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Volumn 7, Issue 11, 2017, Pages

Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ANXIETY DISORDER; ARTICLE; ATTENTION DEFICIT DISORDER; BIOBANK; CHROMOSOME 14; CHROMOSOME 18; CHROMOSOME 8; CHROMOSOME 9; CONTROLLED STUDY; DCC GENE; EIF2B2 GENE; FEMALE; GENE; GENE LOCUS; GENETIC CORRELATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MENTAL INSTABILITY; MIDDLE AGED; PGF GENE; PHENOTYPE; POSTTRAUMATIC STRESS DISORDER; PTPRD GENE; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED KINGDOM; AFFECT; AGED; BIPOLAR DISORDER; GENETICS; MULTIFACTORIAL INHERITANCE; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES;

EID: 85036586536     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/s41398-017-0012-7     Document Type: Article
Times cited : (61)

References (50)
  • 1
    • 84995505877 scopus 로고    scopus 로고
    • Mood instability and irritability as core symptoms of major depression: An exploration using rasch analysis
    • Balbuena, L., Bowen, R., Baetz, M. & Marwaha, S. Mood instability and irritability as core symptoms of major depression: an exploration using rasch analysis. Front. Psychiatry 7, 174 (2016).
    • (2016) Front. Psychiatry , vol.7 , pp. 174
    • Balbuena, L.1    Bowen, R.2    Baetz, M.3    Marwaha, S.4
  • 2
    • 84873525759 scopus 로고    scopus 로고
    • The prevalence and clinical associations of mood instability in adults living in England: Results from the adult psychiatric morbidity survey 2007
    • Marwaha, S., Parsons, N., Flanagan, S. & Broome, M. The prevalence and clinical associations of mood instability in adults living in England: results from the adult psychiatric morbidity survey 2007. Psychiatr. Res. 205, 262-268 (2013).
    • (2013) Psychiatr. Res. , vol.205 , pp. 262-268
    • Marwaha, S.1    Parsons, N.2    Flanagan, S.3    Broome, M.4
  • 3
    • 84877626914 scopus 로고    scopus 로고
    • Toward the future of psychiatric diagnosis: The seven pillars of RDoC
    • Cuthbert, B. & Insel, T. Toward the future of psychiatric diagnosis: the seven pillars of RDoC. BMC Med. 11, 126 (2013).
    • (2013) BMC Med. , vol.11 , pp. 126
    • Cuthbert, B.1    Insel, T.2
  • 5
    • 84947976079 scopus 로고    scopus 로고
    • Affective instability, childhood trauma and major affective disorders
    • Marwaha, S. et al. Affective instability, childhood trauma and major affective disorders. J. Affect. Disord. 190, 764-771 (2016).
    • (2016) J. Affect. Disord. , vol.190 , pp. 764-771
    • Marwaha, S.1
  • 6
    • 80055001196 scopus 로고    scopus 로고
    • A comprehensive review and model of putative prodromal features of bipolar affective disorder
    • Howes, O. D. et al. A comprehensive review and model of putative prodromal features of bipolar affective disorder. Psychol. Med. 41, 1567-1577 (2011).
    • (2011) Psychol. Med. , vol.41 , pp. 1567-1577
    • Howes, O.D.1
  • 7
    • 84881546092 scopus 로고    scopus 로고
    • Mood instability and functional recovery in bipolar disorders
    • Strejilevich, S. A. et al. Mood instability and functional recovery in bipolar disorders. Acta Psychiatr. Scand. 128, 194-202 (2013).
    • (2013) Acta Psychiatr. Scand. , vol.128 , pp. 194-202
    • Strejilevich, S.A.1
  • 8
    • 84857363259 scopus 로고    scopus 로고
    • Affective intensity and lability: Heritability in adult Male twins
    • Coccaro, E. F.,Ong, A.D., Seroczynski, A.D. & Bergeman, C. S. Affective intensity and lability: heritability in adult male twins. J. Affect. Disord. 136, 1011-1016 (2012).
    • (2012) J. Affect. Disord. , vol.136 , pp. 1011-1016
    • Coccaro, E.F.1    Ong, A.D.2    Seroczynski, A.D.3    Bergeman, C.S.4
  • 9
    • 84901603343 scopus 로고    scopus 로고
    • How is affective instability defined and measured? A systematic review
    • Marwaha, S. et al. How is affective instability defined and measured? A systematic review. Psychol. Med. 44, 1793-1808 (2014).
    • (2014) Psychol. Med. , vol.44 , pp. 1793-1808
    • Marwaha, S.1
  • 10
    • 84926430250 scopus 로고    scopus 로고
    • UK Biobank: An open access resource for identifying the causes of a wide range of complex diseases of middle and old age
    • Sudlow, C. et al. UK Biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 12, e1001779 (2015).
    • (2015) PLoS Med. , vol.12 , pp. e1001779
    • Sudlow, C.1
  • 12
    • 85036582756 scopus 로고    scopus 로고
    • , Interim Data Release, 11 September 2015
    • UK Biobank. Genotype imputation and genetic association studies of UK Biobank, Interim Data Release, 11 September 2015; http://www.ukbiobank.ac. uk/wp-content/uploads/2014/04/imputation-documentation-May2015.pdf.
    • Genotype Imputation and Genetic Association Studies of UK Biobank
  • 13
    • 84871952176 scopus 로고    scopus 로고
    • Improved whole-chromosome phasing for disease and population genetic studies
    • Delaneau, O., Zagury, J.-F. & Marchini, J. Improved whole-chromosome phasing for disease and population genetic studies. Nat. Method 10, 5-6 (2013).
    • (2013) Nat. Method , vol.10 , pp. 5-6
    • Delaneau, O.1    Zagury, J.-F.2    Marchini, J.3
  • 14
    • 84863845193 scopus 로고    scopus 로고
    • Genotype imputation with thousands of genomes
    • Howie, B., Marchini, J. & Stephens, M. Genotype imputation with thousands of genomes. G3 1, 457 (2011).
    • (2011) G3 , vol.1 , pp. 457
    • Howie, B.1    Marchini, J.2    Stephens, M.3
  • 15
    • 84941702459 scopus 로고    scopus 로고
    • Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel
    • Huang, J. et al. Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel. Nat. Commun. 6, 8111 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 8111
    • Huang, J.1
  • 16
    • 85036531428 scopus 로고    scopus 로고
    • Genotyping of 500,000 UK Biobank participants. Description of sample processing workflow and preparation of DNA for genotyping, 11 September
    • UK Biobank. Genotyping of 500,000 UK Biobank participants. Description of sample processing workflow and preparation of DNA for genotyping, 11 September 2015; https://biobank.ctsu.ox.ac.uk/crystal/docs/genotyping- sample-workflow.pdf.
    • (2015)
  • 17
    • 34548292504 scopus 로고    scopus 로고
    • PLINK: A Tool Set for whole-genome association and population-based linkage analyses
    • Purcell S. et al. PLINK: A Tool Set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559-575 (2007).
    • (2007) Am. J. Hum. Genet. , vol.81 , pp. 559-575
    • Purcell, S.1
  • 18
    • 84923946495 scopus 로고    scopus 로고
    • LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
    • Bulik-Sullivan, B. K. et al. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat. Genet. 47, 291-295 (2015).
    • (2015) Nat. Genet. , vol.47 , pp. 291-295
    • Bulik-Sullivan, B.K.1
  • 19
    • 85000692305 scopus 로고    scopus 로고
    • An atlas of genetic correlations across human diseases and traits
    • Bulik-Sullivan, B. et al. An atlas of genetic correlations across human diseases and traits. Nat. Genet. 47, 1236-1241 (2015).
    • (2015) Nat. Genet. , vol.47 , pp. 1236-1241
    • Bulik-Sullivan, B.1
  • 20
    • 80053385384 scopus 로고    scopus 로고
    • Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4
    • Bipolar Disorder Working Group of the Psychiatric Genomics Consortium.
    • Bipolar Disorder Working Group of the Psychiatric Genomics Consortium. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat. Genet. 43, 977-983 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 977-983
  • 21
    • 84904804929 scopus 로고    scopus 로고
    • Biological insights from 108 schizophrenia-associated genetic loci
    • Schizophrenia Working Group of the Psychiatric Genomics Consortium.
    • Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421-427 (2014).
    • (2014) Nature , vol.511 , pp. 421-427
  • 22
    • 84879892380 scopus 로고    scopus 로고
    • A mega-analysis of genome-wide association studies for major depressive disorder
    • Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium.
    • Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. A mega-analysis of genome-wide association studies for major depressive disorder. Mol. Psychiatry 18, 497-511 (2013).
    • (2013) Mol. Psychiatry , vol.18 , pp. 497-511
  • 23
    • 77956178166 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder
    • Neale, B. M. et al. Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 49, 884-897 (2010).
    • (2010) J Am Acad Child Adolesc Psychiatry , vol.49 , pp. 884-897
    • Neale, B.M.1
  • 24
    • 84954550234 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association studies of anxiety disorders
    • Otowa, T. et al. Meta-analysis of genome-wide association studies of anxiety disorders. Mol. Psychiatry 21, 1391-1399 (2016).
    • (2016) Mol. Psychiatry , vol.21 , pp. 1391-1399
    • Otowa, T.1
  • 25
    • 85022143653 scopus 로고    scopus 로고
    • Largest GWAS of PTSD (N = 20[thinsp]070) yields genetic overlap with schizophrenia and sex differences in heritability
    • Duncan, L. E. et al. Largest GWAS of PTSD (N = 20[thinsp]070) yields genetic overlap with schizophrenia and sex differences in heritability. Mol. Psychiatry (2017).
    • (2017) Mol. Psychiatry
    • Duncan, L.E.1
  • 26
    • 84894289421 scopus 로고    scopus 로고
    • Prevalence and characteristics of probable major depression and bipolar disorder within UK Biobank: Cross-sectional study of 172,751 participants
    • Smith, D. J. et al. Prevalence and characteristics of probable major depression and bipolar disorder within UK Biobank: cross-sectional study of 172,751 participants. PLoS ONE 8, e75362 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e75362
    • Smith, D.J.1
  • 27
    • 84884712928 scopus 로고    scopus 로고
    • What, me worry and ruminate about DSM-5 and RDoC? The importance of targeting negative self-referential processing
    • Mennin, D. S. & Fresco, D. M. What, me worry and ruminate about DSM-5 and RDoC? The importance of targeting negative self-referential processing. Clin. Psychol. 20, 258-267 (2013).
    • (2013) Clin. Psychol. , vol.20 , pp. 258-267
    • Mennin, D.S.1    Fresco, D.M.2
  • 28
    • 79958246447 scopus 로고    scopus 로고
    • The Netrin receptor DCC is required in the pubertal organization of mesocortical dopamine circuitry
    • Manitt, C. et al. The Netrin receptor DCC is required in the pubertal organization of mesocortical dopamine circuitry. J. Neurosci. 31, 8381-8394 (2011).
    • (2011) J. Neurosci. , vol.31 , pp. 8381-8394
    • Manitt, C.1
  • 29
    • 85014109975 scopus 로고    scopus 로고
    • Biallelic mutations in human DCC cause developmental split-brain syndrome
    • Jamuar, S. S. et al. Biallelic mutations in human DCC cause developmental split-brain syndrome. Nat. Genet. 49, 606-612 (2017).
    • (2017) Nat. Genet. , vol.49 , pp. 606-612
    • Jamuar, S.S.1
  • 30
    • 85014076089 scopus 로고    scopus 로고
    • Mutations in DCC cause isolated agenesis of the corpus callosum with incomplete penetrance
    • Marsh, A. P. L. et al. Mutations in DCC cause isolated agenesis of the corpus callosum with incomplete penetrance. Nat. Genet. 49, 511-514 (2017).
    • (2017) Nat. Genet. , vol.49 , pp. 511-514
    • Marsh, A.P.L.1
  • 31
    • 84890348119 scopus 로고    scopus 로고
    • Dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients
    • Manitt, C. et al. dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients. Transl. Psychiatry 3, e338 (2013).
    • (2013) Transl. Psychiatry , vol.3 , pp. e338
    • Manitt, C.1
  • 32
    • 77949535474 scopus 로고    scopus 로고
    • Eukaryotic initiation factor 2B (eIF2B) GEF activity as a diagnostic tool for EIF2B-related disorders
    • Horzinski, L. et al. Eukaryotic initiation factor 2B (eIF2B) GEF activity as a diagnostic tool for EIF2B-related disorders. PLoS ONE 4, e8318 (2009).
    • (2009) PLoS ONE , vol.4 , pp. e8318
    • Horzinski, L.1
  • 33
    • 84951951178 scopus 로고    scopus 로고
    • Neuroanatomical correlates of negative emotionality-related traits: A systematic review and meta-analysis
    • Mincic, A. M. Neuroanatomical correlates of negative emotionality-related traits: a systematic review and meta-analysis. Neuropsychologia 77, 97-118 (2015).
    • (2015) Neuropsychologia , vol.77 , pp. 97-118
    • Mincic, A.M.1
  • 34
    • 70349728374 scopus 로고    scopus 로고
    • A systematic review of diffusion tensor imaging studies in affective disorders
    • Sexton, C. E., Mackay, C. E. & Ebmeier, K. P. A systematic review of diffusion tensor imaging studies in affective disorders. Biol. Psychiatry 66, 814-823 (2009).
    • (2009) Biol. Psychiatry , vol.66 , pp. 814-823
    • Sexton, C.E.1    Mackay, C.E.2    Ebmeier, K.P.3
  • 35
    • 84856874924 scopus 로고    scopus 로고
    • The discovery of placenta growth factor and its biological activity
    • De Falco, S. The discovery of placenta growth factor and its biological activity. Exp. Mol. Med. 44, 1-9 (2012).
    • (2012) Exp. Mol. Med. , vol.44 , pp. 1-9
    • De Falco, S.1
  • 36
    • 85014807402 scopus 로고    scopus 로고
    • VEGF-related polymorphisms identified by GWAS and risk for major depression
    • Xie, T. et al. VEGF-related polymorphisms identified by GWAS and risk for major depression. Transl. Psychiatry 7, e1055 (2017).
    • (2017) Transl. Psychiatry , vol.7 , pp. e1055
    • Xie, T.1
  • 37
    • 0028868639 scopus 로고
    • Upregulation of vascular endothelial growth factor (VEGF) and downregulation of placenta growth factor (PlGF) associated with malignancy in human thyroid tumors and cell lines
    • Viglietto, G. et al. Upregulation of vascular endothelial growth factor (VEGF) and downregulation of placenta growth factor (PlGF) associated with malignancy in human thyroid tumors and cell lines. Oncogene 11, 1569-1579 (1995).
    • (1995) Oncogene , vol.11 , pp. 1569-1579
    • Viglietto, G.1
  • 38
    • 84907190308 scopus 로고    scopus 로고
    • Soluble Flt1 and placental growth factor are novel determinants of newborn thyroid (dys)function: The generation R study
    • Korevaar, T. I. et al. Soluble Flt1 and placental growth factor are novel determinants of newborn thyroid (dys)function: the generation R study. J. Clin. Endocrinol. Metab. 99, E1627-E1634 (2014).
    • (2014) J. Clin. Endocrinol. Metab. , vol.99 , pp. E1627-E1634
    • Korevaar, T.I.1
  • 39
    • 0037438583 scopus 로고    scopus 로고
    • A critical role of placental growth factor in the induction of inflammation and edema formation
    • Oura, H. et al. A critical role of placental growth factor in the induction of inflammation and edema formation. Blood 101, 560-567 (2003).
    • (2003) Blood , vol.101 , pp. 560-567
    • Oura, H.1
  • 40
    • 0036344495 scopus 로고    scopus 로고
    • Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
    • Luttun, A. et al. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat. Med. 8, 831-840 (2002).
    • (2002) Nat. Med. , vol.8 , pp. 831-840
    • Luttun, A.1
  • 41
    • 19244379078 scopus 로고    scopus 로고
    • Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
    • Carmeliet, P. et al. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat. Med. 7, 575-583 (2001).
    • (2001) Nat. Med. , vol.7 , pp. 575-583
    • Carmeliet, P.1
  • 42
    • 59649090734 scopus 로고    scopus 로고
    • Role of placenta growth factor and its receptor flt-1 in rheumatoid inflammation: A link between angiogenesis and inflammation
    • Yoo, S. A. et al. Role of placenta growth factor and its receptor flt-1 in rheumatoid inflammation: a link between angiogenesis and inflammation. Arthritis Rheum. 60, 345-354 (2009).
    • (2009) Arthritis Rheum. , vol.60 , pp. 345-354
    • Yoo, S.A.1
  • 43
    • 33750858405 scopus 로고    scopus 로고
    • Impaired adipose tissue development in mice with inactivation of placental growth factor function
    • Lijnen, H. R. et al. Impaired adipose tissue development in mice with inactivation of placental growth factor function. Diabetes 55, 2698-2704 (2006).
    • (2006) Diabetes , vol.55 , pp. 2698-2704
    • Lijnen, H.R.1
  • 44
    • 84887145992 scopus 로고    scopus 로고
    • Diagnostic accuracy of placental growth factor in women with suspected preeclampsia: A prospective multicenter study
    • Chappell, L. C. et al. Diagnostic accuracy of placental growth factor in women with suspected preeclampsia: a prospective multicenter study. Circulation 128, 2121-2131 (2013).
    • (2013) Circulation , vol.128 , pp. 2121-2131
    • Chappell, L.C.1
  • 45
    • 51449093922 scopus 로고    scopus 로고
    • The thyroid-brain interaction in thyroid disorders andmood disorders
    • Bauer, M., Goetz, T., Glenn, T. & Whybrow, P. C. The thyroid-brain interaction in thyroid disorders andmood disorders. J. Neuroendocrinol. 20, 1101-1114 (2008).
    • (2008) J. Neuroendocrinol. , vol.20 , pp. 1101-1114
    • Bauer, M.1    Goetz, T.2    Glenn, T.3    Whybrow, P.C.4
  • 46
    • 84945491025 scopus 로고    scopus 로고
    • Pre-eclampsia and first-onset postpartum psychiatric episodes: A Danish population-based cohort study
    • Bergink, V. et al. Pre-eclampsia and first-onset postpartum psychiatric episodes: a Danish population-based cohort study. Psychol. Med. 45, 3481-3489 (2015).
    • (2015) Psychol. Med. , vol.45 , pp. 3481-3489
    • Bergink, V.1
  • 47
    • 84883821082 scopus 로고    scopus 로고
    • Protein tyrosine phosphatases PTPo, PTPo, and LAR: Presynaptic hubs for synapse organization
    • Takahashi, H. C. A. Protein tyrosine phosphatases PTPo, PTPo, and LAR: presynaptic hubs for synapse organization. Trends Neurosci. 36, 522-534 (2013).
    • (2013) Trends Neurosci. , vol.36 , pp. 522-534
    • Takahashi, H.C.A.1
  • 48
    • 84963502477 scopus 로고    scopus 로고
    • Genome-wide analysis of over 106,000 individuals identifies 9 neuroticism-associated loci
    • Smith, D. J. et al. Genome-wide analysis of over 106,000 individuals identifies 9 neuroticism-associated loci. Mol. Psychiatry 21, 749-757 (2016).
    • (2016) Mol. Psychiatry , vol.21 , pp. 749-757
    • Smith, D.J.1
  • 49
    • 84923016497 scopus 로고    scopus 로고
    • Neurobiological and behavioural studies of affective instability in clinical populations: A systematic review
    • Broome, M. R., He, Z., Iftikhar, M., Eyden, J. & Marwaha, S. Neurobiological and behavioural studies of affective instability in clinical populations: a systematic review. Neurosci. Biobehav. Rev. 51, 243-254 (2015).
    • (2015) Neurosci. Biobehav. Rev. , vol.51 , pp. 243-254
    • Broome, M.R.1    He, Z.2    Iftikhar, M.3    Eyden, J.4    Marwaha, S.5
  • 50
    • 84898752877 scopus 로고    scopus 로고
    • The NIMH research domain criteria (RDoC) project: Precision medicine for psychiatry
    • Insel, T. The NIMH research domain criteria (RDoC) project: precision medicine for psychiatry. Am. J. Psychiatry 171, 395-397 (2014).
    • (2014) Am. J. Psychiatry , vol.171 , pp. 395-397
    • Insel, T.1


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