A Small-Molecule Oligosaccharyltransferase Inhibitor with Pan-flaviviral Activity

Cell Reports

Volumn 21, Issue 11, 2017, Pages 3032-3039

  Puschnik, Andreas S ^a   Marceau, Caleb D ^a   Ooi, Yaw Shin ^a   Majzoub, Karim ^a   Rinis, Natalie ^b   Contessa, Joseph N ^b   Carette, Jan E ^a  

^a STANFORD UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

antiviral; dengue virus; flaviviruses; host directed therapy; oligosaccharyltransferase; West Nile virus; yellow fever virus; Zika virus

Indexed keywords

ANTIVIRUS AGENT; GLYCAN; NGI 1; OLIGOSACCHARYLTRANSFERASE; TRANSFERASE; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; VIRUS RNA; BENZAMIDE DERIVATIVE; CID2519269; GLYCOSYLTRANSFERASE; LUCIFERASE; MEMBRANE PROTEIN; STT3A PROTEIN, HUMAN; STT3B PROTEIN, HUMAN; SULFONAMIDE;

ANTIVIRAL ACTIVITY; ANTIVIRAL RESISTANCE; ARTICLE; CATALYSIS; CELL DIVISION; CONTROLLED STUDY; DENDRITIC CELL LINE; DENGUE VIRUS; DRUG MECHANISM; DRUG TARGETING; EMBRYO; ENZYME ACTIVITY; ENZYME GLYCOSYLATION; ENZYME INHIBITION; FIBROBLAST CELL LINE; FLAVIVIRUS; FLAVIVIRUS INFECTION; GENETIC IDENTIFICATION; HEK293 CELL LINE; HUH-7 CELL LINE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RAJI CELL LINE; RNA REPLICATION; STT3A GENE; STT3B GENE; VIRUS CELL INTERACTION; VIRUS GENE; VIRUS INHIBITION; VIRUS MUTANT; VIRUS REPLICATION; ZIKA VIRUS; ANTAGONISTS AND INHIBITORS; DEFICIENCY; DRUG EFFECT; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HOST PATHOGEN INTERACTION; MICROBIAL SENSITIVITY TEST; REPORTER GENE; SIGNAL TRANSDUCTION; WEST NILE VIRUS; YELLOW FEVER VIRUS;

ANTIVIRAL AGENTS; BENZAMIDES; DENGUE VIRUS; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENES, REPORTER; HEK293 CELLS; HEXOSYLTRANSFERASES; HOST-PATHOGEN INTERACTIONS; HUMANS; LUCIFERASES; MEMBRANE PROTEINS; MICROBIAL SENSITIVITY TESTS; SIGNAL TRANSDUCTION; SULFONAMIDES; VIRUS REPLICATION; WEST NILE VIRUS; YELLOW FEVER VIRUS; ZIKA VIRUS;

EID: 85037843802     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.11.054     Document Type: Article

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