Characterization of fosA5, A new plasmid-mediated fosfomycin resistance gene in Escherichia coli

Letters in Applied Microbiology

Volumn 60, Issue 3, 2015, Pages 259-264

  Ma, Y ^a   Xu, X ^a   Guo, Q ^a   Wang, P ^b   Wang, W ^a   Wang, M ^a  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

Author keywords

Escherichia coli; fos genes; Fosfomycin resistance; Target enzyme; Transport system

Indexed keywords

ANTIBIOTICS; CLONING; DNA; ENZYMES; GENES; POLYMERASE CHAIN REACTION;

CLINICAL STRAINS; DNA FRAGMENT; E. COLI; EXTENDED SPECTRUM Β-LACTAMASES; FOS GENE; FOSFOMYCIN; FOSFOMYCIN RESISTANCE; RESISTANCE GENES; TARGET ENZYME; TRANSPORT SYSTEMS;

ESCHERICHIA COLI;

AMIKACIN; CEPHALOSPORIN DERIVATIVE; CHLORAMPHENICOL; CIPROFLOXACIN; FOSFOMYCIN; GENTAMICIN; IMIPENEM; STREPTOMYCIN; SULFONAMIDE; TETRACYCLINE; ANTIINFECTIVE AGENT; BETA LACTAMASE; ESCHERICHIA COLI PROTEIN; FOSA5 PROTEIN, E COLI;

ANTIBIOTICS; CLONE; CONCENTRATION (COMPOSITION); DNA; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC STRUCTURE; MICROBIAL ACTIVITY; MUTATION; PLASMID; POLYMERASE CHAIN REACTION;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIUM CONJUGATION; ESCHERICHIA COLI; EXTENDED SPECTRUM BETA LACTAMASE PRODUCING ESCHERICHIA COLI; FOSA5 GENE; GENE AMPLIFICATION; GENE INSERTION SEQUENCE; KLEBSIELLA PNEUMONIAE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; DNA SEQUENCE; DRUG EFFECTS; ENZYMOLOGY; ESCHERICHIA COLI INFECTIONS; GENETICS; HUMAN; METABOLISM; MICROBIAL SENSITIVITY TEST; MOLECULAR GENETICS; PLASMID;

ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE;

ANTI-BACTERIAL AGENTS; BASE SEQUENCE; BETA-LACTAMASES; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; ESCHERICHIA COLI PROTEINS; FOSFOMYCIN; HUMANS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PLASMIDS; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA;

EID: 84923071261     PISSN: 02668254     EISSN: 1472765X     Source Type: Journal    
DOI: 10.1111/lam.12366     Document Type: Article

References (20)

1. Arca, P., Rico, M., Brana, A.F., Villar, C.J., Hardisson, C. and Suarez, J.E. (1988) Formation of an adduct between fosfomycin and glutathione: a new mechanism of antibiotic resistance in bacteria. Antimicrob Agents Chemother 32, 1552-1556.
2. Arca, P., Reguera, G. and Hardisson, C. (1997) Plasmid-encoded fosfomycin resistance in bacteria isolated from the urinary tract in a multicentre survey. J Antimicrob Chemother 40, 393-399.
3. Babini, G.S. and Livermore, D.M. (2000) Are SHV beta-lactamases universal in Klebsiella pneumoniae? Antimicrob Agents Chemother 44, 2230.
4. Blattner, F.R., Plunkett, G.R., Bloch, C.A., Perna, N.T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J.D. et al. (1997) The complete genome sequence of Escherichia coli K-12. Science 277, 1453-1462.
5. Carattoli, A., Bertini, A., Villa, L., Falbo, V., Hopkins, K.L. and Threlfall, E.J. (2005) Identification of plasmids by PCR-based replicon typing. J Microbiol Methods 63, 19-228.
6. Clinical and Laboratory Standards Institute. (2012). Performance standards for antimicrobial susceptibility testing; 22th informational supplement (M100-S22). Wayne, PA: Clinical and Laboratory Standards Institute.
7. Dumarche, P., De Champs, C., Sirot, D., Chanal, C., Bonnet, R. and Sirot, J. (2002) TEM derivative-producing Enterobacter aerogenes strains: dissemination of a prevalent clone. Antimicrob Agents Chemother 46, 1128-1131.
8. Falagas, M.E., Kastoris, A.C., Kapaskelis, A.M. and Karageorgopoulos, D.E. (2010) Fosfomycin for the treatment of multidrug-resistant, including extended-spectrum beta-lactamase producing, Enterobacteriaceae infections: a systematic review. Lancet Infect Dis 10, 43-50.
9. Ho, P., Chan, J., Lo, W., Lai, E., Cheung, Y., Lau, T. and Chow, K. (2013) Prevalence and molecular epidemiology of plasmid-mediated fosfomycin resistance genes among blood and urinary Escherichia coli isolates. J Clin Microbiol 62, 1707-1713.
10. Hou, J., Huang, X., Deng, Y., He, L., Yang, T., Zeng, Z., Chen, Z. and Liu, J.H. (2012) Dissemination of the fosfomycin resistance gene fosA3 with CTX-M beta-lactamase genes and rmtB carried on IncFII plasmids among Escherichia coli isolates from pets in China. Antimicrob Agents Chemother 56, 2135-2138.
11. Jacoby, G.A. and Han, P. (1996) Detection of extended-spectrum beta-lactamases in clinical isolates of Klebsiella pneumoniae and Escherichia coli. J Clin Microbiol 34, 908-911.
12. Karageorgopoulos, D.E., Wang, R., Yu, X.H. and Falagas, M.E. (2012) Fosfomycin: evaluation of the published evidence on the emergence of antimicrobial resistance in Gram-negative pathogens. J Antimicrob Chemother 67, 255-268.
13. Lee, S.Y., Park, Y.J., Yu, J.K., Jung, S., Kim, Y., Jeong, S.H. and Arakawa, Y. (2012) Prevalence of acquired fosfomycin resistance among extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae clinical isolates in Korea and IS26-composite transposon surrounding fosA3. J Antimicrob Chemother 67, 2843-2847.
14. Nakamura, G., Wachino, J., Sato, N., Kimura, K., Yamada, K., Jin, W., Shibayama, K., Yagi, T. et al. (2014) Practical agar-based disk potentiation test for detection of fosfomycin-nonsusceptible Escherichia coli clinical isolates producing glutathione S-transferases. J Clin Microbiol 52, 3175-3179.
15. CTX-M-24 from Klebsiella pneumoniae. J Antimicrob Chemother 62, 1252-1256.
16. Suarez, J.E. and Mendoza, M.C. (1991) Plasmid-encoded fosfomycin resistance. Antimicrob Agents Chemother 35, 791-795.
17. Takahata, S., Ida, T., Hiraishi, T., Sakakibara, S., Maebashi, K., Terada, S., Muratani, T., Matsumoto, T. et al. (2010) Molecular mechanisms of fosfomycin resistance in clinical isolates of Escherichia coli. Int J Antimicrob Agents 35, 333-337.
18. Wachino, J., Yamane, K., Suzuki, S., Kimura, K. and Arakawa, Y. (2010) Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes. Antimicrob Agents Chemother 54, 3061-3064.
19. Woodford, N., Fagan, E.J. and Ellington, M.J. (2006) Multiplex PCR for rapid detection of genes encoding CTX-M extended-spectrum (beta)-lactamases. J Antimicrob Chemother 57, 154-155.
20. Xu, H., Miao, V., Kwong, W., Xia, R. and Davies, J. (2011) Identification of a novel fosfomycin resistance gene (fosA2) in Enterobacter cloacae from the Salmon River, Canada. Lett Appl Microbiol 52, 427-429.