Functional analysis of active site residues of the fosfomycin resistance enzyme FosA from Pseudomonas aeruginosa

Journal of Biological Chemistry

Volumn 280, Issue 18, 2005, Pages 17786-17791

  Beharry, Zanna ^a   Palzkill, Timothy ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING ENERGY; CLONING; DRUG PRODUCTS; ESCHERICHIA COLI; HYDROGEN BONDS; MUTAGENESIS; PROTEINS;

ACTIVE SITE RESIDUES; ANTIBIOTIC FOSFOMYCIN; FUNCTIONAL ANALYSIS;

ENZYMES;

ALANINE; BACTERIAL ENZYME; CARBON; ETHYLENE OXIDE; FOSFOMYCIN; GLUTATHIONE; MANGANESE; OXYGEN; PHOSPHONIC ACID DERIVATIVE; POTASSIUM ION; PROTEIN FOSA; PROTEIN FOSX; SERINE; TRANSCRIPTION FACTOR FOSB; TYROSINE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; GLUTATHIONE TRANSFERASE;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; BINDING SITE; CODON; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ESCHERICHIA COLI; HYDROGEN BOND; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SITE DIRECTED MUTAGENESIS; CHEMISTRY; GENETICS; METABOLISM;

ESCHERICHIA COLI; PSEUDOMONAS AERUGINOSA;

BACTERIAL PROTEINS; BINDING SITES; DRUG RESISTANCE, MICROBIAL; ESCHERICHIA COLI; GLUTATHIONE TRANSFERASE; PSEUDOMONAS AERUGINOSA;

EID: 24044523194     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M501052200     Document Type: Article

References (36)

1. Nicolle, L. E. (2002) Am. J. Med. 113, 35S-44S
2. Grif, K., Dierich, M. P., Pfaller, K., Miglioli, P. A., and Allerberger, F. (2001) J. Antimicrob. Chemother. 48, 209-217
3. Monden, K., Ando, E., Iida, M., and Kumon, H. (2002) J. Infect. Chemother. 8, 218-226
4. Okazaki, M., Suzuki, K., Asano, N., Araki, K, Shukuya, N., Egami, T., Higurashi, Y., Morita, K., Uchimura, H., and Watanabe, T. (2002) J. Infect. Chemother. 8, 37-42
5. Arca, P., Hardisson, C., and Suarez, J. E. (1990) Antimicrob. Agents Chemother. 34, 844-848
6. Garcia, P., Arca, P., and Suarez, J. E. (1995) Antimicrob. Agents Chemother. 39, 1569-1573
7. Suarez, J. E., and Mendoza, M. C. (1991) Antimicrob. Agents Chemother. 35, 791-795
8. Shimizu, M., Shigenobu, F., Miyakozawa, I., Nakamura, A., Nakazawa, K., Suzuki, M., Mizukoshi, S., O'Hara, K, and Sawai, T. (2000) Antimicrob. Agents Chemother. 44, 2007-2008
9. Leon, J., Garcia-Lobo, J. M., and Ortiz, J. M. (1982) Antimicrob. Agents Chemother. 21, 608-612
10. Horii, T., Kimura, T., Sato, K., Shibayama, K, and Ohta, M. (1999) Antimicrob. Agents Chemother. 43, 789-793
11. Etienne, J., Gerbaud, G., Courvalin, P., and Fleurette, J. (1989) FEMS Microbiol. Lett. 52, 133-137
12. Arca, P., Reguera, G., and Hardisson, C. (1997) J. Antimicrob. Chemother. 40, 393-399
13. Arca, P., Rico, M., Brana, A. F., Villar, C. J., Hardisson, C., and Suarez, J. E. (1988) Antimicrob. Agents Chemother. 32, 1552-1556
14. Bernat, B. A., Laughlin, L. T., and Armstrong, R. A. (1997) Biochemistry 36, 3050-3055
15. Cao, M., Bernat, B. A., Wang, Z., Armstrong, R. N., and Helmann, J. D. (2001) J. Bacteriol. 183, 2380-2383
16. Bernat, B. A., Laughlin, L. T., and Armstrong, R. A. (1998) J. Org. Chem. 63, 3778-3780
17. Bernat, B. A., Laughlin, L. T., and Armstrong, R. A. (1999) Biochemistry 38, 7462-7469
18. Smoukov, S. K., Telser, J., Bernat, B. A., Rifer, C. L., Armstrong, R. A., and Hoffman, B. M. (2002) J. Am. Chem. Soc. 124, 2318-2326
19. Rife, C. L., Pharris, R. E., Newcomer, M. E., and Armstrong, R. N. (2002) J. Am. Chem. Soc. 124, 11001-11003
20. Armstrong, R. A. (2000) Biochemistry 39, 13625-13632
21. Babbitt, P. C., and Gerlt, J. A. (1997) J. Biol. Chem. 272, 30591-30594
22. Laughlin, L. T., Bernat, B. A., and Armstrong, R. A. (1998) Chem. Biol. Interact. 111-112, 41-50
23. Sheehan, D., Meade, G., Foley, V. M., and Dowd, C. A. (2001) Biochem. J. 360, 1-16
24. Armstrong, R. A. (1997) Chem. Res. Toxicol. 10, 2-18
25. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd Ed., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
26. Schagger, H., and von Jagow, G. (1987) Anal. Biochem. 166, 368-379
27. Petrosino, J., Rudgers, G., Gilbert, H., and Palzkill, T. (1999) J. Biol. Chem. 274, 2394-2400
28. Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K., and Pease, L. R. (1989) Gene (Amst.) 77, 51-59
29. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
30. Allerberger, F., and Klare, I. (1999) J. Antimicrob. Chemother. 43, 211-217
31. Ungheri, D., Albini, E., and Belluco, G. (2002) J. Chemother. 14, 237-240
32. Fillgrove, K. L., Pakhomova, S., Newcomer, M. E., and Armstrong, R. N. (2003) J. Am. Chem. Soc. 125, 15730-15731
33. Johnson, W. W., Liu, S., Ji, X., Gilliland, G. L., and Armstrong, R. N. (1993) J. Biol. Chem. 268, 11508-11511
34. Caccuri, A. M., Antonini, G., Allocati, N., Di Ilio, C., De Maria, F., Innocenti, F., Parker, M. W., Masulli, M., Lo Bello, M., Turella, P., Federici, G., and Ricci, G. (2002) J. Biol. Chem. 277, 18777-18784
35. Liu, S., Zhang, P., Ji, X., Johnson, W. W., Gilliland, G. L., and Armstrong, R. N. (1992) J. Biol. Chem. 267, 4296-4299
36. Corpet, F. (1988) Nucleic Acids Res. 16, 10881-10890