Ligand binding to a G protein–coupled receptor captured in a mass spectrometer

Science Advances

Volumn 3, Issue 6, 2017, Pages

  Yen, Hsin Yung ^a   Hopper, Jonathan T S ^b   Liko, Idlir ^a,b   Allison, Timothy M ^a   Zhu, Ya ^c   Wang, Dejian ^c,d   Stegmann, Monika ^e   Mohammed, Shabaz ^a   Wu, Beili ^c,d   Robinson, Carol V ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b OMass Technologies Ltd   (United Kingdom)

^c SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^d SHANGHAITECH UNIVERSITY   (China)

^e UCB PHARMA   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BINS; BIOLOGICAL MEMBRANES; CELL MEMBRANES; CYTOLOGY; LIGANDS; MASS SPECTROMETERS; MASS SPECTROMETRY; NUCLEOTIDES; SPECTROMETERS; SPECTROMETRY;

BINDING PROTEINS; CONFORMATIONAL CHANGE; COUPLED RECEPTORS; EMBEDDED CELLS; GUANINE NUCLEOTIDES; MEMBRANE PROTEIN COMPLEX; PHYSIOLOGICAL PROCESS; PURINERGIC RECEPTORS;

PROTEINS;

ADENOSINE DIPHOSPHATE; G PROTEIN COUPLED RECEPTOR; LIGAND; PROTEIN BINDING; PURINERGIC P2Y1 RECEPTOR;

CHEMISTRY; CONFORMATION; MASS SPECTROMETRY; METABOLISM; MOLECULAR MODEL; PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION;

ADENOSINE DIPHOSPHATE; LIGANDS; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHOSPHORYLATION; PROTEIN BINDING; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PURINERGIC P2Y1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85032877152     PISSN: None     EISSN: 23752548     Source Type: Journal    
DOI: 10.1126/sciadv.1701016     Document Type: Article

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