Performance of Xpert MTB/RIF and Alternative Specimen Collection Methods for the Diagnosis of Tuberculosis in HIV-Infected Children

Clinical Infectious Diseases

Volumn 62, Issue 9, 2016, Pages 1161-1168

  Marcy, Olivier ^a,b   Ung, Vibol ^c,d   Goyet, Sophie ^a   Borand, Laurence ^a   Msellati, Philippe ^e   Tejiokem, Mathurin ^f   Nguyen Thi, Ngoc Lan ^g   Nacro, Boubacar ^h   Cheng, Sokleaph ^a   Eyangoh, Sara ^f   Pham, Thu Hang ^g   Ouedraogo, Abdoul Salam ^h   Tarantola, Arnaud ^a   Godreuil, Sylvain ^i,j   Blanche, Stephane ^k   Delacourt, Christophe ^l  

^a INSTITUT PASTEUR DU CAMBODGE   (Cambodia)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c HIV Department   (United States)

^d UNIVERSITY OF HEALTH SCIENCES   (Cambodia)

^e UNIVERSITÉ DE MONTPELLIER   (France)

^f CENTRE PASTEUR DU CAMEROUN   (Cameroon)

^g Pham Ngoc Thach Hospital   (Viet Nam)

^h Centre Hospitalier Universitaire Souro Sanou   (Burkina Faso)

ⁱ HÔPITAL ARNAUD DE VILLENEUVE   (France)

^j INSERM   (France)

^k Unite d'Immunologie Hematologie Rhumatologie Pediatrique   (France)

^l HÔPITAL NECKER ENFANTS MALADES   (France)

more..

Author keywords

children; diagnosis; HIV infection; Tuberculosis; Xpert MTB RIF

Indexed keywords

ALTERNATIVE SPECIMEN COLLECTION METHOD; ARTICLE; ASSAY; BACTERIUM CULTURE; CHILD; CHILDHOOD DISEASE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC KIT; DIAGNOSTIC PROCEDURE; FECES; FEMALE; FOLLOW UP; GASTRIC SUCTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; MAJOR CLINICAL STUDY; MALE; NASOPHARYNGEAL ASPIRATION; NEWBORN; PRIORITY JOURNAL; TUBERCULOSIS; XPERT MTB RIF ASSAY; ADOLESCENT; BODILY SECRETIONS; BURKINA FASO; CAMBODIA; CAMEROON; CLINICAL TRIAL; COMPLICATION; GENETICS; MICROBIOLOGY; MIXED INFECTION; MYCOBACTERIUM TUBERCULOSIS; NUCLEIC ACID AMPLIFICATION; PRESCHOOL CHILD; SENSITIVITY AND SPECIFICITY; SPECIMEN HANDLING; VIET NAM;

BACTERIAL DNA;

ADOLESCENT; BODILY SECRETIONS; BURKINA FASO; CAMBODIA; CAMEROON; CHILD; CHILD, PRESCHOOL; COINFECTION; DNA, BACTERIAL; FEMALE; HIV INFECTIONS; HUMANS; INFANT; INFANT, NEWBORN; MALE; MYCOBACTERIUM TUBERCULOSIS; NUCLEIC ACID AMPLIFICATION TECHNIQUES; SENSITIVITY AND SPECIFICITY; SPECIMEN HANDLING; TUBERCULOSIS; VIETNAM;

EID: 84966599692     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/ciw036     Document Type: Article

References (32)

1. World Health Organization. Global tuberculosis report 2015. Geneva, Switzerland: World Health Organization, 2015.
2. Dodd PJ, Gardiner E, Coghlan R, Seddon JA. Burden of childhood tuberculosis in 22 high-burden countries: a mathematical modelling study. Lancet Glob Health 2014; 2:e453-9.
3. Jenkins HE, Tolman AW, Yuen CM, et al. Incidence of multidrug-resistant tuberculosis disease in children: systematic review and global estimates. Lancet 2014; 383:1572-9.
4. Marais BJ, Gie RP, Schaaf HS, Beyers N, Donald PR, Starke JR. Childhood pulmonary tuberculosis: old wisdom and new challenges. Am J Respir Crit Care Med 2006; 173:1078-90.
5. Marais BJ, Gie RP, Hesseling AC, et al. A refined symptom-based approach to diagnose pulmonary tuberculosis in children. Pediatrics 2006; 118:e1350-9.
6. Hesseling AC, Westra AE, Werschkull H, et al. Outcome of HIV infected children with culture confirmed tuberculosis. Arch Dis Child 2005; 90:1171-4.
7. Marais BJ, Graham SM, Cotton MF, Beyers N. Diagnostic and management challenges for childhood tuberculosis in the era of HIV. J Infect Dis 2007; 196(suppl 1):S76-85.
8. Boehme CC, Nabeta P, Hillemann D, et al. Rapid molecular detection of tuberculosis and rifampin resistance. N Engl J Med 2010; 363:1005-15.
9. World Health Organization. Policy statement: automated real-time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and rifampicin resistance: Xpert MTB/RIF system. Geneva, Switzerland: World Health Organization, 2011.
10. Detjen AK, DiNardo AR, Leyden J, et al. Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis in children: a systematic review and meta-analysis. Lancet Respir Med 2015; 3:451-61.
11. World Health Organization. Guidance for national tuberculosis programmes in the management of tuberculosis in children, 2nd ed. Geneva, Switzerland: World Health Organization, 2014.
12. Marais BJ, Pai M. Specimen collection methods in the diagnosis of childhood tuberculosis. Indian J Med Microbiol 2006; 24:249-51.
13. Zar HJ, Hanslo D, Apolles P, Swingler G, Hussey G. Induced sputum versus gastric lavage for microbiological confirmation of pulmonary tuberculosis in infants and young children: a prospective study. Lancet 2005; 365:130-4.
14. Reid MJA, Saito S, Fayorsey R, Carter RJ, Abrams EJ. Assessing capacity for diagnosing tuberculosis in children in sub-Saharan African HIV care settings. Int J Tuberc Lung Dis 2012; 16:924-7.
15. Boehme CC, Nicol MP, Nabeta P, et al. Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study. Lancet 2011; 377:1495-505.
16. Owens S, Abdel-Rahman IE, Balyejusa S, et al. Nasopharyngeal aspiration for diagnosis of pulmonary tuberculosis. Arch Dis Child 2007; 92:693-6.
17. Chow F, Espiritu N, Gilman RH, et al. La cuerda dulce-A tolerability and acceptability study of a novel approach to specimen collection for diagnosis of paediatric pulmonary tuberculosis. BMC Infect Dis 2006; 6:67.
18. Vargas D, Garciá L, Gilman RH, et al. Diagnosis of sputum-scarce HIV-associated pulmonary tuberculosis in Lima, Peru. Lancet 2005; 365:150-2.
19. Graham SM, Ahmed T, Amanullah F, et al. Evaluation of tuberculosis diagnostics in children: 1. Proposed clinical case definitions for classification of intrathoracic tuberculosis disease. Consensus from an expert panel. J Infect Dis 2012; 205(suppl 2):S199-208.
20. Schuetz GM, Schlattmann P, Dewey M. Use of 3×2 tables with an intention to diagnose approach to assess clinical performance of diagnostic tests: meta-analytical evaluation of coronary CT angiography studies. BMJ 2012; 345:e6717.
21. Theron G. Xpert MTB/RIF to diagnose tuberculosis in children. Lancet Respir Med 2015; 3:419-21.
22. Walters E, Gie RP, Hesseling AC, Friedrich SO, Diacon AH, Gie RP. Rapid diagnosis of pediatric intrathoracic tuberculosis from stool samples using the Xpert MTB/RIF assay: a pilot study. Pediatr Infect Dis J 2012; 31:1316.
23. Nicol MP, Spiers K, Workman L, et al. Xpert MTB/RIF testing of stool samples for the diagnosis of pulmonary tuberculosis in children. Clin Infect Dis 2013; 57: e18-21.
24. Donald PR, Schaaf HS, Gie RP, Beyers N, Sirgel FA, Venter A. Stool microscopy and culture to assist the diagnosis of pulmonary tuberculosis in childhood. J Trop Pediatr 1996; 42:311-2.
25. Wolf H, Mendez M, Gilman RH, et al. Diagnosis of pediatric pulmonary tuberculosis by stool PCR. Am J Trop Med Hyg 2008; 79:893-8.
26. Oberhelman RA, Soto-Castellares G, Gilman RH, et al. Diagnostic approaches for paediatric tuberculosis by use of different specimen types, culture methods, and PCR: a prospective case-control study. Lancet Infect Dis 2010; 10:612-20.
27. Oramasionwu GE, Heilig CM, Udomsantisuk N, et al. The utility of stool cultures for diagnosing tuberculosis in people living with the human immunodeficiency virus. Int J Tuberc Lung Dis 2013; 17:1023-8.
28. Zar HJ, Workman L, Isaacs W, et al. Rapid molecular diagnosis of pulmonary tuberculosis in children using nasopharyngeal specimens. Clin Infect Dis 2012; 55:1088-95.
29. Zar HJ, Workman L, Isaacs W, Dheda K, Zemanay W, Nicol MP. Rapid diagnosis of pulmonary tuberculosis in African children in a primary care setting by use of Xpert MTB/RIF on respiratory specimens: a prospective study. Lancet Glob Health 2013; 1:e97-104.
30. World Health Organization. Automated real-time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and rifampicin resistance: Xpert MTB/RIF assay for the diagnosis of pulmonary and extrapulmonary TB in adults and children. Policy update. Geneva, Switzerland: World Health Organization, 2013.
31. Nicol MP, Workman L, Isaacs W, et al. Accuracy of the Xpert MTB/RIF test for the diagnosis of pulmonary tuberculosis in children admitted to hospital in Cape Town, South Africa: a descriptive study. Lancet Infect Dis 2011; 11:819-24.
32. Steingart KR, Sohn H, Schiller I, et al. Xpert® MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults. Cochrane Database Syst Rev 2014; 1:CD009593.