VEGF-related polymorphisms identified by GWAS and risk for major depression

Translational Psychiatry

Volumn 7, Issue 3, 2017, Pages

  Xie, T ^a   Stathopoulou, M G ^b   De Andres F ^b   Siest, G ^a   Murray, H ^c   Martin, M ^d   Cobaleda, J ^e   Delgado, A ^b   Lamont, J ^c   Penas Liedo E ^b   Llerena, A ^b,f   Visvikis Siest, S ^a  

^a UNIVERSITÉ DE LORRAINE   (France)

^b UNIVERSITY OF EXTREMADURA   (Spain)

^c Randox Laboratories Ltd   (United Kingdom)

^d Instituto de Investigación Sanitaria de Navarra   (Spain)

^e Centro de Atención Primaria Ciudad Jardín   (Spain)

^f INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

VASCULOTROPIN; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ADULT; ARTICLE; BODY MASS; CASE CONTROL STUDY; CONTROLLED STUDY; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PREDICTION; RISK; SINGLE NUCLEOTIDE POLYMORPHISM; AGED; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; ODDS RATIO; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 85014807402     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2017.36     Document Type: Article

References (27)

1. Kuehner C. Gender differences in unipolar depression: an update of epidemiological findings and possible explanations. Acta Psychiatr Scand 2003; 108: 163-174.
2. Hoeben A, Landuyt B, Highley MS, Wildiers H, Van Oosterom AT, De Bruijn EA. Vascular endothelial growth factor and angiogenesis. Pharmacol Rev 2004; 56: 549-580.
3. Yasuhara T, Shingo T, Date I. The potential role of vascular endothelial growth factor in the central nervous system. Rev Neurosci 2004; 15: 293-307.
4. Cao L, Jiao X, Zuzga DS, Liu Y, Fong DM, Young D, et al. VEGF links hippocampal activity with neurogenesis, learning and memory. Nat Genet 2004; 36: 827-835.
5. Jin K, Zhu Y, Sun Y, Mao XO, Xie L, Greenberg DA. Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc Natl Acad Sci USA 2002; 99: 11946-11950.
6. Howren MB, Lamkin DM, Suls J. Associations of depression with C-reactive protein, IL-1, IL-6: a meta-analysis. Psychosom Med 2009; 71: 171-186.
7. Mills NT, Scott JG, Wray NR, Cohen-Woods S, Baune BT. Research review: the role of cytokines in depression in adolescents: a systematic review. J Child Psychol Psychiatry Allied Discipl 2013; 54: 816-835.
8. Schmidt HD, Shelton RC, Duman RS. Functional biomarkers of depression: diagnosis, treatment, pathophysiology. Neuropsychopharmacology 2011; 36: 2375-2394.
9. Audet MC, Anisman H. Interplay between pro-inflammatory cytokines and growth factors in depressive illnesses. Front Cell Neurosci 2013; 7: 68.
10. Lee B-H, Kim Y-K. Increased plasma VEGF levels in major depressive or manic episodes in patients with mood disorders. J Affect Disord 2012; 136: 181-184.
11. Ventriglia M, Zanardini R, Pedrini L, Placentino A, Nielsen MG, Gennarelli M, et al. VEGF serum levels in depressed patients during SSRI antidepressant treatment. Prog Neuropsychopharmacol Biol Psychiatry 2009; 33: 146-149.
12. Kotan Z, Sarandol E, Kirhan E, Ozkaya G, Kirli S. Serum brain-derived neurotrophic factor, vascular endothelial growth factor and leptin levels in patients with a diagnosis of severe major depressive disorder with melancholic features. Ther Adv Psychopharmacol 2012; 2: 65-74.
13. Isung J, Mobarrez F, Nordstrom P, Asberg M, Jokinen J. Low plasma vascular endothelial growth factor (VEGF) associated with completed suicide. World J Biol Psychiatry 2012; 13: 468-473.
14. Clark-Raymond A, Halaris A. VEGF and depression: a comprehensive assessment of clinical data. J Psychiatr Res 2013; 47: 1080-1087.
15. Hyde CL, Nagle MW, Tian C, Chen X, Paciga SA, Wendland JR. Identification of 15 genetic loci associated with risk of major depression in individuals of European descent. Nat Genet 2016; 48: 1031-1036.
16. Viikki M, Anttila S, Kampman O, Illi A, Huuhka M, Setala-Soikkeli E, et al. Vascular endothelial growth factor (VEGF) polymorphism is associated with treatment resistant depression. Neurosci Lett 2010; 477: 105-108.
17. Debette S, Visvikis-Siest S, Chen MH, Ndiaye NC, Song C, Destefano A, et al. Identification of cis-and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels. Circul Res 2011; 109: 554-563.
18. APA. Diagnostic and Statistical Manual of Mental Disorders, 4th edn. American Psychiatric Association: Washington, DC, 1994.
19. Lou XY, Chen GB, Yan L, Ma JZ, Zhu J, Elston RC, et al. A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. Am J Hum Genet 2007; 80: 1125-1137.
20. Miller AH, Maletic V, Raison CL. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry 2009; 65: 732-741.
21. Azimi-Nezhad M, Stathopoulou MG, Bonnefond A, Rancier M, Saleh A, Lamont J, et al. Associations of vascular endothelial growth factor (VEGF) with adhesion and inflammation molecules in a healthy population. Cytokine 2013; 61: 602-607.
22. Iwata Y, Suzuki K, Nakamura K, Matsuzaki H, Sekine Y, Tsuchiya KJ, et al. Increased levels of serum soluble L-selectin in unmedicated patients with schizophrenia. Schizophr Res 2007; 89: 154-160.
23. Manfro GG, Pollack MH, Otto MW, Worthington JJ, Rosenbaum JF, Scott EL, et al. Cell-surface expression of L-selectin (CD62L) by blood lymphocytes: correlates with affective parameters and severity of panic disorder. Depress Anxiety 2000; 11: 31-37.
24. Suzuki G, Tokuno S, Nibuya M, Ishida T, Yamamoto T, Mukai Y, et al. Decreased plasma brain-derived neurotrophic factor and vascular endothelial growth factor concentrations during military training. PLoS ONE 2014; 9: e89455.
25. Hoppe C, Elger CE. Depression in epilepsy: a critical review from a clinical perspective. Nat Genet 2011; 7: 462-472.
26. Monroe SM, Simons AD. Diathesis-stress theories in the context of life stress research: implications for the depressive disorders. Psychol Bull 1991; 110: 406-425.
27. Halmai Z, Dome P, Dobos J, Gonda X, Szekely A, Sasvari-Szekely M, et al. Peripheral vascular endothelial growth factor level is associated with antidepressant treatment response: results of a preliminary study. J Affect Disord 2013; 144: 269-273.