Pyrano[3,2-a]carbazole alkaloids as effective agents against ischemic stroke in vitro and in vivo

European Journal of Medicinal Chemistry

Volumn 143, Issue , 2018, Pages 438-448

  Zang, Yingda ^a   Song, Xiuyun ^a   Li, Chuangjun ^a   Ma, Jie ^a   Chu, Shifeng ^a   Liu, Dandan ^a   Ren, Qian ^a   Li, Yan ^a   Chen, Naihong ^a   Zhang, Dongming ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Ischemic stroke; Neuroprotection; Pyrano 3,2 a carbazole alkaloids

Indexed keywords

3',3' DIMETHYL PYRANO[3,2 A]CARBAZOLE 3 CARBALDEHYDE; 3',3',3 TRIMETHYL PYRANO[3,2 A]CARBAZOLE; 3',3',3,9 TETRAMETHYL PYRANO[3,2 A]CARBAZOLE; 3',3',9 TRIMETHYL PYRANO[3,2 A]CARBAZOLE 3 CARBALDEHYDE; 6 METHOXY 3',3',3 TRIMETHYL PYRANO[3,2 A]CARBAZOLE; 6 METHOXY 3',3',3,9 TETRAMETHYL PYRANO[3,2 A]CARBAZOLE; 6 METHOXY 3',3',9 TRIMETHYL PYRANO[3,2 A]CARBAZOLE 3 CARBALDEHYDE; 6 TERT BUTYL 3',3',3 TRIMETHYL PYRANO[3,2 A]CARBAZOLE; 6 TERT BUTYL 3',3',3,9 TETRAMETHYL PYRANO[3,2 A]CARBAZOLE; 6 TERT BUTYL 3',3',9 TRIMETHYL PYRANO[3,2 A]CARBAZOLE 3 CARBALDEHYDE; 6 TRIFLUOROMETHOXY 3',3' DIMETHYL PYRANO[3,2 A]CARBAZOLE 3 CARBALDEHYDE; 6 TRIFLUOROMETHOXY 3',3',3 TRIMETHYL PYRANO[3,2 A]CARBAZOLE; 6 TRIFLUOROMETHOXY 3',3',3,9 TETRAMETHYL PYRANO[3,2 A]CARBAZOLE; 6 TRIFLUOROMETHYL 3',3' DIMETHYL PYRANO[3,2 A]CARBAZOLE 3 CARBALDEHYDE; 6 TRIFLUOROMETHYL 3',3',3 TRIMETHYL PYRANO[3,2 A]CARBAZOLE; 6 TRIFLUOROMETHYL 3',3',3,9 TETRAMETHYL PYRANO[3,2 A]CARBAZOLE; 6 TRIFLUOROMETHYL 3',3',9 TRIMETHYL PYRANO[3,2 A]CARBAZOLE 3 CARBALDEHYDE; ALKALOID; BUTYLPHTHALIDE; CARBAZOLE DERIVATIVE; CLAULANSINE F; N ETHYL 3',3',3 TRIMETHYL PYRANO[3,2 A]CARBAZOLE; N ETHYL 3',3',9 TRIMETHYL PYRANO[3,2 A]CARBAZOLE 3 CARBALDEHYDE; N ETHYL 6 METHOXY 3',3',3 TRIMETHYL PYRANO[3,2 A]CARBAZOLE; N ETHYL 6 METHOXY 3',3',9 TRIMETHYL PYRANO[3,2 A]CARBAZOLE 3 CARBALDEHYDE; N ETHYL 6 TERT BUTYL 3',3',3 TRIMETHYL PYRANO[3,2 A]CARBAZOLE; N ETHYL 6 TRIFLUOROMETHOXY 3',3',3 TRIMETHYL PYRANO[3,2 A]CARBAZOLE; N ETHYL 6 TRIFLUOROMETHYL 3',3',3 TRIMETHYL PYRANO[3,2 A]CARBAZOLE; NORPHENAZONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; 6-TERT-BUTYL-3',3',3-TRIMETHYLPYRANO(3,2-A)CARBAZOLE; HYDROGEN PEROXIDE; NEUROPROTECTIVE AGENT; PYRAN DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CELL; BRAIN CELL CULTURE; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN TISSUE; CELL VIABILITY; CLAUSENA; CLAUSENA LANSIUM; CONTROLLED STUDY; DRUG PENETRATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NEWBORN; NONHUMAN; PC12 CELL LINE; RAT; REPERFUSION INJURY; SURVIVAL RATE; WEIGHT REDUCTION; ANIMAL; CELL CULTURE; CELL SURVIVAL; CEREBROVASCULAR ACCIDENT; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; NERVE CELL; PATHOLOGY; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ALKALOIDS; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN ISCHEMIA; CARBAZOLES; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROGEN PEROXIDE; MALE; MOLECULAR STRUCTURE; NEURONS; NEUROPROTECTIVE AGENTS; PC12 CELLS; PYRANS; RATS; RATS, SPRAGUE-DAWLEY; STROKE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85036579614     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2017.11.084     Document Type: Article

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