The liver–gut microbiota axis modulates hepatotoxicity of tacrine in the rat

Hepatology

Volumn 67, Issue 1, 2018, Pages 282-295

  Yip, Lian Yee ^a,b   Aw, Chiu Cheong ^c   Lee, Sze Han ^a   Hong, Yi Shuen ^a   Ku, Han Chen ^a   Xu, Winston Hecheng ^a   Chan, Jessalyn Mei Xuan ^a   Cheong, Eleanor Jing Yi ^a   Chng, Kern Rei ^d   Ng, Amanda Hui Qi ^d   Nagarajan, Niranjan ^d   Mahendran, Ratha ^e   Lee, Yuan Kun ^e   Browne, Edward R ^c   Chan, Eric Chun Yong ^a,f  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b AGENCY FOR SCIENCE   (Singapore)

^c GSK Neural Pathways DPU   (Singapore)

^d GENOME INSTITUTE OF SINGAPORE   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^f AGENCY FOR SCIENCE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLUCURONIDASE; IMIPENEM; METHYLCELLULOSE; TACRINE; VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BACTEROIDES; BIOMICS; BLOOD SAMPLING; CONTROLLED STUDY; DEGLUCURONIDATION; ENTEROBACTERIACEAE; ENTEROHEPATIC CIRCULATION; GENE EXPRESSION; GENOMICS; GLUCURONIDATION; HYPERTRANSAMINASEMIA; IN VIVO STUDY; INTESTINE FLORA; LACTOBACILLUS; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; LISTER HOODED RAT; LIVER GUT MICROBIOTA AXIS; LIVER TOXICITY; MALE; METABONOMICS; METAGENOMICS; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; RAT; TOXICOLOGY; VALIDATION STUDY; ANIMAL; COMPARATIVE STUDY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; IMMUNOHISTOCHEMISTRY; INBRED RAT STRAIN; LIVER FUNCTION TEST; NEEDLE BIOPSY; PATHOLOGY; RANDOMIZATION; REFERENCE VALUE; SEVERITY OF ILLNESS INDEX; TOXIC HEPATITIS;

ANIMALS; BIOPSY, NEEDLE; CHEMICAL AND DRUG INDUCED LIVER INJURY; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTROINTESTINAL MICROBIOME; IMMUNOHISTOCHEMISTRY; LIVER FUNCTION TESTS; MALE; RANDOM ALLOCATION; RATS; RATS, INBRED STRAINS; REFERENCE VALUES; SEVERITY OF ILLNESS INDEX; TACRINE;

EID: 85034232947     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.29327     Document Type: Article

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