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Volumn 40, Issue 8, 2012, Pages 1612-1619

Brain distribution and bioavailability of elacridar after different routes of administration in the mouse

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; ELACRIDAR; GLYCOPROTEIN P;

EID: 84863945004     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.045930     Document Type: Article
Times cited : (49)

References (27)
  • 1
    • 77953783419 scopus 로고    scopus 로고
    • Distribution of gefitinib to the brain is limited by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2)-mediated active efflux
    • Agarwal S, Sane R, Gallardo JL, Ohlfest JR, and Elmquist WF (2010) Distribution of gefitinib to the brain is limited by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2)-mediated active efflux. J Pharmacol Exp Ther 334:147-155.
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 147-155
    • Agarwal, S.1    Sane, R.2    Gallardo, J.L.3    Ohlfest, J.R.4    Elmquist, W.F.5
  • 2
    • 80053435892 scopus 로고    scopus 로고
    • Delivery of molecularly targeted therapy to malignant glioma, a disease of the whole brain
    • Agarwal S, Sane R, Oberoi R, Ohlfest JR, and Elmquist WF (2011a) Delivery of molecularly targeted therapy to malignant glioma, a disease of the whole brain. Expert Rev Mol Med 13:e17.
    • (2011) Expert Rev Mol Med , vol.13
    • Agarwal, S.1    Sane, R.2    Oberoi, R.3    Ohlfest, J.R.4    Elmquist, W.F.5
  • 3
    • 78650785470 scopus 로고    scopus 로고
    • The role of the breast cancer resistance protein (ABCG2) in the distribution of sorafenib to the brain
    • Agarwal S, Sane R, Ohlfest JR, and Elmquist WF (2011b) The role of the breast cancer resistance protein (ABCG2) in the distribution of sorafenib to the brain. J Pharmacol Exp Ther 336:223-233.
    • (2011) J Pharmacol Exp Ther , vol.336 , pp. 223-233
    • Agarwal, S.1    Sane, R.2    Ohlfest, J.R.3    Elmquist, W.F.4
  • 4
    • 0033199027 scopus 로고    scopus 로고
    • The mouse Bcrp1/Mxr/Abcp gene: Amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin
    • Allen JD, Brinkhuis RF, Wijnholds J, and Schinkel AH (1999) The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin. Cancer Res 59:4237-4241.
    • (1999) Cancer Res , vol.59 , pp. 4237-4241
    • Allen, J.D.1    Brinkhuis, R.F.2    Wijnholds, J.3    Schinkel, A.H.4
  • 6
    • 34548278289 scopus 로고    scopus 로고
    • Influence of breast cancer resistance protein (Abcg2) and p-glycoprotein (Abcb1a) on the transport of imatinib mesylate (Gleevec) across the mouse blood-brain barrier
    • Bihorel S, Camenisch G, Lemaire M, and Scherrmann JM (2007) Influence of breast cancer resistance protein (Abcg2) and p-glycoprotein (Abcb1a) on the transport of imatinib mesylate (Gleevec) across the mouse blood-brain barrier. J Neurochem 102:1749-1757.
    • (2007) J Neurochem , vol.102 , pp. 1749-1757
    • Bihorel, S.1    Camenisch, G.2    Lemaire, M.3    Scherrmann, J.M.4
  • 7
    • 16844384057 scopus 로고    scopus 로고
    • The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): Implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib in patients
    • Breedveld P, Pluim D, Cipriani G, Wielinga P, van Tellingen O, Schinkel AH, and Schellens JH (2005) The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib in patients. Cancer Res 65:2577-2582.
    • (2005) Cancer Res , vol.65 , pp. 2577-2582
    • Breedveld, P.1    Pluim, D.2    Cipriani, G.3    Wielinga, P.4    Van Tellingen, O.5    Schinkel, A.H.6    Schellens, J.H.7
  • 8
    • 70349142722 scopus 로고    scopus 로고
    • P-glycoprotein and breast cancer resistance protein influence brain distribution of dasatinib
    • Chen Y, Agarwal S, Shaik NM, Chen C, Yang Z, and Elmquist WF (2009) P-glycoprotein and breast cancer resistance protein influence brain distribution of dasatinib. J Pharmacol Exp Ther 330:956-963.
    • (2009) J Pharmacol Exp Ther , vol.330 , pp. 956-963
    • Chen, Y.1    Agarwal, S.2    Shaik, N.M.3    Chen, C.4    Yang, Z.5    Elmquist, W.F.6
  • 9
    • 0027275566 scopus 로고
    • Physiological parameters in laboratory animals and humans
    • Davies B and Morris T (1993) Physiological parameters in laboratory animals and humans. Pharm Res 10:1093-1095.
    • (1993) Pharm Res , vol.10 , pp. 1093-1095
    • Davies, B.1    Morris, T.2
  • 10
    • 0035984821 scopus 로고    scopus 로고
    • GF120918, a P-glycoprotein modulator, increases the concentration of unbound amprenavir in the central nervous system in rats
    • Edwards JE, Brouwer KR, and McNamara PJ (2002) GF120918, a P-glycoprotein modulator, increases the concentration of unbound amprenavir in the central nervous system in rats. Antimicrob Agents Chemother 46:2284-2286.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 2284-2286
    • Edwards, J.E.1    Brouwer, K.R.2    McNamara, P.J.3
  • 12
    • 0027524642 scopus 로고
    • In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative
    • Hyafil F, Vergely C, Du Vignaud P, and Grand-Perret T (1993) In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative. Cancer Res 53:4595-4602.
    • (1993) Cancer Res , vol.53 , pp. 4595-4602
    • Hyafil, F.1    Vergely, C.2    Du Vignaud, P.3    Grand-Perret, T.4
  • 14
  • 18
    • 65249151331 scopus 로고    scopus 로고
    • Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment
    • Lagas JS, van Waterschoot RA, van Tilburg VA, Hillebrand MJ, Lankheet N, Rosing H, Beijnen JH, and Schinkel AH (2009) Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment. Clin Cancer Res 15:2344-2351.
    • (2009) Clin Cancer Res , vol.15 , pp. 2344-2351
    • Lagas, J.S.1    Van Waterschoot, R.A.2    Van Tilburg, V.A.3    Hillebrand, M.J.4    Lankheet, N.5    Rosing, H.6    Beijnen, J.H.7    Schinkel, A.H.8
  • 19
    • 0031946026 scopus 로고    scopus 로고
    • Effect of GF120918, a potent P-glycoprotein inhibitor, on morphine pharmacokinetics and pharmacodynamics in the rat
    • Letrent SP, Pollack GM, Brouwer KR, and Brouwer KL (1998) Effect of GF120918, a potent P-glycoprotein inhibitor, on morphine pharmacokinetics and pharmacodynamics in the rat. Pharm Res 15:599-605.
    • (1998) Pharm Res , vol.15 , pp. 599-605
    • Letrent, S.P.1    Pollack, G.M.2    Brouwer, K.R.3    Brouwer, K.L.4
  • 20
    • 42149132635 scopus 로고    scopus 로고
    • Chemoresistance in gliomas
    • Lu C and Shervington A (2008) Chemoresistance in gliomas. Mol Cell Biochem 312:71-80.
    • (2008) Mol Cell Biochem , vol.312 , pp. 71-80
    • Lu, C.1    Shervington, A.2
  • 21
    • 77953315629 scopus 로고    scopus 로고
    • Examination of the ability of the nasal administration route to confer a brain exposure advantage for three chemical inhibitors of P-glycoprotein
    • Padowski JM and Pollack GM (2010) Examination of the ability of the nasal administration route to confer a brain exposure advantage for three chemical inhibitors of P-glycoprotein. J Pharm Sci 99:3226-3233.
    • (2010) J Pharm Sci , vol.99 , pp. 3226-3233
    • Padowski, J.M.1    Pollack, G.M.2
  • 23
    • 0034456656 scopus 로고    scopus 로고
    • Multidrug resistance transporters and modulation
    • Tan B, Piwnica-Worms D, and Ratner L (2000) Multidrug resistance transporters and modulation. Curr Opin Oncol 12:450-458.
    • (2000) Curr Opin Oncol , vol.12 , pp. 450-458
    • Tan, B.1    Piwnica-Worms, D.2    Ratner, L.3
  • 24
    • 80255137111 scopus 로고    scopus 로고
    • Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration
    • Tang SC, Lagas JS, Lankheet NA, Poller B, Hillebrand MJ, Rosing H, Beijnen JH, and Schinkel AH (2012a) Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration. Int J Cancer 130:223-233.
    • (2012) Int J Cancer , vol.130 , pp. 223-233
    • Tang, S.C.1    Lagas, J.S.2    Lankheet, N.A.3    Poller, B.4    Hillebrand, M.J.5    Rosing, H.6    Beijnen, J.H.7    Schinkel, A.H.8
  • 25
    • 84858683187 scopus 로고    scopus 로고
    • P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict brain accumulation of the active sunitinib metabolite N-desethyl sunitinib
    • Tang SC, Lankheet NA, Poller B, Wagenaar E, Beijnen JH, and Schinkel AH (2012b) P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict brain accumulation of the active sunitinib metabolite N-desethyl sunitinib. J Pharmacol Exp Ther 341:164-173.
    • (2012) J Pharmacol Exp Ther , vol.341 , pp. 164-173
    • Tang, S.C.1    Lankheet, N.A.2    Poller, B.3    Wagenaar, E.4    Beijnen, J.H.5    Schinkel, A.H.6
  • 26
    • 3343001907 scopus 로고    scopus 로고
    • Preclinical pharmacokinetic properties of the P-glycoprotein inhibitor GF120918A (HCl salt of GF120918, 9,10-dihydro-5-methoxy-9-oxo-N-[4-[2- (1,2,3,4-tetrahydro-6,7-dimethoxy-2-i soquinolinyl)ethyl]phenyl]-4-acridine- carboxamide) in the mouse, rat, dog, and monkey
    • Ward KW and Azzarano LM (2004) Preclinical pharmacokinetic properties of the P-glycoprotein inhibitor GF120918A (HCl salt of GF120918, 9,10-dihydro-5-methoxy-9-oxo-N-[4-[2- (1,2,3,4-tetrahydro-6,7-dimethoxy-2-i soquinolinyl)ethyl]phenyl]-4-acridine-carboxamide) in the mouse, rat, dog, and monkey. J Pharmacol Exp Ther 310:703-709.
    • (2004) J Pharmacol Exp Ther , vol.310 , pp. 703-709
    • Ward, K.W.1    Azzarano, L.M.2
  • 27
    • 0030041652 scopus 로고    scopus 로고
    • Flow cytometric assay of modulation of P-glycoprotein function in whole blood by the multidrug resistance inhibitor GG918
    • Witherspoon SM, Emerson DL, Kerr BM, Lloyd TL, Dalton WS, and Wissel PS (1996) Flow cytometric assay of modulation of P-glycoprotein function in whole blood by the multidrug resistance inhibitor GG918. Clin Cancer Res 2:7-12.
    • (1996) Clin Cancer Res , vol.2 , pp. 7-12
    • Witherspoon, S.M.1    Emerson, D.L.2    Kerr, B.M.3    Lloyd, T.L.4    Dalton, W.S.5    Wissel, P.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.