-
1
-
-
79952302420
-
Genetic disorders of vitamin B(1)(2) metabolism: eight complementation groups–eight genes
-
Froese, D.S., Gravel, R.A., Genetic disorders of vitamin B(1)(2) metabolism: eight complementation groups–eight genes. Expert Rev. Mol. Med., 12, 2010, e37.
-
(2010)
Expert Rev. Mol. Med.
, vol.12
, pp. e37
-
-
Froese, D.S.1
Gravel, R.A.2
-
2
-
-
33845937432
-
Structure of ATP-bound human ATP:cobalamin adenosyltransferase
-
Schubert, H.L., Hill, C.P., Structure of ATP-bound human ATP:cobalamin adenosyltransferase. Biochemistry 45 (2006), 15188–15196.
-
(2006)
Biochemistry
, vol.45
, pp. 15188-15196
-
-
Schubert, H.L.1
Hill, C.P.2
-
3
-
-
40749148973
-
Methylmalonic acidaemia: examination of genotype and biochemical data in 32 patients belonging to mut, cblA or cblB complementation group
-
Merinero, B., Perez, B., Perez-Cerda, C., Rincon, A., Desviat, L.R., Martinez, M.A., Sala, P.R., Garcia, M.J., Aldamiz-Echevarria, L., Campos, J., Cornejo, V., Del Toro, M., Mahfoud, A., Martinez-Pardo, M., Parini, R., Pedron, C., Pena-Quintana, L., Perez, M., Pourfarzam, M., Ugarte, M., Methylmalonic acidaemia: examination of genotype and biochemical data in 32 patients belonging to mut, cblA or cblB complementation group. J. Inherit. Metab. Dis. 31 (2008), 55–66.
-
(2008)
J. Inherit. Metab. Dis.
, vol.31
, pp. 55-66
-
-
Merinero, B.1
Perez, B.2
Perez-Cerda, C.3
Rincon, A.4
Desviat, L.R.5
Martinez, M.A.6
Sala, P.R.7
Garcia, M.J.8
Aldamiz-Echevarria, L.9
Campos, J.10
Cornejo, V.11
Del Toro, M.12
Mahfoud, A.13
Martinez-Pardo, M.14
Parini, R.15
Pedron, C.16
Pena-Quintana, L.17
Perez, M.18
Pourfarzam, M.19
Ugarte, M.20
more..
-
4
-
-
0037115485
-
Identification of the gene responsible for the cblB complementation group of vitamin B12-dependent methylmalonic aciduria
-
Dobson, C.M., Wai, T., Leclerc, D., Kadir, H., Narang, M., Lerner-Ellis, J.P., Hudson, T.J., Rosenblatt, D.S., Gravel, R.A., Identification of the gene responsible for the cblB complementation group of vitamin B12-dependent methylmalonic aciduria. Hum. Mol. Genet. 11 (2002), 3361–3369.
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 3361-3369
-
-
Dobson, C.M.1
Wai, T.2
Leclerc, D.3
Kadir, H.4
Narang, M.5
Lerner-Ellis, J.P.6
Hudson, T.J.7
Rosenblatt, D.S.8
Gravel, R.A.9
-
5
-
-
45849132005
-
Causes of and diagnostic approach to methylmalonic acidurias
-
Fowler, B., Leonard, J.V., Baumgartner, M.R., Causes of and diagnostic approach to methylmalonic acidurias. J. Inherit. Metab. Dis. 31 (2008), 350–360.
-
(2008)
J. Inherit. Metab. Dis.
, vol.31
, pp. 350-360
-
-
Fowler, B.1
Leonard, J.V.2
Baumgartner, M.R.3
-
6
-
-
84930182323
-
Treatment of methylmalonic acidemia by liver or combined liver-kidney transplantation
-
(e1451)
-
Niemi, A.K., Kim, I.K., Krueger, C.E., Cowan, T.M., Baugh, N., Farrell, R., Bonham, C.A., Concepcion, W., Esquivel, C.O., Enns, G.M., Treatment of methylmalonic acidemia by liver or combined liver-kidney transplantation. J. Pediatr. 166 (2015), 1455–1461 (e1451).
-
(2015)
J. Pediatr.
, vol.166
, pp. 1455-1461
-
-
Niemi, A.K.1
Kim, I.K.2
Krueger, C.E.3
Cowan, T.M.4
Baugh, N.5
Farrell, R.6
Bonham, C.A.7
Concepcion, W.8
Esquivel, C.O.9
Enns, G.M.10
-
7
-
-
77956297615
-
Functional and structural analysis of five mutations identified in methylmalonic aciduria cblB type
-
Jorge-Finnigan, A., Aguado, C., Sanchez-Alcudia, R., Abia, D., Richard, E., Merinero, B., Gamez, A., Banerjee, R., Desviat, L.R., Ugarte, M., Perez, B., Functional and structural analysis of five mutations identified in methylmalonic aciduria cblB type. Hum. Mutat. 31 (2010), 1033–1042.
-
(2010)
Hum. Mutat.
, vol.31
, pp. 1033-1042
-
-
Jorge-Finnigan, A.1
Aguado, C.2
Sanchez-Alcudia, R.3
Abia, D.4
Richard, E.5
Merinero, B.6
Gamez, A.7
Banerjee, R.8
Desviat, L.R.9
Ugarte, M.10
Perez, B.11
-
8
-
-
84882931235
-
Pharmacological chaperones as a potential therapeutic option in methylmalonic aciduria cblB type
-
Jorge-Finnigan, A., Brasil, S., Underhaug, J., Ruiz-Sala, P., Merinero, B., Banerjee, R., Desviat, L.R., Ugarte, M., Martinez, A., Perez, B., Pharmacological chaperones as a potential therapeutic option in methylmalonic aciduria cblB type. Hum. Mol. Genet. 22 (2013), 3680–3689.
-
(2013)
Hum. Mol. Genet.
, vol.22
, pp. 3680-3689
-
-
Jorge-Finnigan, A.1
Brasil, S.2
Underhaug, J.3
Ruiz-Sala, P.4
Merinero, B.5
Banerjee, R.6
Desviat, L.R.7
Ugarte, M.8
Martinez, A.9
Perez, B.10
-
9
-
-
85008496913
-
When proteostasis goes bad: protein aggregation in the cell
-
Radwan, M., Wood, R.J., Sui, X., Hatters, D.M., When proteostasis goes bad: protein aggregation in the cell. IUBMB Life 69 (2017), 49–54.
-
(2017)
IUBMB Life
, vol.69
, pp. 49-54
-
-
Radwan, M.1
Wood, R.J.2
Sui, X.3
Hatters, D.M.4
-
10
-
-
84890204277
-
Protein quality control and elimination of protein waste: the role of the ubiquitin-proteasome system
-
Amm, I., Sommer, T., Wolf, D.H., Protein quality control and elimination of protein waste: the role of the ubiquitin-proteasome system. Biochim. Biophys. Acta 2014 (1843), 182–196.
-
(1843)
Biochim. Biophys. Acta
, vol.2014
, pp. 182-196
-
-
Amm, I.1
Sommer, T.2
Wolf, D.H.3
-
11
-
-
84904099631
-
Innovative strategies to treat protein misfolding in inborn errors of metabolism: pharmacological chaperones and proteostasis regulators
-
Muntau, A.C., Leandro, J., Staudigl, M., Mayer, F., Gersting, S.W., Innovative strategies to treat protein misfolding in inborn errors of metabolism: pharmacological chaperones and proteostasis regulators. J. Inherit. Metab. Dis. 37 (2014), 505–523.
-
(2014)
J. Inherit. Metab. Dis.
, vol.37
, pp. 505-523
-
-
Muntau, A.C.1
Leandro, J.2
Staudigl, M.3
Mayer, F.4
Gersting, S.W.5
-
12
-
-
84973121809
-
From structural biology to designing therapy for inborn errors of metabolism
-
Yue, W.W., From structural biology to designing therapy for inborn errors of metabolism. J. Inherit. Metab. Dis. 39 (2016), 489–498.
-
(2016)
J. Inherit. Metab. Dis.
, vol.39
, pp. 489-498
-
-
Yue, W.W.1
-
13
-
-
84901912352
-
Pharmacological chaperoning: a primer on mechanism and pharmacology
-
Leidenheimer, N.J., Ryder, K.G., Pharmacological chaperoning: a primer on mechanism and pharmacology. Pharmacol. Res. 83 (2014), 10–19.
-
(2014)
Pharmacol. Res.
, vol.83
, pp. 10-19
-
-
Leidenheimer, N.J.1
Ryder, K.G.2
-
14
-
-
84900131626
-
Pharmacological chaperones for enzyme enhancement therapy in genetic diseases
-
Aymami, J., Barril, X., Rodriguez-Pascau, L., Martinell, M., Pharmacological chaperones for enzyme enhancement therapy in genetic diseases. Pharm. Pat. Anal. 2 (2013), 109–124.
-
(2013)
Pharm. Pat. Anal.
, vol.2
, pp. 109-124
-
-
Aymami, J.1
Barril, X.2
Rodriguez-Pascau, L.3
Martinell, M.4
-
15
-
-
84870609952
-
Pharmacological enhancement of alpha-glucosidase by the allosteric chaperone N-acetylcysteine
-
Porto, C., Ferrara, M.C., Meli, M., Acampora, E., Avolio, V., Rosa, M., Cobucci-Ponzano, B., Colombo, G., Moracci, M., Andria, G., Parenti, G., Pharmacological enhancement of alpha-glucosidase by the allosteric chaperone N-acetylcysteine. Mol. Ther. 20 (2012), 2201–2211.
-
(2012)
Mol. Ther.
, vol.20
, pp. 2201-2211
-
-
Porto, C.1
Ferrara, M.C.2
Meli, M.3
Acampora, E.4
Avolio, V.5
Rosa, M.6
Cobucci-Ponzano, B.7
Colombo, G.8
Moracci, M.9
Andria, G.10
Parenti, G.11
-
16
-
-
84873052980
-
A new model for allosteric regulation of phenylalanine hydroxylase: implications for disease and therapeutics
-
Jaffe, E.K., Stith, L., Lawrence, S.H., Andrake, M., Dunbrack, R.L. Jr., A new model for allosteric regulation of phenylalanine hydroxylase: implications for disease and therapeutics. Arch. Biochem. Biophys. 530 (2013), 73–82.
-
(2013)
Arch. Biochem. Biophys.
, vol.530
, pp. 73-82
-
-
Jaffe, E.K.1
Stith, L.2
Lawrence, S.H.3
Andrake, M.4
Dunbrack, R.L.5
-
17
-
-
84901840776
-
Using pharmacological chaperones to restore proteostasis
-
Wang, Y.J., Di, X.J., Mu, T.W., Using pharmacological chaperones to restore proteostasis. Pharmacol. Res. 83 (2014), 3–9.
-
(2014)
Pharmacol. Res.
, vol.83
, pp. 3-9
-
-
Wang, Y.J.1
Di, X.J.2
Mu, T.W.3
-
18
-
-
50249175120
-
Chemical and biological approaches synergize to ameliorate protein-folding diseases
-
Mu, T.W., Ong, D.S., Wang, Y.J., Balch, W.E., Yates, J.R. 3rd, Segatori, L., Kelly, J.W., Chemical and biological approaches synergize to ameliorate protein-folding diseases. Cell 134 (2008), 769–781.
-
(2008)
Cell
, vol.134
, pp. 769-781
-
-
Mu, T.W.1
Ong, D.S.2
Wang, Y.J.3
Balch, W.E.4
Yates, J.R.5
Segatori, L.6
Kelly, J.W.7
-
19
-
-
33645113221
-
Impact of cblB mutations on the function of ATP:cob(I)alamin adenosyltransferase in disorders of vitamin B12 metabolism
-
Zhang, J., Dobson, C.M., Wu, X., Lerner-Ellis, J., Rosenblatt, D.S., Gravel, R.A., Impact of cblB mutations on the function of ATP:cob(I)alamin adenosyltransferase in disorders of vitamin B12 metabolism. Mol. Genet. Metab. 87 (2006), 315–322.
-
(2006)
Mol. Genet. Metab.
, vol.87
, pp. 315-322
-
-
Zhang, J.1
Dobson, C.M.2
Wu, X.3
Lerner-Ellis, J.4
Rosenblatt, D.S.5
Gravel, R.A.6
-
20
-
-
70349735996
-
Ligand-binding by catalytically inactive mutants of the cblB complementation group defective in human ATP:cob(I)alamin adenosyltransferase
-
Zhang, J., Wu, X., Padovani, D., Schubert, H.L., Gravel, R.A., Ligand-binding by catalytically inactive mutants of the cblB complementation group defective in human ATP:cob(I)alamin adenosyltransferase. Mol. Genet. Metab. 98 (2009), 278–284.
-
(2009)
Mol. Genet. Metab.
, vol.98
, pp. 278-284
-
-
Zhang, J.1
Wu, X.2
Padovani, D.3
Schubert, H.L.4
Gravel, R.A.5
-
21
-
-
0024800868
-
Successful first trimester diagnosis in a pregnancy at risk for propionic acidaemia
-
Perez-Cerda, C., Merinero, B., Sanz, P., Jimenez, A., Garcia, M.J., Urbon, A., Diaz Recasens, J., Ramos, C., Ayuso, C., Ugarte, M., Successful first trimester diagnosis in a pregnancy at risk for propionic acidaemia. J. Inherit. Metab. Dis. 12:Suppl. 2 (1989), 274–276.
-
(1989)
J. Inherit. Metab. Dis.
, vol.12
, pp. 274-276
-
-
Perez-Cerda, C.1
Merinero, B.2
Sanz, P.3
Jimenez, A.4
Garcia, M.J.5
Urbon, A.6
Diaz Recasens, J.7
Ramos, C.8
Ayuso, C.9
Ugarte, M.10
-
22
-
-
0002056004
-
Microcalorimetry and the molecular recognition of peptides and proteins
-
Cooper, A., McAuley-Hecht, K., Microcalorimetry and the molecular recognition of peptides and proteins. Philos. Trans. R. Soc. Lond. 345 (1993), 23–35.
-
(1993)
Philos. Trans. R. Soc. Lond.
, vol.345
, pp. 23-35
-
-
Cooper, A.1
McAuley-Hecht, K.2
-
23
-
-
77950571108
-
New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays
-
Baell, J.B., Holloway, G.A., New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. J. Med. Chem. 53 (2010), 2719–2740.
-
(2010)
J. Med. Chem.
, vol.53
, pp. 2719-2740
-
-
Baell, J.B.1
Holloway, G.A.2
-
24
-
-
84862859338
-
Rhodanine as a scaffold in drug discovery: a critical review of its biological activities and mechanisms of target modulation
-
Tomasic, T., Peterlin Masic, L., Rhodanine as a scaffold in drug discovery: a critical review of its biological activities and mechanisms of target modulation. Expert Opin. Drug Discovery 7 (2012), 549–560.
-
(2012)
Expert Opin. Drug Discovery
, vol.7
, pp. 549-560
-
-
Tomasic, T.1
Peterlin Masic, L.2
-
25
-
-
11844253252
-
ALARM NMR: a rapid and robust experimental method to detect reactive false positives in biochemical screens
-
Huth, J.R., Mendoza, R., Olejniczak, E.T., Johnson, R.W., Cothron, D.A., Liu, Y., Lerner, C.G., Chen, J., Hajduk, P.J., ALARM NMR: a rapid and robust experimental method to detect reactive false positives in biochemical screens. J. Am. Chem. Soc. 127 (2005), 217–224.
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 217-224
-
-
Huth, J.R.1
Mendoza, R.2
Olejniczak, E.T.3
Johnson, R.W.4
Cothron, D.A.5
Liu, Y.6
Lerner, C.G.7
Chen, J.8
Hajduk, P.J.9
-
26
-
-
0037030653
-
Molecular properties that influence the oral bioavailability of drug candidates
-
Veber, D.F., Johnson, S.R., Cheng, H.Y., Smith, B.R., Ward, K.W., Kopple, K.D., Molecular properties that influence the oral bioavailability of drug candidates. J. Med. Chem. 45 (2002), 2615–2623.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 2615-2623
-
-
Veber, D.F.1
Johnson, S.R.2
Cheng, H.Y.3
Smith, B.R.4
Ward, K.W.5
Kopple, K.D.6
-
27
-
-
0034609833
-
Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties
-
Ertl, P., Rohde, B., Selzer, P., Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties. J. Med. Chem. 43 (2000), 3714–3717.
-
(2000)
J. Med. Chem.
, vol.43
, pp. 3714-3717
-
-
Ertl, P.1
Rohde, B.2
Selzer, P.3
-
28
-
-
33846078171
-
Identification and evaluation of molecular properties related to preclinical optimization and clinical fate
-
Blake, J.F., Identification and evaluation of molecular properties related to preclinical optimization and clinical fate. Med. Chem. 1 (2005), 649–655.
-
(2005)
Med. Chem.
, vol.1
, pp. 649-655
-
-
Blake, J.F.1
-
29
-
-
0033194752
-
Strategic pooling of compounds for high-throughput screening
-
Hann, M., Hudson, B., Lewell, X., Lifely, R., Miller, L., Ramsden, N., Strategic pooling of compounds for high-throughput screening. J. Chem. Inf. Comput. Sci. 39 (1999), 897–902.
-
(1999)
J. Chem. Inf. Comput. Sci.
, vol.39
, pp. 897-902
-
-
Hann, M.1
Hudson, B.2
Lewell, X.3
Lifely, R.4
Miller, L.5
Ramsden, N.6
-
30
-
-
0012286670
-
Pharmacokinetically based mapping device for chemical space navigation
-
Oprea, T.I., Zamora, I., Ungell, A.L., Pharmacokinetically based mapping device for chemical space navigation. J. Comb. Chem. 4 (2002), 258–266.
-
(2002)
J. Comb. Chem.
, vol.4
, pp. 258-266
-
-
Oprea, T.I.1
Zamora, I.2
Ungell, A.L.3
-
31
-
-
33745172773
-
A journey of hope: lessons learned from studies on rare diseases and orphan drugs
-
Wastfelt, M., Fadeel, B., Henter, J.I., A journey of hope: lessons learned from studies on rare diseases and orphan drugs. J. Intern. Med. 260 (2006), 1–10.
-
(2006)
J. Intern. Med.
, vol.260
, pp. 1-10
-
-
Wastfelt, M.1
Fadeel, B.2
Henter, J.I.3
-
32
-
-
85006097765
-
Pharmacological chaperoning: a potential treatment for PMM2-CDG
-
Yuste-Checa, P., Brasil, S., Gamez, A., Underhaug, J., Desviat, L.R., Ugarte, M., Perez-Cerda, C., Martinez, A., Perez, B., Pharmacological chaperoning: a potential treatment for PMM2-CDG. Hum. Mutat. 38 (2017), 160–168.
-
(2017)
Hum. Mutat.
, vol.38
, pp. 160-168
-
-
Yuste-Checa, P.1
Brasil, S.2
Gamez, A.3
Underhaug, J.4
Desviat, L.R.5
Ugarte, M.6
Perez-Cerda, C.7
Martinez, A.8
Perez, B.9
-
33
-
-
33644644820
-
Mutation and biochemical analysis of patients belonging to the cblB complementation class of vitamin B12-dependent methylmalonic aciduria
-
Lerner-Ellis, J.P., Gradinger, A.B., Watkins, D., Tirone, J.C., Villeneuve, A., Dobson, C.M., Montpetit, A., Lepage, P., Gravel, R.A., Rosenblatt, D.S., Mutation and biochemical analysis of patients belonging to the cblB complementation class of vitamin B12-dependent methylmalonic aciduria. Mol. Genet. Metab. 87 (2006), 219–225.
-
(2006)
Mol. Genet. Metab.
, vol.87
, pp. 219-225
-
-
Lerner-Ellis, J.P.1
Gradinger, A.B.2
Watkins, D.3
Tirone, J.C.4
Villeneuve, A.5
Dobson, C.M.6
Montpetit, A.7
Lepage, P.8
Gravel, R.A.9
Rosenblatt, D.S.10
-
34
-
-
77449098166
-
Treating lysosomal storage diseases with pharmacological chaperones: from concept to clinics
-
Parenti, G., Treating lysosomal storage diseases with pharmacological chaperones: from concept to clinics. EMBO Mol. Med. 1 (2009), 268–279.
-
(2009)
EMBO Mol. Med.
, vol.1
, pp. 268-279
-
-
Parenti, G.1
-
35
-
-
67349206148
-
The pharmacological chaperone N-butyldeoxynojirimycin enhances enzyme replacement therapy in Pompe disease fibroblasts
-
Porto, C., Cardone, M., Fontana, F., Rossi, B., Tuzzi, M.R., Tarallo, A., Barone, M.V., Andria, G., Parenti, G., The pharmacological chaperone N-butyldeoxynojirimycin enhances enzyme replacement therapy in Pompe disease fibroblasts. Mol. Ther. 17 (2009), 964–971.
-
(2009)
Mol. Ther.
, vol.17
, pp. 964-971
-
-
Porto, C.1
Cardone, M.2
Fontana, F.3
Rossi, B.4
Tuzzi, M.R.5
Tarallo, A.6
Barone, M.V.7
Andria, G.8
Parenti, G.9
-
36
-
-
79957628617
-
Identification and characterization of pharmacological chaperones to correct enzyme deficiencies in lysosomal storage disorders
-
Valenzano, K.J., Khanna, R., Powe, A.C., Boyd, R., Lee, G., Flanagan, J.J., Benjamin, E.R., Identification and characterization of pharmacological chaperones to correct enzyme deficiencies in lysosomal storage disorders. Assay Drug Dev. Technol. 9 (2011), 213–235.
-
(2011)
Assay Drug Dev. Technol.
, vol.9
, pp. 213-235
-
-
Valenzano, K.J.1
Khanna, R.2
Powe, A.C.3
Boyd, R.4
Lee, G.5
Flanagan, J.J.6
Benjamin, E.R.7
-
37
-
-
84873397801
-
Novel pharmacological strategies to treat cystic fibrosis
-
Hanrahan, J.W., Sampson, H.M., Thomas, D.Y., Novel pharmacological strategies to treat cystic fibrosis. Trends Pharmacol. Sci. 34 (2013), 119–125.
-
(2013)
Trends Pharmacol. Sci.
, vol.34
, pp. 119-125
-
-
Hanrahan, J.W.1
Sampson, H.M.2
Thomas, D.Y.3
-
38
-
-
84912103263
-
The proteasome inhibitor bortezomib reduced cholesterol accumulation in fibroblasts from Niemann-pick type C patients carrying missense mutations
-
Macias-Vidal, J., Giros, M., Guerrero, M., Gascon, P., Serratosa, J., Bachs, O., Coll, M.J., The proteasome inhibitor bortezomib reduced cholesterol accumulation in fibroblasts from Niemann-pick type C patients carrying missense mutations. FEBS J. 281 (2014), 4450–4466.
-
(2014)
FEBS J.
, vol.281
, pp. 4450-4466
-
-
Macias-Vidal, J.1
Giros, M.2
Guerrero, M.3
Gascon, P.4
Serratosa, J.5
Bachs, O.6
Coll, M.J.7
-
39
-
-
48749132287
-
Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria
-
Pey, A.L., Ying, M., Cremades, N., Velazquez-Campoy, A., Scherer, T., Thony, B., Sancho, J., Martinez, A., Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria. J. Clin. Invest. 118 (2008), 2858–2867.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 2858-2867
-
-
Pey, A.L.1
Ying, M.2
Cremades, N.3
Velazquez-Campoy, A.4
Scherer, T.5
Thony, B.6
Sancho, J.7
Martinez, A.8
-
40
-
-
84859261141
-
Novel pharmacological chaperones that correct phenylketonuria in mice
-
Santos-Sierra, S., Kirchmair, J., Perna, A.M., Reiss, D., Kemter, K., Roschinger, W., Glossmann, H., Gersting, S.W., Muntau, A.C., Wolber, G., Lagler, F.B., Novel pharmacological chaperones that correct phenylketonuria in mice. Hum. Mol. Genet. 21 (2012), 1877–1887.
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 1877-1887
-
-
Santos-Sierra, S.1
Kirchmair, J.2
Perna, A.M.3
Reiss, D.4
Kemter, K.5
Roschinger, W.6
Glossmann, H.7
Gersting, S.W.8
Muntau, A.C.9
Wolber, G.10
Lagler, F.B.11
-
41
-
-
79958701058
-
Growing PAINS in academic drug discovery
-
Whitty, A., Growing PAINS in academic drug discovery. Future Med. Chem. 3 (2011), 797–801.
-
(2011)
Future Med. Chem.
, vol.3
, pp. 797-801
-
-
Whitty, A.1
-
42
-
-
84926291678
-
Mitigating risk in academic preclinical drug discovery
-
Dahlin, J.L., Inglese, J., Walters, M.A., Mitigating risk in academic preclinical drug discovery. Nat. Rev. Drug Discov. 14 (2015), 279–294.
-
(2015)
Nat. Rev. Drug Discov.
, vol.14
, pp. 279-294
-
-
Dahlin, J.L.1
Inglese, J.2
Walters, M.A.3
-
43
-
-
84924708699
-
Screening-based translation of public research encounters painful problems
-
Baell, J.B., Screening-based translation of public research encounters painful problems. ACS Med. Chem. Lett. 6 (2015), 229–234.
-
(2015)
ACS Med. Chem. Lett.
, vol.6
, pp. 229-234
-
-
Baell, J.B.1
-
44
-
-
0035289779
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski, C.A., Lombardo, F., Dominy, B.W., Feeney, P.J., Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 46 (2001), 3–26.
-
(2001)
Adv. Drug Deliv. Rev.
, vol.46
, pp. 3-26
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
45
-
-
13244266921
-
Lead- and drug-like compounds: the rule-of-five revolution
-
Lipinski, C.A., Lead- and drug-like compounds: the rule-of-five revolution. Drug Discov. Today Technol. 1 (2004), 337–341.
-
(2004)
Drug Discov. Today Technol.
, vol.1
, pp. 337-341
-
-
Lipinski, C.A.1
-
46
-
-
85016268657
-
In vitro generated hepatocyte-like cells: a novel tool in regenerative medicine and drug discovery
-
Zakikhan, K., Pournasr, B., Vosough, M., Nassiri-Asl, M., In vitro generated hepatocyte-like cells: a novel tool in regenerative medicine and drug discovery. Cell J. 19 (2017), 204–217.
-
(2017)
Cell J.
, vol.19
, pp. 204-217
-
-
Zakikhan, K.1
Pournasr, B.2
Vosough, M.3
Nassiri-Asl, M.4
-
47
-
-
84873799110
-
Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli
-
Bertani, G., Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. J. Bacteriol. 62 (1951), 293–300.
-
(1951)
J. Bacteriol.
, vol.62
, pp. 293-300
-
-
Bertani, G.1
-
48
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford, M.M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976), 248–254.
-
(1976)
Anal. Biochem.
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
49
-
-
37249005205
-
The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability
-
Niesen, F.H., Berglund, H., Vedadi, M., The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability. Nat. Protoc. 2 (2007), 2212–2221.
-
(2007)
Nat. Protoc.
, vol.2
, pp. 2212-2221
-
-
Niesen, F.H.1
Berglund, H.2
Vedadi, M.3
-
50
-
-
84869413146
-
Oxidative stress and apoptosis in homocystinuria patients with genetic remethylation defects
-
Richard, E., Desviat, L.R., Ugarte, M., Perez, B., Oxidative stress and apoptosis in homocystinuria patients with genetic remethylation defects. J. Cell. Biochem. 114 (2013), 183–191.
-
(2013)
J. Cell. Biochem.
, vol.114
, pp. 183-191
-
-
Richard, E.1
Desviat, L.R.2
Ugarte, M.3
Perez, B.4
-
51
-
-
81355142152
-
Unveiling the mysteries of clopidogrel metabolism and efficacy
-
Bonello, L., Bonello, N., Grosdidier, C., Camoin-Jau, L., Unveiling the mysteries of clopidogrel metabolism and efficacy. Clin. Pharmacol. Ther. 90 (2011), 774–776.
-
(2011)
Clin. Pharmacol. Ther.
, vol.90
, pp. 774-776
-
-
Bonello, L.1
Bonello, N.2
Grosdidier, C.3
Camoin-Jau, L.4
-
52
-
-
79958242366
-
Fast docking using the CHARMM force field with EADock DSS
-
Grosdidier, A., Zoete, V., Michielin, O., Fast docking using the CHARMM force field with EADock DSS. J. Comput. Chem. 32 (2011), 2149–2159.
-
(2011)
J. Comput. Chem.
, vol.32
, pp. 2149-2159
-
-
Grosdidier, A.1
Zoete, V.2
Michielin, O.3
|