Na+/H+ exchanger 3 blockade ameliorates type 2 diabetes mellitus via inhibition of sodium-glucose co-transporter 1-mediated glucose absorption in the small intestine

Diabetes, Obesity and Metabolism

Volumn 20, Issue 3, 2018, Pages 709-717

  Chan, Leo K Y ^a   Wang, Yi ^a   Ng, Enders K W ^b   Leung, Po Sing ^a  

^a Chinese University of Hong Kong   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

diabetes; glucose intolerance; NHE3 inhibitor; postprandial hyperglycaemia

Indexed keywords

5 (N ETHYL N ISOPROPYL)AMILORIDE; ANTIDIABETIC AGENT; GLUCOSE; GLUCOSE TRANSPORTER 2; INSULIN; S 3226; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SODIUM GLUCOSE COTRANSPORTER 1; SODIUM PROTON EXCHANGE PROTEIN 3; UNCLASSIFIED DRUG; AMILORIDE; EPITHELIAL SODIUM CHANNEL BLOCKING AGENT; IMMEDIATE EARLY PROTEIN; PROTEIN SERINE THREONINE KINASE; SERUM-GLUCOCORTICOID REGULATED KINASE; SLC2A2 PROTEIN, MOUSE; SLC5A1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CACO-2 CELL LINE; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFICACY; DRUG POTENCY; DRUG SPECIFICITY; GENE OVEREXPRESSION; GLUCOSE ABSORPTION; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; GLUCOSE TRANSPORT; GLUT2 GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERGLYCEMIA; INSULIN RESISTANCE; INSULIN TOLERANCE TEST; INTESTINE BRUSH BORDER MEMBRANE; LIQUID SCINTILLATION COUNTING; MALE; MOUSE; NHE3 GENE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET CELL FUNCTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS INHIBITION; SGK1 GENE; SGLT1 GENE; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; GENE KNOCKDOWN; GLUCOSE INTOLERANCE; INTESTINE ABSORPTION; INTESTINE MUCOSA; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; POSTPRANDIAL STATE; SMALL INTESTINE;

AMILORIDE; ANIMALS; CACO-2 CELLS; DIABETES MELLITUS, TYPE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; EPITHELIAL SODIUM CHANNEL BLOCKERS; GENE KNOCKDOWN TECHNIQUES; GLUCOSE; GLUCOSE INTOLERANCE; GLUCOSE TRANSPORTER TYPE 2; HUMANS; HYPERGLYCEMIA; IMMEDIATE-EARLY PROTEINS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; INTESTINE, SMALL; MALE; MICE, INBRED C57BL; POSTPRANDIAL PERIOD; PROTEIN-SERINE-THREONINE KINASES; SODIUM-GLUCOSE TRANSPORTER 1; SODIUM-HYDROGEN EXCHANGER 3;

EID: 85037646035     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/dom.13151     Document Type: Article

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