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Volumn 90, Issue 6, 2011, Pages 774-776

Unveiling the mysteries of clopidogrel metabolism and efficacy

Author keywords

[No Author keywords available]

Indexed keywords

ARYLDIALKYLPHOSPHATASE 1; CLOPIDOGREL; CYTOCHROME P450 2C19;

EID: 81355142152     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2011.222     Document Type: Review
Times cited : (4)

References (10)
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    • CURE Investigators Clopidogrel in Unstable angina to prevent Recurrent Events trial
    • CURE Investigators. Clopidogrel in Unstable angina to prevent Recurrent Events trial. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients erspectives undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet 358, 527-533 (2001).
    • (2001) Lancet , vol.358 , pp. 527-533
  • 2
    • 58749090547 scopus 로고    scopus 로고
    • Genetic determinants of response to clopidogrel and cardiovascular events
    • French Registry of ST-Elevation and Non-STElevation Myocardial Infarction (FAST-MI) Investigators
    • French Registry of ST-Elevation and Non-STElevation Myocardial Infarction (FAST-MI) Investigators. Genetic determinants of response to clopidogrel and cardiovascular events. N. Engl. J. Med. 360, 363-375 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , pp. 363-375
  • 3
    • 77953911457 scopus 로고    scopus 로고
    • Consensus and future directions on the definition of high on-treatment platelet reactivity to ADP
    • Working Group on High On-Treatment Platelet Reactivity
    • Bonello, L. et al.; Working Group on High On-Treatment Platelet Reactivity. Consensus and future directions on the definition of high on-treatment platelet reactivity to ADP. J. Am. Coll. Cardiol. 56, 919-933 (2010).
    • (2010) J. Am. Coll. Cardiol. , vol.56 , pp. 919-933
    • Bonello, L.1
  • 4
    • 77952591958 scopus 로고    scopus 로고
    • Impact of cytochrome P450 2C19 loss-of-function polymorphism and of major demographic characteristics on residual platelet function after loading and maintenance treatment with clopidogrel in patients undergoing elective coronary stent placement
    • Hochholzer, W. et al. Impact of cytochrome P450 2C19 loss-of-function polymorphism and of major demographic characteristics on residual platelet function after loading and maintenance treatment with clopidogrel in patients undergoing elective coronary stent placement. J. Am. Coll. Cardiol. 55, 2427-2434 (2010).
    • (2010) J. Am. Coll. Cardiol. , vol.55 , pp. 2427-2434
    • Hochholzer, W.1
  • 5
    • 78651239845 scopus 로고    scopus 로고
    • Paraoxonase-1 is a major determinant of clopidogrel efficacy
    • Bouman, H.J. et al. Paraoxonase-1 is a major determinant of clopidogrel efficacy. Nat. Med. 17, 110-116 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 110-116
    • Bouman, H.J.1
  • 6
    • 80052969477 scopus 로고    scopus 로고
    • Paraoxonase 1 (PON1) gene variants are not associated with clopidogrel response
    • Lewis, J.P. et al. Paraoxonase 1 (PON1) gene variants are not associated with clopidogrel response. Clin. Pharmacol. Ther. 90, 568-574 (2011).
    • (2011) Clin. Pharmacol. Ther. , vol.90 , pp. 568-574
    • Lewis, J.P.1
  • 7
    • 80052964323 scopus 로고    scopus 로고
    • Effect of paraoxonase-1 polymorphism on clinical outcomes in patients treated with clopidogrel after an acute myocardial infarction
    • Simon, T. et al. Effect of paraoxonase-1 polymorphism on clinical outcomes in patients treated with clopidogrel after an acute myocardial infarction. Clin. Pharmacol. Ther. 90, 561-567 (2011).
    • (2011) Clin. Pharmacol. Ther. , vol.90 , pp. 561-567
    • Simon, T.1
  • 8
    • 77958573028 scopus 로고    scopus 로고
    • Clopidogrel loading dose adjustment according to platelet reactivity monitoring in patients carrying the 2C19*2 loss of function polymorphism
    • Bonello, L. et al. Clopidogrel loading dose adjustment according to platelet reactivity monitoring in patients carrying the 2C19*2 loss of function polymorphism. J. Am. Coll. Cardiol. 56, 1630-1636 (2010).
    • (2010) J. Am. Coll. Cardiol. , vol.56 , pp. 1630-1636
    • Bonello, L.1
  • 9
    • 77958105401 scopus 로고    scopus 로고
    • Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: A pharmacogenetic analysis
    • Mega, J.L. et al. Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis. Lancet 376, 1312-1319 (2010).
    • (2010) Lancet , vol.376 , pp. 1312-1319
    • Mega, J.L.1
  • 10
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    • High on-treatment platelet reactivity after prasugrel loading dose and cardiovascular events after percutaneous coronary intervention in coronary syndromes
    • Bonello, L. et al. High on-treatment platelet reactivity after prasugrel loading dose and cardiovascular events after percutaneous coronary intervention in coronary syndromes. J. Am. Coll. Cardiol. 58, 467-473 (2011).
    • (2011) J. Am. Coll. Cardiol. , vol.58 , pp. 467-473
    • Bonello, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.