메뉴 건너뛰기




Volumn 8, Issue 12, 2017, Pages

Synthesis and antioxidant evaluation of lipophilic oleuropein aglycone derivatives†

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; OILS AND FATS; OLIVE OIL;

EID: 85038370870     PISSN: 20426496     EISSN: 2042650X     Source Type: Journal    
DOI: 10.1039/c7fo01105a     Document Type: Article
Times cited : (40)

References (46)
  • 1
    • 0000102060 scopus 로고
    • The constitution of oleuropein, a bitter glucoside of the olive with hypotensive action
    • L. Panizzi, M. L. Scarpati and E. G. Oriente, The constitution of oleuropein, a bitter glucoside of the olive with hypotensive action, Gazz. Chim. Ital., 1960, 90, 1449–1485.
    • (1960) Gazz. Chim. Ital. , vol.90 , pp. 1449-1485
    • Panizzi, L.1    Scarpati, M.L.2    Oriente, E.G.3
  • 2
    • 84907813831 scopus 로고    scopus 로고
    • Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: Focus on protection against cardiovascular and metabolic diseases
    • S. Bulotta, M. Celano, S. M. Lepore, T. Montalcini, A. Pujia and D. Russo, Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases, J. Transl. Med., 2014, 12, 219.
    • (2014) J. Transl. Med. , vol.12 , pp. 219
    • Bulotta, S.1    Celano, M.2    Lepore, S.M.3    Montalcini, T.4    Pujia, A.5    Russo, D.6
  • 3
    • 22744447495 scopus 로고    scopus 로고
    • Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor
    • H. K. Hamdi and R. Castellon, Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor, Biochem. Biophys. Res. Commun., 2005, 334, 769–778.
    • (2005) Biochem. Biophys. Res. Commun. , vol.334 , pp. 769-778
    • Hamdi, H.K.1    Castellon, R.2
  • 4
    • 84991486077 scopus 로고    scopus 로고
    • Anti-cancer properties of olive oil secoiridoid phenols: A systematic review of in vivo studies
    • R. Fabiani, Anti-cancer properties of olive oil secoiridoid phenols: a systematic review of in vivo studies, Food Funct., 2016, 7, 4145–4159.
    • (2016) Food Funct. , vol.7 , pp. 4145-4159
    • Fabiani, R.1
  • 5
    • 0032874140 scopus 로고    scopus 로고
    • On the in-vitro antimicrobial activity of oleuropein and hydroxytyrosol
    • G. Bisignano, A. Tomaino, R. Lo Cascio, G. Crisafi, et al., On the in-vitro antimicrobial activity of oleuropein and hydroxytyrosol, J. Pharm. Pharmacol., 1999, 51, 971–974.
    • (1999) J. Pharm. Pharmacol. , vol.51 , pp. 971-974
    • Bisignano, G.1    Tomaino, A.2    Lo Cascio, R.3    Crisafi, G.4
  • 6
    • 85017120835 scopus 로고    scopus 로고
    • Antimicrobial activity of olea europaea linné extracts and their applicability as natural food preservative agents
    • J. Thielmann, S. Kohnen and C. Hauser, Antimicrobial activity of Olea europaea Linné extracts and their applicability as natural food preservative agents, Int. J. Food Microbiol., 2017, 251, 48–66.
    • (2017) Int. J. Food Microbiol. , vol.251 , pp. 48-66
    • Thielmann, J.1    Kohnen, S.2    Hauser, C.3
  • 7
    • 0028964887 scopus 로고
    • Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil
    • A. Petroni, M. Blasevich, M. Salami, N. Papini, et al., Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil, Thromb. Res., 1995, 78, 151–160.
    • (1995) Thromb. Res. , vol.78 , pp. 151-160
    • Petroni, A.1    Blasevich, M.2    Salami, M.3    Papini, N.4
  • 8
    • 0035219574 scopus 로고    scopus 로고
    • Antiatherogenic components of olive oil
    • F. Visioli and C. Galli, Antiatherogenic components of olive oil, Curr. Atheroscler. Rep., 2001, 3, 64–67.
    • (2001) Curr. Atheroscler. Rep. , vol.3 , pp. 64-67
    • Visioli, F.1    Galli, C.2
  • 9
    • 33645125772 scopus 로고    scopus 로고
    • Noncovalent interaction between amyloid-beta-peptide (1–40) and oleuropein studied by electrospray ionization mass spectrometry
    • F. N. Bazoti, J. Bergquist, K. E. Markides and A. Tsarbopoulos, Noncovalent interaction between amyloid-beta-peptide (1–40) and oleuropein studied by electrospray ionization mass spectrometry, J. Am. Soc. Mass Spectrom., 2006, 17, 568–575.
    • (2006) J. Am. Soc. Mass Spectrom. , vol.17 , pp. 568-575
    • Bazoti, F.N.1    Bergquist, J.2    Markides, K.E.3    Tsarbopoulos, A.4
  • 10
    • 0032499596 scopus 로고    scopus 로고
    • Free radical-scavenging properties of olive oil polyphenols
    • F. Visioli, G. Bellomo and C. Galli, Free radical-scavenging properties of olive oil polyphenols, Biochem. Biophys. Res. Commun., 1998, 247, 60–64.
    • (1998) Biochem. Biophys. Res. Commun. , vol.247 , pp. 60-64
    • Visioli, F.1    Bellomo, G.2    Galli, C.3
  • 11
    • 79951724132 scopus 로고    scopus 로고
    • Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: Comparison with captopril
    • E. Susalit, N. Agus, I. Effendi, R. R. Tjandrawinata, et al., Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: comparison with Captopril, Phytomedicine, 2011, 18, 251–258.
    • (2011) Phytomedicine , vol.18 , pp. 251-258
    • Susalit, E.1    Agus, N.2    Effendi, I.3    Tjandrawinata, R.R.4
  • 12
    • 0000039410 scopus 로고    scopus 로고
    • Isolation of an angiotensin converting enzyme (ACE) inhibitor from olea europaea and olea lancea
    • K. Hansen, A. Adsersen, S. B. Christensen, S. R. Jensen, et al., Isolation of an angiotensin converting enzyme (ACE) inhibitor from Olea europaea and Olea lancea, Phytomedicine, 1996, 2, 319–325.
    • (1996) Phytomedicine , vol.2 , pp. 319-325
    • Hansen, K.1    Adsersen, A.2    Christensen, S.B.3    Jensen, S.R.4
  • 13
    • 55249094771 scopus 로고    scopus 로고
    • Dual inhibition of metallopeptidases ACE and NEP by extracts, and iridoids from ligustrum vulgare l
    • A. K. Kiss, M. Mańk and M. F. Melzig, Dual inhibition of metallopeptidases ACE and NEP by extracts, and iridoids from Ligustrum vulgare L, J. Ethnopharmacol., 2008, 120, 220–225.
    • (2008) J. Ethnopharmacol. , vol.120 , pp. 220-225
    • Kiss, A.K.1    Mańk, M.2    Melzig, M.F.3
  • 14
    • 84865717080 scopus 로고    scopus 로고
    • Anti-inflammatory effect of 3,4-DHPEA-EDA [2-(3,4 -hydroxy-phenyl) ethyl (3S, 4E)-4-formyl-3-(2-oxoethyl)hex-4-enoate] on primary human vascular endothelial cells
    • G. Sindona, A. Caruso, A. Cozza, S. Fiorentini, et al., Anti-inflammatory effect of 3,4-DHPEA-EDA [2-(3,4 -hydroxy-phenyl) ethyl (3S, 4E)-4-formyl-3-(2-oxoethyl)hex-4-enoate] on primary human vascular endothelial cells, Curr. Med. Chem., 2012, 19, 4006–4013.
    • (2012) Curr. Med. Chem. , vol.19 , pp. 4006-4013
    • Sindona, G.1    Caruso, A.2    Cozza, A.3    Fiorentini, S.4
  • 15
    • 84883185036 scopus 로고    scopus 로고
    • Oleuropein and oleacein may restore biological functions of endothelial progenitor cells impaired by angiotensin iI via activation of Nrf2/heme oxygenase-1 pathway
    • A. Parzonko, M. E. Czerwińska, A. K. Kiss and M. Naruszewicz, Oleuropein and oleacein may restore biological functions of endothelial progenitor cells impaired by angiotensin II via activation of Nrf2/heme oxygenase-1 pathway, Phytomedicine, 2013, 20, 1088–1094.
    • (2013) Phytomedicine , vol.20 , pp. 1088-1094
    • Parzonko, A.1    Czerwińska, M.E.2    Kiss, A.K.3    Naruszewicz, M.4
  • 16
    • 0001740068 scopus 로고    scopus 로고
    • 1 h NMR study of phenolics in the vegetation water of three cultivars of olea europaea: Similarities and differences
    • R. Limiroli, R. Consonni, A. Ranalli, G. Bianchi and L. Zetta, 1 H NMR Study of Phenolics in the Vegetation Water of Three Cultivars of Olea europaea: Similarities and Differences, J. Agric. Food Chem., 1996, 44, 2040–2048.
    • (1996) J. Agric. Food Chem. , vol.44 , pp. 2040-2048
    • Limiroli, R.1    Consonni, R.2    Ranalli, A.3    Bianchi, G.4    Zetta, L.5
  • 17
    • 0037132564 scopus 로고    scopus 로고
    • Comparison of the antioxidant activities of extra virgin olive oils
    • V. Lavelli, Comparison of the antioxidant activities of extra virgin olive oils, J. Agric. Food Chem., 2002, 50, 7704–7708.
    • (2002) J. Agric. Food Chem. , vol.50 , pp. 7704-7708
    • Lavelli, V.1
  • 18
    • 84891548692 scopus 로고    scopus 로고
    • Inhibition of human neutrophils NEP activity, cD11b/ cD18 expression and elastase release by 3,4-dihydroxy-phenylethanol-elenolic acid dialdehyde
    • M. E. Czerwińska, A. K. Kiss and M. Naruszewicz, Inhibition of human neutrophils NEP activity, CD11b/ CD18 expression and elastase release by 3,4-dihydroxy-phenylethanol-elenolic acid dialdehyde, oleacein, Food Chem., 2014, 153, 1–8.
    • (2014) Oleacein, Food Chem. , vol.153 , pp. 1-8
    • Czerwińska, M.E.1    Kiss, A.K.2    Naruszewicz, M.3
  • 19
    • 79960700686 scopus 로고    scopus 로고
    • The effects of oleuropein aglycone, an olive oil compound, in a mouse model of carrageenan-induced pleurisy
    • D. Impellizzeri, E. Esposito, E. Mazzon, I. Paterniti, et al., The effects of oleuropein aglycone, an olive oil compound, in a mouse model of carrageenan-induced pleurisy, Clin. Nutr., 2011, 30, 533–540.
    • (2011) Clin. Nutr. , vol.30 , pp. 533-540
    • Impellizzeri, D.1    Esposito, E.2    Mazzon, E.3    Paterniti, I.4
  • 21
    • 28444452301 scopus 로고    scopus 로고
    • Mild and efficient method for the cleavage of benzylidene acetals by using erbium(III) triflate
    • A. Procopio, R. Dalpozzo, A. De Nino, L. Maiuolo, et al., Mild and efficient method for the cleavage of benzylidene acetals by using erbium(III) triflate, Org. Biomol. Chem., 2005, 3, 4129–4133.
    • (2005) Org. Biomol. Chem. , vol.3 , pp. 4129-4133
    • Procopio, A.1    Dalpozzo, R.2    De Nino, A.3    Maiuolo, L.4
  • 22
    • 35748979141 scopus 로고    scopus 로고
    • Simple and efficient MW-assisted cleavage of acetals and ketals in pure water
    • A. Procopio, M. Gaspari, M. Nardi, M. Oliverio, et al., Simple and efficient MW-assisted cleavage of acetals and ketals in pure water, Tetrahedron Lett., 2007, 48, 8623–8627.
    • (2007) Tetrahedron Lett. , vol.48 , pp. 8623-8627
    • Procopio, A.1    Gaspari, M.2    Nardi, M.3    Oliverio, M.4
  • 24
    • 79751485201 scopus 로고    scopus 로고
    • An eco-sustainable erbium(III)-catalyzed method for formation/cleavage of o-tert-butoxy carbonates
    • A. Procopio, G. Cravotto, M. Oliverio, P. Costanzo, et al., An eco-sustainable erbium(III)-catalyzed method for formation/cleavage of O-tert-butoxy carbonates, Green Chem., 2011, 13, 436–463.
    • (2011) Green Chem. , vol.13 , pp. 436-463
    • Procopio, A.1    Cravotto, G.2    Oliverio, M.3    Costanzo, P.4
  • 26
    • 9144252758 scopus 로고    scopus 로고
    • Erbium(III) triflate as an extremely active acylation catalyst
    • A. Procopio, R. Dalpozzo, A. De Nino, L. Maiuolo, et al., Erbium(III) Triflate as an Extremely Active Acylation Catalyst, Adv. Synth. Catal., 2004, 346, 1465–1470.
    • (2004) Adv. Synth. Catal. , vol.346 , pp. 1465-1470
    • Procopio, A.1    Dalpozzo, R.2    De Nino, A.3    Maiuolo, L.4
  • 27
    • 72449145344 scopus 로고    scopus 로고
    • Synthesis, biological evaluation, and molecular modeling of oleuropein and its semisynthetic derivatives as cyclooxy-genase inhibitors
    • A. Procopio, S. Alcaro, M. Nardi, M. Oliverio, et al., Synthesis, biological evaluation, and molecular modeling of oleuropein and its semisynthetic derivatives as cyclooxy-genase inhibitors, J. Agric. Food Chem., 2009, 57, 11161–11167.
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 11161-11167
    • Procopio, A.1    Alcaro, S.2    Nardi, M.3    Oliverio, M.4
  • 28
    • 79953196146 scopus 로고    scopus 로고
    • Antiproliferative and antioxidant effects on breast cancer cells of oleuropein and its semisynthetic peracetylated derivatives
    • S. Bulotta, R. Corradino, M. Celano, M. D’Agostino, et al., Antiproliferative and antioxidant effects on breast cancer cells of oleuropein and its semisynthetic peracetylated derivatives, Food Chem., 2011, 127, 1609–1614.
    • (2011) Food Chem. , vol.127 , pp. 1609-1614
    • Bulotta, S.1    Corradino, R.2    Celano, M.3    D’Agostino, M.4
  • 29
    • 84879972190 scopus 로고    scopus 로고
    • Antioxidant and antigrowth action of peracetylated oleuropein in thyroid cancer cells
    • (a) S. Bulotta, R. Corradino, M. Celano, J. Maiuolo, et al., Antioxidant and antigrowth action of peracetylated oleuropein in thyroid cancer cells, J. Mol. Endocrinol., 2013, 51, 181–189;
    • (2013) J. Mol. Endocrinol. , vol.51 , pp. 181-189
    • Bulotta, S.1    Corradino, R.2    Celano, M.3    Maiuolo, J.4
  • 30
    • 84899838015 scopus 로고    scopus 로고
    • Biomimetic synthesis and antioxidant evaluation of 3,4-DHPEA-EDA [2-(3,4-hydroxyphenyl) ethyl (3S,4E)-4-formyl-3-(2-oxoethyl) hex-4-enoate]
    • (b) M. Nardi, S. Bonacci, G. De Luca, J. Maiuolo, M. Oliverio, G. Sindona and A. Procopio, Biomimetic synthesis and antioxidant evaluation of 3,4-DHPEA-EDA [2-(3,4-hydroxyphenyl) ethyl (3S,4E)-4-formyl-3-(2-oxoethyl) hex-4-enoate], Food Chem., 2014, 162, 89–93.
    • (2014) Food Chem. , vol.162 , pp. 89-93
    • Nardi, M.1    Bonacci, S.2    De Luca, G.3    Maiuolo, J.4    Oliverio, M.5    Sindona, G.6    Procopio, A.7
  • 31
    • 84960192630 scopus 로고    scopus 로고
    • On water” MW-Assisted synthesis of hydroxytyrosol fatty esters
    • M. Oliverio, M. Nardi, L. Cariati, E. Vitale, et al., “On Water” MW-Assisted Synthesis of Hydroxytyrosol Fatty Esters, ACS Sustainable Chem. Eng., 2016, 4, 661–665.
    • (2016) ACS Sustainable Chem. Eng. , vol.4 , pp. 661-665
    • Oliverio, M.1    Nardi, M.2    Cariati, L.3    Vitale, E.4
  • 32
    • 82355187634 scopus 로고    scopus 로고
    • Lipophilic hydroxytyrosol esters: Fatty acid conjugates for potential topical administration
    • A. Procopio, C. Celia, M. Nardi, M. Oliverio, et al., Lipophilic hydroxytyrosol esters: fatty acid conjugates for potential topical administration, J. Nat. Prod., 2011, 74, 2377–2381.
    • (2011) J. Nat. Prod. , vol.74 , pp. 2377-2381
    • Procopio, A.1    Celia, C.2    Nardi, M.3    Oliverio, M.4
  • 33
    • 57049140007 scopus 로고    scopus 로고
    • Enhancing the nail permeability of topically applied drugs
    • S. Murdan, Enhancing the nail permeability of topically applied drugs, Expert Opin. Drug Delivery, 2008, 5, 1267–1282.
    • (2008) Expert Opin. Drug Delivery , vol.5 , pp. 1267-1282
    • Murdan, S.1
  • 34
    • 79952075956 scopus 로고    scopus 로고
    • Determination of n-octanol/water partition coefficient for DDT-related compounds by RP-HPLC with a novel dual-point retention time correction
    • S. Y. Han, J. Q. Qiao, Y. Y. Zhang, L. L. Yang, et al., Determination of n-octanol/water partition coefficient for DDT-related compounds by RP-HPLC with a novel dual-point retention time correction, Chemosphere, 2011, 83, 131–136.
    • (2011) Chemosphere , vol.83 , pp. 131-136
    • Han, S.Y.1    Qiao, J.Q.2    Zhang, Y.Y.3    Yang, L.L.4
  • 35
    • 0034789810 scopus 로고    scopus 로고
    • Application of different RP-HPLC methods for the determination of the octanol/water partition coefficient of selected tetrachloro-benzyltoluenes
    • A. Paschke, M. Manz and G. Schüürmann, Application of different RP-HPLC methods for the determination of the octanol/water partition coefficient of selected tetrachloro-benzyltoluenes, Chemosphere, 2001, 45, 721–728.
    • (2001) Chemosphere , vol.45 , pp. 721-728
    • Paschke, A.1    Manz, M.2    Schüürmann, G.3
  • 36
    • 0032757628 scopus 로고    scopus 로고
    • Determination of octanol-water partition coefficient for terpenoids using reversed-phase high-performance liquid chromatography
    • S. Griffin, S. G. Wyllie and J. Markham, Determination of octanol-water partition coefficient for terpenoids using reversed-phase high-performance liquid chromatography, J. Chromatogr. A, 1999, 864, 221–228.
    • (1999) J. Chromatogr. A , vol.864 , pp. 221-228
    • Griffin, S.1    Wyllie, S.G.2    Markham, J.3
  • 37
    • 20844445334 scopus 로고    scopus 로고
    • Standardized methods for the determination of antioxidant capacity and pheno-lics in foods and dietary supplements
    • R. L. Prior, X. Wu and K. Schaich, Standardized methods for the determination of antioxidant capacity and pheno-lics in foods and dietary supplements, J. Agric. Food Chem., 2005, 53, 4290–4302.
    • (2005) J. Agric. Food Chem. , vol.53 , pp. 4290-4302
    • Prior, R.L.1    Wu, X.2    Schaich, K.3
  • 38
    • 0023847863 scopus 로고
    • Updating of the OECD test guideline 107 “partition coefficient n-octanol/water”: OECD laboratory intercomparison test on the HPLC method
    • W. Klein, W. Kördel, M. Weiß and H. J. Poremski, Updating of the OECD Test Guideline 107 “partition coefficient N-octanol/water”: OECD Laboratory Intercomparison Test on the HPLC method, Chemosphere, 1988, 17, 361–386.
    • (1988) Chemosphere , vol.17 , pp. 361-386
    • Klein, W.1    Kördel, W.2    Weiß, M.3    Poremski, H.J.4
  • 39
    • 0038623975 scopus 로고    scopus 로고
    • Assays for hydrophilic and lipophilic antioxidant capacity (oxygen radical absorbance capacity (ORAC(FL)) of plasma and other biological and food samples
    • R. L. Prior, H. Hoang, L. Gu, X. Wu, et al., Assays for hydrophilic and lipophilic antioxidant capacity (oxygen radical absorbance capacity (ORAC(FL)) of plasma and other biological and food samples, J. Agric. Food Chem., 2003, 51, 3273–3279.
    • (2003) J. Agric. Food Chem. , vol.51 , pp. 3273-3279
    • Prior, R.L.1    Hoang, H.2    Gu, L.3    Wu, X.4
  • 41
    • 0034773950 scopus 로고    scopus 로고
    • Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe
    • B. Ou, M. Hampsch-Woodill and R. L. Prior, Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe, J. Agric. Food Chem., 2001, 49, 4619–4626.
    • (2001) J. Agric. Food Chem. , vol.49 , pp. 4619-4626
    • Ou, B.1    Hampsch-Woodill, M.2    Prior, R.L.3
  • 42
    • 0041732358 scopus 로고    scopus 로고
    • Screening of antioxidant and antimicrobial activities of anise (Pimpinella anisum l.) seed extracts
    • İ. Gülçın, M. Oktay, E. Kıreçcı and Ö. İ. Küfrevıoǧlu, Screening of antioxidant and antimicrobial activities of anise (Pimpinella anisum L.) seed extracts, Food Chem., 2003, 83, 371–382.
    • (2003) Food Chem. , vol.83 , pp. 371-382
    • Gülçın, İ.1    Oktay, M.2    Kıreçcı, E.3    Küfrevıoǧlu, Ö.İ.4
  • 43
    • 0029935490 scopus 로고    scopus 로고
    • Free radical scavenging activity of curcuminoids
    • N. Sreejayan and M. N. Rao, Free radical scavenging activity of curcuminoids, Arzneimittelforschung, 1996, 46, 169–171.
    • (1996) Arzneimittelforschung , vol.46 , pp. 169-171
    • Sreejayan, N.1    Rao, M.N.2
  • 44
    • 34347230544 scopus 로고    scopus 로고
    • Sulforhodamine b colorimetric assay for cytotoxicity screening
    • V. Vichai and K. Kirtikara, Sulforhodamine B colorimetric assay for cytotoxicity screening, Nat. Protoc., 2006, 1, 1112–1116.
    • (2006) Nat. Protoc. , vol.1 , pp. 1112-1116
    • Vichai, V.1    Kirtikara, K.2
  • 45
    • 0025341331 scopus 로고
    • New colorimetric cytotoxicity assay for anticancer-drug screening
    • P. Skehan, R. Storeng, D. Scudiero, A. Monks, et al., New colorimetric cytotoxicity assay for anticancer-drug screening, J. Natl. Cancer Inst., 1990, 82, 1107–1112.
    • (1990) J. Natl. Cancer Inst. , vol.82 , pp. 1107-1112
    • Skehan, P.1    Storeng, R.2    Scudiero, D.3    Monks, A.4
  • 46
    • 84863231493 scopus 로고    scopus 로고
    • Protective effect of theaflavins on neuron against 6-hydroxy-dopamine-induced apoptosis in SH-SY5Y cells
    • L. Zihua, Z. Yan, W. Yuefei, Y. Xianqiang and Z. Baolu, Protective effect of theaflavins on neuron against 6-hydroxy-dopamine-induced apoptosis in SH-SY5Y cells, J. Clin. Biochem. Nutr., 2012, 50(2), 133–138.
    • (2012) J. Clin. Biochem. Nutr. , vol.50 , Issue.2 , pp. 133-138
    • Zihua, L.1    Yan, Z.2    Yuefei, W.3    Xianqiang, Y.4    Baolu, Z.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.