Iron overload results in hepatic oxidative stress, immune cell activation, and hepatocellular ballooning injury, leading to nonalcoholic steatohepatitis in genetically obese mice

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 310, Issue 2, 2016, Pages G117-G127

  Handa, Priya ^a   Morgan Stevenson, Vicki ^a   Maliken, Bryan D ^b   Nelson, James E ^b   Washington, Shenna ^b   Westerman, Mark ^c   Yeh, Matthew M ^d   Kowdley, Kris V ^a,b  

^a SWEDISH MEDICAL CENTER   (United States)

^b BENAROYA RESEARCH INSTITUTE   (United States)

^c Intrinsic Life Sciences   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Hepatocellular ballooning; Immune cell activation; Inflammasome; Iron excess; Reticuloendothelial system

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CD4 ANTIGEN; CD8 ANTIGEN; CRYOPYRIN; FERRITIN; GAMMA INTERFERON; GLUCOSE; GLUTATHIONE PEROXIDASE 1; GLYCOPROTEIN P 15095; HEME OXYGENASE 1; HEPCIDIN; INFLAMMASOME; INOSINATE DEHYDROGENASE; INTERLEUKIN 6; MALONALDEHYDE; MESSENGER RNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; PROTEIN; PROTEIN COX4; PROTEIN PGC1 ALPHA; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR NRF1; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; LEPTIN RECEPTOR; LEPTIN RECEPTOR, MOUSE; REACTIVE OXYGEN METABOLITE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL ACTIVATION; CONTROLLED STUDY; FERRITIN BLOOD LEVEL; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HEPATOCELLULAR BALLOONING INJURY; HORMONE BLOOD LEVEL; HYPERGLYCEMIA; IMMUNOCOMPETENT CELL; IRON INTAKE; IRON OVERLOAD; LIPID METABOLISM; LIVER; LIVER CELL DAMAGE; LIVER WEIGHT; MACROPHAGE; MALE; MITOCHONDRIAL BIOGENESIS; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; OBESITY; OXIDATIVE STRESS; PRIORITY JOURNAL; RETICULOENDOTHELIAL SYSTEM; WHITE ADIPOSE TISSUE; ADAPTIVE IMMUNITY; ANIMAL; COMPLICATION; DISEASE MODEL; GENETICS; INNATE IMMUNITY; METABOLISM; MOUSE MUTANT; NON-ALCOHOLIC FATTY LIVER DISEASE; PATHOLOGY; PHYSIOLOGY;

ADAPTIVE IMMUNITY; ANIMALS; DISEASE MODELS, ANIMAL; IMMUNITY, INNATE; IRON OVERLOAD; LIVER; MALONDIALDEHYDE; MICE; MICE, OBESE; NON-ALCOHOLIC FATTY LIVER DISEASE; OBESITY; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RECEPTORS, LEPTIN;

EID: 84956898190     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00246.2015     Document Type: Article

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