Integrating themes, evidence gaps, and research needs identified by workshop on iron screening and supplementation in iron-replete pregnant women and young children

American Journal of Clinical Nutrition

Volumn 106, Issue , 2017, Pages 1703S-1712S

  Brannon, Patsy M ^a,b   Stover, Patrick J ^a   Taylor, Christine L ^b  

^a Cornell University ^*  (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

infancy; iron excess; iron homeostasis; Iron replete; pregnancy; screening; supplementation; U shaped risk curve

Indexed keywords

IRON;

CHILD; CHILD HEALTH; CLINICAL RESEARCH; CONFERENCE PAPER; DEVELOPED COUNTRY; FEMALE; HUMAN; INFANCY; INFANT; IRON BLOOD LEVEL; IRON DEFICIENCY; IRON DEFICIENCY ANEMIA; IRON HOMEOSTASIS; IRON THERAPY; KNOWLEDGE; MATERNAL WELFARE; PREGNANT WOMAN; UNCERTAINTY; VULNERABLE POPULATION; WORKSHOP; BLOOD; DEFICIENCY; DIETARY SUPPLEMENT; HOMEOSTASIS; MALE; NUTRITIONAL ASSESSMENT; NUTRITIONAL STATUS; PREGNANCY; PREGNANCY OUTCOME; PRESCHOOL CHILD; PREVALENCE; RANDOMIZED CONTROLLED TRIAL (TOPIC);

ANEMIA, IRON-DEFICIENCY; CHILD, PRESCHOOL; DIETARY SUPPLEMENTS; FEMALE; HOMEOSTASIS; HUMANS; INFANT; IRON; MALE; NUTRITION ASSESSMENT; NUTRITIONAL STATUS; PREGNANCY; PREGNANCY OUTCOME; PREVALENCE; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 85037670414     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.117.156083     Document Type: Conference Paper

References (67)

1. NIH Office of Dietary Supplements. Iron screening and supplementation in iron-replete pregnant women and young children workshop, September 28-29 [Internet]. c2016 [cited 2017 Feb 13]. Available from: https://ods.od.nih.gov/pubs/NIH-Iron-Workshop-Agenda.pdf.
2. Taylor CL, Brannon PM. Introduction to workshop on iron screening and supplementation in iron-replete pregnant women and young children. Am J Clin Nutr 2017;106(Suppl):1547S-54S.
3. Siu AL; US Preventive Services Task Force. Screening for iron deficiency anemia and iron supplementation in pregnant women to improve maternal health and birth outcomes: U.S. Preventive Services Task Force Recommendation Statement. Ann Intern Med 2015;163:529-36.
4. Siu AL; US Preventive Services Task Force. Screening for iron deficiency anemia in young children: USPSTF recommendation statement. Pediatrics 2015;136:746-52.
5. McDonagh M, Cantor A, Bougatsos C, Dana T, Blazina I. Routine iron supplementation and screening for iron deficiency anemia in pregnant women: a systematic review to update the U.S. Preventive Services Task Force recommendation. Rockville (MD): Agency for Healthcare Research and Quality; 2015.
6. McDonagh MS, Blazina I, Dana T, Cantor A, Bougatsos C. Screening and routine supplementation for iron deficiency anemia: a systematic review. Pediatrics 2015;135:723-33.
7. CDC. Recommendations to prevent and control iron deficiency in the United States. MMWR Recomm Rep 1998;47:1-29.
8. Baker RD, Greer FR; Committee on Nutrition American Academy of Pediatrics. Diagnosis and prevention of iron deficiency and irondeficiency anemia in infants and young children (0-3 years of age). Pediatrics 2010;126:1040-50.
9. Garner CD. Nutrition in pregnancy. In: Post TW, editor. UpToDate. Waltham (MA): UpToDate; 2017.
10. Domellöf M, Braegger C, Campoy C, Colomb V, Decsi T, Fewtrell M, Hojsak I, Mihatsch W, Molgaard C, Shamir R, et al. Iron requirements of infants and toddlers. J Pediatr Gastroenterol Nutr 2014;58:119-29.
11. Australian Government Department of Health. Clinical practice guidelines antenatal care-module I 10.4 nutritional supplements [Internet]. c2013 [cited 2017 May 5]. Available from: http://www.health.gov.au/internet/publications/publishing.nsf/Content/clinical-practice-guidelines-Ac-mod1~ part-b~lifestyle-considerationsnutritional-supplements.
12. Anderson GJ, Frazer DM. Current understanding of iron homeostasis. Am J Clin Nutr 2017;106(Suppl):1559S-66S.
13. Lönnerdal B. Development of iron homeostasis in infants and young children. Am J Clin Nutr 2017;106(Suppl):1575S-80S.
14. Fisher AL, Nemeth E. Iron homeostasis during pregnancy. Am J Clin Nutr 2017;106(Suppl):1567S-74S.
15. van Santen S, Kroot JJ, Zijderveld G, Wiegerinck ET, Spaanderman ME, Swinkels DW. The iron regulatory hormone hepcidin is decreased in pregnancy: a prospective longitudinal study. Clin Chem Lab Med 2013;51:1395-401.
16. Rehu M, Punnonen K, Ostland V, Heinonen S, Westerman M, Pulkki K, Sankilampi U. Maternal serum hepcidin is low at term and independent of cord blood iron status. Eur J Haematol 2010;85:345-52.
17. Domellöf M, Lönnerdal B, Abrams SA, Hernell O. Iron absorption in breast-fed infants: effects of age, iron status, iron supplements, and complementary foods. Am J Clin Nutr 2002;76:198-204.
18. Leong WI, Bowlus CL, Tallkvist J, Lönnerdal B. Iron supplementation during infancy-effects on expression of iron transporters, iron absorption, and iron utilization in rat pups. Am J Clin Nutr 2003;78:1203-11.
19. Leong WI, Bowlus CL, Tallkvist J, Lönnerdal B. DMT1 and FPN1 expression during infancy: developmental regulation of iron absorption. Am J Physiol Gastrointest Liver Physiol 2003;285:G1153-61.
20. Georgieff MK. Iron assessment to protect the developing brain. Am J Clin Nutr 2017;106(Suppl):1588S-93S.
21. Milman N, Taylor CL, Merkel J, Brannon PM. Iron status in pregnant women and women of reproductive age in Europe. Am J Clin Nutr 2017;106(Suppl):1655S-62S.
22. Gordeuk VR, Brannon PM. Ethnic and genetic factors of iron status in women of reproductive age. Am J Clin Nutr 2017;106(Suppl):1594S-9S.
23. O'Brien KO, Ru Y. Iron status of North American pregnant women: an update on longitudinal data and gaps in knowledge from the United States and Canada. Am J Clin Nutr 2017;106(Suppl):1647S-54S.
24. Petry N, Olofin I, Hurrell RF, Boy E, Wirth JP, Moursi M, Donahue Angel M, Rohner F. The proportion of anemia associated with iron deficiency in low, medium, and high human development index countries: a systematic analysis of national surveys. Nutrients 2016;8:E693.
25. Vricella LK. Emerging understanding and measurement of plasma volume expansion in pregnancy. Am J Clin Nutr 2017;106(Suppl):1620S-5S.
26. Daru J, Colman K, Stanworth SJ, De La Salle B, Wood EM, Pasricha S-R. Serum ferritin as an indicator of iron status: what do we need to know? Am J Clin Nutr 2017;106(Suppl):1634S-9S.
27. Hoofnagle AN. Harmonization of blood-based indicators of iron status: making the hard work matter. Am J Clin Nutr 2017;106(Suppl):1615S-9S.
28. Pfeiffer CM, Looker AC. Laboratory methodologies for indicators of iron status: strengths, limitations, and analytical challenges. Am J Clin Nutr 2017;106(Suppl):1606S-14S.
29. Gupta PM, Hamner HC, Suchdev PS, Flores-Ayala R, Mei Z. Iron status of toddlers, nonpregnant females, and pregnant females in the United States. Am J Clin Nutr 2017;106(Suppl):1640S-6S.
30. Kemper AR, Fan T, Grossman DC, Phipps MG. Gaps in evidence regarding iron deficiency anemia in pregnant women and young children: summary of US Preventive Services Task Force recommendations. Am J Clin Nutr 2017;106(Suppl):1555S-58S.
31. Ross AC. Impact of chronic and acute inflammation on extra-And intracellular iron homeostasis. Am J Clin Nutr 2017;106(Suppl):1581S-7S.
32. Suchdev PS, Williams AM, Mei Z, Flores-Ayala R, Pasricha S-R, Rogers LM, Namaste SML. Assessment of iron status in settings of inflammation: challenges and potential approaches. Am J Clin Nutr 2017;106 (Suppl):1626S-33S.
33. Dewey KG, Oaks BM. U-shaped curve for risk associated with maternal hemoglobin, iron status, or iron supplementation. Am J Clin Nutr 2017;106(Suppl):1694S-702S.
34. Paganini D, Zimmermann MB. The effects of iron fortification and supplementation on the gut microbiome and diarrhea in infants and children: a review. Am J Clin Nutr 2017;106(Suppl):1688S-93S.
35. Velentgas P, Dreyer NA, Wu AW. Outcome definition and measurement. In: Velentgas P, Dreyer NA, Nourjah P, Smith SR, Torchia MM, editors. Developing a protocol for observational comparative effectiveness research: a user's guide AHRQ Publication No 12(13)-EHC099. Rockville (MD): Agency for Healthcare Research and Quality; 2013. p. 71-92.
36. Wessling-Resnick M. Excess iron: considerations related to development and early growth. Am J Clin Nutr 2017;106(Suppl):1600S-5S.
37. Zhang C, Rawal S. Dietary iron intake, iron status, and gestational diabetes. Am J Clin Nutr 2017;106(Suppl):1672S-80S.
38. Brittenham GM, Andersson M, Egli I, Foman JT, Zeder C, Westerman ME, Hurrell RF. Circulating non-transferrin-bound iron after oral administration of supplemental and fortification doses of iron to healthy women: a randomized study. Am J Clin Nutr 2014;100:813-20.
39. Fu S, Li F, Zhou J, Liu Z. The relationship between body iron status, iron intake and gestational diabetes: a systematic review and metaanalysis. Medicine (Baltimore) 2016;95:e2383.
40. Darling AM, Mitchell AA, Werler MM. Preconceptional iron intake and gestational diabetes mellitus. Int J Environ Res Public Health 2016;13:E525.
41. Bao W, Chavarro JE, Tobias DK, Bowers K, Li S, Hu FB, Zhang C. Long-term risk of type 2 diabetes in relation to habitual iron intake in women with a history of gestational diabetes: a prospective cohort study. Am J Clin Nutr 2016;103:375-81.
42. Bo S, Menato G, Villois P, Gambino R, Cassader M, Cotrino I, Cavallo-Perin P. Iron supplementation and gestational diabetes in midpregnancy. Am J Obstet Gynecol 2009;201:158.e1-6.
43. Helin A, Kinnunen TI, Raitanen J, Ahonen S, Virtanen SM, Luoto R. Iron intake, haemoglobin and risk of gestational diabetes: a prospective cohort study. BMJ Open 2012;2:e001730.
44. Bowers K, Yeung E, Williams MA, Qi L, Tobias DK, Hu FB, Zhang C. A prospective study of prepregnancy dietary iron intake and risk for gestational diabetes mellitus. Diabetes Care 2011;34:1557-63.
45. Bowers KA, Olsen SF, Bao W, Halldorsson TI, Strm M, Zhang C. Plasma concentrations of ferritin in early pregnancy are associated with risk of gestational diabetes mellitus in women in the Danish National Birth Cohort. J Nutr 2016;146:1756-61.
46. Chen X, Scholl TO, Stein TP. Association of elevated serum ferritin levels and the risk of gestational diabetes mellitus in pregnant women: the Camden study. Diabetes Care 2006;29:1077-82.
47. Chan KK, Chan BC, Lam KF, Tam S, Lao TT. Iron supplement in pregnancy and development of gestational diabetes-A randomised placebo-controlled trial. BJOG 2009;116:789-97, discussion 97-8.
48. Kinnunen TI, Luoto R, Helin A, Hemminki E. Supplemental iron intake and the risk of glucose intolerance in pregnancy: re-Analysis of a randomised controlled trial in Finland. Matern Child Nutr 2016;12:74-84.
49. Zein S, Sitti F, Osman M, Arnaud J, Batandier C, Gauchez AS, Rachidi S, Couturier K, Hininger-Favier I. Middle iron-enriched fructose diet on gestational diabetes risk and on oxidative stress in offspring rats. Biol Trace Elem Res 2017;175:405-13.
50. Tamura T, Goldenberg RL, Johnston KE, Cliver SP, Hickey CA. Serum ferritin: a predictor of early spontaneous preterm delivery. Obstet Gynecol 1996;87:360-5.
51. Goldenberg RL, Tamura T, DuBard M, Johnston KE, Copper RL, Neggers Y. Plasma ferritin and pregnancy outcome. Am J Obstet Gynecol 1996;175:1356-9.
52. Scholl TO. High third-trimester ferritin concentration: associations with very preterm delivery, infection, and maternal nutritional status. Obstet Gynecol 1998;92:161-6.
53. Lao TT, Tam KF, Chan LY. Third trimester iron status and pregnancy outcome in non-Anaemic women; pregnancy unfavourably affected by maternal iron excess. Hum Reprod 2000;15:1843-8.
54. Hwang JY, Lee JY, Kim KN, Kim H, Ha EH, Park H, Ha M, Kim Y, Hong YC, Chang N. Maternal iron intake at mid-pregnancy is associated with reduced fetal growth: results from Mothers and Children's Environmental Health (MOCEH) study. Nutr J 2013;12:38.
55. Dewey KG, Domellöf M, Cohen RJ, Landa Rivera L, Hernell O, Lönnerdal B. Iron supplementation affects growth and morbidity of breast-fed infants: results of a randomized trial in Sweden and Honduras. J Nutr 2002;132:3249-55.
56. Domellöf M, Cohen RJ, Dewey KG, Hernell O, Rivera LL, Lönnerdal B. Iron supplementation of breast-fed Honduran and Swedish infants from 4 to 9 months of age. J Pediatr 2001;138:679-87.
57. Majumdar I, Paul P, Talib VH, Ranga S. The effect of iron therapy on the growth of iron-replete and iron-deplete children. J Trop Pediatr 2003;49:84-8.
58. Lind T, Seswandhana R, Persson LA, Lönnerdal B. Iron supplementation of iron-replete Indonesian infants is associated with reduced weight-for-Age. Acta Paediatr 2008;97:770-5.
59. Idjradinata P, Watkins WE, Pollitt E. Adverse effect of iron supplementation on weight gain of iron-replete young children. Lancet 1994; 343:1252-4.
60. Pasricha SR, Hayes E, Kalumba K, Biggs BA. Effect of daily iron supplementation on health in children aged 4-23 months: a systematic review and meta-Analysis of randomised controlled trials. Lancet Glob Health 2013;1:e77-86.
61. Lozoff B, Castillo M, Clark KM, Smith JB. Iron-fortified vs low-iron infant formula: developmental outcome at 10 years. Arch Pediatr Adolesc Med 2012;166:208-15.
62. Paganini D, Uyoga MA, Zimmermann MB. Iron fortification of foods for infants and children in low-income countries: effects on the gut microbiome, gut inflammation, and diarrhea. Nutrients 2016;8:494.
63. Dostal A, Lacroix C, Bircher L, Pham VT, Follador R, Zimmermann MB, Chassard C. Iron modulates butyrate production by a child gut microbiota in vitro. MBio 2015;6:e01453-15.
64. Jaeggi T, Kortman GA, Moretti D, Chassard C, Holding P, Dostal A, Boekhorst J, Timmerman HM, Swinkels DW, Tjalsma H, et al. Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants. Gut 2015;64:731-42.
65. Dostal A, Baumgartner J, Riesen N, Chassard C, Smuts CM, Zimmermann MB, Lacroix C. Effects of iron supplementation on dominant bacterial groups in the gut, faecal SCFA and gut inflammation: a randomised, placebo-controlled intervention trial in South African children. Br J Nutr 2014;112:547-56.
66. Zimmermann MB, Chassard C, Rohner F, N'Goran EK, Nindjin C, Dostal A, Utzinger J, Ghattas H, Lacroix C, Hurrell RF. The effects of iron fortification on the gut microbiota in African children: a randomized controlled trial in Cote d'Ivoire. Am J Clin Nutr 2010;92:1406-15
67. Lönnerdal B. Excess iron intake as a factor in growth, infections, and development of infants and young children. Am J Clin Nutr 2017; 106(Suppl):1681S-7S.