A recombinant VSV-vectored MERS-CoV vaccine induces neutralizing antibody and T cell responses in rhesus monkeys after single dose immunization

Antiviral Research

Volumn 150, Issue , 2018, Pages 30-38

  Liu, Renqiang ^a   Wang, Jinliang ^a   Shao, Yu ^a   Wang, Xijun ^a   Zhang, Huilei ^a   Shuai, Lei ^a   Ge, Jinying ^a   Wen, Zhiyuan ^a   Bu, Zhigao ^a  

^a INSTITUTE OF PLANT PROTECTION   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CLATHRIN; DIPEPTIDYL PEPTIDASE IV; GUANINE NUCLEOTIDE BINDING PROTEIN; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS VACCINE; NEUTRALIZING ANTIBODY; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VIRUS VACCINE; VIRUS VECTOR; VITRONECTIN; DPP4 PROTEIN, HUMAN; IMMUNOGLOBULIN G; RECOMBINANT VACCINE; VIRUS ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BHK-21 CELL LINE; CELLULAR IMMUNITY; CONTROLLED STUDY; DRUG FORMULATION; FEMALE; GENE EXPRESSION; IMMUNIZATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MIDDLE EAST RESPIRATORY SYNDROME; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; RHESUS MONKEY; SINGLE DRUG DOSE; T LYMPHOCYTE; VERO CELL LINE; VESICULOVIRUS; VIRUS ENVELOPE; VIRUS GENE; VIRUS IMMUNITY; VIRUS RECOMBINANT; VIRUS STRAIN; ANIMAL; CHLOROCEBUS AETHIOPS; CORONAVIRUS INFECTION; DISEASE MODEL; GENE VECTOR; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; REPORTER GENE; VIRUS ENTRY;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; CERCOPITHECUS AETHIOPS; CORONAVIRUS INFECTIONS; DIPEPTIDYL PEPTIDASE 4; DISEASE MODELS, ANIMAL; GENE EXPRESSION; GENES, REPORTER; GENETIC VECTORS; HUMANS; IMMUNOGLOBULIN G; MACACA MULATTA; MALE; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; T-LYMPHOCYTES; VACCINES, SYNTHETIC; VERO CELLS; VIRAL VACCINES; VIRUS INTERNALIZATION;

EID: 85038018275     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2017.12.007     Document Type: Article

References (42)

1. Agrawal, A.S., Garron, T., Tao, X., Peng, B.H., Wakamiya, M., Chan, T.S., Couch, R.B., Tseng, C.T., Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease. J. Virol. 89 (2015), 3659–3670.
2. Annan, A., Baldwin, H.J., Corman, V.M., Klose, S.M., Owusu, M., Nkrumah, E.E., Badu, E.K., Anti, P., Agbenyega, O., Meyer, B., Oppong, S., Sarkodie, Y.A., Kalko, E.K., Lina, P.H., Godlevska, E.V., Reusken, C., Seebens, A., Gloza-Rausch, F., Vallo, P., Tschapka, M., Drosten, C., Drexler, J.F., Human betacoronavirus 2c EMC/2012-related viruses in bats, Ghana and Europe. Emerg. Infect. Dis. 19 (2013), 456–459.
3. Azhar, E.I., El-Kafrawy, S.A., Farraj, S.A., Hassan, A.M., Al-Saeed, M.S., Hashem, A.M., Madani, T.A., Evidence for camel-to-human transmission of MERS coronavirus. N. Engl. J. Med. 370 (2014), 2499–2505.
4. Cureton, D.K., Massol, R.H., Saffarian, S., Kirchhausen, T.L., Whelan, S.P., Vesicular stomatitis virus enters cells through vesicles incompletely coated with clathrin that depend upon actin for internalization. PLoS Pathog., 5, 2009, e1000394.
5. de Wit, E., Rasmussen, A.L., Falzarano, D., Bushmaker, T., Feldmann, F., Brining, D.L., Fischer, E.R., Martellaro, C., Okumura, A., Chang, J., Scott, D., Benecke, A.G., Katze, M.G., Feldmann, H., Munster, V.J., Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques. Proc. Natl. Acad. Sci. U. S. A. 110 (2013), 16598–16603.
6. de Wit, E., van Doremalen, N., Falzarano, D., Munster, V.J., SARS and MERS: recent insights into emerging coronaviruses. Nat. Rev. Microbiol. 14 (2016), 523–534.
7. Falzarano, D., de Wit, E., Feldmann, F., Rasmussen, A.L., Okumura, A., Peng, X., Thomas, M.J., van Doremalen, N., Haddock, E., Nagy, L., LaCasse, R., Liu, T., Zhu, J., McLellan, J.S., Scott, D.P., Katze, M.G., Feldmann, H., Munster, V.J., Infection with MERS-CoV causes lethal pneumonia in the common marmoset. PLoS Pathog., 10, 2014, e1004250.
8. Ge, J., Wang, X., Tao, L., Wen, Z., Feng, N., Yang, S., Xia, X., Yang, C., Chen, H., Bu, Z., Newcastle disease virus-vectored rabies vaccine is safe, highly immunogenic, and provides long-lasting protection in dogs and cats. J. Virol. 85 (2011), 8241–8252.
9. Ge, J., Wen, Z., Wang, X., Hu, S., Liu, Y., Kong, X., Chen, H., Bu, Z., Generating vesicular stomatitis virus pseudotype bearing the severe acute respiratory syndrome coronavirus spike envelope glycoprotein for rapid and safe neutralization test or cell-entry assay. Ann. N. Y. Acad. Sci. 1081 (2006), 246–248.
10. Geisbert, T.W., Geisbert, J.B., Leung, A., Daddario-DiCaprio, K.M., Hensley, L.E., Grolla, A., Feldmann, H., Single-injection vaccine protects nonhuman primates against infection with marburg virus and three species of ebola virus. J. Virol. 83 (2009), 7296–7304.
11. Grehan, K., Ferrara, F., Temperton, N., An optimised method for the production of MERS-CoV spike expressing viral pseudotypes. MethodsX 2 (2015), 379–384.
12. Haagmans, B.L., van den Brand, J.M., Raj, V.S., Volz, A., Wohlsein, P., Smits, S.L., Schipper, D., Bestebroer, T.M., Okba, N., Fux, R., Bensaid, A., Solanes Foz, D., Kuiken, T., Baumgartner, W., Segales, J., Sutter, G., Osterhaus, A.D., An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels. Science 351 (2016), 77–81.
13. Hemida, M.G., Elmoslemany, A., Al-Hizab, F., Alnaeem, A., Almathen, F., Faye, B., Chu, D.K., Perera, R.A., Peiris, M., Dromedary camels and the transmission of Middle East respiratory syndrome coronavirus (MERS-CoV). Transbound. Emerg. Dis. 64 (2017), 344–353.
14. Henao-Restrepo, A.M., Longini, I.M., Egger, M., Dean, N.E., Edmunds, W.J., Camacho, A., Carroll, M.W., Doumbia, M., Draguez, B., Duraffour, S., Enwere, G., Grais, R., Gunther, S., Hossmann, S., Konde, M.K., Kone, S., Kuisma, E., Levine, M.M., Mandal, S., Norheim, G., Riveros, X., Soumah, A., Trelle, S., Vicari, A.S., Watson, C.H., Keita, S., Kieny, M.P., Rottingen, J.A., Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial. Lancet 386 (2015), 857–866.
15. Jaume, M., Yip, M.S., Cheung, C.Y., Leung, H.L., Li, P.H., Kien, F., Dutry, I., Callendret, B., Escriou, N., Altmeyer, R., Nal, B., Daeron, M., Bruzzone, R., Peiris, J.S., Anti-severe acute respiratory syndrome coronavirus spike antibodies trigger infection of human immune cells via a pH- and cysteine protease-independent FcgammaR pathway. J. Virol. 85 (2011), 10582–10597.
16. Kayali, G., Peiris, M., A more detailed picture of the epidemiology of Middle East respiratory syndrome coronavirus. Lancet Infect. Dis. 15 (2015), 495–497.
17. Kong, D., Wen, Z., Su, H., Ge, J., Chen, W., Wang, X., Wu, C., Yang, C., Chen, H., Bu, Z., Newcastle disease virus-vectored Nipah encephalitis vaccines induce B and T cell responses in mice and long-lasting neutralizing antibodies in pigs. Virology 432 (2012), 327–335.
18. Korea Ministry of Health and Welfare, Press Release: MERS Statistics. 2015, Korea Ministry of Health and Welfare, Sejong Available at: http://www.mohw.go.kr/eng/sg/ssg0111vw.jsp?PAR_MENU_ID=1001&MENU_ID=100111&page=1&CONT_SEQ=326092. (Accessed 2 October 2015)
19. Liu, R.Q., Ge, J.Y., Wang, J.L., Shao, Y., Zhang, H.L., Wang, J.L., Wen, Z.Y., Bu, Z.G., Newcastle disease virus-based MERS-CoV candidate vaccine elicits high-level and lasting neutralizing antibodies in Bactrian camels. J. Integr. Agr. 16 (2017), 2264–2273.
20. Malczyk, A.H., Kupke, A., Prufer, S., Scheuplein, V.A., Hutzler, S., Kreuz, D., Beissert, T., Bauer, S., Hubich-Rau, S., Tondera, C., Eldin, H.S., Schmidt, J., Vergara-Alert, J., Suzer, Y., Seifried, J., Hanschmann, K.M., Kalinke, U., Herold, S., Sahin, U., Cichutek, K., Waibler, Z., Eickmann, M., Becker, S., Muhlebach, M.D., A highly immunogenic and protective Middle East respiratory syndrome coronavirus vaccine based on a recombinant measles virus vaccine platform. J. Virol. 89 (2015), 11654–11667.
21. Marzi, A., Feldmann, F., Geisbert, T.W., Feldmann, H., Safronetz, D., Vesicular stomatitis virus-based vaccines against Lassa and Ebola viruses. Emerg. Infect. Dis. 21 (2015), 305–307.
22. Marzi, A., Robertson, S.J., Haddock, E., Feldmann, F., Hanley, P.W., Scott, D.P., Strong, J.E., Kobinger, G., Best, S.M., Feldmann, H., EBOLA VACCINE. VSV-EBOV rapidly protects macaques against infection with the 2014/15 Ebola virus outbreak strain. Science 349 (2015), 739–742.
23. Memish, Z.A., Mishra, N., Olival, K.J., Fagbo, S.F., Kapoor, V., Epstein, J.H., Alhakeem, R., Durosinloun, A., Al Asmari, M., Islam, A., Kapoor, A., Briese, T., Daszak, P., Al Rabeeah, A.A., Lipkin, W.I., Middle East respiratory syndrome coronavirus in bats, Saudi Arabia. Emerg. Infect. Dis. 19 (2013), 1819–1823.
24. Millet, J.K., Whittaker, G.R., Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein. Proc. Natl. Acad. Sci. U. S. A. 111 (2014), 15214–15219.
25. Modjarrad, K., Moorthy, V.S., Ben Embarek, P., Van Kerkhove, M., Kim, J., Kieny, M.P., A roadmap for MERS-CoV research and product development: report from a World Health Organization consultation. Nat. Med. 22 (2016), 701–705.
26. Munster, V.J., de Wit, E., Feldmann, H., Pneumonia from human coronavirus in a macaque model. N. Engl. J. Med. 368 (2013), 1560–1562.
27. Muthumani, K., Falzarano, D., Reuschel, E.L., Tingey, C., Flingai, S., Villarreal, D.O., Wise, M., Patel, A., Izmirly, A., Aljuaid, A., Seliga, A.M., Soule, G., Morrow, M., Kraynyak, K.A., Khan, A.S., Scott, D.P., Feldmann, F., LaCasse, R., Meade-White, K., Okumura, A., Ugen, K.E., Sardesai, N.Y., Kim, J.J., Kobinger, G., Feldmann, H., Weiner, D.B., A synthetic consensus anti-spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates. Sci. Transl. Med., 7, 2015 301ra132.
28. Pascal, K.E., Coleman, C.M., Mujica, A.O., Kamat, V., Badithe, A., Fairhurst, J., Hunt, C., Strein, J., Berrebi, A., Sisk, J.M., Matthews, K.L., Babb, R., Chen, G., Lai, K.M., Huang, T.T., Olson, W., Yancopoulos, G.D., Stahl, N., Frieman, M.B., Kyratsous, C.A., Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection. Proc. Natl. Acad. Sci. U. S. A. 112 (2015), 8738–8743.
29. Qian, Z., Dominguez, S.R., Holmes, K.V., Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation. PLos One, 8, 2013, e76469.
30. Raj, V.S., Mou, H., Smits, S.L., Dekkers, D.H., Muller, M.A., Dijkman, R., Muth, D., Demmers, J.A., Zaki, A., Fouchier, R.A., Thiel, V., Drosten, C., Rottier, P.J., Osterhaus, A.D., Bosch, B.J., Haagmans, B.L., Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Nature 495 (2013), 251–254.
31. Reusken, C.B., Haagmans, B.L., Muller, M.A., Gutierrez, C., Godeke, G.J., Meyer, B., Muth, D., Raj, V.S., Smits-De Vries, L., Corman, V.M., Drexler, J.F., Smits, S.L., El Tahir, Y.E., De Sousa, R., van Beek, J., Nowotny, N., van Maanen, K., Hidalgo-Hermoso, E., Bosch, B.J., Rottier, P., Osterhaus, A., Gortazar-Schmidt, C., Drosten, C., Koopmans, M.P., Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study. Lancet Infect. Dis. 13 (2013), 859–866.
32. Song, F., Fux, R., Provacia, L.B., Volz, A., Eickmann, M., Becker, S., Osterhaus, A.D., Haagmans, B.L., Sutter, G., Middle East respiratory syndrome coronavirus spike protein delivered by modified vaccinia virus Ankara efficiently induces virus-neutralizing antibodies. J. Virol. 87 (2013), 11950–11954.
33. Volz, A., Kupke, A., Song, F., Jany, S., Fux, R., Shams-Eldin, H., Schmidt, J., Becker, C., Eickmann, M., Becker, S., Sutter, G., Protective efficacy of recombinant modified vaccinia virus ankara delivering Middle East respiratory syndrome coronavirus spike glycoprotein. J. Virol. 89 (2015), 8651–8656.
34. Wang, L., Shi, W., Joyce, M.G., Modjarrad, K., Zhang, Y., Leung, K., Lees, C.R., Zhou, T., Yassine, H.M., Kanekiyo, M., Yang, Z.Y., Chen, X., Becker, M.M., Freeman, M., Vogel, L., Johnson, J.C., Olinger, G., Todd, J.P., Bagci, U., Solomon, J., Mollura, D.J., Hensley, L., Jahrling, P., Denison, M.R., Rao, S.S., Subbarao, K., Kwong, P.D., Mascola, J.R., Kong, W.P., Graham, B.S., Evaluation of candidate vaccine approaches for MERS-CoV. Nat. Commun., 6, 2015, 7712.
35. Wang, Q., Qi, J., Yuan, Y., Xuan, Y., Han, P., Wan, Y., Ji, W., Li, Y., Wu, Y., Wang, J., Iwamoto, A., Woo, P.C., Yuen, K.Y., Yan, J., Lu, G., Gao, G.F., Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26. Cell Host Microbe 16 (2014), 328–337.
36. Wang, X., Ge, J., Hu, S., Wang, Q., Wen, Z., Chen, H., Bu, Z., Efficacy of DNA immunization with F and G protein genes of Nipah virus. Ann. N. Y. Acad. Sci. 1081 (2006), 243–245.
37. WHO, 2017. Middle East respiratory syndrome coronavirus (MERS-CoV).
38. Yang, Y., Du, L., Liu, C., Wang, L., Ma, C., Tang, J., Baric, R.S., Jiang, S., Li, F., Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus. Proc. Natl. Acad. Sci. U. S. A. 111 (2014), 12516–12521.
39. Yang, Z.Y., Kong, W.P., Huang, Y., Roberts, A., Murphy, B.R., Subbarao, K., Nabel, G.J., A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice. Nature 428 (2004), 561–564.
40. Yao, Y., Bao, L., Deng, W., Xu, L., Li, F., Lv, Q., Yu, P., Chen, T., Xu, Y., Zhu, H., Yuan, J., Gu, S., Wei, Q., Chen, H., Yuen, K.Y., Qin, C., An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus. J. Infect. Dis. 209 (2014), 236–242.
41. Ying, T., Du, L., Ju, T.W., Prabakaran, P., Lau, C.C., Lu, L., Liu, Q., Wang, L., Feng, Y., Wang, Y., Zheng, B.J., Yuen, K.Y., Jiang, S., Dimitrov, D.S., Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies. J. Virol. 88 (2014), 7796–7805.
42. Zhao, J., Li, K., Wohlford-Lenane, C., Agnihothram, S.S., Fett, C., Zhao, J., Gale, M.J. Jr., Baric, R.S., Enjuanes, L., Gallagher, T., McCray, P.B. Jr., Perlman, S., Rapid generation of a mouse model for Middle East respiratory syndrome. Proc. Natl. Acad. Sci. U. S. A. 111 (2014), 4970–4975.