Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

Nature Genetics

Volumn 48, Issue 9, 2016, Pages 1043-1048

  Van Rheenen, Wouter ^a,b,c   Shatunov, Aleksey ^a   Dekker, Annelot M ^c   McLaughlin, Russell L ^a   Diekstra, Frank P ^b   Pulit, Sara L ^d,e   Van Der Spek, Rick A A ^f   Võsa, Urmo ^a,g   De Jong, Simone ^h   Robinson, Matthew R ⁱ   Yang, Jian ^a   Fogh, Isabella ^a   Van Doormaal, Perry T C ^d   Tazelaar, Gijs H P ^a   Koppers, Max ^e   Blokhuis, Anna M ^f,g   Sproviero, William ^h   Jones, Ashley R ^a   Kenna, Kevin P ^s   Van Eijk, Kristel R ^t   Harschnitz, Oliver ^u   Schellevis, Raymond D ^i,w   Brands, William J ^a,b,x   Medic, Jelena ^y   Menelaou, Androniki ^z   Vajda, Alice ^z   Ticozzi, Nicola ^ab   Lin, Kuang ^ad   Rogelj, Boris ^ae   Vrabec, Katarina ^af   Ravnik Glava, Metka ^ae   Koritnik, Bla ^ah   Zidar, Janez ^ai   Leonardis, Lea ^aj   Grošelj, Leja Dolenc ^c,ak   Millecamps, Stéphanie ^al   Salachas, François ^am   Meininger, Vincent ^j   De Carvalho, Mamede ^a   Pinto, Susana ^ar   Mora, Jesus S ^d   Rojas García, Ricardo ^e   Polak, Meraida ^k   Chandran, Siddharthan ^aw   Colville, Shuna ^c   Swingler, Robert ^c   Morrison, Karen E ^a   Shaw, Pamela J ^d   Hardy, John ^e   Orrell, Richard W ^e   Pittman, Alan ^g   Sidle, Katie ^a   Fratta, Pietro ^l   Malaspina, Andrea ^b   Topp, Simon ^a   Petri, Susanne ^r   Abdulla, Susanne ^m   Drepper, Carsten ⁿ   Sendtner, Michael ^o   Meyer, Thomas ^p   Ophoff, Roel A ^q   Staats, Kim A ^s   Wiedau Pazos, Martina ^t   Lomen Hoerth, Catherine ^r   Van Deerlin, Vivianna M ^q   Trojanowski, John Q ^s   Elman, Lauren ^t   McCluskey, Leo ^u,bo   Basak, A Nazli ^v,bq   Tunca, Ceren ^w,br   Hamzeiy, Hamid ^x,bs   Parman, Yesim ^y,bt   Meitinger, Thomas ^z   Lichtner, Peter ^aa   Radivojkov Blagojevic, Milena ^bw   Andres, Christian R ^h   Maurel, Cindy ^h   Bensimon, Gilbert ^h   Landwehrmeyer, Bernhard ^c   Brice, Alexis ^j   Payan, Christine A M ^o   Saker Delye, Safaa ^a   Dürr, Alexandra ⁱ   Wood, Nicholas W ^ac   Tittmann, Lukas ^ab   Lieb, Wolfgang ^ac   Franke, Andre ^ad   Rietschel, Marcella ^ae   Cichon, Sven ^ae   Nöthen, Markus M ^aa   Amouyel, Philippe ^af   Tzourio, Christophe ^ae   Dartigues, Jean François ^ag   Uitterlinden, Andre G ^w   Rivadeneira, Fernando ^y   Estrada, Karol ^z   Hofman, Albert ^aa   Curtis, Charles ^ac   Blauw, Hylke M ^ae   Van Der Kooi, Anneke J ^ae   De Visser, Marianne ^af   Goris, An ^ae   Weber, Markus ^ag   Shaw, Christopher E ^ah   Smith, Bradley N ^ai   Pansarasa, Orietta ^aj   Cereda, Cristina ^ak   Del Bo, Roberto ^al   Comi, Giacomo P ^am   D'Alfonso, Sandra ^an   Bertolin, Cinzia ^ao   Sorarù, Gianni ^an   Mazzini, Letizia ^ap   Pensato, Viviana ^aq   Gellera, Cinzia ^aq   Tiloca, Cinzia ^ar   Ratti, Antonia ^as,at   Calvo, Andrea ^au   Moglia, Cristina ^q,r   Brunetti, Maura ^av,aw   Arcuti, Simona ^r   Capozzo, Rosa ^q   Zecca, Chiara ^r   Lunetta, Christian ^r   Penco, Silvana ^ax   Riva, Nilo ^r   Padovani, Alessandro ^ae   Filosto, Massimiliano ^ay   Muller, Bernard ^ay   Stuit, Robbert Jan ^az   Blair, Ian ^ba   Zhang, Katharine ^bb   McCann, Emily P ^bc   Fifita, Jennifer A ^bd   Nicholson, Garth A ^be   Rowe, Dominic B ^bf,bg   Pamphlett, Roger ^bh   Kiernan, Matthew C ^bh   Grosskreutz, Julian ^bi   Witte, Otto W ^bj   Ringer, Thomas ^bk   Prell, Tino ^bl   Stubendorff, Beatrice ^bm   Kurth, Ingo ^bn   Hübner, Christian A ^bo   Nigel Leigh, P ^bp   Casale, Federico ^bo   Chio, Adriano ^bq   Beghi, Ettore ^br,bs   Pupillo, Elisabetta ^bt   Tortelli, Rosanna ^bu   Logroscino, Giancarlo ^bv   Powell, John ^bw,bx   Ludolph, Albert C ^by   Weishaupt, Jochen H ^bz   Robberecht, Wim ^ca   Van Damme, Philip ^ca,cb   Franke, Lude ^cb,cc,cd   Pers, Tune H ^bt   Brown, Robert H ^bt   Glass, Jonathan D ^cg   Landers, John E ^ce,cf,cg,ci   Hardiman, Orla ^cg   Andersen, Peter M ^cl   Corcia, Philippe ^cg   Vourc'H, Patrick ^ch   Silani, Vincenzo ^ci   Wray, Naomi R ^cj   Visscher, Peter M ^ck   De Bakker, Paul I W ^cl   Van Es, Michael A ^cm   Jeroen Pasterkamp, R ^a   Lewis, Cathryn M ^b   Breen, Gerome ^b   Al Chalabi, Ammar ^b   Van Den Berg, Leonard H ^a   Veldink, Jan H ^a   more..

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c TRINITY COLLEGE DUBLIN   (Ireland)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^e MEDICAL RESEARCH COUNCIL   (United Kingdom)

^f King s College London   (United Kingdom)

^g UNIVERSITY OF QUEENSLAND   (Australia)

^h ISTITUTO AUXOLOGICO ITALIANO   (Italy)

ⁱ UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^j BEAUMONT HOSPITAL   (Ireland)

^k UNIVERSITY OF MILAN   (Italy)

^l JO EF STEFAN INSTITUTE   (Slovenia)

^m Biomedical Research Institute BRIS   (Slovenia)

ⁿ INSTITUTE OF PATHOLOGY   (Slovenia)

^o UNIVERSITY OF LJUBLJANA   (Slovenia)

^p UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

^q SORBONNE UNIVERSITÉ   (France)

^r PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^s Hopital des Peupliers   (France)

^t Hématologie Oncologie Pédiatrique   (France)

^u INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^v HOSPITAL DE SANTA MARIA   (Portugal)

^w HOSPITAL SAN RAFAEL   (Spain)

^x UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^y CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^z EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^aa Euan MacDonald Centre for Motor Neurone Disease Research   (United Kingdom)

^ab UNIVERSITY OF EDINBURGH   (United Kingdom)

^ac UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^ad UNIVERSITY OF SHEFFIELD   (United Kingdom)

^ae UNIVERSITY COLLEGE LONDON   (United Kingdom)

^af UNIVERSITY COLLEGE LONDON   (United Kingdom)

^ag QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^ah North East London and Essex MND Care and Research Centre   (United Kingdom)

^ai HANNOVER MEDICAL SCHOOL   (Germany)

^aj OTTO VON GUERICKE UNIVERSITY   (Germany)

^ak UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^al CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^am UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^an UNIVERSITY OF CALIFORNIA   (United States)

^ao UNIVERSITY OF CALIFORNIA   (United States)

^ap UNIVERSITY OF CALIFORNIA   (United States)

^aq UNIVERSITY OF PENNSYLVANIA   (United States)

^ar BOGAZICI UNIVERSITY   (Turkey)

^as ISTANBUL UNIVERSITY   (Turkey)

^at INSTITUTE OF EPIDEMIOLOGY   (Germany)

^au UNIVERSITÉ DE TOURS   (France)

^av NÎMES UNIVERSITY HOSPITAL   (France)

^aw UNIVERSITY HOSPITAL ULM   (Germany)

^ax GÉNÉTHON   (France)

^ay UNIVERSITY OF KIEL   (Germany)

^az UNIVERSITY OF HEIDELBERG   (Germany)

^ba UNIVERSITY OF BONN   (Germany)

^bb Life and Brain Center   (Germany)

^bc UNIVERSITY HOSPITAL BASEL   (Switzerland)

^bd UNIVERSITY OF BASEL   (Switzerland)

^be FORSCHUNGSZENTRUM JÜLICH   (Germany)

^bf UNIV LILLE   (France)

^bg UNIVERSITÉ DE BORDEAUX   (France)

^bh ERASMUS MEDICAL CENTER   (Netherlands)

^bi HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^bj UNIVERSITY OF AMSTERDAM   (Netherlands)

^bk KU LEUVEN UNIVERSITY OF LEUVEN   (Belgium)

^bl CANTONAL HOSPITAL ST GALLEN   (Switzerland)

^bm C MONDINO NATIONAL NEUROLOGICAL INSTITUTE   (Italy)

^bn FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^bo UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^bp UNIVERSITY OF PADOVA   (Italy)

^bq DEPARTMENT OF NEUROSURGERY   (Italy)

^br UNIVERSITY OF TURIN   (Italy)

^bs Azienda Ospedaliera Città della Salute e della Scienza   (Italy)

^bt UNIVERSITY OF BARI   (Italy)

^bu Neuromuscular OnmiCenter   (Italy)

^bv OSPEDALE NIGUARDA CA GRANDA   (Italy)

^bw SAN RAFFAELE HOSPITAL   (Italy)

^bx UNIVERSITY OF BRESCIA   (Italy)

^by Project MinE Foundation   (Netherlands)

^bz MACQUARIE UNIVERSITY   (Australia)

^ca UNIVERSITY OF SYDNEY   (Australia)

^cb JENA UNIVERSITY HOSPITAL   (Germany)

^cc UNIVERSITY OF SUSSEX   (United Kingdom)

^cd MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^ce DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^cf UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^cg BOSTON CHILDREN S HOSPITAL   (United States)

^ch HARVARD MEDICAL SCHOOL   (United States)

^ci BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^cj UMEÅ UNIVERSITY   (Sweden)

^ck UNIVERSITY HOSPITAL OF TOURS   (France)

^cl Fédération des Centres de Ressources et de Compétences de Tours et Limoges   (France)

^cm TRANSLATIONAL RESEARCH INSTITUTE   (Australia)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CHROMOSOME 21; COHORT ANALYSIS; CONTROLLED STUDY; GENE FREQUENCY; GENE LOCUS; GENE MAPPING; GENE REPLICATION; GENE STRUCTURE; GENETIC RISK; GENETIC TRAIT; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; MORBIDITY; MULTICENTER STUDY; OPEN READING FRAME; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; CASE CONTROL STUDY; COMPARATIVE STUDY; GENETIC PREDISPOSITION; GENETICS; MUTATION; NETHERLANDS;

C21ORF2 PROTEIN, HUMAN; MOBP PROTEIN, HUMAN; MUNC18 PROTEIN; MYELIN PROTEIN; PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; CASE-CONTROL STUDIES; COHORT STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MUNC18 PROTEINS; MUTATION; MYELIN PROTEINS; NETHERLANDS; PROTEINS;

EID: 84979596905     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3622     Document Type: Article

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