Genetically tunable frustration controls allostery in an intrinsically disordered transcription factor

eLife

Volumn 6, Issue , 2017, Pages

  Li, Jing ^a,b   White, Jordan T ^a   Saavedra, Harry ^a,b   Wrabl, James O ^a,b   Motlagh, Hesam N ^a,b   Liu, Kaixian ^a   Sowers, James ^a   Schroer, Trina A ^a   Brad Thompson, E ^a,c   Hilser, Vincent J ^a,b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c University of Houston   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID RECEPTOR; INTRINSICALLY DISORDERED PROTEIN; ISOPROTEIN; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR;

ALLOSTERISM; ANISOTROPY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; GENE EXPRESSION; GENE REPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LUCIFERASE ASSAY; MUTATIONAL ANALYSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PLASMID; POINT MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PURIFICATION; THERMODYNAMICS; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; WESTERN BLOTTING; CHEMISTRY; GENE EXPRESSION REGULATION; METABOLISM; PROTEIN CONFORMATION;

ALLOSTERIC REGULATION; GENE EXPRESSION REGULATION; HUMANS; INTRINSICALLY DISORDERED PROTEINS; PROTEIN CONFORMATION; PROTEIN ISOFORMS; RECEPTORS, GLUCOCORTICOID; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS;

EID: 85036494586     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.30688     Document Type: Article

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