Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies

Immunity

Volumn 47, Issue 6, 2017, Pages 1197-1209.e10

  Triller, Gianna ^a   Scally, Stephen W ^b   Costa, Giulia ^c   Pissarev, Maria ^c   Kreschel, Cornelia ^c   Bosch, Alexandre ^b   Marois, Eric ^d   Sack, Brandon K ^e   Murugan, Rajagopal ^a   Salman, Ahmed M ^f,g   Janse, Chris J ^g   Khan, Shahid M ^g   Kappe, Stefan H I ^e   Adegnika, Ayola A ^g,h,i   Mordmüller, Benjamin ⁱ   Levashina, Elena A ^c   Julien, Jean Philippe ^b,j   Wardemann, Hedda ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^c MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

^d UNIVERSITÉ DE STRASBOURG   (France)

^e SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^f UNIVERSITY OF OXFORD   (United Kingdom)

^g LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^h Centre de Recherches Médicales de Lambaréné HÔpital Albert Schweitzer   (Gabon)

ⁱ UNIVERSITY OF TÜBINGEN   (Germany)

^j UNIVERSITY OF TORONTO   (Canada)

more..

Author keywords

affinity maturation; circumsporozoite protein; epitope specificity; human; malaria; memory B cells; natural infection; Plasmodium falciparum; protective antibodies; X ray structures

Indexed keywords

CIRCUMSPOROZOITE PROTEIN; EPITOPE; IMMUNOGLOBULIN; IMMUNOGLOBULIN HEAVY CHAIN COMPLEMENTARITY DETERMINING REGION 3; MALARIA VACCINE; PARASITE ANTIBODY; UNCLASSIFIED DRUG; CIRCUMSPOROZOITE PROTEIN, PROTOZOAN; IMMUNOGLOBULIN HEAVY CHAIN; PARASITE ANTIGEN; PROTEIN BINDING; PROTOZOAL PROTEIN; PROTOZOON ANTIBODY; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; BINDING AFFINITY; BINDING SITE; CLONING; CONFORMATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; LIVER CELL; MALARIA; MEMORY CELL; MOSQUITO VECTOR; MOUSE; NONHUMAN; PARASITE DEVELOPMENT; PARASITE TRANSMISSION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SOMATIC MUTATION; STRUCTURE ANALYSIS; ALPHA HELIX; ANIMAL; B LYMPHOCYTE; BETA SHEET; BIOSYNTHESIS; CHEMISTRY; GENE EXPRESSION; GENETICS; HUMORAL IMMUNITY; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; MALARIA FALCIPARUM; MALE; METABOLISM; MOLECULAR MODEL; PARASITOLOGY; PLASMODIUM BERGHEI; PROTEIN DOMAIN; SPOROZOITE; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; B-LYMPHOCYTES; CRYSTALLOGRAPHY, X-RAY; EPITOPES; FEMALE; GENE EXPRESSION; HUMANS; IMMUNITY, HUMORAL; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOLOGIC MEMORY; MALARIA; MALARIA, FALCIPARUM; MALE; MICE; MODELS, MOLECULAR; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PROTEIN CONFORMATION, ALPHA-HELICAL; PROTEIN CONFORMATION, BETA-STRAND; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS; SPOROZOITES;

EID: 85036540709     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2017.11.007     Document Type: Article

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