Hepatoprotective effect of lactic acid bacteria, inhibitors of β-glucuronidase production against intestinal microflora

Archives of Pharmacal Research

Volumn 28, Issue 3, 2005, Pages 325-329

  Han, Song Yi ^a   Huh, Chul Sung ^b   Ahn, Young Tae ^b   Lim, Kwang Sei ^b   Baek, Young Jin ^b   Kim, Dong Hyun ^a  

^a Kyung Hee University   (South Korea)

^b Korea Yakult Co   (South Korea)

Author keywords

CCl4; Hepatoprotective; Intestinal bacteria; Lactic acid bacteria; t BHP; glucuronidase inhibitor

Indexed keywords

BETA GLUCURONIDASE; LACTIC ACID; TERT BUTYL HYDROPEROXIDE;

ANIMAL; ARTICLE; BIFIDOBACTERIUM; BIOSYNTHESIS; COCULTURE; DRUG ANTAGONISM; ENZYMOLOGY; ESCHERICHIA COLI; GROWTH, DEVELOPMENT AND AGING; INSTITUTE FOR CANCER RESEARCH MOUSE; INTESTINE; INTOXICATION; LACTOBACILLUS; MALE; METABOLISM; MICROBIOLOGY; MOUSE; TOXIC HEPATITIS;

ANIMALS; BIFIDOBACTERIUM; CARBON TETRACHLORIDE POISONING; COCULTURE TECHNIQUES; ESCHERICHIA COLI; GLUCURONIDASE; HEPATITIS, TOXIC; INTESTINES; LACTIC ACID; LACTOBACILLUS; MALE; MICE; MICE, INBRED ICR; TERT-BUTYLHYDROPEROXIDE;

EID: 23344450411     PISSN: 02536269     EISSN: 02536269     Source Type: Journal    
DOI: 10.1007/BF02977800     Document Type: Article

References (18)

1. Dutton, G. J., Glucuronidation of drugs and other compounds. CRC press, Florida pp. 1-42 (1980).
2. Goldin, B. and Gorbach, S. L., The relationship between diet and rat fecal bacterial enzymes implicated in colon cancer. J. Natl. Cancer Ints., 57, 371-375 (1976).
3. Hill, M. J. and Crowther, J. S., Bacteria and bacteriology of colonic polyp patients and control patients. Cancer Res., 35, 3407-3417 (1975)
4. Kinoshita, N. and Gelvoin, H,V., β-Glucuronidase catalyzed hydrolysis of benzo[a]pyrene-3-glucuronide and binding to DNA. Science, 199, 307-309 (1978).
5. Kim, D.-H., Kang, H.-J., Park, S.-H., and Kobashi, K., Characterization of β-glucuronidase and β-glucosidase of alkalotolerant intestinal bacteria. Biol. Pharm. Bull., 17, 423-425 (1994)
6. Kim, D.-H., Lee, J. H., Bae, E. A., and Han, M. J., Induction and inhibition of indole production of intestinal bacterial. Arch. Pharm. Res., 18, 351-355 (1995a).
7. Kim, D.-H., Jang, I. S., Park, J. B., and Lee, S. W., Protective role of mushrooms in experimental colon carcinogenesis. Arch. Pharm. Res., 18, 79-83 (1995b).
8. Kim, D.-H., Jin, Y. H., Jung, E. A., Han, M. J., and Kobashi, K., Purification and characterization of β-glucuronidase from E. coli HGU-3, a human intestinal bacterium. Biol. Pharm. Bull., 18, 1184-1188 (1995c).
9. Levy, G. A., Kerr, L. M. H., and Campbell, J. C., β-Glucuronidase and cell proliferation. Biochem. J., 42, 462-468 (1948).
10. Mills, G. T. and Smith, E. E. B., The β-glucuronidase activity of chemically induced rat hepatoma. Science, 114, 690-692 (1951).
11. Mills, G. T., Paul, J., and Smith, E. E. B., Studies in β-glucuronidase, the influence of age, partial hepatectomy and other factors in the β-glucuronidase activity in rate liver. Biochem. J., 53, 232-245 (1953).
12. Kim, D.-H., Jin, Y.-H., Park, J.-B., and Kobashi, K., Silymarin and its components are inhibitors of β-glucuronidase. Biol. Pharm. Bull., 17, 443-445 (1994).
13. Shim, S. B., Kim, N. J., and Kim, D.-H., β-Glucuronidase inhibitory activity and hepatoprotective effect of 18β-glycrrhetinic acid from the rhizomes of Glycyrrhiza uralensis. Plant Med., 66, 40-43 (2000).
14. Stahl, P. D., and Fishman, W. H., β-Glucuronidase In Bergmeyer, H. U. (ed). Method of Enzymatic Analysis. Verlag Chemie GmbH, Weinheim. 4, pp 246-256 (1983).
15. Pineda, E. P., Goldberg, J. A., Banks, B. M., and Rutenburg, A. M., The significance of serum β-glucuronidase activity in patients with liver disease. Gastroenterology, 36, 202-213 (1959).
16. Reitman, S. and Frankel, S., A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminase. Am. J. Clin. Path., 28, 56-63 (1957).
17. Wang, W. L., Clinical effect of DDB piles on 56 cases of chronic viral hepatitis B. New Drugs Clinic, 3, 13-15 (1984).
18. Weiburger, J. H., Reddy, B. S., and Wynder, E. L., Colon cancer: its epidemiology and experimental production. Cancer, 40, 2414-2420 (1977).