Genetic sharing with cardiovascular disease risk factors and diabetes reveals novel bone mineral density loci

PLoS ONE

Volumn 10, Issue 12, 2015, Pages

  Reppe, Sjur ^a,b,c   Wang, Yunpeng ^a,c,d,e   Thompson, Wesley K ^d   McEvoy, Linda K ^f,g   Schork, Andrew J ^f   Zuber, Verena ^a,c   LeBlanc, Marissa ^c   Bettella, Francesco ^a,c   Mills, Ian G ^c   Desikan, Rahul S ^f,g   Djurovic, Srdjan ^a,c   Gautvik, Kaare M ^a,b,c,cm   Dale, Anders M ^d,e,f,g   Andreassen, Ole A ^a,c,d   Estrada, Karol ^h,i   Styrkarsdottir, Unnur ^j   Evangelou, Evangelos ^k   Hsu, Yi Hsiang ^l,m   Duncan, Emma L ^n,o   Ntzani, Evangelia E ^k   Oei, Ling ^h,i   Albagha, Omar M E ^p   Amin, Najaf ^h   Kemp, John P ^q   Koller, Daniel L ^r   Li, Guo ^s   Liu, Ching Ti ^t   Minster, Ryan L ^u   Moayyeri, Alireza ^v,w   Vandenput, Liesbeth ^x   Willner, Dana ⁿ   Xiao, Su Mei ^y   Yerges Armstrong, Laura M ^z   Zheng, Hou Feng ^aa   Alonso, Nerea ^p   Eriksson, Joel ^x   Kammerer, Candace M ^u   Kaptoge, Stephen K ^v   Leo, Paul J ⁿ   Thorleifsson, Gudmar ^j   Wilson, Scott G ^w,ab,ac   Wilson, James F ^p,ad   Aalto, Ville ^ae,af   Alen, Markku ^ag   Aragaki, Aaron K ^ah   Aspelund, Thor ^ai,aj   Center, Jacqueline R ^ak,al,am   Dailiana, Zoe ^an   Duggan, David J ^ao   Garcia, Melissa ^ap   Garcia Giralt, Natàlia ^aq   Giroux, Sylvie ^ar   Hallmans, Göran ^as   Hocking, Lynne J ^at   Husted, Lise Bjerre ^au   Jameson, Karen A ^av   Khusainova, Rita ^aw,ax   Kim, Ghi Su ^ay   Kooperberg, Charles ^ah   Koromila, Theodora ^az   Kruk, Marcin ^ba   Laaksonen, Marika ^bb   Lacroix, Andrea Z ^ah   Lee, Seung Hun ^ay   Leung, Ping C ^bc   Lewis, Joshua R ^ab,ac   Masi, Laura ^bd   Mencej Bedrac, Simona ^be   Nguyen, Tuan V ^ak,al   Nogues, Xavier ^aq   Patel, Millan S ^bf   Prezelj, Janez ^bg   Rose, Lynda M ^bh   Scollen, Serena ^v   Siggeirsdottir, Kristin ^ai   Smith, Albert V ^ai,aj   Svensson, Olle ^as   Trompet, Stella ^bi   Trummer, Olivia ^bj   Van Schoor, Natasja M ^bk   Woo, Jean ^bc   Zhu, Kun ^ab,ac   Balcells, Susana ^bl   Brandi, Maria Luisa ^bd   Buckley, Brendan M ^bm   Cheng, Sulin ^bn,bo   Christiansen, Claus ^bp   Cooper, Cyrus ^av   Dedoussis, George ^bq   Ford, Ian ^br   Frost, Morten ^bs,bt   Goltzman, David ^bu   González Macías, Jesús ^bv,bw   Kähönen, Mika ^bx,by   Karlsson, Magnus ^bz   Khusnutdinova, Elza ^aw,ax   Koh, Jung Min ^ay   Kollia, Panagoula ^az   Langdahl, Bente Lomholt ^au   Leslie, William D ^ca   Lips, Paul ^bk,cb   Ljunggren, Östen ^cc   Lorenc, Roman S ^ba   Marc, Janja ^be   Mellström, Dan ^x   Obermayer Pietsch, Barbara ^bj   Olmos, José M ^bv,bw   Pettersson Kymmer, Ulrika ^as   Reid, David M ^at   Riancho, José A ^bv,bw   Ridker, Paul M ^m,bh   Rousseau, François ^ar,cd   Slagboom, P Eline ^i,bi   Tang, Nelson L S ^bc   Urreizti, Roser ^bl   Van Hul, Wim ^ce   Viikari, Jorma ^ae,cf   Zarrabeitia, María T ^bv   Aulchenko, Yurii S ^h   Castano Betancourt, Martha ^h,i   Grundberg, Elin ^bu,cg   Herrera, Lizbeth ^h   Ingvarsson, Thorvaldur ^aj,ch,ci   Johannsdottir, Hrefna ^j   Kwan, Tony ^bu   Li, Rui ^aa   Luben, Robert ^v   Medina Gómez, Carolina ^h   Palsson, Stefan Th ^j   Rotter, Jerome I ^cj   Sigurdsson, Gunnar ^aj,ck   Van Meurs, Joyce B J ^h,i   Verlaan, Dominique ^bu   Williams, Frances M K ^w   Wood, Andrew R ^cl   Zhou, Yanhua ^t   Pastinen, Tomi ^bu,cn   Raychaudhuri, Soumya ^bh,co   Cauley, Jane A ^cp   Chasman, Daniel I ^m,bh   Clark, Graeme R ⁿ   Cummings, Steven R ^cq   Danoy, Patrick ⁿ   Dennison, Elaine M ^av   Eastell, Richard ^cr   Eisman, John A ^ak,al,am   Gudnason, Vilmundur ^ai,aj   Hofman, Albert ^h,i   Jackson, Rebecca D ^cs   Jones, Graeme ^ct   Jukema, J Wouter ^bi,cu,cv   Khaw, Kay Tee ^v   Lehtimäki, Terho ^bx,by   Liu, Yongmei ^cw   Lorentzon, Mattias ^x   McCloskey, Eugene ^cr,cx   Mitchell, Braxton D ^z   Nandakumar, Kannabiran ^l,m   Nicholson, Geoffrey C ⁿ   Oostra, Ben A ^h   Peacock, Munro ^r   Pols, Huibert A P ^h   Prince, Richard L ^ab,ac   Raitakari, Olli ^ae,af   Reid, Ian R ^cy   Robbins, John ^cz   Sambrook, Philip N ^da   Sham, Pak Chung ^y   Shuldiner, Alan R ^z,db   Tylavsky, Frances A ^dc   Van Duijn, Cornelia M ^h   Wareham, Nick J ^dd   Cupples, L Adrienne ^t,de   Econs, Michael J ^r   Evans, David M ^q   Harris, Tamara B ^ap   Kung, Annie Wai Chee ^y   Psaty, Bruce M ^df,dg   Reeve, Jonathan ^v   Spector, Timothy D ^w   Streeten, Elizabeth A ^z,db   Zillikens, M Carola ^h   Thorsteinsdottir, Unnur ^j,aj   Ohlsson, Claes ^x   Karasik, David ^l,m   Richards, J Brent ^w,aa   Brown, Matthew A ⁿ   Stefansson, Kari ^j,aj   Uitterlinden, André G ^h,i   Ralston, Stuart H ^p   Ioannidis, John P A ^k,dh   Kiel, Douglas P ^l,m   Rivadeneira, Fernando ^h,i   more..

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b LOVISENBERG DIAKONALE HOSPITAL   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h ERASMUS MEDICAL CENTER   (Netherlands)

ⁱ Netherlands Genomics Initiative   (Netherlands)

^j DECODE GENETICS   (Iceland)

^k UNIVERSITY OF IOANNINA   (Greece)

^l Hebrew Senior Life   (United States)

^m HARVARD MEDICAL SCHOOL   (United States)

ⁿ UNIVERSITY OF QUEENSLAND   (Australia)

^o ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^p UNIVERSITY OF EDINBURGH   (United Kingdom)

^q UNIVERSITY OF BRISTOL   (United Kingdom)

^r INDIANA UNIVERSITY   (United States)

^s UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^t BOSTON UNIVERSITY   (United States)

^u UNIVERSITY OF PITTSBURGH   (United States)

^v UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^w KING'S COLLEGE LONDON   (United Kingdom)

^x UNIVERSITY OF GOTHENBURG   (Sweden)

^y UNIVERSITY OF HONG KONG   (Hong Kong)

^z UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^aa MCGILL UNIVERSITY   (Canada)

^ab UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^ac SIR CHARLES GAIRDNER HOSPITAL   (Australia)

^ad UNIVERSITY OF EDINBURGH   (United Kingdom)

^ae TURKU UNIVERSITY HOSPITAL   (Finland)

^af UNIVERSITY OF TURKU   (Finland)

^ag OULU UNIVERSITY HOSPITAL   (Finland)

^ah Fred Hutchinson Cancer Research Center   (United States)

^ai ICELANDIC HEART ASSOCIATION   (Iceland)

^aj UNIVERSITY OF ICELAND   (Iceland)

^ak GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^al UNIVERSITY OF NEW SOUTH WALES   (Australia)

^am ST VINCENT S HOSPITAL   (Australia)

^an UNIVERSITY OF THESSALY   (Greece)

^ao TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

^ap NATIONAL INSTITUTE ON AGING   (United States)

^aq UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^ar LAVAL UNIVERSITY   (Canada)

^as UMEÅ UNIVERSITY   (Sweden)

^at UNIVERSITY OF ABERDEEN   (United Kingdom)

^au AARHUS UNIVERSITY HOSPITAL   (Denmark)

^av UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^aw INSTITUTE OF BIOCHEMISTRY AND GENETICS   (Russian Federation)

^ax Ufa University of Science and Technology   (Russian Federation)

^ay University of Ulsan College of Medicine   (South Korea)

^az UNIVERSITY OF ATHENS   (Greece)

^ba CHILDREN'S MEMORIAL HEALTH INSTITUTE   (Poland)

^bb UNIVERSITY OF HELSINKI   (Finland)

^bc CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^bd UNIVERSITY OF FLORENCE   (Italy)

^be UNIVERSITY OF LJUBLJANA   (Slovenia)

^bf UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^bg UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

^bh BRIGHAM AND WOMEN S HOSPITAL   (United States)

^bi LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^bj MEDICAL UNIVERSITY OF GRAZ   (Austria)

^bk VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^bl UNIVERSITY OF BARCELONA   (Spain)

^bm UNIVERSITY COLLEGE CORK   (Ireland)

^bn UNIVERSITY OF JYVÄSKYLÄ   (Finland)

^bo KUOPIO UNIVERSITY HOSPITAL   (Finland)

^bp CENTER FOR CLINICAL AND BASIC RESEARCH   (Denmark)

^bq HAROKOPIO UNIVERSITY   (Greece)

^br UNIVERSITY OF GLASGOW   (United Kingdom)

^bs ODENSE UNIVERSITY HOSPITAL   (Denmark)

^bt UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^bu MCGILL UNIVERSITY   (Canada)

^bv UNIVERSITY OF CANTABRIA   (Spain)

^bw HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

^bx TAMPERE UNIVERSITY HOSPITAL   (Finland)

^by TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^bz LUND UNIVERSITY   (Sweden)

^ca UNIVERSITY OF MANITOBA   (Canada)

^cb VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^cc UPPSALA UNIVERSITY   (Sweden)

^cd UNIVERSITÉ LAVAL   (Canada)

^ce UNIVERSITY OF ANTWERP   (Belgium)

^cf UNIVERSITY OF TURKU   (Finland)

^cg WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^ch AKUREYRI HOSPITAL   (Iceland)

^ci UNIVERSITY OF AKUREYRI   (Iceland)

^cj CEDARS SINAI MEDICAL CENTER   (United States)

^ck LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^cl UNIVERSITY OF EXETER   (United Kingdom)

^cm Lovisenberg Deacon Hospital   (Norway)

^cn MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^co BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^cp UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^cq CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^cr UNIVERSITY OF SHEFFIELD   (United Kingdom)

^cs OHIO STATE UNIVERSITY   (United States)

^ct UNIVERSITY OF TASMANIA   (Australia)

^cu Durrer Center for Cardiogenetic Research   (Netherlands)

^cv ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

^cw WAKE FOREST SCHOOL OF MEDICINE   (United States)

^cx UNIVERSITY OF SHEFFIELD   (United Kingdom)

^cy UNIVERSITY OF AUCKLAND   (New Zealand)

^cz University of Davis Cancer Center   (United States)

^da UNIVERSITY OF SYDNEY   (Australia)

^db BALTIMORE VA MEDICAL CENTER   (United States)

^dc UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

^dd MEDICAL RESEARCH COUNCIL   (United Kingdom)

^de FRAMINGHAM HEART STUDY   (United States)

^df UNIVERSITY OF WASHINGTON   (United States)

^dg CENTER FOR HEALTH STUDIES   (United States)

^dh STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL;

ARTICLE; BONE DENSITY; BONE METABOLISM; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CELL LINEAGE; COMORBIDITY; DIABETES MELLITUS; DIASTOLIC BLOOD PRESSURE; GENE EXPRESSION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; NON INSULIN DEPENDENT DIABETES MELLITUS; OSTEOBLAST; OSTEOCYTE; PLEIOTROPY; RISK ASSESSMENT; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; WAIST HIP RATIO; BIOLOGICAL MODEL; GENE REGULATORY NETWORK; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY;

BONE DENSITY; CARDIOVASCULAR DISEASES; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; GENE REGULATORY NETWORKS; GENETIC LOCI; GENETIC PLEIOTROPY; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MODELS, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; WAIST-HIP RATIO;

EID: 84958012773     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0144531     Document Type: Article

References (53)

1. Kanis JA, Oden A, Johnell O, Johansson H, De Laet C, Brown J, et al. (2007) The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporos Int 18: 1033-1046. PMID: 17323110
2. Compston J (2010) Osteoporosis: social and economic impact. Radiol Clin North Am 48: 477-482. S0033-8389(10)00011-4 [pii]; doi: 10.1016/j.rcl.2010.02.010 PMID: 20609886
3. Tanko LB, Christiansen C, Cox DA, Geiger MJ, McNabb MA, Cummings SR (2005) Relationship between osteoporosis and cardiovascular disease in postmenopausal women. J Bone Miner Res 20: 1912-1920. doi: 10.1359/JBMR.050711 PMID: 16234963
4. Kado DM, Browner WS, Blackwell T, Gore R, Cummings SR (2000) Rate of bone loss is associated with mortality in older women: a prospective study. J Bone Miner Res 15: 1974-1980. doi: 10.1359/jbmr.2000.15.10.1974 PMID: 11028450
5. Lawlor DA, Sattar N, Sayers A, Tobias JH (2012) The association of fasting insulin, glucose, and lipids with bone mass in adolescents: findings from a cross-sectional study. J Clin Endocrinol Metab 97: 2068-2076. jc.2011-2721 [pii]; doi: 10.1210/jc.2011-2721 PMID: 22492875
6. Li S, Guo H, Liu Y, Wu F, Zhang H, Zhang Z, et al. (2015) Relationships of serum lipid profiles and bone mineral density in postmenopausal Chinese women. Clin Endocrinol (Oxf) 82: 53-58. doi: 10.1111/cen.12616
7. Kim T, Park S, Pak YS, Lee S, Lee EH (2013) Association between metabolic syndrome and bone mineral density in Korea: the Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV), 2008. J Bone Miner Metab 31: 652-662. doi: 10.1007/s00774-013-0459-4 PMID: 23543212
8. Kim YH, Nam GE, Cho KH, Choi YS, Kim SM, Han BD, et al. (2013) Low bone mineral density is associated with dyslipidemia in South Korean men: the 2008-2010 Korean National Health and Nutrition Examination Survey. Endocr J 60: 1179-1189. DN/JST.JSTAGE/endocrj/EJ13-0224 [pii]. PMID: 23877056
9. Buizert PJ, van Schoor NM, Lips P, Deeg DJ, Eekhoff EM (2009) Lipid levels: a link between cardiovascular disease and osteoporosis? J Bone Miner Res 24: 1103-1109. doi: 10.1359/jbmr.081262 PMID: 19113906
10. Garg MK, Marwaha RK, Tandon N, Bhadra K, Mahalle N (2014) Relationship of lipid parameters with bone mineral density in Indian population. Indian J Endocrinol Metab 18: 325-332. doi: 10.4103/2230-8210.131165;IJEM-18-325 [pii]. PMID: 24944926
11. Liu J, Zhu LP, Yang XL, Huang HL, Ye DQ (2013) HMG-CoA reductase inhibitors (statins) and bone mineral density: a meta-analysis. Bone 54: 151-156. S8756-3282(13)00061-6 [pii]; doi: 10.1016/j.bone.2013.01.044 PMID: 23388418
12. Lee HT, Shin J, Min SY, Lim YH, Kim KS, Kim SG, et al. (2014) The relationship between bone mineral density and blood pressure in the Korean elderly population: the Korea National Health and Nutrition Examination Survey, 2008-2011. Clin Exp Hypertens 1-6. doi: 10.3109/10641963.2014.933971 PMID: 25057784
13. Yazici S, Yazici M, Korkmaz U, Engin EM, Erdem BA, Erden I, et al. (2011) Relationship between blood pressure levels and bone mineral density in postmenopausal Turkish women. Arch Med Sci 7: 264-270. doi: 10.5114/aoms.2011.22077;AMS-7-2-264 [pii]. PMID: 22291766
14. Kaplan S, Smith SR, Zuckerman IH (2010) Blood pressure and bone mineral density in premenopausal and postmenopausal women. J Womens Health (Larchmt) 19: 1209-1215. doi: 10.1089/jwh.2009.1587
15. Jackuliak P, Payer J (2014) Osteoporosis, fractures, and diabetes. Int J Endocrinol 2014: 820615. doi: 10.1155/2014/820615 PMID: 25050121
16. Vestergaard P (2007) Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes - A meta-analysis. Osteoporos Int 18: 427-444. doi: 10.1007/s00198-006-0253-4 PMID: 17068657
17. Oei L, Zillikens MC, Dehghan A, Buitendijk GH, Castano-Betancourt MC, Estrada K, et al. (2013) High bone mineral density and fracture risk in type 2 diabetes as skeletal complications of inadequate glucose control: the Rotterdam Study. Diabetes Care 36: 1619-1628. dc12-1188 [pii]; doi: 10.2337/dc12-1188 PMID: 23315602
18. Khan TS, Fraser LA (2015) Type 1 diabetes and osteoporosis: from molecular pathways to bone phenotype. J Osteoporos 2015: 174186. doi: 10.1155/2015/174186 PMID: 25874154
19. Sayers A, Lawlor DA, Sattar N, Tobias JH (2012) The association between insulin levels and cortical bone: findings from a cross-sectional analysis of pQCT parameters in adolescents. J Bone Miner Res 27: 610-618. doi: 10.1002/jbmr.1467 PMID: 22095452
20. Billings LK, Hsu YH, Ackerman RJ, Dupuis J, Voight BF, Rasmussen-Torvik LJ, et al. (2012) Impact of common variation in bone-related genes on type 2 diabetes and related traits. Diabetes 61: 2176-2186. db11-1515 [pii]; doi: 10.2337/db11-1515 PMID: 22698912
21. Kim CJ, Oh KW, Rhee EJ, Kim KH, Jo SK, Jung CH, et al. (2009) Relationship between body composition and bone mineral density (BMD) in perimenopausal Korean women. Clin Endocrinol (Oxf) 71: 18-26. CEN3452 [pii]; doi: 10.1111/j.1365-2265.2008.03452.x
22. Zillikens MC, Uitterlinden AG, van Leeuwen JP, Berends AL, Henneman P, van Dijk KW, et al. (2010) The role of body mass index, insulin, and adiponectin in the relation between fat distribution and bone mineral density. Calcif Tissue Int 86: 116-125. doi: 10.1007/s00223-009-9319-6 PMID: 19957167
23. Janicka A, Wren TA, Sanchez MM, Dorey F, Kim PS, Mittelman SD, et al. (2007) Fat mass is not beneficial to bone in adolescents and young adults. J Clin Endocrinol Metab 92: 143-147. jc.2006-0794 [pii]; doi: 10.1210/jc.2006-0794 PMID: 17047019
24. Ackert-Bicknell CL (2012) HDL cholesterol and bone mineral density: is there a genetic link? Bone 50: 525-533. S8756-3282(11)01080-5 [pii]; doi: 10.1016/j.bone.2011.07.002 PMID: 21810493
25. Estrada K, Styrkarsdottir U, Evangelou E, Hsu YH, Duncan EL, Ntzani EE, et al. (2012) Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet 44: 491-501. ng.2249 [pii]; doi: 10.1038/ng.2249 PMID: 22504420
26. Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, et al. (2010) Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466: 707-713. nature09270 [pii]; doi: 10.1038/nature09270 PMID: 20686565
27. Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, et al. (2009) Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet 41: 703-707. ng.381 [pii]; doi: 10.1038/ng.381 PMID: 19430480
28. Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, et al. (2010) Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 42: 579-589. ng.609 [pii]; doi: 10.1038/ng.609 PMID: 20581827
29. Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, et al. (2011) Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 478: 103-109. nature10405 [pii]; doi: 10.1038/nature10405 PMID: 21909115
30. Sivakumaran S, Agakov F, Theodoratou E, Prendergast JG, Zgaga L, Manolio T, et al. (2011) Abundant pleiotropy in human complex diseases and traits. Am J Hum Genet 89: 607-618. S0002-9297(11)00438-1 [pii]; doi: 10.1016/j.ajhg.2011.10.004 PMID: 22077970
31. Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium. (2011) Genome-wide association study identifies five new schizophrenia loci. Nat Genet 43: 969-976. ng.940 [pii]; doi: 10.1038/ng.940 PMID: 21926974
32. Liu JZ, Hov JR, Folseraas T, Ellinghaus E, Rushbrook SM, Doncheva NT, et al. (2013) Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis. Nat Genet 45: 670-675. ng.2616 [pii]; doi: 10.1038/ng.2616 PMID: 23603763
33. Andreassen OA, Djurovic S, Thompson WK, Schork AJ, Kendler KS, O'Donovan MC, et al. (2013) Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors. Am J Hum Genet 92: 197-209. S0002-9297(13)00030-X [pii]; doi: 10.1016/j.ajhg.2013.01.001 PMID: 23375658
34. Andreassen OA, McEvoy LK, Thompson WK, Wang Y, Reppe S, Schork AJ, et al. (2014) Identifying common genetic variants in blood pressure due to polygenic pleiotropy with associated phenotypes. Hypertension 63: 819-826. HYPERTENSIONAHA.113.02077 [pii]; doi: 10.1161/HYPERTENSIONAHA.113.02077 PMID: 24396023
35. Schork AJ, Thompson WK, Pham P, Torkamani A, Roddey JC, Sullivan PF, et al. (2013) All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs. PLoS Genet 9: e1003449. doi: 10.1371/journal.pgen.1003449;PGENETICS-D-12-02185 [pii]. PMID: 23637621
36. Lin DY, Sullivan PF (2009) Meta-analysis of genome-wide association studies with overlapping subjects. Am J Hum Genet 85: 862-872. S0002-9297(09)00515-1 [pii]; doi: 10.1016/j.ajhg.2009.11.001 PMID: 20004761
37. Andreassen OA, Zuber V, Thompson WK, Schork AJ, Bettella F, Djurovic S, et al. (2014) Shared common variants in prostate cancer and blood lipids. Int J Epidemiol 43: 1205-1214. dyu090 [pii]; doi: 10.1093/ije/dyu090 PMID: 24786909
38. Reppe S, Refvem H, Gautvik VT, Olstad OK, Hovring PI, Reinholt FP, et al. (2010) Eight genes are highly associated with BMD variation in postmenopausal Caucasian women. Bone 46: 604-612. doi: 10.1016/j.bone.2009.11.007 PMID: 19922823
39. Jemtland R, Holden M, Reppe S, Olstad OK, Reinholt FP, Gautvik VT, et al. (2011) Molecular disease map of bone characterizing the postmenopausal osteoporosis phenotype. J Bone Miner Res 26: 1793-1801. doi: 10.1002/jbmr.396 PMID: 21452281
40. Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, et al. (2013) Discovery and refinement of loci associated with lipid levels. Nat Genet 45: 1274-1283. ng.2797 [pii]; doi: 10.1038/ng.2797 PMID: 24097068
41. Liu Q, Chen Y, Auger-Messier M, Molkentin JD (2012) Interaction between NFkappaB and NFAT coordinates cardiac hypertrophy and pathological remodeling. Circ Res 110: 1077-1086. CIRCRESAHA.111.260729 [pii]; doi: 10.1161/CIRCRESAHA.111.260729 PMID: 22403241
42. Fromigue O, Hay E, Barbara A, Marie PJ (2010) Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate. J Biol Chem 285: 25251-25258. M110.110502 [pii]; doi: 10.1074/jbc.M110.110502 PMID: 20554534
43. Saidak Z, Hay E, Marty C, Barbara A, Marie PJ (2012) Strontium ranelate rebalances bone marrow adipogenesis and osteoblastogenesis in senescent osteopenic mice through NFATc/Maf and Wnt signaling. Aging Cell 11: 467-474. doi: 10.1111/j.1474-9726.2012.00804.x PMID: 22321691
44. Strait KA, Stricklett PK, Kohan RM, Kohan DE (2010) Identification of two nuclear factor of activated T-cells (NFAT)-response elements in the 5′-upstream regulatory region of the ET-1 promoter. J Biol Chem 285: 28520-28528. M110.153189 [pii]; doi: 10.1074/jbc.M110.153189 PMID: 20647310
45. Ge Y, Bagnall A, Stricklett PK, Webb D, Kotelevtsev Y, Kohan DE (2008) Combined knockout of collecting duct endothelin A and B receptors causes hypertension and sodium retention. Am J Physiol Renal Physiol 295: F1635-F1640. 90279.2008 [pii]; doi: 10.1152/ajprenal.90279.2008 PMID: 18784261
46. Goettsch C, Rauner M, Hamann C, Sinningen K, Hempel U, Bornstein SR, et al. (2011) Nuclear factor of activated T cells mediates oxidised LDL-induced calcification of vascular smooth muscle cells. Diabetologia 54: 2690-2701. doi: 10.1007/s00125-011-2219-0 PMID: 21701818
47. Paic F, Igwe JC, Nori R, Kronenberg MS, Franceschetti T, Harrington P, et al. (2009) Identification of differentially expressed genes between osteoblasts and osteocytes. Bone 45: 682-692. S8756-3282(09)01634-2 [pii]; doi: 10.1016/j.bone.2009.06.010 PMID: 19539797
48. Dallas SL, Veno PA (2012) Live imaging of bone cell and organ cultures. Methods Mol Biol 816: 425-457. doi: 10.1007/978-1-61779-415-5-26 PMID: 22130943
49. Pidsley R, CC YW, Volta M, Lunnon K, Mill J, Schalkwyk LC (2013) A data-driven approach to preprocessing Illumina 450K methylation array data. BMC Genomics 14: 293. 1471-2164-14-293 [pii]; doi: 10.1186/1471-2164-14-293 PMID: 23631413
50. Reppe S, Stilgren L, Abrahamsen B, Olstad OK, Cero F, Brixen K, et al. (2007) Abnormal muscle and hematopoietic gene expression may be important for clinical morbidity in primary hyperparathyroidism. Am J Physiol Endocrinol Metab 292: E1465-E1473. PMID: 17227961
51. Gupta M, Cheung CL, Hsu YH, Demissie S, Cupples LA, Kiel DP, et al. (2011) Identification of homogeneous genetic architecture of multiple genetically correlated traits by block clustering of genome-wide associations. J Bone Miner Res 26: 1261-1271. doi: 10.1002/jbmr.333 PMID: 21611967
52. Fitzpatrick DJ, Ryan CJ, Shah N, Greene D, Molony C, Shields DC (2015) Genome-wide epistatic expression quantitative trait loci discovery in four human tissues reveals the importance of local chromosomal interactions governing gene expression. BMC Genomics 16: 109. doi: 10.1186/s12864-015-1300-3;s12864-015-1300-3 [pii]. PMID: 25765234
53. Jin F, Li Y, Dixon JR, Selvaraj S, Ye Z, Lee AY, et al. (2013) A high-resolution map of the three-dimensional chromatin interactome in human cells. Nature 503: 290-294. nature12644 [pii]; doi: 10.1038/nature12644 PMID: 24141950