficient, L-amino acid-defined diet
    • Nakae, D., Yoshiji, H., Maruyama, H., Kinugasa, T., Denda, A., Konishi, Y., Production of both 8-hydroxydeoxyguanosine in liver DNA and gamma-glutamyltransferase-positive hepatocellular lesions in rats given a choline-deficient, L-amino acid-defined diet. Jpn J Cancer Res 81 (1990), 1081–1084.
    • (1990) Jpn J Cancer Res , vol.81 , pp. 1081-1084
    • Nakae, D.1    Yoshiji, H.2    Maruyama, H.3    Kinugasa, T.4    Denda, A.5    Konishi, Y.6
  • 20
    • 0026786299 scopus 로고
    • High incidence of hepatocellular carcinomas induced by a choline deficient L-amino acid defined diet in rats
    • Nakae, D., Yoshiji, H., Mizumoto, Y., et al. High incidence of hepatocellular carcinomas induced by a choline deficient L-amino acid defined diet in rats. Cancer Res 52 (1992), 5042–5045.
    • (1992) Cancer Res , vol.52 , pp. 5042-5045
    • Nakae, D.1    Yoshiji, H.2    Mizumoto, Y.3
  • 21
    • 0027986913 scopus 로고
    • Prevention of fibrosis reduces enzyme-altered lesions in the rat liver
    • Sakaida, I., Kubota, M., Kayano, K., Takenaka, K., Mori, K., Okita, K., Prevention of fibrosis reduces enzyme-altered lesions in the rat liver. Carcinogenesis 15 (1994), 2201–2206.
    • (1994) Carcinogenesis , vol.15 , pp. 2201-2206
    • Sakaida, I.1    Kubota, M.2    Kayano, K.3    Takenaka, K.4    Mori, K.5    Okita, K.6
  • 22
    • 33751423908 scopus 로고    scopus 로고
    • Expression of inducible nitric oxide (NO) synthase but not prevention by its gene ablation of hepatocarcinogenesis with fibrosis caused by a choline-deficient, l-amino acid-defined diet in rats and mice
    • Denda, A., Kitayama, W., Kishida, H., et al. Expression of inducible nitric oxide (NO) synthase but not prevention by its gene ablation of hepatocarcinogenesis with fibrosis caused by a choline-deficient, l-amino acid-defined diet in rats and mice. Nitric Oxide 16 (2007), 164–176.
    • (2007) Nitric Oxide , vol.16 , pp. 164-176
    • Denda, A.1    Kitayama, W.2    Kishida, H.3
  • 23
    • 84875056271 scopus 로고    scopus 로고
    • An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis
    • Matsumoto, M., Hada, N., Sakamaki, Y., Uno, A., Shiga, T., Tanaka, C., et al. An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis. Int J Exp Pathol 94 (2013), 93–103.
    • (2013) Int J Exp Pathol , vol.94 , pp. 93-103
    • Matsumoto, M.1    Hada, N.2    Sakamaki, Y.3    Uno, A.4    Shiga, T.5    Tanaka, C.6
  • 24
    • 34548249277 scopus 로고    scopus 로고
    • Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model
    • Kamada, Y., Matsumoto, H., Tamura, S., et al. Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model. J Hepatol 47 (2007), 556–564.
    • (2007) J Hepatol , vol.47 , pp. 556-564
    • Kamada, Y.1    Matsumoto, H.2    Tamura, S.3
  • 25
    • 0036125222 scopus 로고    scopus 로고
    • Development of hepatocellular adenomas and carcinomas associated with fibrosis in C57BL/6J male mice given a choline-deficient, L-amino acid-defined diet
    • Denda, A., Kitayama, W., Kishida, H., et al. Development of hepatocellular adenomas and carcinomas associated with fibrosis in C57BL/6J male mice given a choline-deficient, L-amino acid-defined diet. Jpn J Cancer Res 93 (2002), 125–132.
    • (2002) Jpn J Cancer Res , vol.93 , pp. 125-132
    • Denda, A.1    Kitayama, W.2    Kishida, H.3
  • 26
    • 70349416501 scopus 로고    scopus 로고
    • C-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice
    • Kodama, Y., Kisseleva, T., Iwaisako, K., et al. C-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. Gastroenterology 137 (2009), 1467–1477.
    • (2009) Gastroenterology , vol.137 , pp. 1467-1477
    • Kodama, Y.1    Kisseleva, T.2    Iwaisako, K.3
  • 27
    • 36348935003 scopus 로고    scopus 로고
    • Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet
    • Matsuzawa, N., Takamura, T., Kurita, S., Misu, H., Ota, T., Ando, H., et al. Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet. Hepatology 46 (2007), 1392–1403.
    • (2007) Hepatology , vol.46 , pp. 1392-1403
    • Matsuzawa, N.1    Takamura, T.2    Kurita, S.3    Misu, H.4    Ota, T.5    Ando, H.6
  • 28
    • 41149120450 scopus 로고    scopus 로고
    • Ezetimibe improves high fat and cholesterol diet-induced non-alcoholic fatty liver disease in mice
    • Zheng, S., Hoos, L., Cook, J., et al. Ezetimibe improves high fat and cholesterol diet-induced non-alcoholic fatty liver disease in mice. Eur J Pharmacol 584 (2008), 118–124.
    • (2008) Eur J Pharmacol , vol.584 , pp. 118-124
    • Zheng, S.1    Hoos, L.2    Cook, J.3
  • 29
    • 80051826073 scopus 로고    scopus 로고
    • Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice
    • Subramanian, S., Goodspeed, L., Wang, S., et al. Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice. J Lipid Res 52 (2011), 1626–1635.
    • (2011) J Lipid Res , vol.52 , pp. 1626-1635
    • Subramanian, S.1    Goodspeed, L.2    Wang, S.3
  • 30
    • 84861975560 scopus 로고    scopus 로고
    • Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis
    • Savard, C., Tartaglione, E.V., Kuver, R., et al. Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis. Hepatology 57 (2013), 81–92.
    • (2013) Hepatology , vol.57 , pp. 81-92
    • Savard, C.1    Tartaglione, E.V.2    Kuver, R.3
  • 31
    • 85006067112 scopus 로고    scopus 로고
    • Animal models of non-alcoholic fatty liver disease: current perspectives and recent advances
    • Lau, J.K., Zhang, X., Yu, J., Animal models of non-alcoholic fatty liver disease: current perspectives and recent advances. J Pathol 241 (2017), 36–44.
    • (2017) J Pathol , vol.241 , pp. 36-44
    • Lau, J.K.1    Zhang, X.2    Yu, J.3
  • 32
    • 0242290378 scopus 로고    scopus 로고
    • Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression
    • Vergnes, L., Phan, J., Strauss, M., Tafuri, S., Reue, K., Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression. J Biol Chem 278 (2003), 42774–42784.
    • (2003) J Biol Chem , vol.278 , pp. 42774-42784
    • Vergnes, L.1    Phan, J.2    Strauss, M.3    Tafuri, S.4    Reue, K.5
  • 33
    • 84861738395 scopus 로고    scopus 로고
    • Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
    • Takahashi, Y., Soejima, Y., Fukusato, T., Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. World J Gastroenterol 18 (2012), 2300–2308.
    • (2012) World J Gastroenterol , vol.18 , pp. 2300-2308
    • Takahashi, Y.1    Soejima, Y.2    Fukusato, T.3
  • 34
    • 84886514011 scopus 로고    scopus 로고
    • Lessons from mouse models of high-fat diet-induced NAFLD
    • Nakamura, A., Terauchi, Y., Lessons from mouse models of high-fat diet-induced NAFLD. Int J Mol Sci 14 (2013), 21240–21257.
    • (2013) Int J Mol Sci , vol.14 , pp. 21240-21257
    • Nakamura, A.1    Terauchi, Y.2
  • 35
    • 3042638625 scopus 로고    scopus 로고
    • Genetic background (C57BL/6J vs. FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice
    • Haluzik, M., Colombo, C., Gavrilova, O., Chua, S., Wolf, N., Chen, M., et al. Genetic background (C57BL/6J vs. FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice. Endocrinology 145 (2004), 3258–3264.
    • (2004) Endocrinology , vol.145 , pp. 3258-3264
    • Haluzik, M.1    Colombo, C.2    Gavrilova, O.3    Chua, S.4    Wolf, N.5    Chen, M.6
  • 36
    • 77956634470 scopus 로고    scopus 로고
    • High-fructose, medium chain trans-fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis
    • Kohli, R., Kirby, M., Xanthakos, S.A., et al. High-fructose, medium chain trans-fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology 52 (2010), 934–944.
    • (2010) Hepatology , vol.52 , pp. 934-944
    • Kohli, R.1    Kirby, M.2    Xanthakos, S.A.3
  • 37
    • 77952692915 scopus 로고    scopus 로고
    • Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease
    • Abdelmalek, M.F., Suzuki, A., Guy, C., Unalp-Arida, A., Colvin, R., Johnson, R.J., et al. Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease. Hepatology 51 (2010), 1961–1971.
    • (2010) Hepatology , vol.51 , pp. 1961-1971
    • Abdelmalek, M.F.1    Suzuki, A.2    Guy, C.3    Unalp-Arida, A.4    Colvin, R.5    Johnson, R.J.6
  • 38
    • 80055026523 scopus 로고    scopus 로고
    • Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition
    • Charlton, M., Krishnan, A., Viker, K., Sanderson, S., Cazanave, S., McConico, A., et al. Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition. Am J Physiol Gastrointest Liver Physiol 301 (2011), G825–G834.
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.301 , pp. G825-G834
    • Charlton, M.1    Krishnan, A.2    Viker, K.3    Sanderson, S.4    Cazanave, S.5    McConico, A.6
  • 39
    • 84930646910 scopus 로고    scopus 로고
    • Histologic and metabolic derangement in high-fat, high-fructose, and combination diet animal models
    • Lee, J.S., Jun, D.W., Kim, E.K., Jeon, H.J., Nam, H.H., Saeed, W.K., Histologic and metabolic derangement in high-fat, high-fructose, and combination diet animal models. Sci World J, 2015, 2015, 306326.
    • (2015) Sci World J , vol.2015 , pp. 306326
    • Lee, J.S.1    Jun, D.W.2    Kim, E.K.3    Jeon, H.J.4    Nam, H.H.5    Saeed, W.K.6
  • 40
    • 84884594542 scopus 로고    scopus 로고
    • A murine model for non-alcoholic steatohepatitis showing evidence of association between diabetes and hepatocellular carcinoma
    • Fujii, M., Shibazaki, Y., Wakamatsu, K., Honda, Y., Kawauchi, Y., Suzuki, K., et al. A murine model for non-alcoholic steatohepatitis showing evidence of association between diabetes and hepatocellular carcinoma. Med Mol Morphol 46 (2013), 141–152.
    • (2013) Med Mol Morphol , vol.46 , pp. 141-152
    • Fujii, M.1    Shibazaki, Y.2    Wakamatsu, K.3    Honda, Y.4    Kawauchi, Y.5    Suzuki, K.6
  • 41
    • 79958022742 scopus 로고    scopus 로고
    • The role of oxidative/nitrosative stress in pathogenesis of paracetamol-induced toxic hepatitis
    • Radosavljević T., Mladenović D., Vucević D., Vukićević R.J., et al. The role of oxidative/nitrosative stress in pathogenesis of paracetamol-induced toxic hepatitis. Med Pregl 63 (2010), 827–832.
    • (2010) Med Pregl , vol.63 , pp. 827-832
    • Radosavljević, T.1    Mladenović, D.2    Vucević, D.3    Vukićević, R.J.4
  • 42
    • 84928405266 scopus 로고    scopus 로고
    • Differential gene expression in liver tissues of streptozotocin-induced diabetic rats in response to resveratrol treatment
    • Sadi, G., Baloğlu, M.C., Pektaş M.B., Differential gene expression in liver tissues of streptozotocin-induced diabetic rats in response to resveratrol treatment. PLoS One, 10, 2015, e0124968.
    • (2015) PLoS One , vol.10 , pp. e0124968
    • Sadi, G.1    Baloğlu, M.C.2    Pektaş, M.B.3
  • 43
    • 84954289151 scopus 로고    scopus 로고
    • Histopathology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
    • Brown, G.T., Kleiner, D.E., Histopathology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Metabolism 65 (2016), 1080–1086.
    • (2016) Metabolism , vol.65 , pp. 1080-1086
    • Brown, G.T.1    Kleiner, D.E.2
  • 44
    • 42949086433 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of liver injury
    • Malhi, H., Gores, G.J., Cellular and molecular mechanisms of liver injury. Gastroenterology 134 (2008), 1641–1654.
    • (2008) Gastroenterology , vol.134 , pp. 1641-1654
    • Malhi, H.1    Gores, G.J.2
  • 45
    • 79952042674 scopus 로고    scopus 로고
    • Gene signatures in hepatocellular carcinoma (HCC)
    • Andrisani, O.M., Studach, L., Merle, P., Gene signatures in hepatocellular carcinoma (HCC). Semin Cancer Biol 21 (2011), 4–9.
    • (2011) Semin Cancer Biol , vol.21 , pp. 4-9
    • Andrisani, O.M.1    Studach, L.2    Merle, P.3
  • 46
    • 67651146952 scopus 로고    scopus 로고
    • Nutritional model of steatohepatitis and metabolic syndrome in the Ossabaw miniature swine
    • Lee, L., Alloosh, M., Saxena, R., Van Alstine, W., Watkins, B.A., Klaunig, J.E., et al. Nutritional model of steatohepatitis and metabolic syndrome in the Ossabaw miniature swine. Hepatology 50 (2009), 56–67.
    • (2009) Hepatology , vol.50 , pp. 56-67
    • Lee, L.1    Alloosh, M.2    Saxena, R.3    Van Alstine, W.4    Watkins, B.A.5    Klaunig, J.E.6
  • 47
    • 34249799917 scopus 로고    scopus 로고
    • The physiology of obese-hyperglycemic mice [ob/ob mice]
    • Lindström, P., The physiology of obese-hyperglycemic mice [ob/ob mice]. Sci World J 29 (2007), 666–685.
    • (2007) Sci World J , vol.29 , pp. 666-685
    • Lindström, P.1
  • 48
    • 84863508993 scopus 로고    scopus 로고
    • Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling
    • Imajo, K., Fujita, K., Yoneda, M., Nozaki, Y., Ogawa, Y., Shinohara, Y., et al. Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling. Cell Metab 16 (2012), 44–54.
    • (2012) Cell Metab , vol.16 , pp. 44-54
    • Imajo, K.1    Fujita, K.2    Yoneda, M.3    Nozaki, Y.4    Ogawa, Y.5    Shinohara, Y.6
  • 49
    • 16244363679 scopus 로고    scopus 로고
    • Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy
    • Javor, E.D., Ghany, M.G., Cochran, E.K., Oral, E.A., DePaoli, A.M., Premkumar, A., et al. Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy. Hepatology 41 (2005), 753–760.
    • (2005) Hepatology , vol.41 , pp. 753-760
    • Javor, E.D.1    Ghany, M.G.2    Cochran, E.K.3    Oral, E.A.4    DePaoli, A.M.5    Premkumar, A.6
  • 50
    • 84879130540 scopus 로고    scopus 로고
    • The liver diseases of lipodystrophy: the long-term effect of leptin treatment
    • Safar Zadeh, E., Lungu, A.O., Cochran, E.K., Brown, R.J., Ghany, M.G., Heller, T., et al. The liver diseases of lipodystrophy: the long-term effect of leptin treatment. J Hepatol 59 (2013), 131–137.
    • (2013) J Hepatol , vol.59 , pp. 131-137
    • Safar Zadeh, E.1    Lungu, A.O.2    Cochran, E.K.3    Brown, R.J.4    Ghany, M.G.5    Heller, T.6
  • 51
    • 84923597485 scopus 로고    scopus 로고
    • Leptin in nonalcoholic fatty liver disease: a narrative review
    • Polyzos, S.A., Kountouras, J., Mantzoros, C.S., Leptin in nonalcoholic fatty liver disease: a narrative review. Metabolism 64 (2015), 60–78.
    • (2015) Metabolism , vol.64 , pp. 60-78
    • Polyzos, S.A.1    Kountouras, J.2    Mantzoros, C.S.3
  • 52
    • 0014004384 scopus 로고
    • Diabetes, a new mutation in the mouse
    • Hummel, K.P., Dickie, M.M., Coleman, D.L., Diabetes, a new mutation in the mouse. Science 153 (1966), 1127–1128.
    • (1966) Science , vol.153 , pp. 1127-1128
    • Hummel, K.P.1    Dickie, M.M.2    Coleman, D.L.3
  • 53
    • 82355191481 scopus 로고    scopus 로고
    • Pathology of the liver in obese and diabetic ob/ob and db/db mice fed a standard or high-calorie diet
    • Trak-Smayra, V., Paradis, V., Massart, J., Nasser, S., Jebara, V., Fromenty, B., Pathology of the liver in obese and diabetic ob/ob and db/db mice fed a standard or high-calorie diet. Int J Exp Pathol 92 (2011), 413–421.
    • (2011) Int J Exp Pathol , vol.92 , pp. 413-421
    • Trak-Smayra, V.1    Paradis, V.2    Massart, J.3    Nasser, S.4    Jebara, V.5    Fromenty, B.6
  • 54
    • 7044241291 scopus 로고    scopus 로고
    • Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: Role of short-form leptin receptors and osteopontin
    • Sahai, A., Malladi, P., Pan, X., Paul, R., Melin-Aldana, H., Green, R.M., et al. Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: Role of short-form leptin receptors and osteopontin. Am J Physiol Gastrointest Liver Physiol 287 (2004), G1035–G1043.
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.287 , pp. G1035-G1043
    • Sahai, A.1    Malladi, P.2    Pan, X.3    Paul, R.4    Melin-Aldana, H.5    Green, R.M.6
  • 55
    • 84956898190 scopus 로고    scopus 로고
    • Iron overload results in hepatic oxidative stress, immune cell activation, and hepatocellular ballooning injury, leading to nonalcoholic steatohepatitis in genetically obese mice
    • Handa, P., Morgan-Stevenson, V., Maliken, B.D., et al. Iron overload results in hepatic oxidative stress, immune cell activation, and hepatocellular ballooning injury, leading to nonalcoholic steatohepatitis in genetically obese mice. Am J Physiol Gastrointest Liver Physiol 310 (2016), G117–G127.
    • (2016) Am J Physiol Gastrointest Liver Physiol , vol.310 , pp. G117-G127
    • Handa, P.1    Morgan-Stevenson, V.2    Maliken, B.D.3
  • 56
    • 34249098685 scopus 로고    scopus 로고
    • Iron depletion by phlebotomy improves insulin resistance in patients with nonalcoholic fatty liver disease and hyperferritinemia: evidence from a case-control study
    • Valenti, L., Fracanzani, A.L., Dongiovanni, P., Bugianesi, E., Marchesini, G., Manzini, P., et al. Iron depletion by phlebotomy improves insulin resistance in patients with nonalcoholic fatty liver disease and hyperferritinemia: evidence from a case-control study. Am J Gastroenterol 102 (2007), 1251–1258.
    • (2007) Am J Gastroenterol , vol.102 , pp. 1251-1258
    • Valenti, L.1    Fracanzani, A.L.2    Dongiovanni, P.3    Bugianesi, E.4    Marchesini, G.5    Manzini, P.6
  • 57
    • 85038953914 scopus 로고    scopus 로고
    • Role of ciliary dysfunction in a new model of obesity and non-alcoholic steatohepatitis: the foz/foz mice
    • Laurence, P., Vanessa, L., Geoffrey, F., Isabelle, L., Role of ciliary dysfunction in a new model of obesity and non-alcoholic steatohepatitis: the foz/foz mice. Arch Public Health, 72, 2014, O7.
    • (2014) Arch Public Health , vol.72 , pp. O7
    • Laurence, P.1    Vanessa, L.2    Geoffrey, F.3    Isabelle, L.4
  • 58
    • 84870761696 scopus 로고    scopus 로고
    • A truncating mutation of Alms1 reduces the number of hypothalamic neuronal cilia in obese mice
    • Heydet, D., Chen, L.X., Larter, C.Z., Inglis, C., Silverman, M.A., Farrell, G.C., et al. A truncating mutation of Alms1 reduces the number of hypothalamic neuronal cilia in obese mice. Dev Neurobiol 73 (2012), 1–13.
    • (2012) Dev Neurobiol , vol.73 , pp. 1-13
    • Heydet, D.1    Chen, L.X.2    Larter, C.Z.3    Inglis, C.4    Silverman, M.A.5    Farrell, G.C.6
  • 60
    • 84856414714 scopus 로고    scopus 로고
    • Coordinated improvement in glucose tolerance, liver steatosis and obesity-associated inflammation by cannabinoid 1 receptor antagonism infat Aussie mice
    • Bell-Anderson, K.S., Aouad, L., Williams, H., et al. Coordinated improvement in glucose tolerance, liver steatosis and obesity-associated inflammation by cannabinoid 1 receptor antagonism infat Aussie mice. Int J Obes (Lond) 35 (2011), 1539–1548.
    • (2011) Int J Obes (Lond) , vol.35 , pp. 1539-1548
    • Bell-Anderson, K.S.1    Aouad, L.2    Williams, H.3
  • 61
    • 0032532152 scopus 로고    scopus 로고
    • Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear srebp-1c in adipose tissue: Model for congenital generalized lipodystrophy
    • Shimomura, I., Hammer, R.E., Richardson, J.A., Ikemoto, S., Bashmakov, Y., Goldstein, J.L., et al. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear srebp-1c in adipose tissue: Model for congenital generalized lipodystrophy. Genes Dev 12 (1998), 3182–3194.
    • (1998) Genes Dev , vol.12 , pp. 3182-3194
    • Shimomura, I.1    Hammer, R.E.2    Richardson, J.A.3    Ikemoto, S.4    Bashmakov, Y.5    Goldstein, J.L.6
  • 62
    • 33750070921 scopus 로고    scopus 로고
    • Exacerbation of dietary steatohepatitis and fibrosis in obese, diabetic kk-a(y) mice
    • Okumura, K., Ikejima, K., Kon, K., Abe, W., Yamashina, S., Enomoto, N., et al. Exacerbation of dietary steatohepatitis and fibrosis in obese, diabetic kk-a(y) mice. Hepatol Res 36 (2006), 217–228.
    • (2006) Hepatol Res , vol.36 , pp. 217-228
    • Okumura, K.1    Ikejima, K.2    Kon, K.3    Abe, W.4    Yamashina, S.5    Enomoto, N.6
  • 63
    • 0032491614 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis
    • Costet, P., Legendre, C., More, J., Edgar, A., Galtier, P., Pineau, T., Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis. J Biol Chem 273 (1998), 29577–29585.
    • (1998) J Biol Chem , vol.273 , pp. 29577-29585
    • Costet, P.1    Legendre, C.2    More, J.3    Edgar, A.4    Galtier, P.5    Pineau, T.6
  • 65
    • 85047694402 scopus 로고    scopus 로고
    • Hepatocyte-specific pten deficiency results in steatohepatitis and hepatocellular carcinomas
    • Horie, Y., Suzuki, A., Kataoka, E., Sasaki, T., Hamada, K., Sasaki, J., et al. Hepatocyte-specific pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest 113 (2004), 1774–1783.
    • (2004) J Clin Invest , vol.113 , pp. 1774-1783
    • Horie, Y.1    Suzuki, A.2    Kataoka, E.3    Sasaki, T.4    Hamada, K.5    Sasaki, J.6
  • 66
    • 0032546929 scopus 로고    scopus 로고
    • Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-coa oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism
    • Fan, C.Y., Pan, J., Usuda, N., Yeldandi, A.V., Rao, M.S., Reddy, J.K., Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-coa oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism. J Biol Chem 273 (1998), 15639–15645.
    • (1998) J Biol Chem , vol.273 , pp. 15639-15645
    • Fan, C.Y.1    Pan, J.2    Usuda, N.3    Yeldandi, A.V.4    Rao, M.S.5    Reddy, J.K.6
  • 67
    • 84962026512 scopus 로고    scopus 로고
    • Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice
    • Morinaga, H., Mayoral, R., Heinrichsdorff, J., et al. Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice. Diabetes 64 (2015), 1120–1130.
    • (2015) Diabetes , vol.64 , pp. 1120-1130
    • Morinaga, H.1    Mayoral, R.2    Heinrichsdorff, J.3
  • 68
    • 84925465211 scopus 로고    scopus 로고
    • Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
    • Gomez Perdiguero, E., Klapproth, K., Schulz, C., et al. Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Nature 518 (2015), 547–551.
    • (2015) Nature , vol.518 , pp. 547-551
    • Gomez Perdiguero, E.1    Klapproth, K.2    Schulz, C.3
  • 70
    • 84906064344 scopus 로고    scopus 로고
    • Kupffer cells: increasingly significant role in nonalcoholic fatty liver disease
    • Wenfeng, Z., Yakun, W., Di, M., Jianping, G., Chuanxin, W., Chun, H., Kupffer cells: increasingly significant role in nonalcoholic fatty liver disease. Ann Hepatol 13 (2014), 489–495.
    • (2014) Ann Hepatol , vol.13 , pp. 489-495
    • Wenfeng, Z.1    Yakun, W.2    Di, M.3    Jianping, G.4    Chuanxin, W.5    Chun, H.6
  • 71
    • 80355146868 scopus 로고    scopus 로고
    • Monocyte recruitment during infection and inflammation
    • Shi, C., Pamer, E.G., Monocyte recruitment during infection and inflammation. Nat Rev Immunol 11 (2011), 762–774.
    • (2011) Nat Rev Immunol , vol.11 , pp. 762-774
    • Shi, C.1    Pamer, E.G.2
  • 72
    • 79954523464 scopus 로고    scopus 로고
    • Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice
    • Csak, T., Velayudham, A., Hritz, I., et al. Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice. Am J Physiol Gastrointest Liver Physiol 300 (2011), G433–G441.
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.300 , pp. G433-G441
    • Csak, T.1    Velayudham, A.2    Hritz, I.3
  • 73
    • 77958536355 scopus 로고    scopus 로고
    • Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice
    • Hosoi, T., Yokoyama, S., Matsuo, S., Akira, S., Ozawa, K., Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice. PLoS One, 5, 2010, e12537.
    • (2010) PLoS One , vol.5 , pp. e12537
    • Hosoi, T.1    Yokoyama, S.2    Matsuo, S.3    Akira, S.4    Ozawa, K.5


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