TGF-β inhibits alveolar protein transport by promoting shedding, regulated intramembrane proteolysis, and transcriptional downregulation of megalin

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 313, Issue 5, 2017, Pages L807-L824

  Mazzocchi, Luciana C ^a   Vohwinkel, Christine U ^a,b   Mayer, Konstantin ^a   Herold, Susanne ^a   Morty, Rory E ^a,c   Seeger, Werner ^a,c   Vadász, István ^a  

^a JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

^b University of Colorado Denver and Children s Hospital Colorado   (United States)

^c MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

Author keywords

Alveolar protein transport; Matrix metalloproteinases; Megalin; Receptor shedding; Regulated intramembrane proteolysis

Indexed keywords

ALBUMIN; ALBUMIN RECEPTOR; GAMMA SECRETASE; GELATINASE A; GELATINASE B; LOW DENSITY LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MATRIX METALLOPROTEINASE 14; MEGALIN; PROTEIN KINASE C; TRANSFORMING GROWTH FACTOR BETA; LOW DENSITY LIPOPROTEIN; MATRIX METALLOPROTEINASE;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; EXTRACELLULAR SPACE; GENE EXPRESSION; LUNG ALVEOLUS EPITHELIUM CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; DRUG EFFECTS; ENDOCYTOSIS; HUMAN; METABOLISM;

ANIMALS; CELL MEMBRANE; CELLS, CULTURED; DOWN-REGULATION; ENDOCYTOSIS; HUMANS; LIPOPROTEINS, LDL; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-2; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASES; PROTEIN KINASE C; PROTEIN TRANSPORT; PROTEOLYSIS; TRANSFORMING GROWTH FACTOR BETA;

EID: 85032927352     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00569.2016     Document Type: Article

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