Association between plant-based diets and plasma lipids: A systematic review and meta-analysis

Nutrition Reviews

Volumn 75, Issue 9, 2017, Pages 683-698

  Yokoyama, Yoko ^a   Levin, Susan M ^b   Barnard, Neal D ^b,c  

^a KEIO UNIVERSITY   (Japan)

^b PHYSICIANS COMMITTEE FOR RESPONSIBLE MEDICINE   (United States)

^c GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

High density lipoprotein cholesterol; Low density lipoprotein cholesterol; Metaanalysis; Plant based diets; Plasma lipids; Systematic review; Total cholesterol

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ARTICLE; CHOLESTEROL BLOOD LEVEL; COCHRANE LIBRARY; CONTROLLED CLINICAL TRIAL (TOPIC); CORRELATION ANALYSIS; DIET; FOOD INTAKE; HUMAN; INTERVENTION STUDY; LIPID BLOOD LEVEL; LIPID METABOLISM; MEDLINE; META ANALYSIS; OBSERVATIONAL STUDY; SYSTEMATIC REVIEW; TRIACYLGLYCEROL BLOOD LEVEL; VEGETARIAN DIET; WEB OF SCIENCE; BLOOD; FACTUAL DATABASE; RANDOMIZED CONTROLLED TRIAL (TOPIC); VEGAN DIET;

CHOLESTEROL, HDL; CHOLESTEROL, LDL; DATABASES, FACTUAL; DIET, VEGAN; DIET, VEGETARIAN; HUMANS; OBSERVATIONAL STUDIES AS TOPIC; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TRIGLYCERIDES;

EID: 85031928328     PISSN: 00296643     EISSN: 17534887     Source Type: Journal    
DOI: 10.1093/nutrit/nux030     Document Type: Article

References (70)

1. Kuklina EV, Yoon PW, Keenan NL. Trends in high levels of low-density lipoprotein cholesterol in the United States, 1999-2006. JAMA. 2009;302:2104-2110
2. Farley TA, Dalal MA, Mostashari F, et al. Deaths preventable in the U.S. by improvements in use of clinical preventive services. Am J Prev Med. 2010;38:600-609
3. Pletcher MJ, Lazar L, Bibbins-Domingo K, et al. Comparing impact and costeffectiveness of primary prevention strategies for lipid-lowering. Ann Intern Med. 2009;150:243-254
4. Lemieux I, Lamarche B, Couillard C, et al. Total cholesterol/HDL cholesterol ratio vs LDL cholesterol/HDL cholesterol ratio as indices of ischemic heart disease risk in men: the Quebec Cardiovascular Study. Arch Intern Med. 2001;161:2685-2692
5. Stone NJ, Robinson JG, Lichtenstein AH, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;63(25 pt B):2889-2934
6. Ferdowsian HR, Barnard ND. Effects of plant-based diets on plasma lipids. Am J Cardiol. 2009;104:947-956
7. Wang F, Zheng J, Yang B, et al. Effects of vegetarian diets on blood lipids: a systematic review and meta-analysis of randomized controlled trials. J Am Heart Assoc. 2015;4:e002408. doi:10.1161/JAHA.115.002408
8. Follmann D, Elliott P, Suh I, et al. Variance imputation for overviews of clinical trials with continuous response. J Clin Epidemiol. 1992;45:769-773
9. Kontopantelis E, Reeves D. Performance of statistical methods for meta-analysis when true study effects are non-normally distributed: a comparison between DerSimonian-Laird and restricted maximum likelihood. Stat Methods Med Res. 2012;21:657-659
10. Sacks FM, Castelli WP, Donner A, et al. Plasma lipids and lipoproteins in vegetarians and controls. N Engl J Med. 1975;292:1148-1151
11. Burslem J, Schonfeld G, Howald MA, et al. Plasma apoprotein and lipoprotein lipid levels in vegetarians. Metabolism. 1978;27:711-719
12. Fisher M, Levine PH, Weiner B, et al. The effect of vegetarian diets on plasma-lipid and platelet levels. Arch Intern Med. 1986;146:1193-1197
13. Harman SK, Parnell WR. The nutritional health of New Zealand vegetarian and non-vegetarian Seventh-day Adventists: selected vitamin, mineral and lipid levels. N Z Med J. 1998;111:91-94
14. Moreira de Almeida Teixeira RdC, Bisi Molina MdC, Zandonade E, et al. Cardiovascular risk in vegetarians and omnivores: a comparative study. Arq Bras Cardiol. 2007;89:237-244
15. Lee HY, Woo J, Chen ZY, et al. Serum fatty acid, lipid profile and dietary intake of Hong Kong Chinese omnivores and vegetarians. Eur J Clin Nutr. 2000;54:768-773
16. Lu SC, Wu WH, Lee CA, et al. LDL of Taiwanese vegetarians are less oxidizable than those of omnivores. J Nutr. 2000;130:1591-1596
17. Fu C-H, Yang CCH, Lin C-L, et al. Alteration of cardiovascular autonomic functions by vegetarian diets in postmenopausal women is related to LDL cholesterol levels. Chin J Physiol. 2008;51:100-105
18. Kim MK, Cho SW, Park YK. Long-term vegetarians have low oxidative stress, body fat, and cholesterol levels. Nutr Res Pract. 2012;6:155-161
19. Yang S-Y, Zhang H-J, Sun S-Y, et al. Relationship of carotid intima-media thickness and duration of vegetarian diet in Chinese male vegetarians. Nutr Metabol (London). 2011;8:63. doi: 10.1186/1743-7075-8-63
20. Jung JG, Kang HW, Hahn SJ, et al. Vegetarianism as a protective factor for reflux esophagitis: a retrospective, cross-sectional study between Buddhist priests and general population. Dig Dis Sci. 2013;58:2244-2252
21. Liebman M, Bazzarre TL. Plasma lipids of vegetarian and nonvegetarian males: effects of egg consumption. Am J Clin Nutr. 1983;38:612-619
22. Chiang J-K, Lin Y-L, Chen C-L, et al. Reduced risk formetabolic syndrome and insulin resistance associated with ovo-lacto-vegetarian behavior in female Buddhists: a case-control study. PLoS One. 2013;8. doi:10.1371/journal.pone.007179
23. Knuiman JT, West CE. W. The concentration of cholesterol in serum and in various serum lipoproteins in macrobiotic, vegetarian and non-vegetarian men and boys. Atherosclerosis. 1982;43:71-82
24. Roshanai F, Sanders TA. Assessment of fatty acid intakes in vegans and omnivores. Hum Nutr Appl Nutr. 1984;38:345-354
25. Li D, Ball M, Bartlett M. Lipoprotein(a), essential fatty acid status and lipoprotein lipids in female Australian vegetarians. Clin Sci (London). 1999;97:175-181
26. Fernandes Dourado K, de Arruda Camara e Siqueira Campos F, Sakugava Shinohara NK. Relation between dietary and circulating lipids in lacto-ovo vegetarians. Nutr Hosp. 2011;26:959-964
27. Lin CL, Fang TC, Gueng MK. Vascular dilatory functions of ovo-lactovegetarians compared with omnivores. Atherosclerosis. 2001;158:247-251
28. Richter V, Purschwitz K, Bohusch A, et al. Lipoproteins and other clinical-chemistry parameters under the conditions of lacto-ovo-vegetarian nutrition. Nutr Res. 1999;19:545-554
29. Sanders TA, Roshanai F. Platelet phospholipid fatty-acid composition and function in vegans compared with age-matched and sex-matched omnivore controls. Eur J Clin Nutr. 1992;46:823-831
30. Nieman DC, Underwood BC, Sherman KM, et al. Dietary status of Seventh-Day Adventist vegetarian and non-vegetarian elderly women. J Am Diet Assoc. 1989;89:1763-1769
31. Chen C-W, Lin C-T, Lin Y-L, et al. Taiwanese female vegetarians have lower lipoprotein-associated phospholipase A2 compared with omnivores. Yonsei Med J. 2011;52:13-19
32. Huang Y-W, Jian Z-H, Chang H-C, et al. Vegan diet and blood lipid profiles: a cross-sectional study of pre and postmenopausal women. BMC Womens Health. 2014;14. doi:10.1186/1472-6874-14-55
33. Jian Z-H, Chiang Y-C, Lung C-C, et al. Vegetarian diet and cholesterol and TAG levels by gender. Public Health Nutr. 2015;18:721-726
34. Krajcovicova-Kudlackova M, Simoncic R, Bederova A, et al. Selected parameters of lipid-metabolism in young vegetarians. Ann Nutr Metabol. 1994;38:331-335
35. GoffLM, Bell JD, So PW, et al. Veganism and its relationship with insulin resistance and intramyocellular lipid. Eur J Clin Nutr. 2005;59:291-298
36. Karabudak E, Kiziltan G, Cigerim N. A comparison of some of the cardiovascular risk factors in vegetarian and omnivorous Turkish females. J Human Nutr Diet. 2008;21:13-22
37. Nestel PJ, Billington T, Smith B. Low density and high density lipoprotein kinetics and sterol balance in vegetarians. Metabolism. 1981;30:941-945
38. Gojda J, Patkova J, Jacek M, et al. Higher insulin sensitivity in vegans is not associated with higher mitochondrial density. Eur J Clin Nutr. 2013;67:1310-1315
39. Huijbregts AW, Van Schaik A, Van Berge-Henegouwen GP, et al. Serum lipids, biliary lipid composition, and bile acid metabolism in vegetarians as compared to normal controls. Eur J Clin Invest. 1980;10:443-449
40. de Mello VDF, Zelmanovitz T, Perassolo MS, et al. Withdrawal of red meat from the usual diet reduces albuminuria and improves serum fatty acid profile in type 2 diabetes patients with macroalbuminuria. Am J Clin Nutr. 2006;83:1032-1038
41. Elkan AC, Sjöberg B, Kolsrud B, et al. Gluten-free vegan diet induces decreased LDL and oxidized LDL levels and raised atheroprotective natural antibodies against phosphorylcholine in patients with rheumatoid arthritis: a randomized study. Arthritis Res Therapy. 2008;10:R34. doi:10.1186/ar2388
42. Ornish D, Scherwitz LW, Billings JH, et al. Intensive lifestyle changes for reversal of coronary heart disease. JAMA. 1998;280:2001-2007
43. Gardner CD, Coulston A, Chatterjee L, et al. The effect of a plant-based diet on plasma lipids in hypercholesterolemic adults-a randomized trial. Ann Intern Med. 2005;142:725-733
44. Kestin M, Rouse IL, Correll RA, et al. Cardiovascular disease risk factors in freeliving men: comparison of two prudent diets, one based on lactoovovegetarianism and the other allowing lean meat. Am J Clin Nutr. 1989;50:280-287
45. Barnard ND, Scialli AR, Bertron P, et al. Effectiveness of a low-fat vegetarian diet in altering serum lipids in healthy premenopausal women. Am J Cardiol. 2000;85:969-972
46. Agren JJ, Tvrzicka E, Nenonen MT, et al. Divergent changes in serumsterols during a strict uncooked vegan diet in patients with rheumatoid arthritis. Br J Nutr. 2001;85:137-139
47. Bunner AE, Agarwal U, Gonzales JF, et al. Nutrition intervention for migraine: a randomized crossover trial. J Headache Pain. 2014;15:69. doi:10.1186/1129-2377-15-69
48. Kahleova H, Matoulek M, Bratova M, et al. Vegetarian diet-induced increase in linoleic acid in serum phospholipids is associated with improved insulin sensitivity in subjects with type 2 diabetes. Nutr Diabetes. 2013;3:e75. doi:10.1038/nutd.2013.12
49. Barnard ND, Cohen J, Jenkins DJ, et al. A low-fat vegan diet and a conventional diabetes diet in the treatment of type 2 diabetes: a randomized, controlled, 74-wk clinical trial. Am J Clin Nutr. 2009;89:1588s-1596s
50. Burke LE, Hudson AG, Warziski MT, et al. Effects of a vegetarian diet and treatment preference on biochemical and dietary variables in overweight and obese adults: a randomized clinical trial. Am J Clin Nutr. 2007;86:588-596
51. Ferdowsian HR, Barnard ND, Hoover VJ, et al. A multicomponent intervention reduces body weight and cardiovascular risk at a GEICO corporate site. Am J Health Promot. 2010;24:384-387
52. Mishra S, Xu J, Agarwal U, et al. A multicenter randomized controlled trial of a plant-based nutrition program to reduce body weight and cardiovascular risk in the corporate setting: the GEICO study. Eur J Clin Nutr. 2013;67:718-724
53. Nicholson AS, Sklar M, Barnard ND, et al. Toward improved management of NIDDM: a randomized, controlled, pilot intervention using a lowfat, vegetarian diet. Prev Med. 1999;29:87-91
54. LingWH, Laitinen M, Hanninen O. Shifting from conventional diet to an uncooked vegan diet reversibly alters serum lipid and apolipoprotein levels. Nutr Res. 1992;122:1431-1440
55. Aldana SG, Greenlaw R, Salberg A, et al. The effects of an intensive lifestyle modification program on carotid artery intima-media thickness: a randomized trial. Am J Health Promot. 2007;21:510-516
56. Miller M, Beach V, Sorkin JD, et al. Comparative effects of three popular diets on lipids, endothelial function, and C-reactive protein during weight maintenance. J Am Diet Assoc. 2009;109:713-717
57. Gardner CD, Kiazand A, Alhassan S, et al. Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women. JAMA. 2007;297:969-977
58. Dansinger ML, Gleason JA, Griffith JL, et al. Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction. JAMA. 2005;293:43-53
59. Michael B, Larry VH, Julian PT. Introduction to Meta-analysis. Chichester, UK: John Wiley & Sons Ltd; 2009
60. Law MR, Wald NJ, Rudnicka AR. Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis. BMJ. 2003;326:1423. doi:https://doi.org/10.1136/bmj.326.7404. 1423
61. Appleby PN, Key TJ. The long-term health of vegetarians and vegans. Proc Nutr Soc. 2016;75:287-293
62. Keys A, Anderson JT, Grande F. Serum cholesterol response to changes in the diet: IV. Particular saturated fatty acids in the diet. Metabolism. 1965;14:776-787
63. Hegsted DM. Serum-cholesterol response to dietary cholesterol: a re-evaluation. Am J Clin Nutr. 1986;44:299-305
64. de Souza RJ, Mente A, Maroleanu A, et al. Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies. BMJ. 2015;351:h3978. doi: https://doi.org/10.1136/bmj.h3978
65. Hopkins PN. Effects of dietary cholesterol on serum cholesterol: a meta-analysis and review. Am J Clin Nutr. 1992;55:1060-1070
66. Emerging Risk Factors Collaboration, Di Angelantonio E, Sarwar N, et al. Major lipids, apolipoproteins, and risk of vascular disease. JAMA. 2009;302:1993-2000
67. Keene D, Price C, Shun-Shin MJ, et al. Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: metaanalysis of randomised controlled trials including 117,411 patients. BMJ. 2014;349:g4379. doi:10.1136/bmj.g4379
68. Frikke-Schmidt R, Nordestgaard BG, Stene MC, et al. Association of loss-offunction mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic heart disease. JAMA. 2008;299:2524-2532
69. US Department of Health and Human Services and US Department of Agriculture. 2015-2020 Dietary Guidelines for Americans. 8th ed. http://health.gov/dietarygui delines/2015/guidelines/. Published 2015. Accessed February 16, 2017
70. Jenkins DJ, Kendall CW, Marchie A, et al. Effects of a dietary portfolio of cholesterol-lowering foods vs lovastatin on serum lipids and C-reactive protein. JAMA. 2003;290:502-510