Ligand-binding by catalytically inactive mutants of the cblB complementation group defective in human ATP:cob(I)alamin adenosyltransferase

Molecular Genetics and Metabolism

Volumn 98, Issue 3, 2009, Pages 278-284

  Zhang, Jun ^a   Wu, Xuchu ^a   Padovani, Dominique ^b   Schubert, Heidi L ^c   Gravel, Roy A ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Adenosylcobalamin; Adenosyltransferase; Cobalamin; Dissociation constant; Methylmalonic aciduria; Mutation

Indexed keywords

ADENOSINE TRIPHOSPHATE; COBALAMIN ADENOSYLTRANSFERASE; COBAMAMIDE; HYDROXOCOBALAMIN; TRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; FLUORESCENCE SPECTROSCOPY; GENE MUTATION; GENETIC COMPLEMENTATION; LIGAND BINDING; METHYLMALONIC ACIDURIA; PRIORITY JOURNAL; WILD TYPE;

ADENOSINE TRIPHOSPHATE; ALKYL AND ARYL TRANSFERASES; BINDING SITES; CATALYSIS; HUMANS; LIGANDS; METABOLISM, INBORN ERRORS; MUTATION; SPECTROMETRY, FLUORESCENCE; VITAMIN B 12;

EID: 70349735996     PISSN: 10967192     EISSN: 10967206     Source Type: Journal    
DOI: 10.1016/j.ymgme.2009.06.014     Document Type: Article

References (34)

1. Cooper B.A., and Rosenblatt D.S. Inherited defects of vitamin B12 metabolism. Annu. Rev. Nutr. 7 (1987) 291-320
2. Fenton W.A., Gravel R.A., and Rosenblatt D.S. Disorders of propionate and methylmalonate metabolism. In: Scriver C.R., Beaudet A.L., Valle D., and Sly W.S. (Eds). The Metabolic and Molecular Bases of Inherited Disease (2001), McGraw Hill, New York 2165-2193
3. Rosenblatt D.S., and Fenton W.A. Inherited disorders of folate and cobalamin transport and metabolism. In: Scriver C.R., Beaudet A.L., Valle D., Sly W.S., Childs B., Kinzler K.W., and Vogelstein B. (Eds). The Metabolic and Molecular Bases of Inherited Disease (2001), McGraw Hill, New York 3897-3934
4. Dobson C.M., Wai T., Kadir H., Narang M., Lerner-Ellis J., Hudson T.J., Rosenblatt D.S., and Gravel R.A. Identification of the gene responsible for the cblB complementation group of vitamin B12-responsive methylmalonic acidemia. Hum. Mol. Genet. 11 (2002) 3361-3369
5. Leal N.A., Park S.D., Kima P.E., and Bobik T.A. Identification of the human and bovine ATP:Cob(I)alamin adenosyltransferase cDNAs based on complementation of a bacterial mutant. J. Biol. Chem. 278 (2003) 9227-9234
6. Leal N.A., Olteanu H., Banerjee R., and Bobik T.A. Human ATP:Cob(I)alamin adenosyltransferase and its interaction with methionine synthase reductase. J Biol. Chem. 279 (2004) 47536-47542
7. Zhang J., Dobson C.M., Wu X., Lerner-Ellis J., Rosenblatt D.S., and Gravel R.A. Impact of cblB mutations on the function of ATP:cob(I)alamin adenosyltransferase in disorders of vitamin B12 metabolism. Mol. Genet. Metab. 87 (2006) 315-322
8. Leclerc D., Wilson A., Dumas R., Gafuik C., Song D., Watkins D., Heng H.H., Rommens J.M., Scherer S.W., Rosenblatt D.S., and Gravel R.A. Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria. Proc. Natl. Acad. Sci. USA 95 (1998) 3059-3064
9. Leclerc D., Odievre M., Wu Q., Wilson A., Huizenga J.J., Rozen R., Scherer S.W., and Gravel R.A. Molecular cloning, expression and physical mapping of the human methionine synthase reductase gene. Gene 240 (1999) 75-88
10. Olteanu H., and Banerjee R. Human methionine synthase reductase, a soluble P-450 reductase-like dual flavoprotein, is sufficient for NADPH-dependent methionine synthase activation. J. Biol. Chem. 276 (2001) 35558-35563
11. Froese D.S., Wu X., Zhang J., Dumas R., Schoel W.M., Amrein M., and Gravel R.A. Restricted role for methionine synthase reductase defined by subcellular localization. Mol. Genet. Metab. 94 (2008) 68-77
12. Escalante-Semerena J.C., Suh S.J., and Roth J.R. CobA function is required for both de novo cobalamin biosynthesis and assimilation of exogenous corrinoids in Salmonella typhimurium. J. Bacteriol. 172 (1990) 273-280
13. Fonseca M.V., and Escalante-Semerena J.C. An in vitro reducing system for the enzymic conversion of cobalamin to adenosylcobalamin. J. Biol. Chem. 276 (2001) 32101-32108
14. Johnson C.L., Pechonick E., Park S.D., Havemann G.D., Leal N.A., and Bobik T.A. Functional genomic, biochemical, and genetic characterization of the Salmonella pduO gene, an ATP:cob(I)alamin adenosyltransferase gene. J. Bacteriol. 183 (2001) 1577-1584
15. Kofoid E., Rappleye C., Stojiljkovic I., and Roth J. The 17-gene ethanolamine (eut) operon of Salmonella typhimurium encodes five homologues of carboxysome shell proteins. J. Bacteriol. 181 (1999) 5317-5329
16. Suh S., and Escalante-Semerena J.C. Purification and initial characterization of the ATP:corrinoid adenosyltransferase encoded by the cobA gene of Salmonella typhimurium. J. Bacteriol. 177 (1995) 921-925
17. Suh S.J., and Escalante-Semerena J.C. Cloning, sequencing and overexpression of cobA which encodes ATP:corrinoid adenosyltransferase in Salmonella typhimurium. Gene 129 (1993) 93-97
18. Moon J.H., Park A.K., Jang E.H., Kim H.S., and Chi Y.M. Crystal structure of a PduO-type ATP:cobalamin adenosyltransferase from Burkholderia thailandensis. Proteins 72 (2008) 1066-1070
19. Saridakis V., Yakunin A., Xu X., Anandakumar P., Pennycooke M., Gu J., Cheung F., Lew J.M., Sanishvili R., Joachimiak A., Arrowsmith C.H., Christendat D., and Edwards A.M. The structural basis for methylmalonic aciduria. The crystal structure of archaeal ATP:cobalamin adenosyltransferase. J. Biol. Chem. 279 (2004) 23646-23653
20. Schubert H.L., and Hill C.P. Structure of ATP-bound human ATP:cobalamin adenosyltransferase. Biochemistry 45 (2006) 15188-15196
21. St. Maurice M., Mera P.E., Taranto M.P., Sesma F., Escalante-Semerena J.C., and Rayment I. Structural characterization of the active site of the PduO-type ATP:Co(I)rrinoid adenosyltransferase from Lactobacillus reuteri. J. Biol. Chem. 282 (2007) 2596-2605
22. Tanaka Y., Sasaki T., Kumagai I., Yasutake Y., Yao M., Tanaka I., and Tsumoto K. Molecular properties of two proteins homologous to PduO-type ATP:cob(I)alamin adenosyltransferase from Sulfolobus tokodaii. Proteins 68 (2007) 446-457
23. St. Maurice M., Mera P., Park K., Brunold T.C., Escalante-Semerena J.C., and Rayment I. Structural characterization of a human-type corrinoid adenosyltransferase confirms that coenzyme B12 is synthesized through a four-coordinate intermediate. Biochemistry 47 (2008) 5755-5766
24. Marsh E.N., and Holloway D.E. Cloning and sequencing of glutamate mutase component S from Clostridium tetanomorphum. Homologies with other cobalamin-dependent enzymes. FEBS Lett. 310 (1992) 167-170
25. 2+ cobalamin species upon binding to the human ATP:cobalamin adenosyltransferase. J. Am. Chem. Soc. 127 (2005) 7660-7661
26. Yamanishi M., Labunska T., and Banerjee R. Mirror "base-off" conformation of coenzyme B12 in human adenosyltransferase and its downstream target, methylmalonyl-CoA mutase. J. Am. Chem. Soc. 127 (2005) 526-527
27. Lerner-Ellis J.P., Gradinger A.B., Watkins D., Tirone J.C., Villeneuve A., Dobson C.M., Montpetit A., Lepage P., Gravel R.A., and Rosenblatt D.S. Mutation and biochemical analysis of patients belonging to the cblB complementation class of vitamin B12-dependent methylmalonic aciduria. Mol. Genet. Metab. 87 (2006) 219-225
28. Martinez M.A., Rincon A., Desviat L.R., Merinero B., Ugarte M., and Perez B. Genetic analysis of three genes causing isolated methylmalonic acidemia: identification of 21 novel allelic variants. Mol. Genet. Metab. 84 (2005) 317-325
29. Fan C., and Bobik T.A. Functional characterization and mutation analysis of human ATP:Cob(I)alamin adenosyltransferase. Biochemistry 47 (2008) 2806-2813
30. Studier F.W. Protein production by auto-induction in high density shaking cultures. Protein Expr. Purif. 41 (2005) 207-234
31. Chowdhury S., and Banerjee R. Role of the dimethylbenzimidazole tail in the reaction catalyzed by coenzyme B12-dependent methylmalonyl-CoA mutase. Biochemistry 38 (1999) 15287-15294
32. Lakowicz Joseph R. Principles of Fluorescence Spectroscopy. third ed. (2008), Springer Press pp. 27-61, (Chapter 2)
33. +-ATPase from Kluyveromyces lactis. Biochemistry 46 (2007) 5616-5622
34. Mera P.E., Maurice M.S., Rayment I., and Escalante-Semerena J.C. Structural and Functional analyses of the human-type corrinoid adenosyltransferase (PduO) from Lactobacillus reuteri. Biochemistry 46 (2007) 13829-13836