-
2
-
-
84970852560
-
The scandal of poor medical research
-
Altman D. The scandal of poor medical research. BMJ 1994; 308: 283-84.
-
(1994)
BMJ
, vol.308
, pp. 283-284
-
-
Altman, D.1
-
3
-
-
67649649676
-
Avoidable waste in the production and reporting of research evidence
-
Chalmers I, Glasziou P. Avoidable waste in the production and reporting of research evidence. Lancet 2009; 374: 86-89.
-
(2009)
Lancet
, vol.374
, pp. 86-89
-
-
Chalmers, I.1
Glasziou, P.2
-
4
-
-
84892370974
-
Biomedical research: Increasing value, reducing waste
-
published online Jan 8
-
Macleod R, Michie S, Roberts I, et al. Biomedical research: increasing value, reducing waste. Lancet 2014; published online Jan 8. http://dx.doi.org/ 10.1016/S0140-6736(13)62329-6.
-
(2014)
Lancet
-
-
Macleod, R.1
Michie, S.2
Roberts, I.3
-
5
-
-
84887379124
-
Mapping of available health research and development data: What's there, what's missing, and what role is there for a global observatory?
-
Rottingen J-A, Regmi S, Eide M, et al. Mapping of available health research and development data: what's there, what's missing, and what role is there for a global observatory? Lancet 2013; 382: 1286-307.
-
(2013)
Lancet
, vol.382
, pp. 1286-1307
-
-
Rottingen, J.-A.1
Regmi, S.2
Eide, M.3
-
6
-
-
33745997739
-
Funding for practice-oriented clinical research
-
Rothwell PM. Funding for practice-oriented clinical research. Lancet 2006; 368: 262-66.
-
(2006)
Lancet
, vol.368
, pp. 262-266
-
-
Rothwell, P.M.1
-
7
-
-
84878769413
-
-
UK Clinical Research Collaboration2009/10. November(accessed Nov 14 2013
-
UK Clinical Research Collaboration. UK health research analysis 2009/10. November, 2012. http://www.ukcrc.org/publications/reports/(accessed Nov 14, 2013).
-
(2012)
UK Health Research Analysis
-
-
-
8
-
-
84864767684
-
NIH basics
-
Collins FS. NIH basics. Science 2012; 337: 503.
-
(2012)
Science
, vol.337
, pp. 503
-
-
Collins, F.S.1
-
9
-
-
0017227860
-
Scientifi c basis for the support of biomedical science
-
Comroe JH, Dripps RD. Scientifi c basis for the support of biomedical science. Science 1976; 192: 105-11.
-
(1976)
Science
, vol.192
, pp. 105-111
-
-
Comroe, J.H.1
Dripps, R.D.2
-
10
-
-
0023667193
-
Comroe and Dripps revisited
-
Smith R. Comroe and Dripps revisited. BMJ 1987; 295: 1404-07.
-
(1987)
BMJ
, vol.295
, pp. 1404-1407
-
-
Smith, R.1
-
11
-
-
1542609237
-
Basic research and health: A reassessment of the scientifi c basis for the support of biomedical science
-
Grant J, Green L, Mason B. Basic research and health: a reassessment of the scientifi c basis for the support of biomedical science. Res Eval 2003; 12: 217-24.
-
(2003)
Res Eval
, vol.12
, pp. 217-224
-
-
Grant, J.1
Green, L.2
Mason, B.3
-
12
-
-
0017108645
-
Deoxyribonucleic acid polymerase from the extreme thermophile Thermus aquaticus
-
Chien A, Edgar DB, Trela JM. Deoxyribonucleic acid polymerase from the extreme thermophile Thermus aquaticus. J Bacteriol 1976; 127: 1550-57.
-
(1976)
J Bacteriol
, vol.127
, pp. 1550-1557
-
-
Chien, A.1
Edgar, D.B.2
Trela, J.M.3
-
13
-
-
37049053957
-
Inhibition of cell division in Escherichia coli by electrolysis products from a platinum electrode
-
Rosenberg B, Van Camp L, Krigas T. Inhibition of cell division in Escherichia coli by electrolysis products from a platinum electrode. Nature 1965; 205: 698-99.
-
(1965)
Nature
, vol.205
, pp. 698-699
-
-
Rosenberg, B.1
Van Camp, L.2
Krigas, T.3
-
14
-
-
0017055252
-
ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium
-
Endo A, Kuroda M, Tsujita Y. ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium. J Antibiot (Tokyo) 1976; 29: 1346-48.
-
(1976)
J Antibiot (Tokyo
, vol.29
, pp. 1346-1348
-
-
Endo, A.1
Kuroda, M.2
Tsujita, Y.3
-
16
-
-
24144486717
-
-
approach, analysis and recommendations(accessed Nov 14 2013
-
Wooding S, Hanney S, Buxton M, Grant J. The returns from arthritis research volume 1: approach, analysis and recommendations. 2004. http://www.rand.org/pubs/monographs/MG251.html (accessed Nov 14, 2013).
-
(2004)
The Returns from Arthritis Research
, vol.1
-
-
Wooding, S.1
Hanney, S.2
Buxton, M.3
Grant, J.4
-
17
-
-
80053580677
-
-
( accessed Nov 14 2013
-
Wooding H, Hanney S, Pollitt A, Buxton M, Grant J. Project Retrosight: understanding the returns from cardiovascular and stroke research: the policy report. 2011. http://www.rand.org/pubs/monographs/MG1079.html (accessed Nov 14, 2013).
-
(2011)
Project Retrosight Understanding the Returns from Cardiovascular and Stroke Research: The Policy Report
-
-
Wooding, H.1
Hanney, S.2
Pollitt, A.3
Buxton, M.4
Grant, J.5
-
19
-
-
84855611836
-
The answer is 17 years, what is the question: Understanding time lags in translational research
-
Morris ZS, Wooding S, Grant J. The answer is 17 years, what is the question: understanding time lags in translational research. J R Soc Med 2011; 104: 510-20.
-
(2011)
J R Soc Med
, vol.104
, pp. 510-520
-
-
Morris, Z.S.1
Wooding, S.2
Grant, J.3
-
21
-
-
0242320488
-
Descriptive survey of non-commercial randomised controlled trials in the United Kingdom 1980-2002
-
Chalmers I, Rounding C, Lock K. Descriptive survey of non-commercial randomised controlled trials in the United Kingdom, 1980-2002. BMJ 2003; 327: 1017-19.
-
(2003)
BMJ
, vol.327
, pp. 1017-1019
-
-
Chalmers, I.1
Rounding, C.2
Lock, K.3
-
22
-
-
33845937823
-
-
December( accessed Nov 14 2013
-
Cooksey D. A review of UK health research funding. December, 2006. http://www.offi cial-documents.gov.uk/document/other/0118404881/0118404881.pdf (accessed Nov 14, 2013).
-
(2006)
A Review of UK Health Research Funding
-
-
Cooksey, D.1
-
24
-
-
74049103320
-
Feasibility and challenges of independent research on drugs: The Italian Medicines Agency (AIFA) experience
-
Italian Medicines Agency (AIFA) Research Development Working Group
-
Italian Medicines Agency (AIFA) Research and Development Working Group. Feasibility and challenges of independent research on drugs: the Italian Medicines Agency (AIFA) experience. Eur J Clin Invest 2010; 40: 69-86.
-
(2010)
Eur J Clin Invest
, vol.40
, pp. 69-86
-
-
-
25
-
-
21044453564
-
Wanted: Better benchmarks
-
Marburger JH. Wanted: better benchmarks. Science 2005; 308: 1087.
-
(2005)
Science
, vol.308
, pp. 1087
-
-
Marburger, J.H.1
-
26
-
-
80053345207
-
Fund people not projects
-
Ioannidis JPA. Fund people not projects. Nature 2011; 477: 529-31.
-
(2011)
Nature
, vol.477
, pp. 529-531
-
-
Jpa, I.1
-
27
-
-
84870656615
-
White House panel urges agencies to take more risks
-
Mervis J. White House panel urges agencies to take more risks. Science 2012; 338: 1274.
-
(2012)
Science
, vol.338
, pp. 1274
-
-
Mervis, J.1
-
28
-
-
0025015169
-
The philosophiocal basis of peer review and the suppression of innovation
-
Horrobin D. The philosophiocal basis of peer review and the suppression of innovation. JAMA 1990; 263: 1438-41.
-
(1990)
JAMA
, vol.263
, pp. 1438-1441
-
-
Horrobin, D.1
-
30
-
-
84870549232
-
Research grants: Conform and be funded
-
Nicholson JM, Ioannidis JPA. Research grants: conform and be funded. Nature 2012; 492: 34-36.
-
(2012)
Nature
, vol.492
, pp. 34-36
-
-
Nicholson, J.M.1
Jpa, I.2
-
31
-
-
84875741750
-
Evidence in agenda setting new directions for the cochrane collaboration
-
Nasser M, Welch V, Ueffi ng E, Crowe S, Oliver S, Carlo R. Evidence in agenda setting: new directions for the Cochrane Collaboration. J Clin Epidemiol 2013; 66: 469-71.
-
(2013)
J Clin Epidemiol
, vol.66
, pp. 469-471
-
-
Nasser, M.1
Welch, V.2
Ueffing, E.3
Crowe, S.4
Oliver, S.5
Carlo, R.6
-
32
-
-
79952087469
-
NIH disease funding levels and burden of disease
-
Gillum LA, Gouveia C, Dorsey ER, et al. NIH disease funding levels and burden of disease. PLoS One 2011; 6: e16837.
-
(2011)
PLoS One
, vol.6
-
-
Gillum, L.A.1
Gouveia, C.2
Dorsey, E.R.3
-
33
-
-
81555217863
-
Need to realign patient-oriented and commercial and academic research
-
Liberati A. Need to realign patient-oriented and commercial and academic research. Lancet 2011; 378: 1777-78.
-
(2011)
Lancet
, vol.378
, pp. 1777-1778
-
-
Liberati, A.1
-
34
-
-
0034631451
-
Relation between agendas of the research community and the research consumer
-
Tallon D, Chard J, Dieppe P. Relation between agendas of the research community and the research consumer. Lancet 2000; 355: 2037-40.
-
(2000)
Lancet
, vol.355
, pp. 2037-2040
-
-
Tallon, D.1
Chard, J.2
Dieppe, P.3
-
35
-
-
33947369143
-
The research priorities of patients attending UK cancer treatment centres: Findings from a modified nominal group study
-
Corner J, Wright D, Hopkinson J, Gunaratnam Y, McDonald JW, Foster C. The research priorities of patients attending UK cancer treatment centres: fi ndings from a modifi ed nominal group study. Br J Cancer 2007; 96: 875-81.
-
(2007)
Br J Cancer
, vol.96
, pp. 875-881
-
-
Corner, J.1
Wright, D.2
Hopkinson, J.3
Gunaratnam, Y.4
McDonald, J.W.5
Foster, C.6
-
36
-
-
69949138133
-
Ethics in clinical research
-
Garattini S, Bertele V. Ethics in clinical research. J Hepatol 2009; 51: 792-97.
-
(2009)
J Hepatol
, vol.51
, pp. 792-797
-
-
Garattini, S.1
Bertele, V.2
-
37
-
-
85043088144
-
-
July 20 2012(accessed Nov 14 2013
-
Milne R. Burden of disease and research funding. July 20, 2012. http://rm21.typepad.com/blog/2012/07/burden-of-disease.html (accessed Nov 14, 2013).
-
Burden of Disease and Research Funding
-
-
Milne, R.1
-
38
-
-
77956308457
-
Improving the translational hit of experimental treatments in multiple sclerosis
-
Vesterinen HM, Sena ES, ff rench-Constant C, Williams A, Chandran S, Macleod MR. Improving the translational hit of experimental treatments in multiple sclerosis. Mult Scler 2010; 16: 1044-55.
-
(2010)
Mult Scler
, vol.16
, pp. 1044-1055
-
-
Vesterinen, H.M.1
Sena, E.S.2
Ffrench-Constant, C.3
Williams, A.4
Chandran, S.5
Macleod, M.R.6
-
39
-
-
84886862466
-
Meta-analysis of data from animal studies: A practical guide
-
Vesterinen HM, Irvine CMJ, Macleod MR, et al. Meta-analysis of data from animal studies: a practical guide. J Neurosci Methods 2013; 221: 92-102.
-
(2013)
J Neurosci Methods
, vol.221
, pp. 92-102
-
-
Vesterinen, H.M.1
Cmj, I.2
Macleod, M.R.3
-
40
-
-
33745635341
-
Stakeholder participation in health research agenda setting: The case of asthma and COPD research in the Netherlands
-
Caron-Flinterman F, Broerse JEW, Teerling J, et al. Stakeholder participation in health research agenda setting: the case of asthma and COPD research in the Netherlands. Sci Public Policy 2006; 33: 291-304.
-
(2006)
Sci Public Policy
, vol.33
, pp. 291-304
-
-
Caron-Flinterman, F.1
Jew, B.2
Teerling, J.3
-
42
-
-
84882985976
-
Trial unpredictability yields predictable therapy gains
-
Djulbegovic B, Kumar A, Glasziou P, Miladinovic B, Chalmers I. Trial unpredictability yields predictable therapy gains. Nature 2013; 500: 395-96.
-
(2013)
Nature
, vol.500
, pp. 395-396
-
-
Djulbegovic, B.1
Kumar, A.2
Glasziou, P.3
Miladinovic, B.4
Chalmers, I.5
-
43
-
-
84892370875
-
Increasing value and reducing waste in research design, conduct, and analysis
-
published online Jan 8
-
Ioannidis JPA, Greenland S, Hlatky MA, et al. Increasing value and reducing waste in research design, conduct, and analysis. Lancet 2014; published online Jan 8. http://dx.doi.org/10.1016/S0140- 6736(13)62227-8.
-
(2014)
Lancet
-
-
Jpa, I.1
Greenland, S.2
Hlatky, M.A.3
-
44
-
-
80055088241
-
Believe it or not: How much can we rely on published data on potential drug targets?
-
Prinz F, Schlange T, Asadullah K. Believe it or not: how much can we rely on published data on potential drug targets? Nat Rev Drug Discov 2011; 10: 712-13.
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 712-713
-
-
Prinz, F.1
Schlange, T.2
Asadullah, K.3
-
45
-
-
84859169880
-
Drug development: Raise standards for preclinical cancer research
-
Begley CG, Ellis LM. Drug development: raise standards for preclinical cancer research. Nature 2012; 483: 531-33.
-
(2012)
Nature
, vol.483
, pp. 531-533
-
-
Begley, C.G.1
Ellis, L.M.2
-
46
-
-
85043065881
-
-
April 14 2011(accessed Nov 26 2013
-
Osherovich L. Hedging against academic risk. April 14, 2011. http://www.nature.com/scibx/journal/v4/n15/full/scibx.2011.416.html (accessed Nov 26, 2013).
-
Hedging Against Academic Risk
-
-
Osherovich, L.1
-
47
-
-
77955653161
-
Expectations, validity, and reality in omics
-
Ioannidis JPA. Expectations, validity, and reality in omics. J Clin Epidemiol 2010; 63: 945-49.
-
(2010)
J Clin Epidemiol
, vol.63
, pp. 945-949
-
-
Jpa, I.1
-
48
-
-
18844423324
-
Early extreme contradictory estimates may appear in published research: The Proteus phenomenon in molecular genetics research and randomized trials
-
Ioannidis JPA, Trikalinos TA. Early extreme contradictory estimates may appear in published research: the Proteus phenomenon in molecular genetics research and randomized trials. J Clin Epidemiol 2005; 58: 543-49.
-
(2005)
J Clin Epidemiol
, vol.58
, pp. 543-549
-
-
Jpa, I.1
Trikalinos, T.A.2
-
49
-
-
84876539070
-
Raising standards
-
Nature Immunology. Raising standards. Nat Immunol 2013; 14: 415.
-
(2013)
Nat Immunol
, vol.14
, pp. 415
-
-
Immunology, N.1
-
50
-
-
84868306129
-
Identifying research needs for improving health care
-
Chang SM, Carey T, Kato EU, Guise J-M, Sanders GD. Identifying research needs for improving health care. Ann Intern Med 2012; 157: 439-45.
-
(2012)
Ann Intern Med
, vol.157
, pp. 439-445
-
-
Chang, S.M.1
Carey, T.2
Kato, E.U.3
Guise, J.-M.4
Sanders, G.D.5
-
51
-
-
84863426446
-
Epidemiology of multimorbidity and implications for health care, research, and medical education: A cross-sectional study
-
Barnett K, Mercer SW, Norbury M, Watt G, Wyke S, Guthrie B. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet 2012; 380: 37-43.
-
(2012)
Lancet
, vol.380
, pp. 37-43
-
-
Barnett, K.1
Mercer, S.W.2
Norbury, M.3
Watt, G.4
Wyke, S.5
Guthrie, B.6
-
52
-
-
0002670088
-
-
Chalmers I, Maynard A, eds. Non-random refl ections on health services research. London: BMJ Publishing Group
-
Oliver S. Exploring lay perspectives on questions of eff ectiveness. In: Chalmers I, Maynard A, eds. Non-random refl ections on health services research. London: BMJ Publishing Group, 1997: 272-91.
-
(1997)
Exploring Lay Perspectives on Questions of Effectiveness
, pp. 272-291
-
-
Oliver, S.1
-
53
-
-
84892189377
-
-
Hood S, Mayall B, Oliver S, eds. Critical issues in social research: power and prejudice. Buckingham: Open University Press
-
Oliver S. Users of health services: following their agenda. In: Hood S, Mayall B, Oliver S, eds. Critical issues in social research: power and prejudice. Buckingham: Open University Press, 1999: 139-53.
-
(1999)
Users of Health Services: Following Their Agenda
, pp. 139-153
-
-
Oliver, S.1
-
54
-
-
2542644098
-
Qualitative studies of stroke: A systematic review
-
McKevitt C, Redfern J, Mold F, Wolfe C. Qualitative studies of stroke: a systematic review. Stroke 2004; 35: 1499-1505.
-
(2004)
Stroke
, vol.35
, pp. 1499-1505
-
-
McKevitt, C.1
Redfern, J.2
Mold, F.3
Wolfe, C.4
-
56
-
-
0003767164
-
-
Department of Health Feb 28(accessed Nov 14 2013
-
Department of Health. Research governance framework for health and social care. Feb 28, 2001. http://webarchive.nationalarchives. gov.uk/+/www.dh.gov.uk/ en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/ DH-4008777 (accessed Nov 14, 2013).
-
(2001)
Research Governance Framework for Health and Social Care
-
-
-
57
-
-
84875322691
-
The use of systematic reviews in the planning, design and conduct of randomised trials: A retrospective cohort of NIHR HTA funded trials
-
Jones AP, Conroy E, Williamson PR, Clarke M, Gamble C. The use of systematic reviews in the planning, design and conduct of randomised trials: a retrospective cohort of NIHR HTA funded trials. BMC Med Res Methodol 2013; 13: 50.
-
(2013)
BMC Med Res Methodol
, vol.13
, pp. 50
-
-
Jones, A.P.1
Conroy, E.2
Williamson, P.R.3
Clarke, M.4
Gamble, C.5
-
58
-
-
77957048552
-
The need to consider the wider agenda in systematic reviews and meta-analyses: Breadth, timing, and depth of the evidence
-
Ioannidis JPA, Karassa FB. The need to consider the wider agenda in systematic reviews and meta-analyses: breadth, timing, and depth of the evidence. BMJ 2010; 341: c4875.
-
(2010)
BMJ
, vol.341
-
-
Jpa, I.1
Karassa, F.B.2
-
59
-
-
21344435080
-
Randomized controlled trials of aprotinin in cardiac surgery: Could clinical equipoise have stopped the bleeding?
-
Fergusson D, Glass KC, Hutton B, Shapiro S. Randomized controlled trials of aprotinin in cardiac surgery: could clinical equipoise have stopped the bleeding? Clin Trials 2005; 2: 218-29.
-
(2005)
Clin Trials
, vol.2
, pp. 218-229
-
-
Fergusson, D.1
Glass, K.C.2
Hutton, B.3
Shapiro, S.4
-
60
-
-
84861503406
-
Effect of tranexamic acid on surgical bleeding: Systematic review and cumulative meta-analysis
-
Ker K, Edwards P, Perel P, Shakur H, Roberts I. Eff ect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. BMJ 2012; 344: e3054.
-
(2012)
BMJ
, vol.344
-
-
Ker, K.1
Edwards, P.2
Perel, P.3
Shakur, H.4
Roberts, I.5
-
61
-
-
79551611126
-
A systematic examination of the citation of prior research in reports of randomized, controlled trials
-
Robinson KA, Goodman SN. A systematic examination of the citation of prior research in reports of randomized, controlled trials. Ann Intern Med 2011; 154: 50-55.
-
(2011)
Ann Intern Med
, vol.154
, pp. 50-55
-
-
Robinson, K.A.1
Goodman, S.N.2
-
62
-
-
21344450770
-
The use of systematic reviews when designing studies
-
Cooper N, Jones D, Sutton A. The use of systematic reviews when designing studies. Clin Trials 2005; 2: 260-64.
-
(2005)
Clin Trials
, vol.2
, pp. 260-264
-
-
Cooper, N.1
Jones, D.2
Sutton, A.3
-
63
-
-
77955663786
-
Empirical assessment suggests that existing evidence could be used more fully in designing randomised controlled trials
-
Goudie AC, Sutton AJ, Jones DR, Donald A. Empirical assessment suggests that existing evidence could be used more fully in designing randomised controlled trials. J Clin Epidemiol 2010; 63: 983-91.
-
(2010)
J Clin Epidemiol
, vol.63
, pp. 983-991
-
-
Goudie, A.C.1
Sutton, A.J.2
Jones, D.R.3
Donald, A.4
-
64
-
-
84885740540
-
Many reports of randomised trials still don't begin or end with a systematic review of the relevant evidence
-
Clarke M, Hopewell S. Many reports of randomised trials still don't begin or end with a systematic review of the relevant evidence. J Bahrain Med Soc 2013; 24: 145-48.
-
(2013)
J Bahrain Med Soc
, vol.24
, pp. 145-148
-
-
Clarke, M.1
Hopewell, S.2
-
65
-
-
84875845125
-
Sample size determinations in original research protocols for randomised clinical trials submitted to UK research ethics committees: Review
-
Clark T, Berger U, Mansmann U. Sample size determinations in original research protocols for randomised clinical trials submitted to UK research ethics committees: review. BMJ 2013; 346: f1136.
-
(2013)
BMJ
, vol.346
-
-
Clark, T.1
Berger, U.2
Mansmann, U.3
-
66
-
-
32144444865
-
What are the implications of optimism bias in clinical research?
-
Chalmers I, Matthews R. What are the implications of optimism bias in clinical research? Lancet 2006; 367: 449-50.
-
(2006)
Lancet
, vol.367
, pp. 449-450
-
-
Chalmers, I.1
Matthews, R.2
-
67
-
-
79954993726
-
Optimism bias leads to inconclusive results-an empirical study
-
Djulbegovic B, Kumar A, Magazin A, et al. Optimism bias leads to inconclusive results-an empirical study. J Clin Epidemiol 2011; 64: 583-93.
-
(2011)
J Clin Epidemiol
, vol.64
, pp. 583-593
-
-
Djulbegovic, B.1
Kumar, A.2
Magazin, A.3
-
68
-
-
0023245353
-
Reference bias in reports of drug trials
-
Gotzsche P. Reference bias in reports of drug trials. BMJ 1987; 295: 654-56.
-
(1987)
BMJ
, vol.295
, pp. 654-656
-
-
Gotzsche, P.1
-
69
-
-
72849150548
-
How citation distortions create unfounded authority: Analysis of citation network
-
Greenberg SA. How citation distortions create unfounded authority: analysis of citation network. BMJ 2009; 339: b2680.
-
(2009)
BMJ
, vol.339
-
-
Greenberg, S.A.1
-
70
-
-
78649692665
-
Factors aff ecting the apparent effi cacy and safety of tissue plasminogen activator in thrombotic occlusion models of stroke: Systematic review and meta-analysis
-
Sena ES, Briscoe CL, Howells DW, Donnan GA, Sandercock PA, Macleod MR. Factors aff ecting the apparent effi cacy and safety of tissue plasminogen activator in thrombotic occlusion models of stroke: systematic review and meta-analysis. J Cereb Blood Flow Metab 2010; 30: 1905-13.
-
(2010)
J Cereb Blood Flow Metab
, vol.30
, pp. 1905-1913
-
-
Sena, E.S.1
Briscoe, C.L.2
Howells, D.W.3
Donnan, G.A.4
Sandercock, P.A.5
Macleod, M.R.6
-
71
-
-
0035841630
-
Is clinical research still too haphazard?
-
Clark O, Clark L, Djulbegovic B. Is clinical research still too haphazard? Lancet 2001; 358: 1648.
-
(2001)
Lancet
, vol.358
, pp. 1648
-
-
Clark, O.1
Clark, L.2
Djulbegovic, B.3
-
72
-
-
33749648484
-
Establishing risk of human experimentation with drugs: Lessons from TGN1412
-
Kenter MJH, Cohen AF. Establishing risk of human experimentation with drugs: lessons from TGN1412. Lancet 2006; 368: 1387-91.
-
(2006)
Lancet
, vol.368
, pp. 1387-1391
-
-
Mjh, K.1
Cohen, A.F.2
-
73
-
-
0034792905
-
Nimodipine in animal model experiments of focal cerebral ischemia: A systematic review
-
Horn J, de Haan RJ, Vermeulen M, Luiten PGM, Limburg M. Nimodipine in animal model experiments of focal cerebral ischemia: a systematic review. Stroke 2001; 32: 2433-38.
-
(2001)
Stroke
, vol.32
, pp. 2433-2438
-
-
Horn, J.1
De Haan, R.J.2
Vermeulen, M.3
Pgm, L.4
Limburg, M.5
-
74
-
-
0242268070
-
Meta-analysis of ther efects of endothelin receptor blockade on survival in experimental heart failure
-
Lee DS, Nguyen QT, Lapointe N, et al. Meta-analysis of ther efects of endothelin receptor blockade on survival in experimental heart failure. J Card Fail 2003; 9: 368-74.
-
(2003)
J Card Fail
, vol.9
, pp. 368-374
-
-
Lee, D.S.1
Nguyen, Q.T.2
Lapointe, N.3
-
76
-
-
84892148591
-
Increasing value and reducing waste in biomedical research regulation and management
-
published online Jan 8
-
Al-Shahi Salman R, Beller E, Kagan J, et al. Increasing value and reducing waste in biomedical research regulation and management. Lancet 2014; published online Jan 8. http://dx.doi.org/10.1016/S0140-6736(13)62297-7.
-
(2014)
Lancet
-
-
Al-Shahi Salman, R.1
Beller, E.2
Kagan, J.3
-
77
-
-
0029119434
-
Meta-analysis of randomized controlled trials of antenatal corticosteroid for the prevention of respiratory distress syndrome: Discussion
-
Sinclair JC. Meta-analysis of randomized controlled trials of antenatal corticosteroid for the prevention of respiratory distress syndrome: discussion. Am J Obstet Gynecol 1995; 173: 335-44.
-
(1995)
Am J Obstet Gynecol
, vol.173
, pp. 335-344
-
-
Sinclair, J.C.1
-
78
-
-
22244486380
-
Infant sleeping position and the sudden infant death syndrome: Systematic review of observational studies and historical review of recommendations from 1940 to 2002
-
Gilbert R, Salanti G, Harden M, See S. Infant sleeping position and the sudden infant death syndrome: systematic review of observational studies and historical review of recommendations from 1940 to 2002. Int J Epidemiol 2005; 34: 874-87.
-
(2005)
Int J Epidemiol
, vol.34
, pp. 874-887
-
-
Gilbert, R.1
Salanti, G.2
Harden, M.3
See, S.4
-
80
-
-
0031577652
-
Meta-analyses of randomised controlled trials
-
Rothwell PM, Robertson G. Meta-analyses of randomised controlled trials. Lancet 1997; 350: 1181-82.
-
(1997)
Lancet
, vol.350
, pp. 1181-1182
-
-
Rothwell, P.M.1
Robertson, G.2
-
81
-
-
0031577652
-
Meta-analyses of randomised controlled trials
-
Davey Smith G, Egger M. Meta-analyses of randomised controlled trials. Lancet 1997; 350: 1182.
-
(1997)
Lancet
, vol.350
, pp. 1182
-
-
Davey Smith, G.1
Egger, M.2
-
82
-
-
84867731905
-
Empirical evaluation of very large treatment eff ects of medical interventions
-
Pereira TV, Horwitz RI, Ioannidis JP. Empirical evaluation of very large treatment eff ects of medical interventions. JAMA 2012; 308: 1676-84.
-
(2012)
JAMA
, vol.308
, pp. 1676-1684
-
-
Pereira, T.V.1
Horwitz, R.I.2
Ioannidis, J.P.3
-
84
-
-
84892614609
-
Increasing value and reducing waste: Addressing inaccessible research
-
published online Jan 8
-
Chan A-W, Song F, Vickers A, et al. Increasing value and reducing waste: addressing inaccessible research. Lancet 2014; published online Jan 8. http://dx.doi.org/10.1016/S0140-6736(13)62296-5.
-
(2014)
Lancet
-
-
Chan, A.-W.1
Song, F.2
Vickers, A.3
-
86
-
-
80052025553
-
Statistically signifi cant meta-analyses of clinical trials have modest credibility and infl ated eff ects
-
Pereira TV, Ioannidis JPA. Statistically signifi cant meta-analyses of clinical trials have modest credibility and infl ated eff ects. J Clin Epidemiol 2011; 64: 1060-69.
-
(2011)
J Clin Epidemiol
, vol.64
, pp. 1060-1069
-
-
Pereira, T.V.1
Jpa, I.2
-
87
-
-
84875880985
-
If a job is worth doing, it is worth doing twice
-
Filley J. If a job is worth doing, it is worth doing twice. Nature 2013; 496: 7.
-
(2013)
Nature
, vol.496
, pp. 7
-
-
Filley, J.1
-
89
-
-
84864503158
-
Developing core outcome sets for clinical trials: Issues to consider
-
Williamson P, Altman DG, Blazeby JM, et al. Developing core outcome sets for clinical trials: issues to consider. Trials 2012; 13: 132.
-
(2012)
Trials
, vol.13
, pp. 132
-
-
Williamson, P.1
Altman, D.G.2
Blazeby, J.M.3
-
90
-
-
84888623939
-
Tackling treatment uncertainties together: The evolution of the James Lind Initiative (JLI) 2003-2013
-
published online July 3 DOI:10.1177/0141076813493063
-
Chalmers I, Atkinson P, Fenton M, Firkins L, Crowe S, Cowan K. Tackling treatment uncertainties together: the evolution of the James Lind Initiative (JLI), 2003-2013. J R Soc Med 2013; published online July 3. DOI:10.1177/0141076813493063.
-
(2013)
J R Soc Med
-
-
Chalmers, I.1
Atkinson, P.2
Fenton, M.3
Firkins, L.4
Crowe, S.5
Cowan, K.6
-
92
-
-
79959251379
-
Democratizing clinical research
-
Lloyd K, White J. Democratizing clinical research. Nature 2011; 474: 277-78.
-
(2011)
Nature
, vol.474
, pp. 277-278
-
-
Lloyd, K.1
White, J.2
-
94
-
-
77952949439
-
Identifying and prioritizing uncertainties: Patient and clinician engagement in the identifi cation of research questions
-
Elwyn G, Crowe S, Fenton M, et al. Identifying and prioritizing uncertainties: patient and clinician engagement in the identifi cation of research questions. J Eval Clin Pract 2010; 16: 627-31.
-
(2010)
J Eval Clin Pract
, vol.16
, pp. 627-631
-
-
Elwyn, G.1
Crowe, S.2
Fenton, M.3
-
95
-
-
76349113581
-
Involving burn survivors in agenda setting on burn research: An added value?
-
Broerse JE, Zweekhorst MB, van Rensen AJ, de Haan MJ. Involving burn survivors in agenda setting on burn research: an added value? Burns 2012; 36: 217-31.
-
(2012)
Burns
, vol.36
, pp. 217-231
-
-
Broerse, J.E.1
Zweekhorst, M.B.2
Van Rensen, A.J.3
De Haan, M.J.4
-
96
-
-
80052814951
-
The James Lind Alliance approach to priority setting for prostate cancer research: An integrative methodology based on patient and clinician participation
-
Lophatananon A, Tyndale-Biscoe S, Malcolm E, et al. The James Lind Alliance approach to priority setting for prostate cancer research: an integrative methodology based on patient and clinician participation. BJU Int 2011; 108: 1040-43.
-
(2011)
BJU Int
, vol.108
, pp. 1040-1043
-
-
Lophatananon, A.1
Tyndale-Biscoe, S.2
Malcolm, E.3
-
97
-
-
84899658585
-
But is it a question worth asking? A refl ective case study describing how public involvement can lead to researchers' ideas being abandoned
-
published online May 31 DOI:10.1111/j.1369-7625.2012.00771.x
-
Boote JD, Dalgleish M, Freeman J, Jones Z, Miles M, Rodgers H. But is it a question worth asking? A refl ective case study describing how public involvement can lead to researchers' ideas being abandoned. Health Expect 2012; published online May 31. DOI:10.1111/j.1369-7625.2012.00771.x.
-
(2012)
Health Expect
-
-
Boote, J.D.1
Dalgleish, M.2
Freeman, J.3
Jones, Z.4
Miles, M.5
Rodgers, H.6
-
98
-
-
77149157143
-
Public involvement infl uences a national research agenda
-
Oliver S, Armes DG, Gyte G. Public involvement infl uences a national research agenda. Patient 2009; 2: 179-90.
-
(2009)
Patient
, vol.2
, pp. 179-190
-
-
Oliver, S.1
Armes, D.G.2
Gyte, G.3
-
99
-
-
35748968176
-
What factors predict scientists' intentions to participate in public engagement of science activities?
-
Poliakoff E, Webb TL. What factors predict scientists' intentions to participate in public engagement of science activities? Sci Commun 2007; 29: 242-63.
-
(2007)
Sci Commun
, vol.29
, pp. 242-263
-
-
Poliakoff, E.1
Webb, T.L.2
-
101
-
-
84973746860
-
After the meta-analytic revolution
-
Bausell BB. After the meta-analytic revolution. Eval Health Prof 1993; 16: 3-12.
-
(1993)
Eval Health Prof
, vol.16
, pp. 3-12
-
-
Bausell, B.B.1
-
102
-
-
67649215130
-
Methodological problems in the use of indirect comparisons for evaluating healthcare interventions: Survey of published systematic reviews
-
Song F, Loke YK, Walsh T, et al. Methodological problems in the use of indirect comparisons for evaluating healthcare interventions: survey of published systematic reviews. BMJ 2009; 338: b1147.
-
(2009)
BMJ
, vol.338
-
-
Song, F.1
Loke, Y.K.2
Walsh, T.3
-
104
-
-
77954669061
-
Expediting systematic reviews: Methods and implications of rapid reviews
-
Ganann R, Ciliska D, Thomas H. Expediting systematic reviews: methods and implications of rapid reviews. Implement Sci 2010; 5: 56.
-
(2010)
Implement Sci
, vol.5
, pp. 56
-
-
Ganann, R.1
Ciliska, D.2
Thomas, H.3
-
106
-
-
84892575232
-
Reducing waste from incomplete or unusable reports of biomedical research
-
published online Jan 8
-
Glasziou P, Altman DH, Bossuyt P, et al. Reducing waste from incomplete or unusable reports of biomedical research. Lancet 2014; published online Jan 8. http://dx.doi.org/10.1016/S0140- 6736(13)62228-X.
-
(2014)
Lancet
-
-
Glasziou, P.1
Altman, D.H.2
Bossuyt, P.3
-
107
-
-
79151471543
-
An international registry of systematic review protocols
-
Booth A, Clarke M, Ghersi D, Moher D, Petticrew M, Stewart L. An international registry of systematic review protocols. Lancet 2011; 377: 108-09.
-
(2011)
Lancet
, vol.377
, pp. 108-109
-
-
Booth, A.1
Clarke, M.2
Ghersi, D.3
Moher, D.4
Petticrew, M.5
Stewart, L.6
-
108
-
-
79951565128
-
Preregistration of epidemiology protocols: A commentary in support
-
Bracken MB. Preregistration of epidemiology protocols: a commentary in support. Epidemiology 2011; 22: 135-37.
-
(2011)
Epidemiology
, vol.22
, pp. 135-137
-
-
Bracken, M.B.1
-
109
-
-
77949449339
-
Registering observational research: Second thoughts
-
Vandenbroucke JP. Registering observational research: second thoughts. Lancet 2010; 375: 982-83.
-
(2010)
Lancet
, vol.375
, pp. 982-983
-
-
Vandenbroucke, J.P.1
-
110
-
-
84881253940
-
Progress in using systematic reviews of animal studies to improve translational research
-
Hooijmans CR, Ritskes-Hotinga M. Progress in using systematic reviews of animal studies to improve translational research. PLoS Med 2013; 10: e1001482.
-
(2013)
PLoS Med
, vol.10
-
-
Hooijmans, C.R.1
Ritskes-Hotinga, M.2
-
111
-
-
84948750458
-
-
Egger M, Davey Smith G, Altman D, eds. Systematic reviews in health care: meta-analysis in context, 2nd edn. London BMJ Books
-
Chalmers I. Using systematic reviews and registers of ongoing trials for scientifi c and ethical trial design, monitoring, and reporting. In: Egger M, Davey Smith G, Altman D, eds. Systematic reviews in health care: meta-analysis in context, 2nd edn. London: BMJ Books, 2001: 429-43.
-
(2001)
Using Systematic Reviews and Registers of Ongoing Trials for Scientifi C and Ethical Trial Design, Monitoring, and Reporting
, pp. 429-443
-
-
Chalmers, I.1
|