Serum ferritin as an indicator of iron status: What do we need to know?

American Journal of Clinical Nutrition

Volumn 106, Issue , 2017, Pages 1634S-1639S

  Daru, Jahnavi ^a   Colman, Katherine ^b   Stanworth, Simon J ^c   De La Salle, Barbara ^d   Wood, Erica M ^b   Pasricha, Sant Rayn ^e  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b MONASH UNIVERSITY   (Australia)

^c NHS BLOOD AND TRANSPLANT   (United Kingdom)

^d National External Quality Assessment Scheme   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

cutoffs; diagnostic test; ferritin; hepcidin; iron deficiency; iron deficiency anemia; Iron status

Indexed keywords

FERRITIN; HEMOGLOBIN; HEPCIDIN; IRON; TRANSFERRIN RECEPTOR;

BONE MARROW BIOPSY; CHILD; CLINICAL LABORATORY; COMPARATIVE STUDY; CONFERENCE PAPER; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; FERRITIN BLOOD LEVEL; GOLD STANDARD; HEMOGLOBIN BLOOD LEVEL; HUMAN; IRON ABSORPTION; IRON BLOOD LEVEL; IRON DEFICIENCY ANEMIA; IRON DEPLETION; IRON STORAGE; IRON THERAPY; PREGNANT WOMAN; RECEIVER OPERATING CHARACTERISTIC; REFERENCE VALUE; SENSITIVITY AND SPECIFICITY; BLOOD; METABOLISM; NUTRITIONAL STATUS; PREGNANCY; PRESCHOOL CHILD;

ANEMIA, IRON-DEFICIENCY; CHILD, PRESCHOOL; FEMALE; FERRITINS; HEMOGLOBINS; HUMANS; IRON; NUTRITIONAL STATUS; PREGNANCY; RECEPTORS, TRANSFERRIN; SENSITIVITY AND SPECIFICITY;

EID: 85037652530     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.117.155960     Document Type: Conference Paper

References (46)

1. Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, et al. Diagnosis and management of iron deficiency anaemia: a clinical update. Med J Aust 2010;193:525-32.
2. Pavord S, Myers B, Robinson S, Allard S, Strong J, Oppenheimer C; British Committee for Standards in Haematology. UK guidelines on the management of iron deficiency in pregnancy. Br J Haematol 2012;156:588-600.
3. Pfeiffer CM, Looker AC. Laboratory methodologies for indicators of iron status: strengths, limitations, and analytical challenges. Am J Clin Nutr 2017;106(Suppl):1606S-14S.
4. Pratt JJ, Khan KS. Non-Anaemic iron deficiency-A disease looking for recognition of diagnosis: a systematic review. Eur J Haematol 2016;96: 618-28.
5. McDonagh M, Blazina I, Dana T, Cantor A, Bougatsos C. Routine iron supplementation and screening for iron deficiency anemia in children ages 6 to 24 months: a systematic review to update the U.S. Preventive Services Task Force recommendation. Rockville (MD): Agency for Healthcare Research and Quality; 2015.
6. McDonagh M, Cantor A, Bougatsos C, Dana T, Blazina I. Routine iron supplementation and screening for iron deficiency anemia in pregnant women: a systematic review to update the U.S. Preventive Services Task Force recommendation. Rockville (MD): Agency for Healthcare Research and Quality; 2015.
7. Mei Z, Cogswell ME, Parvanta I, Lynch S, Beard JL, Stoltzfus RJ, Grummer-Strawn LM. Hemoglobin and ferritin are currently the most efficient indicators of population response to iron interventions: an analysis of nine randomized controlled trials. J Nutr 2005;135:1974-80.
8. Muckenthaler MU, Galy B, Hentze MW. Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network. Annu Rev Nutr 2008;28:197-213.
9. Elin RJ, Wolff SM, Finch CA. Effect of induced fever on serum iron and ferritin concentrations in man. Blood 1977;49:147-53.
10. Cohen LA, Gutierrez L, Weiss A, Leichtmann-Bardoogo Y, Zhang DL, Crooks DR, Sougrat R, Morgenstern A, Galy B, Hentze MW, et al. Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway. Blood 2010;116:1574-84.
11. Garcia-Casal MN, Pasricha S-R, Martinez RX, Lopez-Perez L, Peña-Rosas JP. Serum or plasma ferritin concentration as an index of iron deficiency and overload (Protocol). Cochrane Database Syst Rev 2015; 7:CD011817.
12. Blake DR, Waterworth RF, Bacon PA. Assessment of iron stores in inflammation by assay of serum ferritin concentrations. Br Med J (Clin Res Ed) 1981;283:1147-8.
13. Dale JC, Burritt MF, Zinsmeister AR. Diurnal variation of serum iron, iron-binding capacity, transferrin saturation, and ferritin levels. Am J Clin Pathol 2002;117:802-8.
14. Hallberg L, Bengtsson C, Lapidus L, Lindstedt G, Lundberg PA, Hulten L. Screening for iron deficiency: an analysis based on bonemarrow examinations and serum ferritin determinations in a population sample of women. Br J Haematol 1993;85:787-98.
15. Jonker FA, Boele van Hensbroek M, Leenstra T, Vet RJ, Brabin BJ, Maseko N, Gushu MB, Emana M, Kraaijenhagen R, Tjalsma H, et al. Conventional and novel peripheral blood iron markers compared against bone marrow in Malawian children. J Clin Pathol 2014;67:717-23.
16. Milman N, Bangsboll S, Strandberg Pedersen N, Visfeldt J. Serum ferritin in non-dialysis patients with chronic renal failure: relation to bone marrow iron stores. Scand J Haematol 1983;30:337-44.
17. Sorbie J, Valberg LS, Corbett WE, Ludwig J. Serum ferritin, cobalt excretion and body iron status. Can Med Assoc J 1975;112:1173-8.
18. van den Broek NR, Letsky EA, White SA, Shenkin A. Iron status in pregnant women: which measurements are valid? Br J Haematol 1998; 103:817-24.
19. Pasricha SR, Casey GJ, Phuc TQ, Mihrshahi S, MacGregor L, Montresor A, Tien N, Biggs BA. Baseline iron indices as predictors of hemoglobin improvement in anemic Vietnamese women receiving weekly iron-folic acid supplementation and deworming. Am J Trop Med Hyg 2009;81:1114-9.
20. Pasricha SR, Hayes E, Kalumba K, Biggs BA. Effect of daily iron supplementation on health in children aged 4-23 months: a systematic review and meta-Analysis of randomised controlled trials. Lancet Glob Health 2013;1:e77-86.
21. Garcia-Casal MN, Peña-Rosas JP, Pasricha S-R. Rethinking ferritin cutoffs for iron deficiency and overload. Lancet Haematol 2014;1:e92-4.
22. Reitsma JB, Rutjes AWS, Whiting P, Vlassov VV, Leeflang MMG, Deeks JJ. Assessing methodological quality. In: Deeks JJ, Bossuyt PM, Gatsonis C, editors. Cochrane handbook for systematic reviews of diagnostic test accuracy version 100: the Cochrane collaboration. London: The Cochrane Collaboration; 2009.
23. Kirkwood BR, Sterne JAC. Essential medical statistics. Oxford (United Kingdom): Blackwell Science; 2003.
24. Mallett S, Halligan S, Thompson M, Collins GS, Altman DG. Interpreting diagnostic accuracy studies for patient care. BMJ 2012;345:e3999.
25. Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 1982;143:29-36.
26. Fluss R, Faraggi D, Reiser B. Estimation of the Youden index and its associated cutoff point. Biom J 2005;47:458-72.
27. Deeks JJ, Altman DG. Diagnostic tests 4: likelihood ratios. BMJ 2004; 329:168-9.
28. Man-Son-Hing M, Laupacis A, O'Connor AM, Coyle D, Berquist R, McAlister F. Patient preference-based treatment thresholds and recommendations: a comparison of decision-Analytic modeling with the probability-tradeoff technique. Med Decis Making 2000;20:394-403.
29. WHO. Serum ferritin concentrations for the assessment of iron status and iron deficiency in populations. Geneva (Switzerland): Vitamin and Mineral Nutrition Information System; 2011.
30. WHO, CDC. Assessing the iron status of populations: including literature reviews. Report of a Joint World Health Organization/Centers for Disease Control and Prevention Technical Consultation on the assessment of iron status at the population level, Geneva, Switzerland, 6-8 April 2004. 2nd ed. Geneva (Switzerland): WHO/CDC; 2007.
31. Recommendations to prevent and control iron deficiency in the United States. MMWR Recomm Rep 1998;47:1-29.
32. RCPA. Iron studies standardised reporting protocol. Surry Hills (New South Wales): Royal College of Pathologists of Australasia; 2013.
33. Friedman AJ, Shander A, Martin SR, Calabrese RK, Ashton ME, Lew I, Seid MH, Goodnough LT. Iron deficiency anemia in women: a practical guide to detection, diagnosis, and treatment. Obstet Gynecol Surv 2015;70:342-53.
34. Grant CC, Wall CR, Brewster D, Nicholson R, Whitehall J, Super L, Pitcher L. Policy statement on iron deficiency in pre-school-Aged children. J Paediatr Child Health 2007;43:513-21.
35. AABB. Management of risk for iron deficiency in female blood donors with HB levels of 12.0-,12.5 g/dL using ferritin testing [Internet]. [cited 2016 Oct 4]. Available from: http://www.aabb.org/advocacy/regulatorygovernment/donoreligibility/hsim/Pages/Management-of-Riskfor-Iron-Deficiency-in%20Female-Blood-Donors-with-HB-Levels-12.0-12.5.aspx.
36. Guagnozzi D, Severi C, Ialongo P, Viscido A, Patrizi F, Testino G, Vannella L, Labriola R, Strom R, Caprilli R. Ferritin as a simple indicator of iron deficiency in anemic IBD patients. Inflamm Bowel Dis 2006;12:150-1.
37. Ong KH, Tan HL, Lai HC, Kuperan P. Accuracy of various iron parameters in the prediction of iron deficiency in an acute care hospital. Ann Acad Med Singapore 2005;34:437-40.
38. Witte DL, Angstadt DS, Davis SH, Schrantz RD. Predicting bone marrow iron stores in anemic patients in a community hospital using ferritin and erythrocyte sedimentation rate. Am J Clin Pathol 1988;90: 85-7.
39. Harju E, Pakarinen A, Larmi T. A comparison between serum ferritin concentration and the amount of bone marrow stainable iron. Scand J Clin Lab Invest 1984;44:555-6.
40. Scholl TO, Reilly T. Anemia, iron and pregnancy outcome. J Nutr 2000;130:443S-7S.
41. Prentice AM, Doherty CP, Abrams SA, Cox SE, Atkinson SH, Verhoef H, Armitage AE, Drakesmith H. Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African children. Blood 2012;119:1922-8.
42. Hicks PD, Zavaleta N, Chen Z, Abrams SA, Lönnerdal B. Iron deficiency, but not anemia, upregulates iron absorption in breast-fed peruvian infants. J Nutr 2006;136:2435-8.
43. Pasricha SR, Atkinson SH, Armitage AE, Khandwala S, Veenemans J, Cox SE, Eddowes LA, Hayes T, Doherty CP, Demir AY, et al. Expression of the iron hormone hepcidin distinguishes different types of anemia in African children. Sci Transl Med 2014;6:235re3.
44. Schrier SL, Auerbach M. Treatment of iron deficiency anemia in adults. In: Post TW, ed. UpToDate. Waltham (MA): Wolters Kluwer; 2016.
45. Bacon BR, Adams PC, Kowdley KV, Powell LW, Tavill AS. American Association for the Study of Liver D. Diagnosis and management of hemochromatosis: 2011 practice guideline by the American Association for the Study of Liver Diseases. Hepatology 2011;54:328-43.
46. Whittaker PG, Lind T, Williams JG. Iron absorption during normal human pregnancy: a study using stable isotopes. Br J Nutr 1991;65: 457-63.