Exercise for patients with major depression: A systematic review with meta-analysis and trial sequential analysis

BMJ Open

Volumn 7, Issue 9, 2017, Pages

  Krogh, Jesper ^a   Hjorthøj, Carsten ^a   Speyer, Helene ^a   Gluud, Christian ^b   Nordentoft, Merete ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Rigshospitalet   (Denmark)

Author keywords

Evidence Based Medicine; Exercise; Meta analysis; Randomised Clinical Trials; Systematic Review

Indexed keywords

ADVERSE OUTCOME; ARTICLE; CLINICAL OUTCOME; COMORBIDITY; DIABETES MELLITUS; DISEASE SEVERITY; EMBASE; EVALUATION AND FOLLOW UP; EVIDENCE BASED PRACTICE; FOLLOW UP; GRADING OF RECOMMENDATIONS ASSESSMENT DEVELOPMENT AND EVALUATION; HUMAN; INJURY; INTERVENTION STUDY; KINESIOTHERAPY; MAJOR DEPRESSION; MALIGNANT NEOPLASM; MATHEMATICAL AND STATISTICAL PROCEDURES; MEDLINE; MENTAL PATIENT; QUALITY OF LIFE; RANDOM ERROR; RANDOMIZED CONTROLLED TRIAL (TOPIC); REMISSION; RISK BENEFIT ANALYSIS; RISK FACTOR; SCISEARCH; SEQUENTIAL ANALYSIS; SUICIDE; SYSTEMATIC REVIEW; THERAPY EFFECT; WANFANG DATABASE; WEB OF SCIENCE; EXERCISE; META ANALYSIS; PSYCHOLOGY; STATISTICAL BIAS;

BIAS; DEPRESSIVE DISORDER, MAJOR; EXERCISE; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 85035018885     PISSN: None     EISSN: 20446055     Source Type: Journal    
DOI: 10.1136/bmjopen-2016-014820     Document Type: Article

References (105)

1. Lepine JP, Gastpar M, Mendelwicz J, et al. Depression in the community: the first pan-european study DEPRES (Depression Research in European Society). Int Clin Psychopharmocol 1997;12:19-29.
2. Pedersen CB, Mors O, Bertelsen A, et al. A comprehensive nationwide study of the incidence rate and lifetime risk for treated mental disorders. JAMA Psychiatry 2014;71:573-81.
3. Ustün TB, Ayuso-Mateos JL, Chatterji S, et al. Global burden of depressive disorders in the year 2000. Br J Psychiatry 2004;184:386-92.
4. Kirsch I, Deacon BJ, Huedo-Medina TB, et al. Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration. PLoS Med 2008;5:e45.
5. Turner EH, Matthews AM, Linardatos E, et al. Selective publication of antidepressant trials and its influence on apparent efficacy. N Engl J Med 2008;358:252-60.
6. Jakobsen JC, Katakam KK, Schou A, et al. Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder. A systematic review with meta-analysis and trial sequential analysis. BMC Psychiatry 2017;17:58.
7. Jakobsen JC, Hansen JL, StorebøOJ, et al. The effects of cognitive therapy versus 'no intervention' for major depressive disorder. PLoS One 2011;6:e28299.
8. Jakobsen JC, Hansen JL, Simonsen E, et al. The effect of interpersonal psychotherapy and other psychodynamic therapies versus 'treatment as usual' in patients with major depressive disorder. PLoS One 2011;6:e19044.
9. Jakobsen JC, Hansen JL, Simonsen E, et al. The effect of adding psychodynamic therapy to antidepressants in patients with major depressive disorder. A systematic review of randomized clinical trials with meta-analyses and trial sequential analyses. J Affect Disord 2012;137:4-14.
10. Cipriani A, Furukawa TA, Salanti G, et al. Comparative efficacy and acceptability of 12 new-generation antidepressants: a multipletreatments meta-analysis. Lancet 2009;373:746-58.
11. Krogh J, Nordentoft M, Sterne JA, et al. The effect of exercise in clinically depressed adults: systematic review and meta-analysis of randomized controlled trials. J Clin Psychiatry 2011;72:529-38.
12. Schuch FB, Vancampfort D, Richards J, et al. Exercise as a treatment for depression: a meta-analysis adjusting for publication Bias. J Psychiatr Res 2016;77:42-51.
13. Bridle C, Spanjers K, Patel S, et al. Effect of exercise on depression severity in older people: systematic review and meta-analysis of randomised controlled trials. Br J Psychiatry 2012;201:180-5.
14. Herring MP, Puetz TW, O'Connor PJ, et al. Effect of exercise training on depressive symptoms among patients with a chronic illness: a systematic review and meta-analysis of randomized controlled trials. Arch Intern Med 2012;172:101-11.
15. World Health Organisation. International Statistical Classificationclassification of Diseasesdiseases, 10th Revision (ICD-10. Geneva, Switzerland, 1992.
16. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington DC, 1994.
17. Beck AT, Steer RA, Brown GK. BDI-II manual. 2 ed. New York: Psychological Corporation, 1996.
18. Krogh J, Speyer H, Gluud C, et al. Exercise for patients with major depression: a protocol for a systematic review with meta-analysis and trial sequential analysis. Syst Rev 2015;4:40.
19. Spitzer RL, Endicott J, Williams JB, et al. Research diagnostic criteria. Arch Gen Psychiatry 1979;36:1381-3.
20. ICH-secretariat. International Conference on Harmonisation (ICH) Harmonised Tripartite Guideline (Step 4). Guideline for Good Clinical practice. Geneva, 1996.
21. Krogh J, Saltin B, Gluud C, et al. The DEMO trial: a randomized, parallel-group, observer-blinded clinical trial of strength versus aerobic versus relaxation training for patients with mild to moderate depression. J Clin Psychiatry 2009;70:790-800.
22. Krogh J, Videbech P, Thomsen C, et al. DEMO-II trial. Aerobic exercise versus stretching exercise in patients with major depression-a randomised clinical trial. PLoS One 2012;7:e48316.
23. GSe H. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0: The Cochrane Collaboration, 2009. www. cochrane- handbook. org
24. Cooney GM, Dwan K, Greig CA, et al. Exercise for depression. Cochrane Database Syst Rev 2013;9:CD004366.
25. Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ 2003;327:557-60.
26. Wetterslev J, Thorlund K, Brok J, et al. Trial sequential analysis may establish when firm evidence is reached in cumulative metaanalysis. J Clin Epidemiol 2008;61:64-75.
27. Brok J, Thorlund K, Gluud C, et al. Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses. J Clin Epidemiol 2008;61:763-9.
28. Thorlund K, Walter SD, Johnston BC, et al. Pooling health-related quality of life outcomes in meta-analysis-a tutorial and review of methods for enhancing interpretability. Res Synth Methods 2011;2:188-203.
29. Jakobsen JC, Wetterslev J, Winkel P, et al. Thresholds for statistical and clinical significance in systematic reviews with meta-analytic methods. BMC Med Res Methodol 2014;14:120.
30. Hollis S, Campbell F. What is meant by intention to treat analysis? survey of published randomised controlled trials. BMJ 1999;319:670-4.
31. Duval S, Tweedie R. Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in metaanalysis. Biometrics 2000;56:455-63.
32. Guyatt GH, Oxman AD, Vist GE, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008;336:924-6.
33. Andrews J, Guyatt G, Oxman AD, et al. GRADE guidelines: 14. going from evidence to recommendations: the significance and presentation of recommendations. J Clin Epidemiol 2013;66:719-25.
34. Zheng YP, Lin KM, Zhao JP, et al. Comparative study of diagnostic systems: Chinese classification of mental Disorders-Second Edition versus DSM-III-R. Compr Psychiatry 1994;35:441-9.
35. Babyak M, Blumenthal JA, Herman S, et al. Exercise treatment for major depression: maintenance of therapeutic benefit at 10 months. Psychosom Med 2000;62:633-8.
36. Baxter H, Winder R, Chalder M, et al. Physical activity as a treatment for depression: the TREAD randomised trial protocol. Trials 2010;11:105.
37. Hoffman BM, Blumenthal JA, Babyak MA, et al. Exercise fails to improve neurocognition in depressed middle-aged and older adults. Med Sci Sports Exerc 2008;40:1344-52.
38. Blumenthal JA, Babyak MA, Moore KA, et al. Effects of exercise training on older patients with Major depression. Arch Intern Med 1999;159:2349-56.
39. Blumenthal JA, Babyak MA, Doraiswamy PM, et al. Exercise and pharmacotherapy in the treatment of major depressive disorder. Psychosom Med 2007;69:587-96.
40. Chalder M, Wiles NJ, Campbell J, et al. Facilitated physical activity as a treatment for depressed adults: randomised controlled trial. BMJ 2012;344:e2758.
41. Chalder M, Wiles NJ, Campbell J, et al. A pragmatic randomised controlled trial to evaluate the cost-effectiveness of a physical activity intervention as a treatment for depression: the treating depression with physical activity (TREAD) trial. Health Technol Assess 2012;16:1-iv.
42. Combs K, Smith PJ, Sherwood A, et al. Impact of sleep complaints and depression outcomes among participants in the standard medical intervention and long-term exercise study of exercise and pharmacotherapy for depression. J Nerv Ment Dis 2014;202:167-71.
43. Doyne EJ, Ossip-Klein DJ, Bowman ED, et al. Running versus weight lifting in the treatment of depression. J Consult Clin Psychol 1987;55:748-54.
44. Dunn AL, Trivedi MH, Kampert JB, et al. The DOSE study: a clinical trial to examine efficacy and dose response of exercise as treatment for depression. Control Clin Trials 2002;23:584-603.
45. Dunn AL, Trivedi MH, Kampert JB, et al. Exercise treatment for depression: efficacy and dose response. Am J Prev Med 2005;28:1-8.
46. Herman S, Blumenthal JA, Babyak M, et al. Exercise therapy for depression in middle-aged and older adults: predictors of early dropout and treatment failure. Health Psychol 2002;21:553-63.
47. Ho Cwh, Chan SC, Wong JS, et al. Effect of Aerobic Exercise Training on Chinese Population with Mild to Moderate Depression in Hong Kong. Rehabilitation Research and Practice 2014. doi:10.1155/2014/627376
48. Hoffman BM, Babyak MA, Craighead WE, et al. Exercise and pharmacotherapy in patients with Major depression: one-year follow-up of the SMILE study. Psychosom Med 2011;73:127-33.
49. Kerling A, Tegtbur U, Gützlaff E, et al. Effects of adjunctive exercise on physiological and psychological parameters in depression: a randomized pilot trial. J Affect Disord 2015;177 1:-6.
50. Khatri P, Blumenthal JA, Babyak MA, et al. Effects of Exercise training on cognitive functioning among depressed older men and women. J Aging Phys Act 2001;9:43-57.
51. Krogh J, Petersen L, Timmermann M, et al. Design paper: the DEMO trial: a randomized, parallel-group, observer-blinded clinical trial of aerobic versus non-aerobic versus relaxation training for patients with light to moderate depression. Contemp Clin Trials 2007;28:79-89.
52. Mather AS, Rodriguez C, Guthrie MF, et al. Effects of exercise on depressive symptoms in older adults with poorly responsive depressive disorder: randomised controlled trial. Br J Psychiatry 2002;180:411-5.
53. Mota-Pereira J, Silverio J, Carvalho S, et al. Moderate exercise improves depression parameters in treatment-resistant patients with Major depressive disorder. J Psychiatr Res 2011;45:1005-11.
54. Pfaff JJ, Alfonso H, Newton RU, et al. ACTIVEDEP: a randomised, controlled trial of a home-based exercise intervention to alleviate depression in middle-aged and older adults. Br J Sports Med 2014;48:226-32.
55. Pilu A, Sorba M, Hardoy MC, et al. Efficacy of physical activity in the adjunctive treatment of major depressive disorders: preliminary results. Clin Pract Epidemiol Ment Health 2007;3:8.
56. Schuch FB, Vasconcelos-Moreno MP, Borowsky C, et al. Exercise and severe depression: preliminary results of an add-on study. J Affect Disord 2011;133:615-8.
57. Singh NA, Clements KM, Fiatarone MA. A randomized controlled trial of the effect of exercise on sleep. Sleep 1997;20:95-101.
58. Singh NA, Stavrinos TM, Scarbek Y, et al. A randomized controlled trial of high versus low intensity weight training versus general practitioner care for clinical depression in older adults. J Gerontol A Biol Sci Med Sci 2005;60:768-76.
59. Singh NA, Clements KM, Singh MA. The efficacy of exercise as a long-term antidepressant in elderly subjects: a randomized, controlled trial. J Gerontol A Biol Sci Med Sci 2001;56:M497-M504.
60. Singh NA, Clements KM, Fiatarone MA. A randomized controlled trial of progressive resistance training in depressed elders. J Gerontol A Biol Sci Med Sci 1997;52:M27-M35.
61. Toni G, Belvederi MM, Zanetidou S, et al. Physical exercise for late life Major depression: the SEEDS study. Eur J Prev Cardiol 2014;21:S107.
62. Veale D, Fk L, Pantelis C, et al. Aerobic exercise in the adjunctive treatment of depression: a randomized controlled trial. J R Soc Med 1992;85:541-4.
63. Vieira JLL, Porcu M, da Rocha PGM. The regular physical exercise's practice as complementary therapy to the treatment of depressed women. J Bras Psiquiatr 2007;56:23-8.
64. Epstein D. Aerobic activity versus group cognitive therapy: an evaluative study of contrasting interventions for the alleviation of clinical depression (dissertation). Reno: University of Nevada, 1986.
65. Danielsson L, Papoulias I, Petersson EL, et al. Exercise or basic body awareness therapy as add-on treatment for major depression: a controlled study. J Affect Disord 2014;168:98-106.
66. Carneiro LS, Fonseca AM, Vieira-Coelho MA, et al. Effects of structured exercise and pharmacotherapy vs. pharmacotherapy for adults with depressive symptoms: A randomized clinical trial. J Psychiatr Res 2015;71:48-55.
67. Legrand FD, Neff EM. Efficacy of exercise as an adjunct treatment for clinically depressed inpatients during the initial stages of antidepressant pharmacotherapy: an open randomized controlled trial. J Affect Disord 2016;191:139-44.
68. Doose M, Ziegenbein M, Hoos O, et al. Self-selected intensity exercise in the treatment of Major depression: a pragmatic RCT. Int J Psychiatry Clin Pract 2015;19:266-75.
69. Salehi I, Hosseini SM, Haghighi M, et al. Electroconvulsive therapy (ECT) and aerobic exercise training (AET) increased plasma BDNF and ameliorated depressive symptoms in patients suffering from Major depressive disorder. J Psychiatr Res 2016;76:1-8.
70. Huipeng F, Xiaohui Z. Curative effect and observation of exercise on patients with depression. Chin Med Pharm 2013;3:187-8.
71. Jinchun W, Bo Y, Rong X, et al. Effect of exercise therapy in improving social function and quality of life in patients with depression. Nurs J Chin PLA 2015;32:24.
72. Guifeng S. The role of setting - up exercise on rehabilitation in patients with depressive episode. Chin J Health Psychol 2015;23:184-6.
73. Fang D, Min R, Ai-qin W. The effect of aerobic exercise with different intensity and frequency on depressive symptoms. Chin J Behav Med & Brain Sci 2013;22:830-2.
74. Olson RL, Brush CJ, Ehmann PJ, et al. A randomized trial of aerobic exercise on cognitive control in Major depression. Clin Neurophysiol 2017;128:903-13.
75. Euteneuer F, Dannehl K, Del Rey A, et al. Immunological effects of behavioral activation with exercise in major depression: an exploratory randomized controlled trial. Transl Psychiatry 2017;7:e1132.
76. Patten CA, Bronars CA, Vickers Douglas KS, et al. Supervised, vigorous intensity exercise intervention for depressed female smokers: A pilot study. Nicotine Tob Res 2017;19:77-86.
77. Pentecost C, Farrand P, Greaves CJ, et al. Combining behavioural activation with physical activity promotion for adults with depression: findings of a parallel-group pilot randomised controlled trial (BAcPAc). Trials 2015;16:367.
78. Farrand P, Pentecost C, Greaves C, et al. A written self-help intervention for depressed adults comparing behavioural activation combined with physical activity promotion with a self-help intervention based upon behavioural activation alone: study protocol for a parallel group pilot randomised controlled trial (BAcPAc). Trials 2014;15:196.
79. Martinsen EW, Medhus A, Sandvik L. Effects of aerobic exercise on depression: a controlled study. BMJ 1985;291:109.
80. Veale D, Le Fevre K, Pantelis C, et al. Aerobic exercise in the adjunctive treatment of depression: a randomized controlled trial. J R Soc Med 1992;85:541-4.
81. Ossip-Klein DJ, Doyne EJ, Bowman ED, et al. Effects of running or weight lifting on self-concept in clinically depressed women. J Consult Clin Psychol 1989;57:158-61.
82. Blumenthal JA, Babyak MA, Moore KA, et al. Effects of exercise training on older patients with Major depression. Arch Intern Med 1999;159:2349-56.
83. Belvederi Murri M, Amore M, Menchetti M, et al. . Physical exercise for late-life major depression. Br J Psychiatry 2015;207:235-42.
84. Schuch FB, Vasconcelos-Moreno MP, Borowsky C, et al. Exercise and severe Major depression: effect on symptom severity and quality of life at discharge in an inpatient cohort. J Psychiatr Res 2015;61:25-32.
85. Carta MG, Hardoy MC, Pilu A, et al. Improving physical quality of life with group physical activity in the adjunctive treatment of Major depressive disorder. Clin Pract Epidemiol Ment Health 2008;4:1.
86. Klein MH, Greist JH, Gurman AS, et al. A Comparative Outcome Study of Group Psychotherapy vs. Exercise Treatments for Depression. Int J Ment Health 1985;13:148-76.
87. Roberts I, Ker K, Edwards P, et al. The knowledge system underpinning healthcare is not fit for purpose and must change. BMJ 2015;350:h2463.
88. Gluud C, Jakobsen J, Imberger G, et al. Re: The knowledge system underpinning healthcare is not fit for purpose and must change - Responses to the opposing viewpoints of Roberts and colleagues and Tovey and colleagues. BMJ 2015;350.
89. Thorlund K, Engstrø J, Wetterslev J, et al. User manual for Trial Sequential Analysis (TSA). Copenhagen, Denmark: Copenhagen Trial Unit, Centre for Clinical Intervention Research:1-115. https:// www ctu dk/tsa
90. Krogh J, Hjorthøj CR, Jakobsen JC, et al. DEPERROR: Risks of systematic errors in drug and non-drug randomized clinical trials assessing intervention effects in patients with unipolar depression. J Affect Disord 2015;179:121-7.
91. Savović J, Jones HE, Altman DG, et al. Influence of reported study design characteristics on intervention effect estimates from randomized, controlled trials. Ann Intern Med 2012;157:429-38.
92. Poole C, Greenland S. Random-effects meta-analyses are not always conservative. Am J Epidemiol 1999;150:469-75.
93. Ioannidis JP, Greenland S, Hlatky MA, et al. Increasing value and reducing waste in research design, conduct, and analysis. Lancet 2014;383:166-75.
94. Chan AW, Song F, Vickers A, et al. Increasing value and reducing waste: addressing inaccessible research. Lancet 2014;383:257-66.
95. Moher D, Glasziou P, Chalmers I, et al. Increasing value and reducing waste in biomedical research: who's listening? Lancet 2016;387:1573-86.
96. Glasziou P, Altman DG, Bossuyt P, et al. Reducing waste from incomplete or unusable reports of biomedical research. Lancet 2014;383:267-76.
97. Chalmers I, Bracken MB, Djulbegovic B, et al. How to increase value and reduce waste when research priorities are set. Lancet 2014;383:156-65.
98. Al-Shahi Salman R, Beller E, Kagan J, et al. Increasing value and reducing waste in biomedical research regulation and management. Lancet 2014;383:176-85.
99. Garattini S, Jakobsen JC, Wetterslev J, et al. Evidence-based clinical practice: overview of threats to the validity of evidence and how to minimise them. Eur J Intern Med 2016;32:13-21.
100. Sterne JA, Sutton AJ, Ioannidis JP, et al. Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ 2011;343:d4002.
101. Slade SC, Dionne CE, Underwood M, et al. Consensus on Exercise Reporting Template (CERT): Explanation and elaboration statement. Br J Sports Med 2016:1428-37.
102. Stubbs B, Rosenbaum S, Vancampfort D, et al. Exercise improves cardiorespiratory fitness in people with depression: a meta-analysis of randomized control trials. J Affect Disord 2016;190:249-53.
103. Schulz KF. CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials. Ann Intern Med 2010;152:726-32.
104. Chan AW, Tetzlaff JM, Gøtzsche PC, et al. SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials. BMJ 2013;346:e7586.
105. Skoog M, Saarimäki J, luud C, et al. Transparency and registration in clinical research in the nordic countries: Nordic Trial Alliance, NordForsk, 2015:1-108.