Electroconvulsive therapy (ECT) and aerobic exercise training (AET) increased plasma BDNF and ameliorated depressive symptoms in patients suffering from major depressive disorder

Journal of Psychiatric Research

Volumn 76, Issue , 2016, Pages 1-8

  Salehi, Iraj ^a   Hosseini, Seyed Mohammad ^a   Haghighi, Mohammad ^a   Jahangard, Leila ^a   Bajoghli, Hafez ^b   Gerber, Markus ^c   Pühse, Uwe ^c   Holsboer Trachsler, Edith ^d   Brand, Serge ^c,d  

^a HAMADAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c UNIVERSITY OF BASEL   (Switzerland)

^d UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Aerobic exercise training; Electroconvulsive therapy; Major depressive disorder; Plasma BDNF

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

ADULT; AEROBIC EXERCISE; ARTICLE; BECK DEPRESSION INVENTORY; CONTROLLED STUDY; ELECTROCONVULSIVE THERAPY; FEMALE; HAMILTON DEPRESSION RATING SCALE; HUMAN; INTERVENTION STUDY; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MEDICAL HISTORY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REMISSION; SELF EVALUATION; SELF REPORT; TREADMILL EXERCISE; ANALYSIS OF VARIANCE; BLOOD; DEPRESSIVE DISORDER, MAJOR; KINESIOTHERAPY; PROCEDURES; PSYCHOLOGICAL RATING SCALE; STATISTICS; TREATMENT OUTCOME; YOUNG ADULT;

ADULT; ANALYSIS OF VARIANCE; BRAIN-DERIVED NEUROTROPHIC FACTOR; DEPRESSIVE DISORDER, MAJOR; ELECTROCONVULSIVE THERAPY; EXERCISE THERAPY; FEMALE; HUMANS; MALE; PSYCHIATRIC STATUS RATING SCALES; SELF REPORT; STATISTICS AS TOPIC; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84960102122     PISSN: 00223956     EISSN: 18791379     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2016.01.012     Document Type: Article

References (62)

1. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 2000, American Psychiatric Association, Washington, DC. 4 ed.
2. Barekatain M., Jahangard L., Haghighi M., Ranjkesh F. Bifrontal versus bitemporal electroconvulsive therapy in severe manic patients. J. ECT 2008, 24:199-202.
3. Beck A.T. Beck Depression Inventory 1961, Center for Cognitive Therapy, Philadelphia PA.
4. Beck J., Gerber M., Brand S., Pühse U., Holsboer-Trachsler E. Executive function performance is reduced during occupational burnout but can recover to the level of healthy controls. J. Psychiatr. Res. 2013 Nov, 47(11):1824-1830.
5. Beste C., Kolev V., Yordanova J., Domschke K., Falkenstein M., Baune B.T., Konrad C. The role of the BDNF Val66Met polymorphism for the synchronization of error-specific neural networks. J. Neurosci. 2010, 30:10727-10733.
6. Binder D.K., Scharfman H.E. Brain-derived neurotrophic factor. Growth Factors 2004, 22:123-131.
7. Bocchio-Chiavetto L., Zanardini R., Bortolomasi M., Abate M., Segala M., Giacopuzzi M., Riva M.A., Marchina E., Pasqualetti P., Perez J., Gennarelli M. Electroconvulsive Therapy (ECT) increases serum brain derived neurotrophic factor (BDNF) in drug resistant depressed patients. Eur. Neuropsychopharmacol. 2006, 16:620-624.
8. Bowley M.P., Drevets W.C., Ongür D., Price J.L. Low glial numbers in the amygdala in major depressive disorder. Biol. Psychiatry 2002, 52:404-412.
9. Brunoni A.R., Baeken C., Machado-Vieira R., Gattaz W.F., Vanderhasselt M.A. BDNF blood levels after electroconvulsive therapy in patients with mood disorders: a systematic review and meta-analysis. World J. Biol. Psychiatry 2014.
10. Campbell S., Marriott M., Nahmias C., MacQueen G.M. Lower hippocampal volume in patients suffering from depression: a meta-analysis. Am. J. Psychiatry 2004, 161:598-607.
11. Castrén E., Võikar V., Rantamäki T. Role of neurotrophic factors in depression. Curr. Opin. Pharmacol. 2007, 7:18-21.
12. Cho H.C., Kim J., Kim S., Son Y.H., Lee N., Jung S.H. The concentrations of serum, plasma and platelet BDNF are all increased by treadmill VO'max performance in healthy college men. Neurosci. Lett. 2012, 519:78-83.
13. Cotter D., Mackay D., Landau S., Kerwin R., Everall I. Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder. Arch. Gen. Psychiatry 2001, 58:545-553.
14. Duman R.S., Monteggia L.M. A neurotrophic model for stress-related mood disorders. Biol. Psychiatry 2006, 59:1116-1127.
15. Erickson K.I., Voss M.W., Prakash R.S., Basak C., Szabo A., Chaddock L., Kim J.S., Heo S., Alves H., White S.M., Wojcicki T.R., Mailey E., Vieira V.J., Martin S.A., Pence B.D., Woods J.A., McAuley E., Kramer A.F. Exercise training increases size of hippocampus and improves memory. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:3017-3022.
16. Fava G.A., Fabbri S., Sonino N. Residual symptoms in depression: an emerging therapeutic target. Prog. Neuropsychopharmacol. Biol. Psychiatry 2002, 26:1019-1027.
17. Fernandes B., Gama C.S., Massuda R., Torres M., Camargo D., Kunz M., Belmonte-de-Abreu P.S., Kapczinski F., de Almeida Fleck M.P., Inês Lobato M. Serum brain-derived neurotrophic factor (BDNF) is not associated with response to electroconvulsive therapy (ECT): a pilot study in drug resistant depressed patients. Neurosci. Lett. 2009, 453:195-198.
18. Gedge L., Beaudoin A., Lazowski L., du Toit R., Jokic R., Milev R. Effects of electroconvulsive therapy and repetitive transcranial magnetic stimulation on serum brain-derived neurotrophic factor levels in patients with depression. Front. Psychiatry 2012, 3:12.
19. Gerber M., Lindwall M., Lindegård A., Börjesson M., Jonsdottir I.H. Cardiorespiratory fitness protects against stress-related symptoms of burnout and depression. Patient Educ. Couns. 2013, 93:146-152.
20. Ghassemzadeh H., Mojtabai R., Karamghadiri N., Ebrahimkhani N. Psychometric properties of a Persian-language version of the Beck Depression Inventory-Second edition: BDI-II-PERSIAN. Depress Anxiety 2005, 21(4):185-192.
21. Giese M., Unternaehrer E., Brand S., Calabrese P., Holsboer-Trachsler E., Eckert A. The interplay of stress and sleep impacts BDNF level. PLoS One 2013, 8:e76050.
22. Giese M., Unternährer E., Hüttig H., Beck J., Brand S., Calabrese P., Holsboer-Trachsler E., Eckert A. BDNF- an indicator of insomnia?. Mol. Psychiatry 2014, 19:151-152.
23. Grønli O., Stensland G.Ø., Wynn R., Olstad R. Neurotrophic factors in serum following ECT: a pilot study. World J. Biol. Psychiatry 2009, 10:295-301.
24. Guilloux J.P., Douillard-Guilloux G., Kota R., Wang X., Gardier A.M., Martinowich K., Tseng G.C., Lewis D.A., Sibille E. Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression. Mol. Psychiatry 2012, 17:1130-1142.
25. Haghighi M., Salehi I., Erfani P., Jahangard L., Bajoghli H., Holsboer-Trachsler E., Brand S. Additional ECT increases BDNF-levels in patients suffering from major depressive disorders compared to patients treated with citalopram only. J. Psychiatr. Res. 2013, 47:908-915.
26. Hamidi M., Drevets W.C., Price J.L. Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes. Biol. Psychiatry 2004, 55:563-569.
27. Hamilton M. A rating scale for depression. Journal of Neurolology. Neurosurg. Psychiatry 1960, 23:56-62.
28. Hasselbalch B.J., Knorr U., Bennike B., Hasselbalch S.G., Søndergaard M.H., Vedel Kessing L. Decreased levels of brain-derived neurotrophic factor in the remitted state of unipolar depressive disorder. Acta Psychiatr. Scand. 2012, 126:157-164.
29. Hibel L.C., Senguttuvan U., Bauer N.S. Do state factors moderate the relationship between depressive symptoms and morning cortisol?. Hormones Behav. 2013, 63:484-490.
30. Holsboer F., Ising M. Stress hormone regulation: biological role and translation into therapy. Annu. Rev. Psychol. 2010, 61:81-109. C1-11.
31. Josefsson T., Lindwall M., Archer T. Physical exercise intervention in depressive disorders: meta-analysis and systematic review. Scand. J. Med. Sci. Sports 2014, 24:259-272.
32. Judd L.L., Akiskal H.S., Maser J.D., Zeller P.J., Endicott J., Coryell W., Paulus M.P., Kunovac J.L., Leon A.C., Mueller T.I., Rice J.A., Keller M.B. Major depressive disorder: a prospective study of residual subthreshold depressive symptoms as predictor of rapid relapse. J. Affect. Disord. 1998, 50:97-108.
33. Karege F., Perret G., Bondolfi G., Schwald M., Bertschy G., Aubry J.M. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res. 2002, 109:143-148.
34. Kennedy N., Paykel E.S. Residual symptoms at remission from depression: impact on long-term outcome. J. Affect. Disord. 2004, 80:135-144.
35. Lindwall M., Gerber M., Jonsdottir I.H., Börjesson M., Ahlborg G. The Relationships of change in physical activity with change in depression, anxiety, and burnout: a Longitudinal study of Swedish Healthcare Workers. Health Psychol. 2014, 33:1309-1318.
36. Lockwood L.E., Su S., Youssef N.A. The role of epigenetics in depression and suicide: a platform for gene-environment interactions. Psychiatry Res. 2015, 228(3):235-242. 30.
37. Marano C.M., Phatak P., Vemulapalli U.R., Sasan A., Nalbandyan M.R., Ramanujam S., Soekadar S., Demosthenous M., Regenold W.T. Increased plasma concentration of brain-derived neurotrophic factor with electroconvulsive therapy: a pilot study in patients with major depression. J. Clin. Psychiatry 2007, 68:512-517.
38. Matrisciano F., Bonaccorso S., Ricciardi A., Scaccianoce S., Panaccione I., Wang L., Ruberto A., Tatarelli R., Nicoletti F., Girardi P., Shelton R.C. Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxine. J. Psychiatric Res. 2009, 43:247-254.
39. Mikoteit T., Beck J., Eckert A., Hemmeter U., Brand S., Bischof R., Holsboer-Trachsler E., Delini-Stula A. High baseline BDNF serum levels and early psychopathological improvement are predictive of treatment outcome in major depression. Psychopharmacology 2014, 231:2955-2965.
40. Molendijk M.L., Bus B.A., Spinhoven P., Penninx B.W., Kenis G., Prickaerts J., Voshaar R.C., Elzinga B.M. Serum levels of brain-derived neurotrophic factor in major depressive disorder: state-trait issues, clinical features and pharmacological treatment. Mol. Psychiatry 2011, 16:1088-1095.
41. Mota-Pereira J., Silverio J., Carvalho S., Ribeiro J.C., Fonte D., Ramos J. Moderate exercise improves depression parameters in treatment-resistant patients with major depressive disorder. J. Psychiatr. Res. 2011, 45:1005-1011.
42. Mura G., Moro M.F., Patten S.B., Carta M.G. Exercise as an add-on strategy for the treatment of major depressive disorder: a systematic review. CNS Spectr. 2014, 19:496-508.
43. Murray C.J., Lopez A.D. Global mortality, disability, and the contribution of risk factors: global burden of disease study. Lancet 1997, 349:1436-1442.
44. Naert G., Ixart G., Maurice T., Tapia-Arancibia L., Givalois L. Brain-derived neurotrophic factor and hypothalamic-pituitary-adrenal axis adaptation processes in a depressive-like state induced by chronic restraint stress. Mol. Cell. Neurosci. 2011, 46:55-66.
45. Piccinni A., Del Debbio A., Medda P., Bianchi C., Roncaglia I., Veltri A., Zanello S., Massimetti E., Origlia N., Domenici L., Marazziti D., Dell'Osso L. Plasma Brain-Derived Neurotrophic Factor in treatment-resistant depressed patients receiving electroconvulsive therapy. Eur. Neuropsychopharmacol. 2009, 19:349-355.
46. Rajkowska G., Halaris A., Selemon L.D. Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder. Biol. Psychiatry 2001, 49:741-752.
47. Rethorst C.D., Trivedi M.H. Evidence-based recommendations for the prescription of exercise for major depressive disorder. J. Psychiatr. Pract. 2013, 19:204-212.
48. Rosenbaum S., Tiedemann A., Sherrington C., Curtis J., Ward P.B. Physical activity interventions for people with mental illness: a systematic review and meta-analysis. J. Clin. Psychiatry 2014, 75:964-974.
49. Salehi I., Hosseini S.M., Haghighi M., Jahangard L., Bajoghli H., Gerber M., Pühse U., Kirov R., Holsboer-Trachsler E., Brand S. Electroconvulsive therapy and aerobic exercise training increased BDNF and ameliorated depressive symptoms in patients suffering from treatment-resistant major depressive disorder. J. Psychiatr. Res. 2014, 57:117-124.
50. Salehi I., Hosseini S.M., Haghighi M., Jahangard L., Bajoghli H., Gerber M., Pühse U., Kirov R., Holsboer-Trachsler E., Brand S. Retraction notice to: electroconvulsive therapy and aerobic exercise training increased BDNF and ameliorated depressive symptoms in patients suffering from treatment-resistant major depressive disorder. J. Psychiatr. Res. 2015, 69:94.
51. Scott B.W., Wojtowicz J.M., Burnham W.M. Neurogenesis in the dentate gyrus of the rat following electroconvulsive shock seizures. Exp. Neurol. 2000, 165:231-236.
52. Seifert T., Brassard P., Wissenberg M., Rasmussen P., Nordby P., Stallknecht B., Adser H., Jakobsen A.H., Pilegaard H., Nielsen H.B., Secher N.H. Endurance training enhances BDNF release from the human brain. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2010, 298:R372-R377.
53. Sen S., Duman R., Sanacora G. Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biol. Psychiatry 2008, 64:527-532.
54. Serra-Millàs M., López-Vílchez I., Navarro V., Galán A.M., Escolar G., Penadés R., Catalán R., Fañanás L., Arias B., Gastó C. Changes in plasma and platelet BDNF levels induced by S-citalopram in major depression. Psychopharmacology 2011, 216:1-8.
55. Shabani A., Akbari M., Dadashi M. Reliability and validity of the Hamilton depression rating scale (HDRS) on an Iranian sample. Arch. Iran. Med. 2010, 13(3):217-222.
56. Shirayama Y., Chen A.C., Nakagawa S., Russell D.S., Duman R.S. Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J. Neurosci. 2002, 22:3251-3261.
57. Siuciak J.A., Lewis D.R., Wiegand S.J., Lindsay R.M. Antidepressant-like effect of brain-derived neurotrophic factor (BDNF). Pharmacol. Biochem. Behav. 1997, 56:131-137.
58. Stanton R., Happell B., Haymann M., Reaburn P. Exercise interventions for the treatment of affective disorders - research to practice. Front. Psychiatry 2014, 5:46.
59. Toups M.S., Greer T.L., Kurian B.T., Grannemann B.D., Carmody T.J., Huebinger R., Rethorst C., Trivedi M.H. Effects of serum Brain Derived Neurotrophic Factor on exercise augmentation treatment of depression. J. Psychiatr. Res. 2011, 45:1301-1306.
60. Vancampfort D., Stubbs B., Sienaert P., Wyckaert S., De Hert M., Rosenbaum S., Probst M. What are the factors that influence physical activity participation in individuals with depression? A review of physical activity correlates from 59 studies. Psychiatr. Danub 2015, 27:210-224.
61. Videbech P., Ravnkilde B. Hippocampal volume and depression: a meta-analysis of MRI studies. Am. J. Psychiatry 2004, 161:1957-1966.
62. Wolkowitz O.M., Wolf J., Shelly W., Rosser R., Burke H.M., Lerner G.K., Reus V.I., Nelson J.C., Epel E.S., Mellon S.H. Serum BDNF levels before treatment predict SSRI response in depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 2011, 35:1623-1630.