Stool Xpert MTB/RIF and urine lipoarabinomannan for the diagnosis of tuberculosis in hospitalized HIV-infected children

AIDS

Volumn 32, Issue 1, 2018, Pages 69-78

  Lacourse, Sylvia M ^a   Pavlinac, Patricia B ^b   Cranmer, Lisa M ^c   Njuguna, Irene N ^b,d   Mugo, Cyrus ^e   Gatimu, John ^e   Stern, Joshua ^f   Walson, Judd L ^a,b,g   Maleche Obimbo, Elizabeth ^e   Oyugi, Julius ^e   Wamalwa, Dalton ^e   John Stewart, Grace ^a,b,g  

^a Allergy and Infectious Diseases   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d KENYATTA NATIONAL HOSPITAL   (Kenya)

^e UNIVERSITY OF NAIROBI   (Kenya)

^f Department of Biostatistics ^*  (Kenya)

^g UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

children; GeneXpert MTB RIF; HIV; lipoarabinomannan; stool; tuberculosis; urine

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; LIPOARABINOMANNAN; LIPOPOLYSACCHARIDE;

ANTIRETROVIRAL THERAPY; ARTICLE; BACTERIUM CULTURE; CD4 LYMPHOCYTE COUNT; CHILD; COMPARATIVE STUDY; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; EVALUATION STUDY; FECES ANALYSIS; FEMALE; GASTRIC SUCTION; HOSPITAL PATIENT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOCOMPROMISED PATIENT; KENYA; LUNG TUBERCULOSIS; MAJOR CLINICAL STUDY; MALE; PREDICTIVE VALUE; PRESCHOOL CHILD; PREVALENCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SENSITIVITY AND SPECIFICITY; SPUTUM CULTURE; THORAX RADIOGRAPHY; URINE LEVEL; CHEMISTRY; COMPLICATION; HOSPITALIZATION; INFANT; MOLECULAR DIAGNOSIS; PROCEDURES; RANDOMIZED CONTROLLED TRIAL (TOPIC); URINALYSIS; URINE;

CHILD; CHILD, PRESCHOOL; FEMALE; HIV INFECTIONS; HOSPITALIZATION; HUMANS; INFANT; KENYA; LIPOPOLYSACCHARIDES; MALE; MOLECULAR DIAGNOSTIC TECHNIQUES; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SENSITIVITY AND SPECIFICITY; TUBERCULOSIS, PULMONARY; URINALYSIS; URINE;

EID: 85037368260     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0000000000001662     Document Type: Article

References (43)

1. Global Tuberculosis Report 2016. World Health Organization, 2016. [Accessed 15 February 2017] http://www.who.int/tb/publications/global-report/en/)
2. Jenkins HE, Yuen CM, Rodriguez CA, Nathavitharana RR, McLaughlin MM, Donald P, et al. Mortality in children diagnosed with tuberculosis: A systematic review and meta-Analysis. Lancet Infect Dis 2017; 17:285-295.
3. Jenkins HE. Global burden of childhood tuberculosis. Pneumonia (Nathan) 2016; 8:.
4. Oliwa JN, Karumbi JM, Marais BJ, Madhi SA, Graham SM. Tuberculosis as a cause or comorbidity of childhood pneumonia in tuberculosis-endemic areas: A systematic review. Lancet Respir Med 2015; 3:235-243.
5. Gupta RK, Lucas SB, Fielding KL, Lawn SD. Prevalence of tuberculosis in postmortem studies of HIV-infected adults and children in resource-limited settings: A systematic review and meta-Analysis. AIDS 2015; 29:1987-2002.
6. Chintu C, Mudenda V, Lucas S, Nunn A, Lishimpi K, Maswahu D, et al., UNZA-UCLMS Project Paediatric Post-mortem Study Group. Lung diseases at necropsy in African children dying from respiratory illnesses: A descriptive necropsy study. Lancet 2002; 360:985-990.
7. Bates M, Shibemba A, Mudenda V, Chimoga C, Tembo J, Kabwe M, et al. Burden of respiratory tract infections at post mortem in Zambian children. BMC Med 2016; 14:99.
8. Perez-Velez CM, Marais BJ. Tuberculosis in children. N Engl J Med 2012; 367:348-361.
9. Pai M, Behr MA, Dowdy D, Dheda K, Divangahi M, Boehme CC, et al. Tuberculosis. Nat Rev Dis Primers 2016; 2:16076.
10. Venturini E, Turkova A, Chiappini E, Galli L, de Martino M, Thorne C. Tuberculosis and HIV co-infection in children. BMC Infect Dis 2014; 14 (Suppl 1):S5.
11. Connell TG, Zar HJ, Nicol MP. Advances in the diagnosis of pulmonary tuberculosis in HIV-infected and HIV-uninfected children. J Infect Dis 2011; 204 (Suppl 4):S1151-S1158.
12. Roadmap for childhood tuberculosis. World Health Organization, 2013. http://apps.who.int/iris/bitstream/10665/89506/1/9789241506137-eng.pdf. [Accessed 1 February 2017]
13. Automated real-Time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and rifampicin resistance: Xpert MTB/RIF system for the diagnosis of pulmonary and extrapulmonary TB in adults and children. World Health Organization, 2013. http://apps.who.int/iris/handle/10665/112472). [Accessed 10 February 2017]
14. Shah M, Hanrahan C, Wang ZY, Dendukuri N, Lawn SD, Denkinger CM, Steingart KR. Lateral flow urine lipoarabinomannan assay for detecting active tuberculosis in HIV-positive adults. Cochrane Database Syst Rev 2016:CD011420.
15. The use of lateral flow urine lipoarabinomannan assay (LF-LAM) for the diagnosis and screening of active tuberculosis in people living with HIV. World Health Organization, 2015. http://www.who.int/tb/publications/use-of-lf-lam-Tb-hiv/en/). [Accessed 21 March 2017]
16. Nicol MP, Spiers K, Workman L, Isaacs W, Munro J, Black F, et al. Xpert MTB/RIF testing of stool samples for the diagnosis of pulmonary tuberculosis in children. Clin Infect Dis 2013; 57:e18-e21.
17. Walters E, van der Zalm MM, Palmer M, Bosch C, Demers AM, Draper H, et al. Xpert MTB/RIF on stool is useful for the rapid diagnosis of tuberculosis in young children with severe pulmonary disease. Pediatr Infect Dis J 2017; 36:837-843.
18. Chipinduro M, Mateveke K, Makamure B, Ferrand RA, Gomo E. Stool Xpert(R) MTB/RIF test for the diagnosis of childhood pulmonary tuberculosis at primary clinics in Zimbabwe. Int J Tuberc Lung Dis 2017; 21:161-166.
19. Hasan Z, Arif F, Shakoor S, Mehnaz A, Akber A, Kanji A, et al. Effective testing for pulmonary tuberculosis using Xpert MTB/RIF assay for stool specimens in immunocompetent Pakistani children. Int J Mycobacteriol 2016; 5 (Suppl 1):S8-S9.
20. Moussa H, Bayoumi FS, Mohamed AM. Gene Xpert for direct detection of Mycobacterium tuberculosis in stool specimens from children with presumptive pulmonary tuberculosis. Ann Clin Lab Sci 2016; 46:198-203.
21. Marcy O, Ung V, Goyet S, Borand L, Msellati P, Tejiokem M, et al. Performance of Xpert MTB/RIF and alternative specimen collection methods for the diagnosis of tuberculosis in HIV-infected children. Clin Infect Dis 2016; 62:1161-1168.
22. Njuguna IN, Cranmer LM, Otieno VO, et al. Urgent versus poststabilization ART in hospitalized children: A randomized trial, Abstract #38. Conference on Retroviruses and Oportunisic Infections (CROI). Boston, Massachusetts, 22-25 February 2016
23. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach. World Health Organization, 2013. http://www.who.int/hiv/pub/guidelines/arv2013/download/en/). [Accessed 1 February 2017]
24. Graham SM, Ahmed T, Amanullah F, Browning R, Cardenas V, Casenghi M, et al. Evaluation of tuberculosis diagnostics in children: 1. Proposed clinical case definitions for classification of intrathoracic tuberculosis disease. Consensus from an expert panel. J Infect Dis 2012; 205 (Suppl 2):S199-S208.
25. Walters E, Gie RP, Hesseling AC, Friedrich SO, Diacon AH, Gie RP. Rapid diagnosis of pediatric intrathoracic tuberculosis from stool samples using the Xpert MTB/RIF Assay: A pilot study. Pediatr Infect Dis J 2012; 31:1316.
26. Alere Determine ( TB LAM Ag Package Insert. 2013. http://www.alere.com/ww/en/product-details/determine-Tblam. html). [Accessed 1 February 2017]
27. WHO case definitions of HIV for surveillance and revised clinical staging and immunological classification of HIV-related disease in adults and children.WorldHealth Organization, 2007. http://www.who.int/hiv/pub/guidelines/HIVstaging150307.pdf. [Accessed 17 February 2017]
28. Graham SM, Cuevas LE, Jean-Philippe P, Browning B, Casenghi M, Detjen AK, et al. Clinical case definitions for classification of intrathoracic tuberculosis in children: An update. Clin Infect Dis 2015; 61 (Suppl 3):S179-S187.
29. WHO Anthro (version 3.2.2, January 2011) and macros. 2011. http://www.who.int/childgrowth/software/en/). [Accessed 1 February 2017]
30. Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap): A metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform 2009; 42:377-381.
31. Detjen AK, DiNardo AR, Leyden J, Steingart KR, Menzies D, Schiller I, et al. Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis in children: A systematic review and meta-Analysis. Lancet Respir Med 2015; 3:451-461.
32. Nicol MP, Allen V, Workman L, Isaacs W, Munro J, Pienaar S, et al. Urine lipoarabinomannan testing for diagnosis of pulmonary tuberculosis in children: A prospective study. Lancet Glob Health 2014; 2:e278-e284.
33. Kroidl I, Clowes P, Reither K, Mtafya B, Rojas-Ponce G, Ntinginya EN, et al. Performance of urine lipoarabinomannan assays for paediatric tuberculosis in Tanzania. Eur Respir J 2015; 46:761-770.
34. Dheda K, Davids V, Lenders L, Roberts T, Meldau R, Ling D, et al. Clinical utility of a commercial LAM-ELISA assay for TB diagnosis in HIV-infected patients using urine and sputum samples. PLoS One 2010; 5:e9848.
35. Kroidl I, Clowes P, Mwakyelu J, Maboko L, Kiangi A, Rachow A, et al. Reasons for false-positive lipoarabinomannan ELISA results in a Tanzanian population. Scand J Infect Dis 2014; 46:144-148.
36. Lawn SD. Point-of-care detection of lipoarabinomannan (LAM) in urine for diagnosis of HIV-Associated tuberculosis: A state of the art review. BMC Infect Dis 2012; 12:103.
37. Gounder CR, Kufa T, Wada NI, Mngomezulu V, Charalambous S, Hanifa Y, et al. Diagnostic accuracy of a urine lipoarabinomannan enzyme-linked immunosorbent assay for screening ambulatory HIV-infected persons for tuberculosis. J Acquir Immune Defic Syndr 2011; 58:219-223.
38. Qvist T, Johansen IS, Pressler T, Høiby N, Andersen AB, Katzenstein TL, Bjerrum S. Urine lipoarabinomannan point-of-care testing in patients affected by pulmonary nontuberculous mycobacteria: experiences from the Danish Cystic Fibrosis cohort study. BMC Infect Dis 2014; 14:655.
39. Torok ME, Yen NT, Chau TT, Mai NT, Phu NH, Mai PP, et al. Timing of initiation of antiretroviral therapy in human immunodeficiency virus (HIV): Associated tuberculous meningitis. Clin Infect Dis 2011; 52:1374-1383.
40. Makadzange AT, Ndhlovu CE, Takarinda K, Reid M, Kurangwa M, Gona P, Hakim JG. Early versus delayed initiation of antiretroviral therapy for concurrent HIV infection and cryptococcal meningitis in sub-saharan Africa. Clin Infect Dis 2010; 50:1532-1538.
41. Reid MJ, Saito S, Fayorsey R, Carter RJ, Abrams EJ. Assessing capacity for diagnosing tuberculosis in children in sub-Saharan African HIV care settings. Int J Tuberc Lung Dis 2012; 16: 924-927.
42. Lawn SD, Kerkhoff AD, Burton R, Schutz C, Boulle A, Vogt M, et al. Diagnostic accuracy, incremental yield and prognostic value of Determine TB-LAM for routine diagnostic testing for tuberculosis in HIV-infected patients requiring acute hospital admission in South Africa: A prospective cohort. BMC Med 2017; 15:67.
43. Huerga H, Ferlazzo G, Bevilacqua P, Kirubi B, Ardizzoni E, Wanjala S, et al. Incremental yield of including determine-TB LAM assay in diagnostic algorithms for hospitalized and ambulatory HIV-positive patients in Kenya. PLoS One 2017; 12:e0170976.