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Volumn 6, Issue 4, 2016, Pages

Pleiotropy between neuroticism and physical and mental health: Findings from 108038 men and women in UK biobank

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ANOREXIA NERVOSA; ARTICLE; BIOBANK; BIPOLAR DISORDER; BODY MASS; BORDERLINE STATE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC CORRELATION; GENETIC RISK; GENOME-WIDE ASSOCIATION STUDY; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MENTAL DISEASE; MULTIFACTORIAL INHERITANCE; NEUROSIS; PHYSICAL DISEASE; PLEIOTROPY; SCHIZOPHRENIA; SMOKING; UNITED KINGDOM; ANXIETY DISORDERS; GENETICS; HEALTH STATUS; MENTAL DISORDERS; MIDDLE AGED; RISK FACTOR;

EID: 85016119837     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2016.56     Document Type: Article
Times cited : (83)

References (49)
  • 2
    • 67049086461 scopus 로고    scopus 로고
    • Public health significance of neuroticism
    • Lahey BB. Public health significance of neuroticism. Am Psychol 2009; 64: 241–256.
    • (2009) Am Psychol , vol.64 , pp. 241-256
    • Lahey, B.B.1
  • 3
    • 77956506330 scopus 로고    scopus 로고
    • Linking “big” personality traits to anxiety, depressive, and substance use disorders: A meta-analysis
    • Kotov R, Gamez W, Schmidt F, Watson D. Linking “big” personality traits to anxiety, depressive, and substance use disorders: a meta-analysis. Psychol Bull 2010; 136: 768–821.
    • (2010) Psychol Bull , vol.136 , pp. 768-821
    • Kotov, R.1    Gamez, W.2    Schmidt, F.3    Watson, D.4
  • 4
    • 14544300500 scopus 로고    scopus 로고
    • The relationship between the five-factor model of personality and symptoms of clinical disorders: A meta-analysis
    • Malouff JM, Thorsteinsson EB, Schutte NS. The relationship between the five-factor model of personality and symptoms of clinical disorders: a meta-analysis. J Psychopathol Behav Assess 2005; 27: 101–114.
    • (2005) J Psychopathol Behav Assess , vol.27 , pp. 101-114
    • Malouff, J.M.1    Thorsteinsson, E.B.2    Schutte, N.S.3
  • 5
    • 65849470031 scopus 로고    scopus 로고
    • Premorbid personality factors in schizophrenia and bipolar disorder: Results from a large cohort study of male conscripts
    • Lonnqvist JE, Verkasalo M, Haukka J, Nyman K, Tiihonen J, Laaksonen I et al. Premorbid personality factors in schizophrenia and bipolar disorder: results from a large cohort study of male conscripts. J Abnorm Psychol 2009; 118: 418–423.
    • (2009) J Abnorm Psychol , vol.118 , pp. 418-423
    • Lonnqvist, J.E.1    Verkasalo, M.2    Haukka, J.3    Nyman, K.4    Tiihonen, J.5    Laaksonen, I.6
  • 6
    • 84928207051 scopus 로고    scopus 로고
    • Attention deficit hyperactivity disorder and personality characteristics in older adults in the general Dutch population
    • Michielsen M, Comijs HC, Semeijn EJ, Beekman AT, Deeg DJ, Kooij JJ. Attention deficit hyperactivity disorder and personality characteristics in older adults in the general Dutch population. Am J Geriatr Psychiatry 2014; 22: 1623–1632.
    • (2014) Am J Geriatr Psychiatry , vol.22 , pp. 1623-1632
    • Michielsen, M.1    Comijs, H.C.2    Semeijn, E.J.3    Beekman, A.T.4    Deeg, D.J.5    Kooij, J.J.6
  • 7
    • 0346654076 scopus 로고    scopus 로고
    • The five-factor model and personality disorder empirical literature: A meta-analytic review
    • Saulsman LM, Page AC. The five-factor model and personality disorder empirical literature: a meta-analytic review. Clin Psychol Rev 2004; 23: 1055–1085.
    • (2004) Clin Psychol Rev , vol.23 , pp. 1055-1085
    • Saulsman, L.M.1    Page, A.C.2
  • 10
    • 22344451575 scopus 로고    scopus 로고
    • Does neuroticism explain variations in care service use for mental health problems in the general popu-lation? Results from the Netherlands Mental Health Survey and Incidence Study (NEMESIS)
    • ten Have M, Oldehinkel A, Vollebergh W, Ormel J. Does neuroticism explain variations in care service use for mental health problems in the general popu-lation? Results from the Netherlands Mental Health Survey and Incidence Study (NEMESIS). Soc Psychiatry Psychiatr Epidemiol 2005; 40: 425–431.
    • (2005) Soc Psychiatry Psychiatr Epidemiol , vol.40 , pp. 425-431
    • Ten Have, M.1    Oldehinkel, A.2    Vollebergh, W.3    Ormel, J.4
  • 13
    • 0023354366 scopus 로고
    • Neuroticism, somatic complaints, and disease—is the bark worse than the bite
    • Costa PT, Mccrae RR. Neuroticism, somatic complaints, and disease—is the bark worse than the bite. J Pers 1987; 55: 299–316.
    • (1987) J Pers , vol.55 , pp. 299-316
    • Costa, P.T.1    McCrae, R.R.2
  • 15
    • 0036171377 scopus 로고    scopus 로고
    • Personality and the perception of health in the general population
    • Goodwin R, Engstrom G. Personality and the perception of health in the general population. Psychol Med 2002; 32: 325–332.
    • (2002) Psychol Med , vol.32 , pp. 325-332
    • Goodwin, R.1    Engstrom, G.2
  • 16
    • 0024651715 scopus 로고
    • Health complaints, stress, and distress: Exploring the central role of negative affectivity
    • Watson D, Pennebaker JW. Health complaints, stress, and distress: exploring the central role of negative affectivity. Psychol Rev 1989; 96: 234–254.
    • (1989) Psychol Rev , vol.96 , pp. 234-254
    • Watson, D.1    Pennebaker, J.W.2
  • 17
    • 2342439413 scopus 로고    scopus 로고
    • Neuroticism, a central link between somatic and psychiatric morbidity: Path analysis of prospective data
    • Neeleman J, Bijl R, Ormel J. Neuroticism, a central link between somatic and psychiatric morbidity: path analysis of prospective data. Psychol Med 2004; 34: 521–531.
    • (2004) Psychol Med , vol.34 , pp. 521-531
    • Neeleman, J.1    Bijl, R.2    Ormel, J.3
  • 18
    • 33744490617 scopus 로고    scopus 로고
    • Neuroticism and physical disorders among adults in the community: Results from the national comorbidity survey
    • Goodwin RD, Cox BJ, Clara I. Neuroticism and physical disorders among adults in the community: Results from the national comorbidity survey. J Behav Med 2006; 29: 229–238.
    • (2006) J Behav Med , vol.29 , pp. 229-238
    • Goodwin, R.D.1    Cox, B.J.2    Clara, I.3
  • 19
    • 36349012456 scopus 로고    scopus 로고
    • Neuroticism, extraversion, and mortality in the UK Health and Lifestyle Survey: A 21-year prospective cohort study
    • Shipley BA, Weiss A, Der G, Taylor MD, Deary IJ. Neuroticism, extraversion, and mortality in the UK Health and Lifestyle Survey: a 21-year prospective cohort study. Psychosom Med 2007; 69: 923–931.
    • (2007) Psychosom Med , vol.69 , pp. 923-931
    • Shipley, B.A.1    Weiss, A.2    Der, G.3    Taylor, M.D.4    Deary, I.J.5
  • 20
    • 84886972789 scopus 로고    scopus 로고
    • Personality traits as risk factors for stroke and coronary heart disease mortality: Pooled analysis of three cohort studies
    • Jokela M, Pulkki-Raback L, Elovainio M, Kivimaki M. Personality traits as risk factors for stroke and coronary heart disease mortality: pooled analysis of three cohort studies. J Behav Med 2014; 37: 881–889.
    • (2014) J Behav Med , vol.37 , pp. 881-889
    • Jokela, M.1    Pulkki-Raback, L.2    Elovainio, M.3    Kivimaki, M.4
  • 22
    • 79955476525 scopus 로고    scopus 로고
    • Big-Five personality factors, obesity and 2-year weight gain in Australian adults
    • Magee CA, Heaven PCL. Big-Five personality factors, obesity and 2-year weight gain in Australian adults. J Res Pers 2011; 45: 332–335.
    • (2011) J Res Pers , vol.45 , pp. 332-335
    • Magee, C.A.1    Heaven, P.C.L.2
  • 24
    • 84883472298 scopus 로고    scopus 로고
    • Personality and all-cause mortality: Individual-participant meta-analysis of 3,947 deaths in 76,150 adults
    • Jokela M, Batty GD, Nyberg ST, Virtanen M, Nabi H, Singh-Manoux A et al. Personality and all-cause mortality: individual-participant meta-analysis of 3,947 deaths in 76,150 adults. Am J Epidemiol 2013; 178: 667–675.
    • (2013) Am J Epidemiol , vol.178 , pp. 667-675
    • Jokela, M.1    Batty, G.D.2    Nyberg, S.T.3    Virtanen, M.4    Nabi, H.5    Singh-Manoux, A.6
  • 25
    • 84876022740 scopus 로고    scopus 로고
    • The associations between personality, diet and body mass index in older people
    • Mottus R, McNeill G, Jia X, Craig LC, Starr JM, Deary IJ. The associations between personality, diet and body mass index in older people. Health Psychol 2013; 32: 353–360.
    • (2013) Health Psychol , vol.32 , pp. 353-360
    • Mottus, R.1    McNeill, G.2    Jia, X.3    Craig, L.C.4    Starr, J.M.5    Deary, I.J.6
  • 29
    • 85047696382 scopus 로고    scopus 로고
    • A population-based twin study of the relationship between neuroticism and internalizing disorders
    • Hettema JM, Neale MC, Myers JM, Prescott CA, Kendler KS. A population-based twin study of the relationship between neuroticism and internalizing disorders. Am J Psychiatry 2006; 163: 857–864.
    • (2006) Am J Psychiatry , vol.163 , pp. 857-864
    • Hettema, J.M.1    Neale, M.C.2    Myers, J.M.3    Prescott, C.A.4    Kendler, K.S.5
  • 30
    • 77952427364 scopus 로고    scopus 로고
    • The genetic and environmental relationship between major depression and the five-factor model of personality
    • Kendler KS, Myers J. The genetic and environmental relationship between major depression and the five-factor model of personality. Psychol Med 2010; 40: 801–806.
    • (2010) Psychol Med , vol.40 , pp. 801-806
    • Kendler, K.S.1    Myers, J.2
  • 31
    • 84937399367 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association studies for neuroticism, and the polygenic association with major depressive disorder
    • Genetics of Personality Consortium, de Moor MH, van den Berg SM, Verweij KJ, Krueger RF, Luciano M et al. Meta-analysis of genome-wide association studies for neuroticism, and the polygenic association with major depressive disorder. JAMA Psychiatry 2015; 72: 642–650.
    • (2015) JAMA Psychiatry , vol.72 , pp. 642-650
    • de Moor, M.H.1    van den Berg, S.M.2    Verweij, K.J.3    Krueger, R.F.4    Luciano, M.5
  • 32
    • 84923946495 scopus 로고    scopus 로고
    • Schizophrenia Working Group of the Psychiatric Genomics C, et al. LD score regression distinguishes confounding from polygenicity in genome-wide association studies
    • Bulik-Sullivan BK, Loh PR, Finucane HK, Ripke S, Yang J, Schizophrenia Working Group of the Psychiatric Genomics C, et al. LD score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet 2015; 47: 291–295.
    • (2015) Nat Genet , vol.47 , pp. 291-295
    • Bulik-Sullivan, B.K.1    Loh, P.R.2    Finucane, H.K.3    Ripke, S.4    Yang, J.5
  • 33
  • 34
    • 84926430250 scopus 로고    scopus 로고
    • UK biobank: An open access resource for identifying the causes of a wide range of complex diseases of middle and old age
    • Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J et al. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med 2015; 12: e1001779.
    • (2015) Plos Med , vol.12
    • Sudlow, C.1    Gallacher, J.2    Allen, N.3    Beral, V.4    Burton, P.5    Danesh, J.6
  • 35
    • 79953161413 scopus 로고    scopus 로고
    • Some origins and evolution of the EPQ-R (Short form) neuroticism and extraversion items
    • Deary IJ, Bedford A. Some origins and evolution of the EPQ-R (short form) neuroticism and extraversion items. Pers Indiv Differ 2011; 50: 1213–1217.
    • (2011) Pers Indiv Differ , vol.50 , pp. 1213-1217
    • Deary, I.J.1    Bedford, A.2
  • 36
    • 20444435066 scopus 로고    scopus 로고
    • Goldberg’s ‘IPIP’ Big-Five factor markers: Internal consistency and concurrent validation in Scotland
    • Gow AJ, Whiteman MC, Pattie A, Deary IJ. Goldberg’s ‘IPIP’ Big-Five factor markers: Internal consistency and concurrent validation in Scotland. Pers Indiv Differ 2005; 39: 317–329.
    • (2005) Pers Indiv Differ , vol.39 , pp. 317-329
    • Gow, A.J.1    Whiteman, M.C.2    Pattie, A.3    Deary, I.J.4
  • 37
    • 33750913546 scopus 로고    scopus 로고
    • The Eysenck personality factors: Psychometric reliability, heritability and phenotypic and genetic correlations with psychological distress in an isolated Croatian population
    • Ivkovic V, Vitart V, Rudan I, Janicijevic B, Smolej-Narancic N, Skaric-Juric T et al. The Eysenck personality factors: psychometric reliability, heritability and phenotypic and genetic correlations with psychological distress in an isolated Croatian population. Pers Indiv Differ 2007; 42: 123–133.
    • (2007) Pers Indiv Differ , vol.42 , pp. 123-133
    • Ivkovic, V.1    Vitart, V.2    Rudan, I.3    Janicijevic, B.4    Smolej-Narancic, N.5    Skaric-Juric, T.6
  • 38
    • 84943428582 scopus 로고    scopus 로고
    • Soler Artigas M. Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pul-monary disease (UK BiLEVE): A genetic association study in UK Biobank
    • Wain LV, Shrine N, Miller S, Jackson VE, Ntalla I, Soler Artigas M. Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pul-monary disease (UK BiLEVE): a genetic association study in UK Biobank. Lancet Respir Med 2015; 3: 769–781.
    • (2015) Lancet Respir Med , vol.3 , pp. 769-781
    • Wain, L.V.1    Shrine, N.2    Miller, S.3    Jackson, V.E.4    Ntalla, I.5
  • 43
    • 0001677717 scopus 로고
    • Controlling the false discovery rate—a practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y. Controlling the false discovery rate—a practical and powerful approach to multiple testing. J Roy Stat Soc B Met 1995; 57: 289–300.
    • (1995) J Roy Stat Soc B Met , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 44
    • 84894289421 scopus 로고    scopus 로고
    • Prevalence and characteristics of probable major depression and bipolar disorder within UK Biobank: Cross-sectional study of 172,751 participants
    • Smith DJ, Nicholl BI, Cullen B, Martin D, Ul-Haq Z, Evans J et al. Prevalence and characteristics of probable major depression and bipolar disorder within UK Biobank: cross-sectional study of 172,751 participants. PLoS One 2013; 8: e75362.
    • (2013) Plos One , vol.8
    • Smith, D.J.1    Nicholl, B.I.2    Cullen, B.3    Martin, D.4    Ul-Haq, Z.5    Evans, J.6
  • 46
    • 80054799096 scopus 로고    scopus 로고
    • The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data
    • Middeldorp CM, de Moor MH, McGrath LM, Gordon SD, Blackwood DH, Costa PT et al. The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data. Transl Psychiatry 2011; 1: e50.
    • (2011) Transl Psychiatry , vol.1 , pp. e50
    • Middeldorp, C.M.1    de Moor, M.H.2    McGrath, L.M.3    Gordon, S.D.4    Blackwood, D.H.5    Costa, P.T.6
  • 48
    • 0034898198 scopus 로고    scopus 로고
    • Neuroticism as a risk factor for schizophrenia
    • Van Os J, Jones PB. Neuroticism as a risk factor for schizophrenia. Psychol Med 2001; 31: 1129–1134.
    • (2001) Psychol Med , vol.31 , pp. 1129-1134
    • van Os, J.1    Jones, P.B.2


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