Proteolytic Cleavage Governs Interleukin-11 Trans-signaling

Cell Reports

Volumn 14, Issue 7, 2016, Pages 1761-1773

  Lokau, Juliane ^a   Nitz, Rebecca ^b   Agthe, Maria ^a   Monhasery, Niloufar ^b   Aparicio Siegmund, Samadhi ^a   Schumacher, Neele ^a   Wolf, Janina ^a   Möller Hackbarth, Katja ^a   Waetzig, Georg H ^d   Grötzinger, Joachim ^a   Müller Newen, Gerhard ^c   Rose John, Stefan ^a   Scheller, Jürgen ^b   Garbers, Christoph ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b Department of Orthopedic Surgery   (Germany)

^c RWTH AACHEN UNIVERSITY   (Germany)

^d CONARIS Research Institute AG ^*  (Germany)

Author keywords

ADAM10; ADAM17; Interleukin 11; Proteolysis; Signal transduction

Indexed keywords

ADAM10 ENDOPEPTIDASE; ADAM17 PROTEIN; CHEMICAL COMPOUND; GLYCOPROTEIN GP 130; INTERLEUKIN 11; INTERLEUKIN 11 RECEPTOR; INTERLEUKIN 6 RECEPTOR; LEUKOCYTE ELASTASE; METALLOPROTEINASE; MYELOBLASTIN; SGP130FC; STAT3 PROTEIN; UNCLASSIFIED DRUG; ADAM PROTEIN; ADAM10 PROTEIN, HUMAN; ANTIINFLAMMATORY AGENT; HYBRID PROTEIN; IL11 PROTEIN, HUMAN; MEMBRANE PROTEIN; PROTEIN BINDING; SECRETASE; SGP130FC PROTEIN; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME REGULATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; TRANS SIGNALING; AMINO ACID SEQUENCE; CELL LINE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; IMMUNOLOGY; INFLAMMATION; MOLECULAR GENETICS; MONOCYTE; PATHOLOGY;

ADAM PROTEINS; ADAM10 PROTEIN; ADAM17 PROTEIN; AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANTI-INFLAMMATORY AGENTS; CELL LINE; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; INFLAMMATION; INTERLEUKIN-11; LEUKOCYTE ELASTASE; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MONOCYTES; MYELOBLASTIN; PROTEIN BINDING; PROTEOLYSIS; RECEPTORS, INTERLEUKIN-11; RECEPTORS, INTERLEUKIN-6; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION;

EID: 84959150965     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.01.053     Document Type: Article

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