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Volumn 17, Issue 1, 2017, Pages

The evidence base for circulating tumour DNA blood-based biomarkers for the early detection of cancer: A systematic mapping review

(13)  Cree, Ian A a,b,c   Uttley, Lesley d   Buckley Woods, Helen d   Kikuchi, Hugh e   Reiman, Anne b   Harnan, Susan d   Whiteman, Becky L f   Philips, Sian Taylor g   Messenger, Michael h   Cox, Angela i   Teare, Dawn d   Sheils, Orla j   Shaw, Jacqui k  


Author keywords

Cancer; CfDNA; CtDNA; Detection; Diagnosis; Liquid biopsy

Indexed keywords

ADAM PROTEIN; B RAF KINASE; BASONUCLIN; BRCA1 PROTEIN; CHLOROPLAST DNA; CYCLOPHILIN A; CYSTEINE DIOXYGENASE; E1A ASSOCIATED P300 PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FRAGILE HISTIDINE TRIAD PROTEIN; GLUTATHIONE TRANSFERASE P1; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MITOCHONDRIAL DNA; MUTL PROTEIN HOMOLOG 1; MYOD1 PROTEIN; PENDRIN; PROTEIN P21; PROTEIN P53; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; SECRETED FRIZZLED RELATED PROTEIN 5; SEPTIN; SODIUM GLUCOSE COTRANSPORTER; TELOMERASE REVERSE TRANSCRIPTASE; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TRANSCRIPTION FACTOR RUNX3; TRANSCRIPTION FACTOR SOX17; UNINDEXED DRUG; UVOMORULIN; VASCULOTROPIN; VON HIPPEL LINDAU PROTEIN; CIRCULATING TUMOR DNA; TUMOR MARKER;

EID: 85031914389     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/s12885-017-3693-7     Document Type: Article
Times cited : (89)

References (128)
  • 1
    • 85027947063 scopus 로고    scopus 로고
    • Stage at diagnosis and early mortality from cancer in England
    • McPhail S, et al. Stage at diagnosis and early mortality from cancer in England. Br J Cancer. 2015;112 Suppl 1:S108-15.
    • (2015) Br J Cancer. , vol.112 , pp. S108-S115
    • McPhail, S.1
  • 2
    • 84871722734 scopus 로고    scopus 로고
    • Tumor markers in clinical practice: a review focusing on common solid cancers
    • Duffy MJ. Tumor markers in clinical practice: a review focusing on common solid cancers. Med Princ Pract. 2013;22(1):4-11.
    • (2013) Med Princ Pract , vol.22 , Issue.1 , pp. 4-11
    • Duffy, M.J.1
  • 3
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646-74.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 4
    • 82255173787 scopus 로고    scopus 로고
    • Improved blood tests for cancer screening: general or specific?
    • Cree IA. Improved blood tests for cancer screening: general or specific? BMC Cancer. 2011;11:499.
    • (2011) BMC Cancer , vol.11 , pp. 499
    • Cree, I.A.1
  • 5
    • 0342618532 scopus 로고    scopus 로고
    • Presence of fetal DNA in maternal plasma and serum
    • Lo YM, et al. Presence of fetal DNA in maternal plasma and serum. Lancet. 1997;350(9076):485-7.
    • (1997) Lancet , vol.350 , Issue.9076 , pp. 485-487
    • Lo, Y.M.1
  • 6
    • 0036320933 scopus 로고    scopus 로고
    • Plasma nucleic acids in the diagnosis and management of malignant disease
    • Johnson PJ, Lo YM. Plasma nucleic acids in the diagnosis and management of malignant disease. Clin Chem. 2002;48(8):1186-93.
    • (2002) Clin Chem , vol.48 , Issue.8 , pp. 1186-1193
    • Johnson, P.J.1    Lo, Y.M.2
  • 7
    • 84917709184 scopus 로고    scopus 로고
    • A novel Alu-based real-time PCR method for the quantitative detection of plasma circulating cell-free DNA: sensitivity and specificity for the diagnosis of myocardial infarction
    • Lou X, et al. A novel Alu-based real-time PCR method for the quantitative detection of plasma circulating cell-free DNA: sensitivity and specificity for the diagnosis of myocardial infarction. Int J Mol Med. 2015;35(1):72-80.
    • (2015) Int J Mol Med , vol.35 , Issue.1 , pp. 72-80
    • Lou, X.1
  • 8
    • 33847129200 scopus 로고    scopus 로고
    • Circulating (cell-free) nucleic acids--a promising, non-invasive tool for early detection of several human diseases
    • Swarup V, Rajeswari MR. Circulating (cell-free) nucleic acids--a promising, non-invasive tool for early detection of several human diseases. FEBS Lett. 2007;581(5):795-9.
    • (2007) FEBS Lett , vol.581 , Issue.5 , pp. 795-799
    • Swarup, V.1    Rajeswari, M.R.2
  • 9
    • 84920545864 scopus 로고    scopus 로고
    • Noninvasive prenatal diagnosis: from dream to reality
    • Lo YM. Noninvasive prenatal diagnosis: from dream to reality. Clin Chem. 2015;61(1):32-7.
    • (2015) Clin Chem , vol.61 , Issue.1 , pp. 32-37
    • Lo, Y.M.1
  • 10
    • 84952719744 scopus 로고    scopus 로고
    • Assessment of DNA integrity, applications for cancer research
    • Zonta E, Nizard P, Taly V. Assessment of DNA integrity, applications for cancer research. Adv Clin Chem. 2015;70:197-246.
    • (2015) Adv Clin Chem , vol.70 , pp. 197-246
    • Zonta, E.1    Nizard, P.2    Taly, V.3
  • 11
    • 78650207098 scopus 로고    scopus 로고
    • Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus
    • Lo YM, et al. Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus. Sci Transl Med. 2010;2(61):61ra91.
    • (2010) Sci Transl Med , vol.2 , Issue.61 , pp. 61ra91
    • Lo, Y.M.1
  • 12
    • 84877806778 scopus 로고    scopus 로고
    • Establishment of tumor-specific copy number alterations from plasma DNA of patients with cancer
    • Heitzer E, et al. Establishment of tumor-specific copy number alterations from plasma DNA of patients with cancer. Int J Cancer. 2013;133(2):346-56.
    • (2013) Int J Cancer , vol.133 , Issue.2 , pp. 346-356
    • Heitzer, E.1
  • 13
    • 84985915610 scopus 로고    scopus 로고
    • Building the evidence base of blood-based biomarkers for early detection of cancer: a rapid systematic mapping review
    • Uttley L, et al. Building the evidence base of blood-based biomarkers for early detection of cancer: a rapid systematic mapping review. EBioMedicine. 2016;10:164-73.
    • (2016) EBioMedicine , vol.10 , pp. 164-173
    • Uttley, L.1
  • 14
    • 79954431896 scopus 로고    scopus 로고
    • Detection of HER2 amplification in circulating free DNA in patients with breast cancer
    • Page K, et al. Detection of HER2 amplification in circulating free DNA in patients with breast cancer. Br J Cancer. 2011;104(8):1342-8.
    • (2011) Br J Cancer , vol.104 , Issue.8 , pp. 1342-1348
    • Page, K.1
  • 15
    • 84945925969 scopus 로고    scopus 로고
    • Detection of clonal and subclonal copy-number variants in cell-free DNA from patients with breast cancer using a massively multiplexed PCR methodology
    • Kirkizlar E, et al. Detection of clonal and subclonal copy-number variants in cell-free DNA from patients with breast cancer using a massively multiplexed PCR methodology. Transl Oncol. 2015;8(5):407-16.
    • (2015) Transl Oncol , vol.8 , Issue.5 , pp. 407-416
    • Kirkizlar, E.1
  • 16
    • 84896371874 scopus 로고    scopus 로고
    • Detection of circulating tumor DNA in early- and late-stage human malignancies
    • Bettegowda C, et al. Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med. 2014;6(224):224ra24.
    • (2014) Sci Transl Med , vol.6 , Issue.224 , pp. 224
    • Bettegowda, C.1
  • 17
    • 84898786810 scopus 로고    scopus 로고
    • Analytical validation of BRAF mutation testing from circulating free DNA using the amplification refractory mutation testing system
    • Aung KL, et al. Analytical validation of BRAF mutation testing from circulating free DNA using the amplification refractory mutation testing system. J Mol Diagn. 2014;16(3):343-9.
    • (2014) J Mol Diagn , vol.16 , Issue.3 , pp. 343-349
    • Aung, K.L.1
  • 18
    • 77950689916 scopus 로고    scopus 로고
    • Detection of PIK3CA mutations in circulating free DNA in patients with breast cancer
    • Board, R.E., et al., Detection of PIK3CA mutations in circulating free DNA in patients with breast cancer. Breast Cancer Res Treat, 2010. 120(2): p. 461-467.
    • (2010) Breast Cancer Res Treat , vol.120 , Issue.2 , pp. 461-467
    • Board, R.E.1
  • 19
    • 84903692972 scopus 로고    scopus 로고
    • Plasma DNA integrity as a biomarker for primary and metastatic breast cancer and potential marker for early diagnosis
    • Madhavan D, et al. Plasma DNA integrity as a biomarker for primary and metastatic breast cancer and potential marker for early diagnosis. Breast Cancer Res Treat. 2014;146(1):163-74.
    • (2014) Breast Cancer Res Treat , vol.146 , Issue.1 , pp. 163-174
    • Madhavan, D.1
  • 20
    • 79960266530 scopus 로고    scopus 로고
    • Circulating tumour markers can define patients with normal colons, benign polyps, and cancers
    • Mead R, et al. Circulating tumour markers can define patients with normal colons, benign polyps, and cancers. Br J Cancer. 2011;105(2):239-45.
    • (2011) Br J Cancer , vol.105 , Issue.2 , pp. 239-245
    • Mead, R.1
  • 21
    • 84938055998 scopus 로고    scopus 로고
    • Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial
    • Tabernero J, et al. Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial. Lancet Oncol. 2015;16(8):937-48.
    • (2015) Lancet Oncol , vol.16 , Issue.8 , pp. 937-948
    • Tabernero, J.1
  • 22
    • 84867560594 scopus 로고    scopus 로고
    • Circulating cell-free DNA: a promising marker of regional lymphonode metastasis in breast cancer patients
    • Agostini M, et al. Circulating cell-free DNA: a promising marker of regional lymphonode metastasis in breast cancer patients. Cancer Biomark. 2012;11(2-3):89-98.
    • (2012) Cancer Biomark , vol.11 , Issue.2-3 , pp. 89-98
    • Agostini, M.1
  • 23
    • 84908672066 scopus 로고    scopus 로고
    • Circulating cell-free DNA in serum as a biomarker for diagnosis and prognostic prediction of colorectal cancer
    • Hao TB, et al. Circulating cell-free DNA in serum as a biomarker for diagnosis and prognostic prediction of colorectal cancer. Br J Cancer. 2014;111(8):1482-9.
    • (2014) Br J Cancer , vol.111 , Issue.8 , pp. 1482-1489
    • Hao, T.B.1
  • 24
    • 84887611777 scopus 로고    scopus 로고
    • Circulating cell-free DNA, SLC5A8 and SLC26A4 hypermethylation, BRAF(V600E): a non-invasive tool panel for early detection of thyroid cancer
    • Zane M, et al. Circulating cell-free DNA, SLC5A8 and SLC26A4 hypermethylation, BRAF(V600E): a non-invasive tool panel for early detection of thyroid cancer. Biomed Pharmacother. 2013;67(8):723-30.
    • (2013) Biomed Pharmacother , vol.67 , Issue.8 , pp. 723-730
    • Zane, M.1
  • 25
    • 84929049678 scopus 로고    scopus 로고
    • Evaluation of cell-free DNA as a biomarker for pancreatic malignancies
    • Sikora K, et al. Evaluation of cell-free DNA as a biomarker for pancreatic malignancies. Int J Biol Markers. 2014:e136-41.
    • (2014) Int J Biol Markers
    • Sikora, K.1
  • 26
    • 84863146536 scopus 로고    scopus 로고
    • Cell-free DNA in blood is a potential diagnostic biomarker of breast cancer
    • Gong B, et al. Cell-free DNA in blood is a potential diagnostic biomarker of breast cancer. Oncol Lett. 2012;3(4):897-900.
    • (2012) Oncol Lett , vol.3 , Issue.4 , pp. 897-900
    • Gong, B.1
  • 27
    • 34548596600 scopus 로고    scopus 로고
    • Elevated level of cell-free plasma DNA is associated with breast cancer
    • Zhong XY, et al. Elevated level of cell-free plasma DNA is associated with breast cancer. Arch Gynecol Obstet. 2007;276(4):327-31.
    • (2007) Arch Gynecol Obstet , vol.276 , Issue.4 , pp. 327-331
    • Zhong, X.Y.1
  • 28
    • 52249100773 scopus 로고    scopus 로고
    • Parallel assessment of circulatory cell-free DNA by PCR and nucleosomes by ELISA in breast tumors
    • Seefeld M, et al. Parallel assessment of circulatory cell-free DNA by PCR and nucleosomes by ELISA in breast tumors. Int J Biol Markers. 2008;23(2):69-73.
    • (2008) Int J Biol Markers , vol.23 , Issue.2 , pp. 69-73
    • Seefeld, M.1
  • 29
    • 34447324901 scopus 로고    scopus 로고
    • Levels of circulating cell-free serum DNA in benign and malignant breast lesions
    • Zanetti-Dallenbach RA, et al. Levels of circulating cell-free serum DNA in benign and malignant breast lesions. Int J Biol Markers. 2007;22(2):95-9.
    • (2007) Int J Biol Markers , vol.22 , Issue.2 , pp. 95-99
    • Zanetti-Dallenbach, R.A.1
  • 30
    • 84901468108 scopus 로고    scopus 로고
    • Circulating free DNA in a screening program for early colorectal cancer detection
    • Perrone F, et al. Circulating free DNA in a screening program for early colorectal cancer detection. Tumori. 2014;100(2):115-21.
    • (2014) Tumori , vol.100 , Issue.2 , pp. 115-121
    • Perrone, F.1
  • 31
    • 40549120297 scopus 로고    scopus 로고
    • PAI-1, t-PA and circulating hTERT DNA as related to virus infection in liver carcinogenesis
    • Divella R, et al. PAI-1, t-PA and circulating hTERT DNA as related to virus infection in liver carcinogenesis. Anticancer Res. 2008;28(1A):223-8.
    • (2008) Anticancer Res , vol.28 , Issue.1A , pp. 223-228
    • Divella, R.1
  • 32
    • 80051804456 scopus 로고    scopus 로고
    • Quantification of plasma hTERT DNA in hepatocellular carcinoma patients by quantitative fluorescent polymerase chain reaction
    • Yang YJ, et al. Quantification of plasma hTERT DNA in hepatocellular carcinoma patients by quantitative fluorescent polymerase chain reaction. Clin Invest Med. 2011;34(4):E238.
    • (2011) Clin Invest Med , vol.34 , Issue.4
    • Yang, Y.J.1
  • 33
    • 84960503648 scopus 로고    scopus 로고
    • Assessment of the total cfDNA and HPV16/18 detection in plasma samples of head and neck squamous cell carcinoma patients
    • Mazurek AM, et al. Assessment of the total cfDNA and HPV16/18 detection in plasma samples of head and neck squamous cell carcinoma patients. Oral Oncol. 2016;54:36-41.
    • (2016) Oral Oncol , vol.54 , pp. 36-41
    • Mazurek, A.M.1
  • 34
    • 84880835793 scopus 로고    scopus 로고
    • Ultradeep sequencing detects GNAQ and GNA11 mutations in cell-free DNA from plasma of patients with uveal melanoma
    • Metz CH, et al. Ultradeep sequencing detects GNAQ and GNA11 mutations in cell-free DNA from plasma of patients with uveal melanoma. Cancer Med. 2013;2(2):208-15.
    • (2013) Cancer Med , vol.2 , Issue.2 , pp. 208-215
    • Metz, C.H.1
  • 35
    • 84871630944 scopus 로고    scopus 로고
    • Mutation-based detection and monitoring of cell-free tumor DNA in peripheral blood of cancer patients
    • Benesova L, et al. Mutation-based detection and monitoring of cell-free tumor DNA in peripheral blood of cancer patients. Anal Biochem. 2013;433(2):227-34.
    • (2013) Anal Biochem , vol.433 , Issue.2 , pp. 227-234
    • Benesova, L.1
  • 36
    • 84881479047 scopus 로고    scopus 로고
    • Liquid biopsy: monitoring cancer-genetics in the blood
    • Crowley E, et al. Liquid biopsy: monitoring cancer-genetics in the blood. Nat Rev Clin Oncol. 2013;10(8):472-84.
    • (2013) Nat Rev Clin Oncol , vol.10 , Issue.8 , pp. 472-484
    • Crowley, E.1
  • 37
    • 84993967978 scopus 로고    scopus 로고
    • Cell-free DNA as a diagnostic marker for cancer: current insights
    • Salvi S, et al. Cell-free DNA as a diagnostic marker for cancer: current insights. Onco Targets Ther. 2016;9:6549-59.
    • (2016) Onco Targets Ther , vol.9 , pp. 6549-6559
    • Salvi, S.1
  • 38
    • 84908491991 scopus 로고    scopus 로고
    • Guidance for laboratories performing molecular pathology for cancer patients
    • Cree IA, et al. Guidance for laboratories performing molecular pathology for cancer patients. J Clin Pathol. 2014;67(11):923-31.
    • (2014) J Clin Pathol , vol.67 , Issue.11 , pp. 923-931
    • Cree, I.A.1
  • 39
    • 84948669109 scopus 로고    scopus 로고
    • STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies
    • Bossuyt PM, et al. STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies. Clin Chem. 2015;61(12):1446-52.
    • (2015) Clin Chem , vol.61 , Issue.12 , pp. 1446-1452
    • Bossuyt, P.M.1
  • 40
    • 84884130685 scopus 로고    scopus 로고
    • Colorectal cancer screening with blood-based biomarkers: cost-effectiveness of methylated septin 9 DNA versus current strategies
    • Ladabaum U, et al. Colorectal cancer screening with blood-based biomarkers: cost-effectiveness of methylated septin 9 DNA versus current strategies. Cancer Epidemiol Biomark Prev. 2013;22(9):1567-76.
    • (2013) Cancer Epidemiol Biomark Prev , vol.22 , Issue.9 , pp. 1567-1576
    • Ladabaum, U.1
  • 41
    • 84920508228 scopus 로고    scopus 로고
    • Circulating tumor DNA as a liquid biopsy for cancer
    • Heitzer E, Ulz P, Geigl JB. Circulating tumor DNA as a liquid biopsy for cancer. Clin Chem. 2015;61(1):112-23.
    • (2015) Clin Chem , vol.61 , Issue.1 , pp. 112-123
    • Heitzer, E.1    Ulz, P.2    Geigl, J.B.3
  • 42
    • 84941762500 scopus 로고    scopus 로고
    • Circulating free DNA as non-invasive diagnostic biomarker for childhood solid tumors
    • Kurihara S, et al. Circulating free DNA as non-invasive diagnostic biomarker for childhood solid tumors. J Pediatr Surg. 2015;50(12):2094-7.
    • (2015) J Pediatr Surg , vol.50 , Issue.12 , pp. 2094-2097
    • Kurihara, S.1
  • 43
    • 84931287940 scopus 로고    scopus 로고
    • Noninvasive monitoring of diffuse large B-cell lymphoma by immunoglobulin high-throughput sequencing
    • Kurtz DM, et al. Noninvasive monitoring of diffuse large B-cell lymphoma by immunoglobulin high-throughput sequencing. Blood. 2015;125(24):3679-87.
    • (2015) Blood , vol.125 , Issue.24 , pp. 3679-3687
    • Kurtz, D.M.1
  • 44
    • 84903218109 scopus 로고    scopus 로고
    • An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage
    • Newman AM, et al. An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage. Nat Med. 2014;20(5):548-54.
    • (2014) Nat Med , vol.20 , Issue.5 , pp. 548-554
    • Newman, A.M.1
  • 45
    • 84930532904 scopus 로고    scopus 로고
    • Rapid identification of plasma DNA samples with increased ctDNA levels by a modified FAST-SeqS approach
    • Belic J, et al. Rapid identification of plasma DNA samples with increased ctDNA levels by a modified FAST-SeqS approach. Clin Chem. 2015;61(6):838-49.
    • (2015) Clin Chem , vol.61 , Issue.6 , pp. 838-849
    • Belic, J.1
  • 46
    • 84910024271 scopus 로고    scopus 로고
    • Improved sensitivity of circulating tumor DNA measurement using short PCR amplicons
    • Andersen RF, et al. Improved sensitivity of circulating tumor DNA measurement using short PCR amplicons. Clin Chim Acta. 2015;439:97-101.
    • (2015) Clin Chim Acta , vol.439 , pp. 97-101
    • Andersen, R.F.1
  • 47
    • 66749190952 scopus 로고    scopus 로고
    • CpG island hypermethylation of cell-free circulating serum DNA in patients with testicular cancer
    • Ellinger J, et al. CpG island hypermethylation of cell-free circulating serum DNA in patients with testicular cancer. J Urol. 2009;182(1):324-9.
    • (2009) J Urol , vol.182 , Issue.1 , pp. 324-329
    • Ellinger, J.1
  • 48
    • 56149088621 scopus 로고    scopus 로고
    • Quantitative detection of methylated ESR1 and 14-3-3-sigma gene promoters in serum as candidate biomarkers for diagnosis of breast cancer and evaluation of treatment efficacy
    • Martinez-Galan J, et al. Quantitative detection of methylated ESR1 and 14-3-3-sigma gene promoters in serum as candidate biomarkers for diagnosis of breast cancer and evaluation of treatment efficacy. Cancer Biol Ther. 2008;7(6):958-65.
    • (2008) Cancer Biol Ther , vol.7 , Issue.6 , pp. 958-965
    • Martinez-Galan, J.1
  • 49
    • 84867184362 scopus 로고    scopus 로고
    • Methylation profiling of normal individuals reveals mosaic promoter methylation of cancer-associated genes
    • Kristensen LS, et al. Methylation profiling of normal individuals reveals mosaic promoter methylation of cancer-associated genes. Oncotarget. 2012;3(4):450-61.
    • (2012) Oncotarget , vol.3 , Issue.4 , pp. 450-461
    • Kristensen, L.S.1
  • 50
    • 84885704404 scopus 로고    scopus 로고
    • Influence of plasma processing on recovery and analysis of circulating nucleic acids
    • Page K, et al. Influence of plasma processing on recovery and analysis of circulating nucleic acids. PLoS One. 2013;8(10):e77963.
    • (2013) PLoS One , vol.8 , Issue.10
    • Page, K.1
  • 51
    • 85006516024 scopus 로고    scopus 로고
    • A comparison of cell-free DNA isolation kits: isolation and quantification of cell-free DNA in plasma
    • Sorber L, et al. A comparison of cell-free DNA isolation kits: isolation and quantification of cell-free DNA in plasma. J Mol Diagn. 2017;19(1):162-8.
    • (2017) J Mol Diagn , vol.19 , Issue.1 , pp. 162-168
    • Sorber, L.1
  • 52
    • 84946719441 scopus 로고    scopus 로고
    • Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma
    • De Mattos-Arruda L, et al. Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma. Nat Commun. 2015;6:8839.
    • (2015) Nat Commun , vol.6 , pp. 8839
    • De Mattos-Arruda, L.1
  • 53
    • 33749557860 scopus 로고    scopus 로고
    • Comparative analysis of mesenteric and peripheral blood circulating tumor DNA in colorectal cancer patients
    • Taback B, Saha S, Hoon DS. Comparative analysis of mesenteric and peripheral blood circulating tumor DNA in colorectal cancer patients. Ann N Y Acad Sci. 2006;1075:197-203.
    • (2006) Ann N Y Acad Sci , vol.1075 , pp. 197-203
    • Taback, B.1    Saha, S.2    Hoon, D.S.3
  • 54
    • 84942519785 scopus 로고    scopus 로고
    • Diagnostic accuracy of noninvasive genotyping of EGFR in lung cancer patients by deep sequencing of plasma cell-free DNA
    • Uchida J, et al. Diagnostic accuracy of noninvasive genotyping of EGFR in lung cancer patients by deep sequencing of plasma cell-free DNA. Clin Chem. 2015;61(9):1191-6.
    • (2015) Clin Chem , vol.61 , Issue.9 , pp. 1191-1196
    • Uchida, J.1
  • 55
    • 85027949239 scopus 로고    scopus 로고
    • Identification of circulating tumor DNA for the early detection of small-cell lung cancer
    • Fernandez-Cuesta L, et al. Identification of circulating tumor DNA for the early detection of small-cell lung cancer. EBioMedicine. 2016;10:117-23.
    • (2016) EBioMedicine , vol.10 , pp. 117-123
    • Fernandez-Cuesta, L.1
  • 56
    • 85039764762 scopus 로고    scopus 로고
    • Methylation of cell-free circulating DNA in the diagnosis of cancer
    • Warton K, Samimi G. Methylation of cell-free circulating DNA in the diagnosis of cancer. Front Mol Biosci. 2015;2:13.
    • (2015) Front Mol Biosci , vol.2 , pp. 13
    • Warton, K.1    Samimi, G.2
  • 57
    • 77955442473 scopus 로고    scopus 로고
    • From discovery to the clinic: the novel DNA methylation biomarker (m)SEPT9 for the detection of colorectal cancer in blood
    • Payne SR. From discovery to the clinic: the novel DNA methylation biomarker (m)SEPT9 for the detection of colorectal cancer in blood. Epigenomics. 2010;2(4):575-85.
    • (2010) Epigenomics , vol.2 , Issue.4 , pp. 575-585
    • Payne, S.R.1
  • 58
    • 84891743167 scopus 로고    scopus 로고
    • Prospective evaluation of methylated SEPT9 in plasma for detection of asymptomatic colorectal cancer
    • Church TR, et al. Prospective evaluation of methylated SEPT9 in plasma for detection of asymptomatic colorectal cancer. Gut. 2014;63(2):317-25.
    • (2014) Gut , vol.63 , Issue.2 , pp. 317-325
    • Church, T.R.1
  • 59
    • 84906828290 scopus 로고    scopus 로고
    • Validation of a real-time PCR-based qualitative assay for the detection of methylated SEPT9 DNA in human plasma
    • Potter NT, et al. Validation of a real-time PCR-based qualitative assay for the detection of methylated SEPT9 DNA in human plasma. Clin Chem. 2014;60(9):1183-91.
    • (2014) Clin Chem , vol.60 , Issue.9 , pp. 1183-1191
    • Potter, N.T.1
  • 60
    • 85031939582 scopus 로고    scopus 로고
    • Circadian rhythm of methylated Septin 9, cell-free DNA amount and tumor markers in colorectal cancer patients
    • Toth K, et al. Circadian rhythm of methylated Septin 9, cell-free DNA amount and tumor markers in colorectal cancer patients. Pathol Oncol Res. 2016;
    • (2016) Pathol Oncol Res.
    • Toth, K.1
  • 61
    • 84947939223 scopus 로고    scopus 로고
    • Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis
    • Zhao QT, et al. Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis. Onco Targets Ther. 2015;8:3433-9.
    • (2015) Onco Targets Ther , vol.8 , pp. 3433-3439
    • Zhao, Q.T.1
  • 62
    • 79960311742 scopus 로고    scopus 로고
    • An epigenetic marker panel for detection of lung cancer using cell-free serum DNA
    • Begum S, et al. An epigenetic marker panel for detection of lung cancer using cell-free serum DNA. Clin Cancer Res. 2011;17(13):4494-503.
    • (2011) Clin Cancer Res , vol.17 , Issue.13 , pp. 4494-4503
    • Begum, S.1
  • 63
    • 84890276015 scopus 로고    scopus 로고
    • Novel methylation biomarker panel for the early detection of pancreatic cancer
    • Yi JM, et al. Novel methylation biomarker panel for the early detection of pancreatic cancer. Clin Cancer Res. 2013;19(23):6544-55.
    • (2013) Clin Cancer Res , vol.19 , Issue.23 , pp. 6544-6555
    • Yi, J.M.1
  • 64
    • 28044468634 scopus 로고    scopus 로고
    • Detection and quantification of mutations in the plasma of patients with colorectal tumors
    • Diehl F, et al. Detection and quantification of mutations in the plasma of patients with colorectal tumors. Proc Natl Acad Sci U S A. 2005;102(45):16368-73.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.45 , pp. 16368-16373
    • Diehl, F.1
  • 65
    • 84939886668 scopus 로고    scopus 로고
    • Clinical relevance of alterations in quantity and quality of plasma DNA in colorectal cancer patients: based on the mutation spectra detected in primary tumors
    • Lin JK, et al. Clinical relevance of alterations in quantity and quality of plasma DNA in colorectal cancer patients: based on the mutation spectra detected in primary tumors. Ann Surg Oncol, 2014 21 Suppl. 4:S680-6.
    • (2014) Ann Surg Oncol , vol.21 , pp. S680-S686
    • Lin, J.K.1
  • 66
    • 4143133293 scopus 로고    scopus 로고
    • Molecular detection of APC, K- ras, and p53 mutations in the serum of colorectal cancer patients as circulating biomarkers
    • Wang JY, et al. Molecular detection of APC, K- ras, and p53 mutations in the serum of colorectal cancer patients as circulating biomarkers. World J Surg. 2004;28(7):721-6.
    • (2004) World J Surg , vol.28 , Issue.7 , pp. 721-726
    • Wang, J.Y.1
  • 67
    • 84879095890 scopus 로고    scopus 로고
    • A multiplex methylation-specific PCR assay for the detection of early-stage ovarian cancer using cell-free serum DNA
    • Zhang Q, et al. A multiplex methylation-specific PCR assay for the detection of early-stage ovarian cancer using cell-free serum DNA. Gynecol Oncol. 2013;130(1):132-9.
    • (2013) Gynecol Oncol , vol.130 , Issue.1 , pp. 132-139
    • Zhang, Q.1
  • 68
    • 84891349450 scopus 로고    scopus 로고
    • Serum DNA hypermethylation in patients with kidney cancer: results of a prospective study
    • Hauser S, et al. Serum DNA hypermethylation in patients with kidney cancer: results of a prospective study. Anticancer Res. 2013;33(10):4651-6.
    • (2013) Anticancer Res , vol.33 , Issue.10 , pp. 4651-4656
    • Hauser, S.1
  • 69
    • 79551513940 scopus 로고    scopus 로고
    • Hypermethylation of tumor suppressor genes involved in critical regulatory pathways for developing a blood-based test in breast cancer
    • Radpour R, et al. Hypermethylation of tumor suppressor genes involved in critical regulatory pathways for developing a blood-based test in breast cancer. PLoS One. 2011;6(1):e16080.
    • (2011) PLoS One , vol.6 , Issue.1
    • Radpour, R.1
  • 70
    • 79951850937 scopus 로고    scopus 로고
    • Methylation of multiple genes as a candidate biomarker in non-small cell lung cancer
    • Zhang Y, et al. Methylation of multiple genes as a candidate biomarker in non-small cell lung cancer. Cancer Lett. 2011;303(1):21-8.
    • (2011) Cancer Lett , vol.303 , Issue.1 , pp. 21-28
    • Zhang, Y.1
  • 71
    • 84990922467 scopus 로고    scopus 로고
    • Concentration and methylation of cell-free DNA from blood plasma as diagnostic markers of renal cancer
    • Skrypkina I, et al. Concentration and methylation of cell-free DNA from blood plasma as diagnostic markers of renal cancer. Dis Markers. 2016;2016:3693096.
    • (2016) Dis Markers , vol.2016 , pp. 3693096
    • Skrypkina, I.1
  • 72
    • 84872598584 scopus 로고    scopus 로고
    • Usefulness of plasma epigenetic changes of five major genes involved in the pathogenesis of colorectal cancer
    • Pack SC, et al. Usefulness of plasma epigenetic changes of five major genes involved in the pathogenesis of colorectal cancer. Int J Color Dis. 2013;28(1):139-47.
    • (2013) Int J Color Dis , vol.28 , Issue.1 , pp. 139-147
    • Pack, S.C.1
  • 73
    • 84929049678 scopus 로고    scopus 로고
    • Evaluation of cell-free DNA as a biomarker for pancreatic malignancies
    • Sikora K, et al. Evaluation of cell-free DNA as a biomarker for pancreatic malignancies. Int J Biol Markers. 2015;30(1):e136-41.
    • (2015) Int J Biol Markers , vol.30 , Issue.1 , pp. e136-e141
    • Sikora, K.1
  • 74
    • 35648953334 scopus 로고    scopus 로고
    • Characterization of a multiple epigenetic marker panel for lung cancer detection and risk assessment in plasma
    • Hsu HS, et al. Characterization of a multiple epigenetic marker panel for lung cancer detection and risk assessment in plasma. Cancer. 2007;110(9):2019-26.
    • (2007) Cancer , vol.110 , Issue.9 , pp. 2019-2026
    • Hsu, H.S.1
  • 75
    • 84936132730 scopus 로고    scopus 로고
    • Noninvasive diagnosis of actionable mutations by deep sequencing of circulating free DNA in lung cancer from never-smokers: a proof-of-concept study from BioCAST/IFCT-1002
    • Couraud S, et al. Noninvasive diagnosis of actionable mutations by deep sequencing of circulating free DNA in lung cancer from never-smokers: a proof-of-concept study from BioCAST/IFCT-1002. Clin Cancer Res. 2014;20(17):4613-24.
    • (2014) Clin Cancer Res , vol.20 , Issue.17 , pp. 4613-4624
    • Couraud, S.1
  • 76
    • 84922372527 scopus 로고    scopus 로고
    • Prospective blinded study of BRAFV600E mutation detection in cell-free DNA of patients with systemic histiocytic disorders
    • Hyman DM, et al. Prospective blinded study of BRAFV600E mutation detection in cell-free DNA of patients with systemic histiocytic disorders. Cancer Discov. 2015;5(1):64-71.
    • (2015) Cancer Discov , vol.5 , Issue.1 , pp. 64-71
    • Hyman, D.M.1
  • 77
    • 84898476658 scopus 로고    scopus 로고
    • Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA
    • Thierry AR, et al. Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA. Nat Med. 2014;20(4):430-5.
    • (2014) Nat Med , vol.20 , Issue.4 , pp. 430-435
    • Thierry, A.R.1
  • 78
    • 84926312642 scopus 로고    scopus 로고
    • Detection of plasma BRAF(V600E) mutation is associated with lung metastasis in papillary thyroid carcinomas
    • Kim BH, et al. Detection of plasma BRAF(V600E) mutation is associated with lung metastasis in papillary thyroid carcinomas. Yonsei Med J. 2015;56(3):634-40.
    • (2015) Yonsei Med J , vol.56 , Issue.3 , pp. 634-640
    • Kim, B.H.1
  • 79
    • 77954247556 scopus 로고    scopus 로고
    • Clinical significance of promoter hypermethylation of DNA repair genes in tumor and serum DNA in invasive ductal breast carcinoma patients
    • Sharma G, et al. Clinical significance of promoter hypermethylation of DNA repair genes in tumor and serum DNA in invasive ductal breast carcinoma patients. Life Sci. 2010;87(3-4):83-91.
    • (2010) Life Sci , vol.87 , Issue.3-4 , pp. 83-91
    • Sharma, G.1
  • 80
    • 4644271551 scopus 로고    scopus 로고
    • Tumor cell-specific BRCA1 and RASSF1A hypermethylation in serum, plasma, and peritoneal fluid from ovarian cancer patients
    • Ibanez de Caceres I, et al. Tumor cell-specific BRCA1 and RASSF1A hypermethylation in serum, plasma, and peritoneal fluid from ovarian cancer patients. Cancer Res. 2004;64(18):6476-81.
    • (2004) Cancer Res , vol.64 , Issue.18 , pp. 6476-6481
    • Ibanez de Caceres, I.1
  • 81
    • 58849140824 scopus 로고    scopus 로고
    • Differential methylation profile of ovarian cancer in tissues and plasma
    • Melnikov A, et al. Differential methylation profile of ovarian cancer in tissues and plasma. J Mol Diagn. 2009;11(1):60-5.
    • (2009) J Mol Diagn , vol.11 , Issue.1 , pp. 60-65
    • Melnikov, A.1
  • 82
    • 78649907173 scopus 로고    scopus 로고
    • Distinctive DNA methylation patterns of cell-free plasma DNA in women with malignant ovarian tumors
    • Liggett, T.E., et al., Distinctive DNA methylation patterns of cell-free plasma DNA in women with malignant ovarian tumors. Gynecol Oncol, 2011. 120(1): p. 113-20.
    • (2011) Gynecol Oncol , vol.120 , Issue.1 , pp. 113-120
    • Liggett, T.E.1
  • 83
    • 85014071750 scopus 로고    scopus 로고
    • Early detection of lung cancer using DNA promoter Hypermethylation in plasma and sputum
    • Hulbert A, et al. Early detection of lung cancer using DNA promoter Hypermethylation in plasma and sputum. Clin Cancer Res. 2016;
    • (2016) Clin Cancer Res.
    • Hulbert, A.1
  • 84
    • 84871969613 scopus 로고    scopus 로고
    • CST6 promoter methylation in circulating cell-free DNA of breast cancer patients
    • Chimonidou M, et al. CST6 promoter methylation in circulating cell-free DNA of breast cancer patients. Clin Biochem. 2013;46(3):235-40.
    • (2013) Clin Biochem , vol.46 , Issue.3 , pp. 235-240
    • Chimonidou, M.1
  • 85
    • 84863230241 scopus 로고    scopus 로고
    • Hypermethylated FAM5C and MYLK in serum as diagnosis and pre-warning markers for gastric cancer
    • Chen L, et al. Hypermethylated FAM5C and MYLK in serum as diagnosis and pre-warning markers for gastric cancer. Dis Markers. 2012;32(3):195-202.
    • (2012) Dis Markers , vol.32 , Issue.3 , pp. 195-202
    • Chen, L.1
  • 86
    • 84896400177 scopus 로고    scopus 로고
    • Commonality and differences of methylation signatures in the plasma of patients with pancreatic cancer and colorectal cancer
    • Melson J, et al. Commonality and differences of methylation signatures in the plasma of patients with pancreatic cancer and colorectal cancer. Int J Cancer. 2014;134(11):2656-62.
    • (2014) Int J Cancer , vol.134 , Issue.11 , pp. 2656-2662
    • Melson, J.1
  • 87
    • 84884153858 scopus 로고    scopus 로고
    • Promoter hypermethylation of tumor suppressor genes in serum as potential biomarker for the diagnosis of nasopharyngeal carcinoma
    • Tian F, et al. Promoter hypermethylation of tumor suppressor genes in serum as potential biomarker for the diagnosis of nasopharyngeal carcinoma. Cancer Epidemiol. 2013;37(5):708-13.
    • (2013) Cancer Epidemiol , vol.37 , Issue.5 , pp. 708-713
    • Tian, F.1
  • 88
    • 84961741245 scopus 로고    scopus 로고
    • Methylation of the DCLK1 promoter region in circulating free DNA and its prognostic value in lung cancer patients
    • Powrozek T, et al. Methylation of the DCLK1 promoter region in circulating free DNA and its prognostic value in lung cancer patients. Clin Transl Oncol. 2015;
    • (2015) Clin Transl Oncol.
    • Powrozek, T.1
  • 89
    • 84961155174 scopus 로고    scopus 로고
    • Methylation of the DCLK1 promoter region in circulating free DNA and its prognostic value in lung cancer patients
    • Powrozek T, et al. Methylation of the DCLK1 promoter region in circulating free DNA and its prognostic value in lung cancer patients. Clin Transl Oncol. 2016;18(4):398-404.
    • (2016) Clin Transl Oncol , vol.18 , Issue.4 , pp. 398-404
    • Powrozek, T.1
  • 90
    • 84872168031 scopus 로고    scopus 로고
    • Promoter hypermethylation of the tumor-suppressor genes ITIH5, DKK3, and RASSF1A as novel biomarkers for blood-based breast cancer screening
    • Kloten V, et al. Promoter hypermethylation of the tumor-suppressor genes ITIH5, DKK3, and RASSF1A as novel biomarkers for blood-based breast cancer screening. Breast Cancer Res. 2013;15(1):R4.
    • (2013) Breast Cancer Res , vol.15 , Issue.1 , pp. R4
    • Kloten, V.1
  • 91
    • 84882762092 scopus 로고    scopus 로고
    • Use of a new generation of capillary electrophoresis to quantify circulating free DNA in non-small cell lung cancer
    • Chiappetta C, et al. Use of a new generation of capillary electrophoresis to quantify circulating free DNA in non-small cell lung cancer. Clin Chim Acta. 2013;425:93-6.
    • (2013) Clin Chim Acta , vol.425 , pp. 93-96
    • Chiappetta, C.1
  • 92
    • 84975736118 scopus 로고    scopus 로고
    • Plasma cell-free DNA levels and integrity in patients with chest radiological findings: NSCLC versus benign lung nodules
    • Szpechcinski A, et al. Plasma cell-free DNA levels and integrity in patients with chest radiological findings: NSCLC versus benign lung nodules. Cancer Lett. 2016;374(2):202-7.
    • (2016) Cancer Lett , vol.374 , Issue.2 , pp. 202-207
    • Szpechcinski, A.1
  • 93
    • 84944746986 scopus 로고    scopus 로고
    • Quantitative analysis of cell-free DNA in ovarian cancer
    • Shao X, et al. Quantitative analysis of cell-free DNA in ovarian cancer. Oncol Lett. 2015;10(6):3478-82.
    • (2015) Oncol Lett , vol.10 , Issue.6 , pp. 3478-3482
    • Shao, X.1
  • 94
    • 79953784640 scopus 로고    scopus 로고
    • Detection of erbB2 copy number variations in plasma of patients with esophageal carcinoma
    • Andolfo I, et al. Detection of erbB2 copy number variations in plasma of patients with esophageal carcinoma. BMC Cancer. 2011;11:126.
    • (2011) BMC Cancer , vol.11 , pp. 126
    • Andolfo, I.1
  • 95
    • 33749567871 scopus 로고    scopus 로고
    • Cell-free DNA and RNA in plasma as a new molecular marker for prostate and breast cancer
    • Papadopoulou E, et al. Cell-free DNA and RNA in plasma as a new molecular marker for prostate and breast cancer. Ann N Y Acad Sci. 2006;1075:235-43.
    • (2006) Ann N Y Acad Sci , vol.1075 , pp. 235-243
    • Papadopoulou, E.1
  • 96
    • 84899886835 scopus 로고    scopus 로고
    • Prostate cancer molecular detection in plasma samples by glutathione S-transferase P1 (GSTP1) methylation analysis
    • Dumache R, et al. Prostate cancer molecular detection in plasma samples by glutathione S-transferase P1 (GSTP1) methylation analysis. Clin Lab. 2014;60(5):847-52.
    • (2014) Clin Lab , vol.60 , Issue.5 , pp. 847-852
    • Dumache, R.1
  • 97
    • 84986313415 scopus 로고    scopus 로고
    • Molecular diagnostic of prostate cancer from body fluids using methylation-specific PCR (MS-PCR) method
    • Minciu R, et al. Molecular diagnostic of prostate cancer from body fluids using methylation-specific PCR (MS-PCR) method. Clin Lab. 2016;62(6):1183-6.
    • (2016) Clin Lab , vol.62 , Issue.6 , pp. 1183-1186
    • Minciu, R.1
  • 98
    • 84863229057 scopus 로고    scopus 로고
    • DNA methylation patterns in blood of patients with colorectal cancer and adenomatous colorectal polyps
    • Cassinotti E, et al. DNA methylation patterns in blood of patients with colorectal cancer and adenomatous colorectal polyps. Int J Cancer. 2012;131(5):1153-7.
    • (2012) Int J Cancer , vol.131 , Issue.5 , pp. 1153-1157
    • Cassinotti, E.1
  • 99
    • 84975523022 scopus 로고    scopus 로고
    • Detection of aberrant methylation of a six-gene panel in serum DNA for diagnosis of breast cancer
    • Shan M, et al. Detection of aberrant methylation of a six-gene panel in serum DNA for diagnosis of breast cancer. Oncotarget. 2016;7(14):18485-94.
    • (2016) Oncotarget , vol.7 , Issue.14 , pp. 18485-18494
    • Shan, M.1
  • 100
    • 84903585680 scopus 로고    scopus 로고
    • Evaluation of INK4A promoter methylation using pyrosequencing and circulating cell-free DNA from patients with hepatocellular carcinoma
    • Huang G, et al. Evaluation of INK4A promoter methylation using pyrosequencing and circulating cell-free DNA from patients with hepatocellular carcinoma. Clin Chem Lab Med. 2014;52(6):899-909.
    • (2014) Clin Chem Lab Med , vol.52 , Issue.6 , pp. 899-909
    • Huang, G.1
  • 101
    • 84899114624 scopus 로고    scopus 로고
    • Comparison of KRAS mutation analysis of primary tumors and matched circulating cell-free DNA in plasmas of patients with colorectal cancer
    • Kuo YB, et al. Comparison of KRAS mutation analysis of primary tumors and matched circulating cell-free DNA in plasmas of patients with colorectal cancer. Clin Chim Acta. 2014;433:284-9.
    • (2014) Clin Chim Acta , vol.433 , pp. 284-289
    • Kuo, Y.B.1
  • 102
    • 84927615702 scopus 로고    scopus 로고
    • Circulating free DNA as biomarker and source for mutation detection in metastatic colorectal cancer
    • Spindler KL, et al. Circulating free DNA as biomarker and source for mutation detection in metastatic colorectal cancer. PLoS One. 2015;10(4):e0108247.
    • (2015) PLoS One , vol.10 , Issue.4
    • Spindler, K.L.1
  • 103
    • 84942888495 scopus 로고    scopus 로고
    • Circulating tumor DNA outperforms circulating tumor cells for KRAS mutation detection in thoracic malignancies
    • Freidin MB, et al. Circulating tumor DNA outperforms circulating tumor cells for KRAS mutation detection in thoracic malignancies. Clin Chem. 2015;61(10):1299-304.
    • (2015) Clin Chem , vol.61 , Issue.10 , pp. 1299-1304
    • Freidin, M.B.1
  • 104
    • 0032696782 scopus 로고    scopus 로고
    • Detection of microsatellite alterations in plasma DNA of non-small cell lung cancer patients: a prospect for early diagnosis
    • Sozzi G, et al. Detection of microsatellite alterations in plasma DNA of non-small cell lung cancer patients: a prospect for early diagnosis. Clin Cancer Res. 1999;5(10):2689-92.
    • (1999) Clin Cancer Res , vol.5 , Issue.10 , pp. 2689-2692
    • Sozzi, G.1
  • 105
    • 33750306596 scopus 로고    scopus 로고
    • The detection of oesophageal adenocarcinoma by serum microsatellite analysis
    • Eisenberger CF, et al. The detection of oesophageal adenocarcinoma by serum microsatellite analysis. Eur J Surg Oncol. 2006;32(9):954-60.
    • (2006) Eur J Surg Oncol , vol.32 , Issue.9 , pp. 954-960
    • Eisenberger, C.F.1
  • 106
    • 34547899186 scopus 로고    scopus 로고
    • Microsatellite analysis of induced sputum DNA in patients with lung cancer in heavy smokers and in healthy subjects
    • Castagnaro A, et al. Microsatellite analysis of induced sputum DNA in patients with lung cancer in heavy smokers and in healthy subjects. Exp Lung Res. 2007;33(6):289-301.
    • (2007) Exp Lung Res , vol.33 , Issue.6 , pp. 289-301
    • Castagnaro, A.1
  • 107
    • 0345687975 scopus 로고    scopus 로고
    • Detecting lung cancer in plasma with the use of multiple genetic markers
    • Andriani F, et al. Detecting lung cancer in plasma with the use of multiple genetic markers. Int J Cancer. 2004;108(1):91-6.
    • (2004) Int J Cancer , vol.108 , Issue.1 , pp. 91-96
    • Andriani, F.1
  • 108
    • 75649085302 scopus 로고    scopus 로고
    • Decreased mitochondrial DNA content in blood samples of patients with stage I breast cancer
    • Xia P, et al. Decreased mitochondrial DNA content in blood samples of patients with stage I breast cancer. BMC Cancer. 2009;9:454.
    • (2009) BMC Cancer , vol.9 , pp. 454
    • Xia, P.1
  • 109
    • 84862670402 scopus 로고    scopus 로고
    • Quantitative measurement of cell-free plasma DNA and applications for detecting tumor genetic variation and promoter methylation in a clinical setting
    • Kadam SK, Farmen M, Brandt JT. Quantitative measurement of cell-free plasma DNA and applications for detecting tumor genetic variation and promoter methylation in a clinical setting. J Mol Diagn. 2012;14(4):346-56.
    • (2012) J Mol Diagn , vol.14 , Issue.4 , pp. 346-356
    • Kadam, S.K.1    Farmen, M.2    Brandt, J.T.3
  • 110
    • 84885392318 scopus 로고    scopus 로고
    • Cell-free DNA concentration and integrity as a screening tool for cancer
    • Zaher ER, et al. Cell-free DNA concentration and integrity as a screening tool for cancer. Indian J Cancer. 2013;50(3):175-83.
    • (2013) Indian J Cancer , vol.50 , Issue.3 , pp. 175-183
    • Zaher, E.R.1
  • 111
    • 84883171525 scopus 로고    scopus 로고
    • Epigenetic alteration: new insights moving from tissue to plasma - the example of PCDH10 promoter methylation in colorectal cancer
    • Danese E, et al. Epigenetic alteration: new insights moving from tissue to plasma - the example of PCDH10 promoter methylation in colorectal cancer. Br J Cancer. 2013;109(3):807-13.
    • (2013) Br J Cancer , vol.109 , Issue.3 , pp. 807-813
    • Danese, E.1
  • 112
    • 33646847495 scopus 로고    scopus 로고
    • Cell-free and cell-bound circulating DNA in breast tumours: DNA quantification and analysis of tumour-related gene methylation
    • Skvortsova TE, et al. Cell-free and cell-bound circulating DNA in breast tumours: DNA quantification and analysis of tumour-related gene methylation. Br J Cancer. 2006;94(10):1492-5.
    • (2006) Br J Cancer , vol.94 , Issue.10 , pp. 1492-1495
    • Skvortsova, T.E.1
  • 113
    • 33749024160 scopus 로고    scopus 로고
    • Detection of aberrant methylation of four genes in plasma DNA for the detection of breast cancer
    • Hoque MO, et al. Detection of aberrant methylation of four genes in plasma DNA for the detection of breast cancer. J Clin Oncol. 2006;24(26):4262-9.
    • (2006) J Clin Oncol , vol.24 , Issue.26 , pp. 4262-4269
    • Hoque, M.O.1
  • 114
    • 85016144570 scopus 로고    scopus 로고
    • Tumor-related methylated cell-free DNA and circulating tumor cells in melanoma
    • Salvianti F, et al. Tumor-related methylated cell-free DNA and circulating tumor cells in melanoma. Front Mol Biosci. 2015;2:76.
    • (2015) Front Mol Biosci , vol.2 , pp. 76
    • Salvianti, F.1
  • 115
    • 7644238385 scopus 로고    scopus 로고
    • Investigation of tumor-derived extracellular DNA in blood of cancer patients by methylation-specific PCR
    • Rykova EY, et al. Investigation of tumor-derived extracellular DNA in blood of cancer patients by methylation-specific PCR. Nucleosides Nucleotides Nucleic Acids. 2004;23(6-7):855-9.
    • (2004) Nucleosides Nucleotides Nucleic Acids , vol.23 , Issue.6-7 , pp. 855-859
    • Rykova, E.Y.1
  • 116
    • 84868301113 scopus 로고    scopus 로고
    • Is serum level of methylated RASSF1A valuable in diagnosing hepatocellular carcinoma in patients with chronic viral hepatitis C?
    • Mohamed NA, et al. Is serum level of methylated RASSF1A valuable in diagnosing hepatocellular carcinoma in patients with chronic viral hepatitis C? Arab J Gastroenterol. 2012;13(3):111-5.
    • (2012) Arab J Gastroenterol , vol.13 , Issue.3 , pp. 111-115
    • Mohamed, N.A.1
  • 117
    • 34247895661 scopus 로고    scopus 로고
    • Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA
    • Zhang YJ, et al. Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA. Clin Cancer Res. 2007;13(8):2378-84.
    • (2007) Clin Cancer Res , vol.13 , Issue.8 , pp. 2378-2384
    • Zhang, Y.J.1
  • 118
    • 83855162906 scopus 로고    scopus 로고
    • Serum cell-free DNA in renal cell carcinoma: a diagnostic and prognostic marker
    • de Martino M, et al. Serum cell-free DNA in renal cell carcinoma: a diagnostic and prognostic marker. Cancer. 2012;118(1):82-90.
    • (2012) Cancer , vol.118 , Issue.1 , pp. 82-90
    • de Martino, M.1
  • 119
    • 67650077151 scopus 로고    scopus 로고
    • Circulating methylated SEPT9 DNA in plasma is a biomarker for colorectal cancer
    • deVos T, et al. Circulating methylated SEPT9 DNA in plasma is a biomarker for colorectal cancer. Clin Chem. 2009;55(7):1337-46.
    • (2009) Clin Chem , vol.55 , Issue.7 , pp. 1337-1346
    • deVos, T.1
  • 120
    • 56649094216 scopus 로고    scopus 로고
    • Sensitive detection of colorectal cancer in peripheral blood by septin 9 DNA methylation assay
    • Grutzmann R, et al. Sensitive detection of colorectal cancer in peripheral blood by septin 9 DNA methylation assay. PLoS One. 2008;3(11):e3759.
    • (2008) PLoS One , vol.3 , Issue.11
    • Grutzmann, R.1
  • 121
    • 84919491632 scopus 로고    scopus 로고
    • Detection of methylated septin 9 in tissue and plasma of colorectal patients with neoplasia and the relationship to the amount of circulating cell-free DNA
    • Toth K, et al. Detection of methylated septin 9 in tissue and plasma of colorectal patients with neoplasia and the relationship to the amount of circulating cell-free DNA. PLoS One. 2014;9(12):e115415.
    • (2014) PLoS One , vol.9 , Issue.12
    • Toth, K.1
  • 122
    • 84898816773 scopus 로고    scopus 로고
    • Septin 9 promoter region methylation in free circulating DNA-potential role in noninvasive diagnosis of lung cancer: preliminary report
    • Powrozek T, et al. Septin 9 promoter region methylation in free circulating DNA-potential role in noninvasive diagnosis of lung cancer: preliminary report. Med Oncol. 2014;31(4):917.
    • (2014) Med Oncol , vol.31 , Issue.4 , pp. 917
    • Powrozek, T.1
  • 123
    • 84926675759 scopus 로고    scopus 로고
    • Performance of a second-generation methylated SEPT9 test in detecting colorectal neoplasm
    • Jin P, et al. Performance of a second-generation methylated SEPT9 test in detecting colorectal neoplasm. J Gastroenterol Hepatol. 2015;30(5):830-3.
    • (2015) J Gastroenterol Hepatol , vol.30 , Issue.5 , pp. 830-833
    • Jin, P.1
  • 124
    • 83355163991 scopus 로고    scopus 로고
    • Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer
    • Warren JD, et al. Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer. BMC Med. 2011;9:133.
    • (2011) BMC Med , vol.9 , pp. 133
    • Warren, J.D.1
  • 125
    • 80052967970 scopus 로고    scopus 로고
    • SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer in plasma
    • Kneip C, et al. SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer in plasma. J Thorac Oncol. 2011;6(10):1632-8.
    • (2011) J Thorac Oncol , vol.6 , Issue.10 , pp. 1632-1638
    • Kneip, C.1
  • 126
    • 85009941784 scopus 로고    scopus 로고
    • Validation of the SHOX2/PTGER4 DNA methylation marker panel for plasma-based discrimination between patients with malignant and nonmalignant lung disease
    • Weiss G, et al. Validation of the SHOX2/PTGER4 DNA methylation marker panel for plasma-based discrimination between patients with malignant and nonmalignant lung disease. J Thorac Oncol. 2017;12(1):77-84.
    • (2017) J Thorac Oncol , vol.12 , Issue.1 , pp. 77-84
    • Weiss, G.1
  • 127
    • 84872031717 scopus 로고    scopus 로고
    • SOX17 promoter methylation in circulating tumor cells and matched cell-free DNA isolated from plasma of patients with breast cancer
    • Chimonidou M, et al. SOX17 promoter methylation in circulating tumor cells and matched cell-free DNA isolated from plasma of patients with breast cancer. Clin Chem. 2013;59(1):270-9.
    • (2013) Clin Chem , vol.59 , Issue.1 , pp. 270-279
    • Chimonidou, M.1
  • 128
    • 84870326702 scopus 로고    scopus 로고
    • Genome-scale discovery of DNA-methylation biomarkers for blood-based detection of colorectal cancer
    • Lange CP, et al. Genome-scale discovery of DNA-methylation biomarkers for blood-based detection of colorectal cancer. PLoS One. 2012;7(11):e50266.
    • (2012) PLoS One , vol.7 , Issue.11
    • Lange, C.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.