A Mediterranean-style dietary intervention supplemented with fish oil improves diet quality and mental health in people with depression: A randomized controlled trial (HELFIMED)

Nutritional Neuroscience

Volumn 22, Issue 7, 2019, Pages 474-487

  Parletta, Natalie ^a   Zarnowiecki, Dorota ^a   Cho, Jihyun ^a   Wilson, Amy ^b   Bogomolova, Svetlana ^b   Villani, Anthony ^c   Itsiopoulos, Catherine ^d   Niyonsenga, Theo ^a,e   Blunden, Sarah ^f   Meyer, Barbara ^g   Segal, Leonie ^a   Baune, Bernhard T ^h   O’Dea, Kerin ^a  

^a UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^b UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^c UNIVERSITY OF THE SUNSHINE COAST   (Australia)

^d LA TROBE UNIVERSITY   (Australia)

^e UNIVERSITY OF CANBERRA   (Australia)

^f CENTRAL QUEENSLAND UNIVERSITY   (Australia)

^g UNIVERSITY OF WOLLONGONG   (Australia)

^h UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Depression; Fish oil; Intervention; Mediterranean diet; Mental health; Omega 3; Omega 6; Quality of life

Indexed keywords

FISH OIL; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID;

ADULT; ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DEPRESSION; DEPRESSION ANXIETY STRESS SCALE; DIET THERAPY; FEMALE; GAS CHROMATOGRAPHY; HEALTH BEHAVIOUR QUESTIONNAIRE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDITERRANEAN DIET; MEDITERRANEAN DIET QUESTIONNAIRE; MENTAL HEALTH; NUTRITION; PHYSICAL ACTIVITY; POSITIVE AND NEGATIVE AFFECT SCHEDULE; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); SIMPLE DIETARY QUESTIONNAIRE; SOCIAL STATUS; ADOLESCENT; AGED; BLOOD; DIETARY SUPPLEMENT; MIDDLE AGED; PSYCHOLOGY; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; DEPRESSION; DIET, MEDITERRANEAN; DIETARY SUPPLEMENTS; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; FEMALE; FISH OILS; HUMANS; MALE; MENTAL HEALTH; MIDDLE AGED; QUALITY OF LIFE; TREATMENT OUTCOME; YOUNG ADULT;

EID: 85038010724     PISSN: 1028415X     EISSN: 14768305     Source Type: Journal    
DOI: 10.1080/1028415X.2017.1411320     Document Type: Article

References (59)

1. World Health Organisation. Global status report on noncommunicable diseases. Geneva: WHO Press; 2014.
2. Global Burden of Disease Study 2013 Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 2013 acute and chronic diseases and injuries in 188 countries, 1990–2103: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2015;386(9995):743–800. doi: 10.1016/S0140-6736(15)60692-4
3. Rudisch B, Nemeroff CB., Epidemiology of comorbid coronary artery disease and depression. Biol Psychiatry 2003;54(3):227–40. doi: 10.1016/S0006-3223(03)00587-0
4. Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, et al. A meta-analysis of cytokines in major depression. Biol Psychiatry 2010;67:446–57. doi: 10.1016/j.biopsych.2009.09.033
5. Howren MB, Lamkin DM, Suls J., Associations of depression with C-reactive protein, IL-1, and IL-6: A meta-analysis. Psychosom Med 2009;71:171–86. doi: 10.1097/PSY.0b013e3181907c1b
6. Pasco JA, Nicholson GC, Williams LJ, Jacka FN, Henry MJ, Kotowicz MA, et al. Association of high-sensitivity C-reactive protein with de novo major depression. Br J Psychiatry 2010;197:372–7. doi: 10.1192/bjp.bp.109.076430
7. Frasure-Smith N, Lespérance F, Julien P., Major depression is associated with lower omega-3 fatty acid levels in patients with recent acute coronary syndromes. Biol Psychiatry 2004;55:891–6. doi: 10.1016/j.biopsych.2004.01.021
8. Parletta N, Milte CM, Meyer B., Nutritional modulation of cognitive function and mental health. J Nutr Biochem 2013;24(5):725–43. doi: 10.1016/j.jnutbio.2013.01.002
9. Sinn N, Howe PRC., Mental health benefits of omega-3 fatty acids may be mediated by improvements in cerebral vascular function. Biosci Hypotheses 2008;1(2):103–8. doi: 10.1016/j.bihy.2008.02.003
10. Bach-Faig A, Berry EM, Lairon D, Reguant J, Trichopoulou A, Dernini S, et al. Mediterranean diet pyramid today. Science and cultural updates. Pub Health Nutr 2011;14(12A):2274–84. doi: 10.1017/S1368980011002515
11. Estruch R, Ros E, Salas-Salvado J, Covas M-I, Corella D, Aros F, et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 2013;368(14):1279–90. doi: 10.1056/NEJMoa1200303
12. Nordmann AJ, Suter-Zimmermann K, Bucher HC, Shai I, Tuttle KR, Estruch R, et al. Meta-analysis comparing Mediterranean to low-fat diets for modification of cardiovascular risk factors. Am J Med 2011;124:841–51. doi: 10.1016/j.amjmed.2011.04.024
13. Lai JS, Hiles S, Bisquera A, Hure AJ, McEvoy M, Attia J., A systematic review and meta-analysis of dietary patterns and depression in community-dwelling adults. Am J Clin Nutr 2014;99:181–97. doi: 10.3945/ajcn.113.069880
14. Psaltopoulou T, Sergentanis TN, Panagiotakos DB, Sergentanis IN, Kosti R, Scarmeas N., Mediterranean diet, stroke, cognitive impairment, and depression: A meta-analysis. Ann Neurol 2013;74(4):580–91. doi: 10.1002/ana.23944
15. Parletta N, Aljeesh Y, Baune BT., Health behaviours, knowledge, life satisfaction and wellbeing in people with mental illness across four countries and comparisons with normative sample. Front Psychiatry 2016. doi:10.3389/fpsyt.2016.00145.
16. Zazpe I, Sanchez-Tainta A, Estruch R, Lamuela-Raventos RM, Schröder H, Salas-Salvado J, et al. A large randomised individual and group intervention conducted by registered dietitians increased adherence to Mediterranean-type diets: The PREDIMED study. J Am Diet Assoc 2008;108(7):1134–44. doi: 10.1016/j.jada.2008.04.011
17. Sanchez-Villegas A, Martínez-Gonzalez MA, Estruch R, Salas-Salvadó J, Corella D, Covas M-I, et al. Mediterranean dietary pattern and depression: the PREDIMED randomized trial. BMC Med 2013;11(208). doi:10.1186/741-7015-11-208.
18. Zarnowiecki D, Cho J, Wilson AM, Bogomolova S, Villani A, Itsiopoulos C, et al. A 6-month randomised controlled trial investigating effects of Mediterranean-style diet and fish oil supplementation on dietary behaviour change, mental and cardiometabolic health and health-related quality of life in adults with depression (HELFIMED): study protocol. BMC Nutr 2016;2:e132. doi:10.1186/s40795-016-0095-1 doi: 10.1186/s40795-016-0095-1
19. O’Neil A, Berk M, Itsiopoulos C, Castle D, Opie R, Pizzinga J, et al. A randomised, controlled trial of a dietary intervention for adults with major depression (the ‘SMILES’ trial): study protocol. BMC Psychiatry 2013;13. doi:10.1186/1471-244X-13-114):114.
20. Kleinert S, Horton R., Rethinking and reframing obesity - comment. Lancet 2015. doi:10.1016/S0140-6736(15)60163-5.
21. Johnson PM, Kenny PJ., Addiction-like reward dysfunction and compulsive eating in obese rats: role for dopamine D2 receptors. Nat Neurosci 2010;13(5):635–41. doi: 10.1038/nn.2519
22. Deckersbach T, Das SK, Urban LE, Salinardi T, Batra P, Rodman AM, et al. Pilot randomized trial demonstrating reversal of obesity related abnormalities in reward system responsivity to food cues with a behavioural intervention. Nutr Diab 2014;4:e129. doi:10.1038/nutd.2014.26 doi: 10.1038/nutd.2014.26
23. Milte C, Sinn N, Howe PRC., Polyunsaturated fatty acid status in ADHD, depression and dementia: towards an omega-3 index for mental health? Nutr Rev 2009;67(10):573–90. doi: 10.1111/j.1753-4887.2009.00229.x
24. Parletta N, Zarnowiecki D, Cho J, Wilson A, Procter N, Gordon A, et al. People with schizophrenia and depression have a low omega-3 index. Prostaglandins Leukot Essent Fatty Acids 2016;110:42–7. doi: 10.1016/j.plefa.2016.05.007
25. Cohen J., A power primer. Psychol Bull 1992;112(1):155–9. doi: 10.1037/0033-2909.112.1.155
26. Stuart AL, Pasco JA, Jacka FN, Brennan SL, Berk M, Williams LJ., Comparison of self-report and structured clinical interview in the identification of depression. Compr Psychiatry 2014;55:866–9. doi: 10.1016/j.comppsych.2013.12.019
27. Altman DG, Bland JM., Treatment allocation by minimisation. Br Med J 2005;330:843. doi: 10.1136/bmj.330.7495.843
28. Bogomolova S, Zarnowiecki D, Wilson A, Fielder A, Procter N, Itsiopoulos C, et al. Dietary intervention for people with mental illness in South Australia. Health Promot Int 2016. doi:10.1093/heapro/daw055.
29. Pink B., Socio-economic indexes for areas (SEIFA). Canberra: Australian Bureau of Statistics; 2011.
30. Henry JD, Crawford JR., The short-form version of the depression anxiety stress scales (DASS-21): construct validity and normative data in a large non-clinical sample. Br J Clin Psychol 2005;44(2):227–39. doi: 10.1348/014466505X29657
31. Crawford JR, Cayley C, Lovibond PF, Wilson PH, Hartley C., Percentile norms and accompanying interval estimates from an Australian general adult population sample for self-report mood scales (BAI, BDI, CRSD, CES-D, DASS, DASS-21, STAI-X, STAI-Y, SRDS, and SRAS). Aust Psychol 2011;46(1):3–14. doi: 10.1111/j.1742-9544.2010.00003.x
32. Lovibond SH, Lovibond PF., Manual for the depression anxiety stress scales, 2nd ed. Sydney: Psychology Foundation; 1995.
33. Richardson J, Iezzi A, Khan MA, Maxwell A., Validity and reliability of the assessment of quality of life (AQoL)-8D multi-attribute utility instrument. Patient 2014;7(1):85–96. doi: 10.1007/s40271-013-0036-x
34. Crawford JR, Henry JD., The positive and negative affect schedule (PANAS): construct validity, measurement properties and normative data in a large non-clinical sample. Br J Clin Psychol 2004;43(3):245–65. doi: 10.1348/0144665031752934
35. Martinez-Gonzalez MA, Garcia-Arellano A, Toledo E, Salas-Salvado J, Buil-Cosiales P, Corella D, et al. A 14-item Mediterranean diet assessment tool and obesity indexes among high-risk subjects: the PREDIMED trial. PLoS ONE 2012;7(8):e43134. doi: 10.1371/journal.pone.0043134
36. Martinez-Gonzalez MA, Bes-Rastrollo M., Dietary patterns, Mediterranean diet, and cardiovascular disease. Curr Opin Lipidol 2014;25(1):20–6. doi: 10.1097/MOL.0000000000000044
37. Slavin JL, Lloyd B., Health benefits of fruit and vegetables. Adv Nutr 2012;3:506–16. doi: 10.3945/an.112.002154
38. Swierk M, Williams PG, Wilcox J, Russell KG, Meyer BJ., Validation of an Australian electronic food frequency questionnaire to measure polyunsaturated fatty acid intake. Nutrition 2011;27:641–6. doi: 10.1016/j.nut.2010.06.011
39. Lepage G, Roy CC., Direct transesterification of all classes of lipids in a one-step reaction. J Lipid Res 1986;27:114–20.
40. Kessler RC., Epidemiology of women and depression. J Affect Disord 2003;74(1):5–13. doi: 10.1016/S0165-0327(02)00426-3
41. Loewenstein G, Brennan T, Volpp KG., Asymmetric paternalism to improve health behaviors. JAMA 2007;298(20):2415–7. doi: 10.1001/jama.298.20.2415
42. Cooke L., The importance of exposure for healthy eating in childhood: a review. J Hum Nutr Diet 2007;20(4):294–301. doi: 10.1111/j.1365-277X.2007.00804.x
43. Hartmann C, Dohle S, Siegrist M., Importance of cooking skills for balanced food choices. Appetite 2013;65:125–31. doi: 10.1016/j.appet.2013.01.016
44. Larson NI, Perry CL, Story M, Neumark-Sztainer D., Food preparation by young adults is associated with better diet quality. J Am Diet Assoc 2006;106(12):2001–7. doi: 10.1016/j.jada.2006.09.008
45. Milte CM, Parletta N, Buckley J, Coates A, Young R, Howe P., Increased erythrocyte eicosapentaenoic acid and docosahexaenoic acid are associated with improved attention and behaviour in children with ADHD in a 12-month randomised controlled three-way crossover trial. J Atten Disord 2015;19(11):954–64. doi: 10.1177/1087054713510562
46. Milte CM, Parletta N, Buckley JD, Coates AM, Young RM, Howe PRC., Eicosapentaenoic and docosahexaenoic acids, cognition, and behavior in children with attention deficit hyperactivity disorder: A randomized controlled trial. Nutrition 2012;28(6):670–7. doi: 10.1016/j.nut.2011.12.009
47. Sinn N, Milte CM, Street SJ, Buckley JD, Coates AM, Petkov J, et al. Effects of omega-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: A 6-month randomised controlled trial. Br J Nutr 2012;107(11):1682–93. doi: 10.1017/S0007114511004788
48. Simopoulos AP., The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp Biol Med 2008;233(6):674–88. doi: 10.3181/0711-MR-311
49. Meyer BJ, Mann NJ, Lewis JL, Milligan GC, Sinclair AJ, Howe PRC., Dietary intakes and food sources of omega-6 and omega-3 polyunsaturated fatty acids. Lipids 2003;38:391–8. doi: 10.1007/s11745-003-1074-0
50. Sinn N, Milte C, Howe PRC., Oiling the brain: A review of randomised controlled trials of omega-3 fatty acids in psychopathology across the lifespan. Nutrients 2010;2(2):128–70. doi: 10.3390/nu2020128
51. Stahl LA, Begg DP, Weisinger RS, Sinclair AJ., The role of omega-3 fatty acids in mood disorders. Curr Opin Investig Drugs 2008;9(1):57–64.
52. Jernerén F, Elshorbagy AK, Oulhaj A, Smith SM, Refsum H, Smith AD., Brain atrophy in cognitively imparied elderly: the importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial. Am J Clin Nutr 2015. doi:10.3945/ajcn.114.103283.
53. Pfeiffer PN, Heisler M, Piette JD, Rogers MAM, Valenstein M., Efficacy of peer support interventions for depression: a meta-analysis. Gen Hosp Psychiatry 2011;33(1):29–36. doi: 10.1016/j.genhosppsych.2010.10.002
54. Kaplan BJ, Crawford SG, Field CJ, Simpson JSA., Vitamins, minerals and mood. Psychol Bull 2007;133(5):747–60. doi: 10.1037/0033-2909.133.5.747
55. Kaplan BJ, Rucklidge JJ, Romjin A, McLeod K., The emerging field of nutritional mental health: inflammation, the microbiome, oxidative stress, and mitochondrial function. Clin Psychol Sci 2015. doi:10.1177/2167702614555413:1017.
56. Agrawal R, Gomez-Pinilla F., ‘Metabolic syndrome’ in the brain: deficiency in omega-3 fatty acid exacerbates dysfunctions in insulin receptor signalling and cognition. J Physiol 2012;590(10):2485–99. doi: 10.1113/jphysiol.2012.230078
57. Perez-Cornago A, Lopez-Legarrea P, de la Iglesia R, Lahortiga F, Martinez JA, Zulet MA., Longitudinal relationship of diet and oxidative stress with depressive symptoms in patients with metabolic syndrome after following a weight loss treatment: the Resmena Project. Clin Nutr 2014;33:1061–7. doi: 10.1016/j.clnu.2013.11.011
58. Stahl ST, Albert SM, Dew MA, Lockovich MH, Reynolds CF., Coaching in healthy dietary practices in at-risk older adults: a case of indicated depression prevention. Am J Psychiatry 2014;171(5):499–505. doi: 10.1176/appi.ajp.2013.13101373
59. Jacka FN, O’Neil A, Itsiopoulos C, Opie R, Cotton S, Mohebbi M, et al. A randomised, controlled trial of dietary improvement for adults with major depression (the ‘SMILES’ trial). BMC Med 2017;15:181. doi:10.1186/s12916-017-0791-y doi: 10.1186/s12916-017-0791-y