Inhibition of tissue matrix metalloproteinases interferes with Mycobacterium tuberculosis-induced granuloma formation and reduces bacterial load in a human lung tissue model

Frontiers in Microbiology

Volumn 8, Issue DEC, 2017, Pages

  Parasa, Venkata R ^a   Muvva, Jagadeeswara R ^b   Rose, Jeronimo F ^a   Braian, Clara ^a   Brighenti, Susanna ^b   Lerm, Maria ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Granuloma; Matrix metalloproteinases; Tissue inhibitor of matrix metalloproteinases; Tissue models; Tuberculosis

Indexed keywords

GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERSTITIAL COLLAGENASE; MACROPHAGE ELASTASE; MARIMASTAT; MATRIX METALLOPROTEINASE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; STROMELYSIN;

ARTICLE; BACTERIAL LOAD; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME INHIBITION; FLOW CYTOMETRY; GENE EXPRESSION; GRANULOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG BIOPSY; LUNG PARENCHYMA; MACROPHAGE; MONOCYTE; MYCOBACTERIUM TUBERCULOSIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; UPREGULATION;

EID: 85036660785     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2017.02370     Document Type: Article

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