Postmortem MRI and histology demonstrate differential iron accumulation and cortical myelin organization in early- and late-onset Alzheimer's disease

Neurobiology of Aging

Volumn 62, Issue , 2018, Pages 231-242

  Bulk, Marjolein ^a,b   Abdelmoula, Walid M ^a   Nabuurs, Rob J A ^a   van der Graaf, Linda M ^a   Mulders, Coen W H ^a   Mulder, Aat A ^a   Jost, Carolina R ^a   Koster, Abraham J ^a   van Buchem, Mark A ^a   Natté, Remco ^a   Dijkstra, Jouke ^a   van der Weerd, Louise ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b PERCUROS B V   (Netherlands)

Author keywords

Amyloid; Microglia; Nonlinear alignment; Postmortem MRI; Susceptibility

Indexed keywords

AMYLOID PROTEIN; IRON; MYELIN; TAU PROTEIN; AMYLOID BETA PROTEIN;

ALZHEIMER DISEASE; ARTICLE; AUTOPSY; BIOACCUMULATION; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DISEASE COURSE; EX VIVO STUDY; FRONTAL CORTEX; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IRON TRANSPORT; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; ADULT; AGED; BRAIN CORTEX; DIAGNOSTIC IMAGING; DIFFUSION WEIGHTED IMAGING; DISEASE PREDISPOSITION; FEMALE; MALE; METABOLISM; MIDDLE AGED; MYELIN SHEATH; PATHOLOGY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AUTOPSY; CEREBRAL CORTEX; DIFFUSION MAGNETIC RESONANCE IMAGING; DISEASE SUSCEPTIBILITY; FEMALE; HUMANS; IRON; MALE; MIDDLE AGED; MYELIN SHEATH; TAU PROTEINS;

EID: 85035770967     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2017.10.017     Document Type: Article

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