Split2 Protein-Ligation Generates Active IL-6-Type Hyper-Cytokines from Inactive Precursors

ACS Synthetic Biology

Volumn 6, Issue 12, 2017, Pages 2260-2272

  Moll, Jens M ^a   Wehmöller, Melanie ^a   Frank, Nils C ^a   Homey, Lisa ^a   Baran, Paul ^a   Garbers, Christoph ^b   Lamertz, Larissa ^a   Axelrod, Jonathan H ^c   Galun, Eithan ^c   Mootz, Henning D ^d   Scheller, Jürgen ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

^c HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^d UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

IL 11; IL 6; split inteins; trans signaling

Indexed keywords

HYBRID PROTEIN; INTERLEUKIN 11; INTERLEUKIN 6; IL11 PROTEIN, HUMAN; IL6 PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; COS-7 CELL LINE; CYTOKINE RELEASE; GENETIC TRANSFECTION; HEK293 CELL LINE; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN ASSEMBLY; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; CHLOROCEBUS AETHIOPS; CV-1 CELL LINE; GENETICS; HUMAN; IMMUNOGLOBULIN CONSTANT REGION; TRANS SPLICING;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; HEK293 CELLS; HUMANS; IMMUNOGLOBULIN CONSTANT REGIONS; INTERLEUKIN-11; INTERLEUKIN-6; RECOMBINANT FUSION PROTEINS; TRANS-SPLICING;

EID: 85038632476     PISSN: None     EISSN: 21615063     Source Type: Journal    
DOI: 10.1021/acssynbio.7b00208     Document Type: Article

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