Synthesis, biological evaluation, and molecular modeling of oleuropein and its semisynthetic derivatives as cyclooxygenase inhibitors

Journal of Agricultural and Food Chemistry

Volumn 57, Issue 23, 2009, Pages 11161-11167

  Procopio, Antonio ^a   Alcaro, Stefano ^a   Nardi, Monica ^b   Oliverio, Manuela ^a   Ortuso, Francesco ^a   Sacchetta, Paolo ^c,d   Pieragostino, Damiana ^c,d   Sindona, Giovanni ^b  

^a Dipartimento di Scienze Farmacobiologiche   (Italy)

^b UNIVERSITY OF CALABRIA   (Italy)

^c UNIVERSITY OF CHIETI   (Italy)

^d Centro Studi sull'Invecchiamento   (Italy)

Author keywords

COX 1 and COX 2 inhibitor; Hydroxytyrosol; Lanthanoid triflates; Lewis acid catalyst; Molecular modeling; Oleuropein

Indexed keywords

OLEUROPEIN; PLANT EXTRACT; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; PYRAN DERIVATIVE;

ARTICLE; BINDING SITE; CHEMISTRY; CONFORMATION; OLIVE TREE; PROTEIN BINDING; SYNTHESIS;

BINDING SITES; CYCLOOXYGENASE INHIBITORS; MOLECULAR CONFORMATION; OLEA; PLANT EXTRACTS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN BINDING; PYRANS;

EID: 72449145344     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf9033305     Document Type: Article

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