Structure and dynamics of FosA-mediated fosfomycin resistance in Klebsiella pneumoniae and Escherichia coli

Antimicrobial Agents and Chemotherapy

Volumn 61, Issue 11, 2017, Pages

  Klontz, Erik H ^a   Tomich, Adam D ^b   Günther, Sebastian ^a   Lemkul, Justin A ^c   Deredge, Daniel ^c   Silverstein, Zach ^a   Shaw, JoAnna F ^b   McElheny, Christi ^b   Doi, Yohei ^b   Wintrode, Patrick L ^c   MacKerell, Alexander D ^c   Sluis Cremer, Nicolas ^b   Sundberg, Eric J ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

Escherichia coli; FosA; FosA3; FosAKP; FosAPA; Fosfomycin; Klebsiella; X ray crystallography

Indexed keywords

ENZYME; FOSA ENZYME; FOSA3 ENZYME; FOSFOMYCIN; MONOMER; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; ESCHERICHIA COLI PROTEIN; FOSA(3) PROTEIN, E COLI; POTASSIUM;

AMINO ACID SEQUENCE; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; CATALYST; CATALYTIC EFFICIENCY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEUTERIUM HYDROGEN EXCHANGE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ESCHERICHIA COLI; KINETIC PARAMETERS; KLEBSIELLA PNEUMONIAE; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; PSEUDOMONAS AERUGINOSA; WESTERN BLOTTING; CHEMISTRY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MICROBIAL SENSITIVITY TEST; PHYSIOLOGY; PROTEIN MULTIMERIZATION; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DEUTERIUM EXCHANGE MEASUREMENT; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FOSFOMYCIN; GENE EXPRESSION REGULATION, BACTERIAL; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; MOLECULAR DYNAMICS SIMULATION; POTASSIUM; PROTEIN MULTIMERIZATION;

EID: 85032463025     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/aac.01572-17     Document Type: Article

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