Reversing SKI-SMAD4-mediated suppression is essential for TH17 cell differentiation

Nature

Volumn 551, Issue 7678, 2017, Pages 105-109

  Zhang, Song ^a,b   Takaku, Motoki ^c   Zou, Liyun ^a,b   Gu, Ai Di ^a,b   Chou, Wei Chun ^a,b   Zhang, Ge ^a,b,d   Wu, Bing ^a,b   Kong, Qing ^a,b   Thomas, Seddon Y ^c   Serody, Jonathan S ^a,b   Chen, Xian ^a,b   Xu, Xiaojiang ^c   Wade, Paul A ^c   Cook, Donald N ^c   Ting, Jenny P Y ^a,b   Wan, Yisong Y ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H3; INTERLEUKIN 6; PEPTIDES AND PROTEINS; RETINOIC ACID RECEPTOR GAMMA; SKI PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; MULTIPROTEIN COMPLEX; ONCOPROTEIN; REPRESSOR PROTEIN; RETINOID RELATED ORPHAN RECEPTOR GAMMA; RORC PROTEIN, MOUSE; SKI PROTEIN, MOUSE; SMAD4 PROTEIN, MOUSE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ALLELE; CELLS AND CELL COMPONENTS; CHEMICAL REACTION; CHEMORECEPTION; DIFFERENTIATION; GENE EXPRESSION; GROWTH; ORGANIC ACID; PROTEIN; PROTEOMICS;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DEACETYLATION; HISTONE ACETYLATION; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; T CELL CULTURE; TH17 CELL; ANIMAL; CELL DIFFERENTIATION; CHEMISTRY; CYTOLOGY; DEFICIENCY; FEMALE; GENE DELETION; GENETICS; HUMAN; MALE; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIFFERENTIATION; DNA-BINDING PROTEINS; FEMALE; GENE DELETION; HUMANS; INTERLEUKIN-6; MALE; MICE; MULTIPROTEIN COMPLEXES; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; PROTO-ONCOGENE PROTEINS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SMAD4 PROTEIN; TH17 CELLS; TRANSFORMING GROWTH FACTOR BETA;

EID: 85032917113     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature24283     Document Type: Article

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