Exposure to organophosphate flame retardant chemicals in the U.S. general population: Data from the 2013–2014 National Health and Nutrition Examination Survey

Environment International

Volumn 110, Issue , 2018, Pages 32-41

  Ospina, Maria ^a   Jayatilaka, Nayana K ^a   Wong, Lee Yang ^a   Restrepo, Paula ^a   Calafat, Antonia M ^a  

^a NATIONAL CENTER FOR ENVIRONMENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMARKERS; CHEMICAL CONTAMINATION; CONSUMER PRODUCTS; ENZYMATIC HYDROLYSIS; FLAME RETARDANTS; MASS SPECTROMETERS; NUTRITION; ORGANIC POLLUTANTS; PHASE SEPARATION; POPULATION STATISTICS; REGRESSION ANALYSIS; SOLVENTS; SURVEYS;

AGE GROUPS; ANALYTES; GENERAL POPULATION; GEOMETRIC MEAN; HUMAN EXPOSURES; ORGANOPHOSPHATE FLAME RETARDANTS; POLYBROMINATED DIPHENYLETHERS; POPULATION DATA; REPRESENTATIVE SAMPLE; SURVEY DATA;

MASS SPECTROMETRY;

2,3,4,5 TETRABROMOBENZOIC ACID; BIOLOGICAL MARKER; BIS (1 CHLORO 2 PROPYL) PHOSPHATE; BIS 2 CHLOROETHYL PHOSPHATE; BIS(1,3 DICHLORO 2 PROPYL)PHOSPHATE; CREATININE; DI N BUTYL PHOSPHATE; DI ORTHO CRESYLPHOSPHATE; DI PARA CRESYLPHOSPHATE; DIBENZYL PHOSPHATE; DIPHENYL PHOSPHATE; FLAME RETARDANT; ORGANOPHOSPHATE; POLYBROMINATED DIPHENYL ETHER; TRIPHENYL PHOSPHATE; TRIS 2 CHLOROETHYL PHOSPHATE; TRIS(1 CHLORO 2 PROPYL)PHOSPHATE; TRIS(1,3 DICHLORO 2 PROPYL)PHOSPHATE; UNCLASSIFIED DRUG;

FLAME RETARDANT; HEALTH SURVEY; NUTRITION; ORGANOPHOSPHATE; POLLUTION EXPOSURE;

ADOLESCENT; ADULT; AGE; ARTICLE; CHILD; CONTROLLED STUDY; DEMOGRAPHY; ENVIRONMENTAL EXPOSURE; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; SEX DIFFERENCE; UNITED STATES; URINE LEVEL; URINE SAMPLING; EPIDEMIOLOGY; ETHNIC GROUP; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MIDDLE AGED; NUTRITION; SOLID PHASE EXTRACTION; URINE; YOUNG ADULT;

UNITED STATES;

ADOLESCENT; ADULT; CHILD; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENVIRONMENTAL EXPOSURE; ETHNIC GROUPS; FEMALE; FLAME RETARDANTS; HUMANS; MALE; MIDDLE AGED; NUTRITION SURVEYS; ORGANOPHOSPHATES; SOLID PHASE EXTRACTION; UNITED STATES; YOUNG ADULT;

EID: 85033383188     PISSN: 01604120     EISSN: 18736750     Source Type: Journal    
DOI: 10.1016/j.envint.2017.10.001     Document Type: Article

References (74)

1. Ali, N., Dirtu, A.C., Van den Eede, N., Goosey, E., Harrad, S., Neels, H., t Mannetje, A., Coakley, J., Douwes, J., Covaci, A., Occurrence of alternative flame retardants in indoor dust from New Zealand: indoor sources and human exposure assessment. Chemosphere 88:11 (2012), 1276–1282, 10.1016/j.chemosphere.2012.03.100.
2. Ali, N., Ali, L., Mehdi, T., Dirtu, A.C., Al-Shammari, F., Neels, H., Covaci, A., Levels and profiles of organochlorines and flame retardants in car and house dust from Kuwait and Pakistan: implication for human exposure via dust ingestion. Environ. Int. 55 (2013), 62–70, 10.1016/j.envint.2013.02.001.
3. Andresen, J.A., Grundmann, A., Bester, K., Organophosphorus flame retardants and plasticisers in surface waters. Sci. Total Environ. 332:1–3 (2004), 155–166, 10.1016/j.scitotenv.2004.04.021.
4. Araki, A., Saito, I., Kanazawa, A., Morimoto, K., Nakayama, K., Shibata, E., Tanaka, M., Takigawa, T., Yoshimura, T., Chikara, H., Saijo, Y., Kishi, R., Phosphorus flame retardants in indoor dust and their relation to asthma and allergies of inhabitants. Indoor Air 24:1 (2014), 3–15, 10.1111/ina.12054.
5. Baldwin, K.R., Phillips, A.L., Horman, B., Arambula, S.E., Rebuli, M.E., Stapleton, H.M., Patisaul, H.B., Sex specific placental accumulation and behavioral effects of developmental Firemaster 550 exposure in Wistar rats. Sci Rep, 7(1), 2017, 7118, 10.1038/s41598-017-07216-6.
6. Bearr, J.S., Mitchelmore, C.L., Roberts, S.C., Stapleton, H.M., Species specific differences in the in vitro metabolism of the flame retardant mixture, Firemaster® BZ-54. Aquat. Toxicol. 124 (2012), 41–47, 10.1016/j.aquatox.2012.06.006.
7. Bergman, A., Ryden, A., Law, R.J., de Boer, J., Covaci, A., Alaee, M., Birnbaum, L., Petreas, M., Rose, M., Sakai, S., Van den Eede, N., van der Veen, I., A novel abbreviation standard for organobromine, organochlorine and organophosphorus flame retardants and some characteristics of the chemicals. Environ. Int. 49 (2012), 57–82, 10.1016/j.envint.2012.08.003.
8. Betts, K., Court bans widely used flame retardant. Environ. Sci. Technol., 42(11), 2008, 3910, 10.1021/es0871199.
9. Butt, C.M., Congleton, J., Hoffman, K., Fang, M., Stapleton, H.M., Metabolites of organophosphate flame retardants and 2-ethylhexyl tetrabromobenzoate in urine from paired mothers and toddlers. Environ. Sci. Technol. 48:17 (2014), 10432–10438, 10.1021/es5025299.
10. Butt, C.M., Hoffman, K., Chen, A., Lorenzo, A., Congleton, J., Stapleton, H.M., Regional comparison of organophosphate flame retardant (PFR) urinary metabolites and tetrabromobenzoic acid (TBBA) in mother-toddler pairs from California and New Jersey. Environ. Int. 94 (2016), 627–634, 10.1016/j.envint.2016.06.029.
11. Carignan, C.C., McClean, M.D., Cooper, E.M., Watkins, D.J., Fraser, A.J., Heiger-Bernays, W., Stapleton, H.M., Webster, T.F., Predictors of tris(1,3-dichloro-2-propyl) phosphate metabolite in the urine of office workers. Environ. Int. 55 (2013), 56–61, 10.1016/j.envint.2013.02.004.
12. Carlsson, H., Nilsson, U., Ostman, C., Video display units: an emission source of the contact allergenic flame retardant triphenyl phosphate in the indoor environment. Environ. Sci. Technol. 34 (2000), 3885–3889.
13. CDC, About the National Health and Nutrition Examination Survey. 2014, National Center for Health Statistics https://www.cdc.gov/nchs/nhanes/about_nhanes.htm. (Accessed 17 July 2017)
14. CDC, National Health and Nutrition Examination Survey. 2013–2014 Overview. https://wwwn.cdc.gov/nchs/nhanes/continuousnhanes/default.aspx?BeginYear=2013, 2017. (Accessed 20 July 2017)
15. Cequier, E., Marce, R.M., Becher, G., Thomsen, C., A high-throughput method for determination of metabolites of organophosphate flame retardants in urine by ultra performance liquid chromatography-high resolution mass spectrometry. Anal. Chim. Acta 845 (2014), 98–104, 10.1016/j.aca.2014.06.026.
16. Cequier, E., Sakhi, A.K., Marce, R.M., Becher, G., Thomsen, C., Human exposure pathways to organophosphate triesters - a biomonitoring study of mother-child pairs. Environ. Int. 75 (2015), 159–165, 10.1016/j.envint.2014.11.009.
17. Cooper, E.M., Covaci, A., van Nuijs, A.L., Webster, T.F., Stapleton, H.M., Analysis of the flame retardant metabolites bis(1,3-dichloro-2-propyl) phosphate (BDCPP) and diphenyl phosphate (DPP) in urine using liquid chromatography-tandem mass spectrometry. Anal. Bioanal. Chem. 401:7 (2011), 2123–2132, 10.1007/s00216-011-5294-7.
18. Cooper, E.M., Kroeger, G., Davis, K., Clark, C.R., Ferguson, P.L., Stapleton, H.M., Results from screening polyurethane foam based consumer products for flame retardant chemicals: assessing impacts on the change in the furniture flammability standards. Environ. Sci. Technol. 50:19 (2016), 10653–10660, 10.1021/acs.est.6b01602.
19. Covaci, A., Harrad, S., Abdallah, M.A., Ali, N., Law, R.J., Herzke, D., de Wit, C.A., Novel brominated flame retardants: a review of their analysis, environmental fate and behaviour. Environ. Int. 37:2 (2011), 532–556, 10.1016/j.envint.2010.11.007.
20. de Wit, C.A., An overview of brominated flame retardants in the environment. Chemosphere 46:5 (2002), 583–624, 10.1016/S0045-6535(01)00225-9.
21. Dishaw, L.V., Powers, C.M., Ryde, I.T., Roberts, S.C., Seidler, F.J., Slotkin, T.A., Stapleton, H.M., Is the PentaBDE replacement, tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells. Toxicol. Appl. Pharmacol. 256:3 (2011), 281–289, 10.1016/j.taap.2011.01.005.
22. Dishaw, L.V., Macaulay, L.J., Roberts, S.C., Stapleton, H.M., Exposures, mechanisms, and impacts of endocrine-active flame retardants. Curr. Opin. Pharmacol. 19 (2014), 125–133, 10.1016/j.coph.2014.09.018.
23. Dodson, R.E., Perovich, L.J., Covaci, A., Van den Eede, N., Ionas, A.C., Dirtu, A.C., Brody, J.G., Rudel, R.A., After the PBDE phase-out: a broad suite of flame retardants in repeat house dust samples from California. Environ. Sci. Technol. 46:24 (2012), 13056–13066, 10.1021/es303879n.
24. Dodson, R.E., Van den Eede, N., Covaci, A., Perovich, L.J., Brody, J.G., Rudel, R.A., Urinary biomonitoring of phosphate flame retardants: levels in California adults and recommendations for future studies. Environ. Sci. Technol. 48:23 (2014), 13625–13633, 10.1021/es503445c.
25. ECHA, Tris(2-Chloroethyl) Phosphate. 2017, European Chemicals Agency https://www.echa.europa.eu/web/guest/substance-information/-/substanceinfo/100.003.744. (Accessed 28 July 2017)
26. EPA, Polybrominated Diphenyl Ethers (PBDEs) Action Plan. https://www.epa.gov/sites/production/files/2015-09/documents/pbdes_ap_2009_1230_final.pdf, 2009. (Accessed 7 March 2017)
27. EPA, Technical Fact Sheet - Polybrominated Diphenyl Ethers (PBDEs) and Polybrominated Biphenyls (PBBs). https://www.epa.gov/sites/production/files/2014-03/documents/ffrrofactsheet_contaminant_perchlorate_january2014_final_0.pdf, 2014.
28. EPA, Flame Retardants Used in Flexible Polyurethane Foam: An Alternatives Assessment Update. 744-R-15-02. https://www.epa.gov/sites/production/files/2015-08/documents/ffr_final.pdf, 2015. (Accessed 8 February 2017)
29. García, M., Rodríguez, I., Cela, R., Microwave-assisted extraction of organophosphate flame retardants and plasticizers from indoor dust samples. J. Chromatogr. A 1152:1 (2007), 280–286, 10.1016/j.chroma.2006.11.046.
30. Greaves, A.K., Letcher, R.J., A review of organophosphate esters in the environment from biological effects to distribution and fate. Bull. Environ. Contam. Toxicol. 98:1 (2017), 2–7, 10.1007/s00128-016-1898-0.
31. Greaves, A.K., Su, G., Letcher, R.J., Environmentally relevant organophosphate triesters in herring gulls: in vitro biotransformation and kinetics and diester metabolite formation using a hepatic microsomal assay. Toxicol. Appl. Pharmacol. 308 (2016), 59–65, 10.1016/j.taap.2016.08.007.
32. Heitkamp, M.A., Freeman, J.P., McMillan, D.C., Cerniglia, C.E., Fungal metabolism of tert-butylphenyl diphenyl phosphate. Appl. Environ. Microbiol. 50:2 (1985), 265–273.
33. Hoffman, K., Daniels, J.L., Stapleton, H.M., Urinary metabolites of organophosphate flame retardants and their variability in pregnant women. Environ. Int. 63 (2014), 169–172, 10.1016/j.envint.2013.11.013.
34. Hoffman, K., Butt, C.M., Chen, A., Limkakeng, A.T. Jr., Stapleton, H.M., High exposure to organophosphate flame retardants in infants: associations with baby products. Environ. Sci. Technol. 49:24 (2015), 14554–14559, 10.1021/acs.est.5b03577.
35. Hoffman, K., Garantziotis, S., Birnbaum, L.S., Stapleton, H.M., Monitoring indoor exposure to organophosphate flame retardants: hand wipes and house dust. Environ. Health Perspect. 123:2 (2015), 160–165, 10.1289/ehp.1408669.
36. Hoffman, K., Butt, C.M., Webster, T.F., Preston, E.V., Hammel, S.C., Makey, C., Lorenzo, A.M., Cooper, E.M., Carignan, C., Meeker, J.D., Hauser, R., Soubry, A., Murphy, S.K., Price, T.M., Hoyo, C., Mendelsohn, E., Congleton, J., Daniels, J.L., Stapleton, H.M., Temporal trends in exposure to organophosphate flame retardants in the United States. Environ. Sci. Technol. Lett. 4:3 (2017), 112–118, 10.1021/acs.estlett.6b00475.
37. Hoffman, K., Lorenzo, A., Butt, C.M., Adair, L., Herring, A.H., Stapleton, H.M., Daniels, J.L., Predictors of urinary flame retardant concentration among pregnant women. Environ. Int. 98 (2017), 96–101, 10.1016/j.envint.2016.10.007.
38. Hoffman, K., Sosa, J.A., Stapleton, H.M., Do flame retardant chemicals increase the risk for thyroid dysregulation and cancer?. Curr. Opin. Oncol. 29:1 (2017), 7–13, 10.1097/cco.0000000000000335.
39. Hornung, R.W., Reed, L.D., Estimation of average concentration in the presence of nondetectable values. Appl. Occup. Environ. Hyg. 5:1 (1990), 46–51, 10.1080/1047322X.1990.10389587.
40. Hou, R., Xu, Y., Wang, Z., Review of OPFRs in animals and humans: absorption, bioaccumulation, metabolism, and internal exposure research. Chemosphere 153 (2016), 78–90, 10.1016/j.chemosphere.2016.03.003.
41. Jayatilaka, N.K., Restrepo, P., Williams, L., Ospina, M., Valentin-Blasini, L., Calafat, A.M., Quantification of three chlorinated dialkyl phosphates, diphenyl phosphate, 2,3,4,5-tetrabromobenzoic acid, and four other organophosphates in human urine by solid phase extraction-high performance liquid chromatography-tandem mass spectrometry. Anal. Bioanal. Chem. 409:5 (2017), 1323–1332, 10.1007/s00216-016-0061-4.
42. Kile, M.L., Scott, R.P., O'Connell, S.G., Lipscomb, S., MacDonald, M., McClelland, M., Anderson, K.A., Using silicone wristbands to evaluate preschool children's exposure to flame retardants. Environ. Res. 147 (2016), 365–372, 10.1016/j.envres.2016.02.034.
43. Lipscomb, S.T., McClelland, M.M., MacDonald, M., Cardenas, A., Anderson, K.A., Kile, M.L., Cross-sectional study of social behaviors in preschool children and exposure to flame retardants. Environ. Health, 16(1), 2017, 23, 10.1186/s12940-017-0224-6.
44. Luongo, G., Ostman, C., Organophosphate and phthalate esters in settled dust from apartment buildings in Stockholm. Indoor Air 26:3 (2016), 414–425, 10.1111/ina.12217.
45. Makiguchi, K., Satoh, T., Kakuchi, T., Diphenyl phosphate as an efficient cationic organocatalyst for controlled/living ring-opening polymerization of δ-valerolactone and ε-caprolactone. Macromolecules 44:7 (2011), 1999–2005, 10.1021/ma200043x.
46. Makiguchi, K., Ogasawara, Y., Kikuchi, S., Satoh, T., Kakuchi, T., Diphenyl phosphate as an efficient acidic organocatalyst for controlled/living ring-opening polymerization of trimethylene carbonates leading to block, end-functionalized, and macrocyclic polycarbonates. Macromolecules 46:5 (2013), 1772–1782, 10.1021/ma4000495.
47. Marklund, A., Andersson, B., Haglund, P., Organophosphorus flame retardants and plasticizers in air from various indoor environments. J. Environ. Monit. 7:8 (2005), 814–819, 10.1039/b505587c.
48. Meeker, J.D., Cooper, E.M., Stapleton, H.M., Hauser, R., Exploratory analysis of urinary metabolites of phosphorus-containing flame retardants in relation to markers of male reproductive health. Endocr. Disruptors (Austin Tex.), 1(1), 2013, e26306, 10.4161/endo.26306.
49. Meeker, J.D., Cooper, E.M., Stapleton, H.M., Hauser, R., Urinary metabolites of organophosphate flame retardants: temporal variability and correlations with house dust concentrations. Environ. Health Perspect. 121:5 (2013), 580–585, 10.1289/ehp.1205907.
50. Mendelsohn, E., Hagopian, A., Hoffman, K., Butt, C.M., Lorenzo, A., Congleton, J., Webster, T.F., Stapleton, H.M., Nail polish as a source of exposure to triphenyl phosphate. Environ. Int. 86 (2016), 45–51, 10.1016/j.envint.2015.10.005.
51. Mizouchi, S., Ichiba, M., Takigami, H., Kajiwara, N., Takamuku, T., Miyajima, T., Kodama, H., Someya, T., Ueno, D., Exposure assessment of organophosphorus and organobromine flame retardants via indoor dust from elementary schools and domestic houses. Chemosphere 123 (2015), 17–25, 10.1016/j.chemosphere.2014.11.028.
52. Nishimaki-Mogami, T., Minegishi, K., Tanaka, A., Sato, M., Isolation and identification of metabolites of 2-ethylhexyl diphenyl phosphate in rats. Arch. Toxicol. 61:4 (1988), 259–264.
53. OEHHA, Current Proposition 65 List. 2016, California Office of Environmental Health Hazard Assessment https://oehha.ca.gov/proposition-65/proposition-65-list. (Accessed 7 March 2017)
54. OEHHA, Fact Sheet-Chlorinated Tris. https://www.p65warnings.ca.gov/sites/default/files/downloads/factsheets/chlorinated_tris_fact_sheet.pdf, 2016. (Accessed 4 August 2017)
55. Oliveri, A.N., Bailey, J.M., Levin, E.D., Developmental exposure to organophosphate flame retardants causes behavioral effects in larval and adult zebrafish. Neurotoxicol. Teratol. 52:Pt B (2015), 220–227, 10.1016/j.ntt.2015.08.008.
56. Ouyang, X., Weiss, J.M., de Boer, J., Lamoree, M.H., Leonards, P.E.G., Non-target analysis of household dust and laundry dryer lint using comprehensive two-dimensional liquid chromatography coupled with time-of-flight mass spectrometry. Chemosphere 166:Supplement C (2017), 431–437, 10.1016/j.chemosphere.2016.09.107.
57. Preston, E.V., McClean, M.D., Claus Henn, B., Stapleton, H.M., Braverman, L.E., Pearce, E.N., Makey, C.M., Webster, T.F., Associations between urinary diphenyl phosphate and thyroid function. Environ. Int. 101 (2017), 158–164, 10.1016/j.envint.2017.01.020.
58. Roberts, S.C., Macaulay, L.J., Stapleton, H.M., In vitro metabolism of the brominated flame retardants 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (TBB) and bis(2-ethylhexyl) 2,3,4,5-tetrabromophthalate (TBPH) in human and rat tissues. Chem. Res. Toxicol. 25:7 (2012), 1435–1441, 10.1021/tx300086x.
59. Sasaki, K., Suzuki, T., Takeda, M., Uchiyama, M., Metabolism of phosphoric acid triesters by rat liver homogenate. Bull. Environ. Contam. Toxicol. 33:3 (1984), 281–288.
60. Schreder, E.D., La Guardia, M.J., Flame retardant transfers from U.S. households (dust and laundry wastewater) to the aquatic environment. Environ. Sci. Technol. 48:19 (2014), 11575–11583, 10.1021/es502227h.
61. Schreder, E.D., Uding, N., La Guardia, M.J., Inhalation a significant exposure route for chlorinated organophosphate flame retardants. Chemosphere 150 (2016), 499–504, 10.1016/j.chemosphere.2015.11.084.
62. Solbu, K., Thorud, S., Hersson, M., Ovrebo, S., Ellingsen, D.G., Lundanes, E., Molander, P., Determination of airborne trialkyl and triaryl organophosphates originating from hydraulic fluids by gas chromatography-mass spectrometry. Development of methodology for combined aerosol and vapor sampling. J. Chromatogr. A 1161:1–2 (2007), 275–283, 10.1016/j.chroma.2007.05.087.
63. Stapleton, H.M., Allen, J.G., Kelly, S.M., Konstantinov, A., Klosterhaus, S., Watkins, D., McClean, M.D., Webster, T.F., Alternate and new brominated flame retardants detected in U.S. house dust. Environ. Sci. Technol. 42:18 (2008), 6910–6916.
64. Stapleton, H.M., Klosterhaus, S., Eagle, S., Fuh, J., Meeker, J.D., Blum, A., Webster, T.F., Detection of organophosphate flame retardants in furniture foam and U.S. house dust. Environ. Sci. Technol. 43:19 (2009), 7490–7495.
65. Stapleton, H.M., Klosterhaus, S., Keller, A., Ferguson, P.L., van Bergen, S., Cooper, E., Webster, T.F., Blum, A., Identification of flame retardants in polyurethane foam collected from baby products. Environ. Sci. Technol. 45:12 (2011), 5323–5331, 10.1021/es2007462.
66. Stapleton, H.M., Sharma, S., Getzinger, G., Ferguson, P.L., Gabriel, M., Webster, T.F., Blum, A., Novel and high volume use flame retardants in US couches reflective of the 2005 PentaBDE phase out. Environ. Sci. Technol. 46:24 (2012), 13432–13439, 10.1021/es303471d.
67. Stapleton, H.M., Misenheimer, J., Hoffman, K., Webster, T.F., Flame retardant associations between children's handwipes and house dust. Chemosphere 116 (2014), 54–60, 10.1016/j.chemosphere.2013.12.100.
68. Su, G., Crump, D., Letcher, R.J., Kennedy, S.W., Rapid in vitro metabolism of the flame retardant triphenyl phosphate and effects on cytotoxicity and mRNA expression in chicken embryonic hepatocytes. Environ. Sci. Technol. 48:22 (2014), 13511–13519, 10.1021/es5039547.
69. Ta, N., Li, C., Fang, Y., Liu, H., Lin, B., Jin, H., Tian, L., Zhang, H., Zhang, W., Xi, Z., Toxicity of TDCPP and TCEP on PC12 cell: changes in CAMKII, GAP43, tubulin and NF-H gene and protein levels. Toxicol. Lett. 227:3 (2014), 164–171, 10.1016/j.toxlet.2014.03.023.
70. Tullo, A., Great Lakes to phase out flame retardants. Chem. Eng. News Arch., 81(45), 2003, 13, 10.1021/cen-v081n045.p013a.
71. Van den Eede, N., Maho, W., Erratico, C., Neels, H., Covaci, A., First insights in the metabolism of phosphate flame retardants and plasticizers using human liver fractions. Toxicol. Lett. 223:1 (2013), 9–15, 10.1016/j.toxlet.2013.08.012.
72. Van den Eede, N., Heffernan, A.L., Aylward, L.L., Hobson, P., Neels, H., Mueller, J.F., Covaci, A., Age as a determinant of phosphate flame retardant exposure of the Australian population and identification of novel urinary PFR metabolites. Environ. Int. 74 (2015), 1–8, 10.1016/j.envint.2014.09.005.
73. Van den Eede, N., Tomy, G., Tao, F., Halldorson, T., Harrad, S., Neels, H., Covaci, A., Kinetics of tris (1-chloro-2-propyl) phosphate (TCIPP) metabolism in human liver microsomes and serum. Chemosphere 144 (2016), 1299–1305, 10.1016/j.chemosphere.2015.09.049.
74. van der Veen, I., de Boer, J., Phosphorus flame retardants: properties, production, environmental occurrence, toxicity and analysis. Chemosphere 88:10 (2012), 1119–1153, 10.1016/j.chemosphere.2012.03.067.