Novel hybrids of optically active ring-opened 3-n-butylphthalide derivative and isosorbide as potential anti-ischemic stroke agents

Journal of Medicinal Chemistry

Volumn 56, Issue 7, 2013, Pages 3078-3089

  Wang, Xiaoli ^a   Wang, Linna ^a   Li, Tingting ^a   Huang, Zhangjian ^a   Lai, Yisheng ^a   Ji, Hui ^a   Wan, Xiaolong ^b   Xu, Jinyi ^a   Tian, Jide ^c   Zhang, Yihua ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b SHANGHAI UNIVERSITY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 BUTYLPHTHALIDE; ADENOSINE DIPHOSPHATE; ARACHIDONIC ACID; ISOSORBIDE; LIPID; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PARTITION COEFFICIENT; REPERFUSION INJURY; THROMBOCYTE AGGREGATION; THROMBOSIS;

ANIMALS; BENZOFURANS; BLOOD-BRAIN BARRIER; ISOSORBIDE; PLATELET AGGREGATION INHIBITORS; RATS; STEREOISOMERISM; STROKE;

EID: 84876279075     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm4001693     Document Type: Article

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