Circulating tumour markers can define patients with normal colons, benign polyps, and cancers

British Journal of Cancer

Volumn 105, Issue 2, 2011, Pages 239-245

  Mead, R ^a   Duku, M ^a   Bhandari, P ^a   Cree, I A ^a  

^a QUEEN ALEXANDRA HOSPITAL   (United Kingdom)

Author keywords

CEA; circulating; colorectal cancer; DNA; plasma; tumour marker

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; DNA; DNA FRAGMENT; DNA MARKER; TUMOR MARKER;

ADULT; AGED; ALU SEQUENCE; ARTICLE; CANCER DIAGNOSIS; CANCER SCREENING; COLON ADENOMA; COLON CANCER; COLON CARCINOMA; COLON POLYP; COLONOSCOPY; COLORECTAL ADENOMA; COLORECTAL CARCINOMA; CONTROLLED STUDY; DNA DETERMINATION; DNA ISOLATION; ENDOSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MARKER GENE; MITOCHONDRION; OCCULT BLOOD TEST; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC;

ADENOMA; ADULT; AGED; AGED, 80 AND OVER; CARCINOEMBRYONIC ANTIGEN; CARCINOMA; COLON; COLONIC POLYPS; COLORECTAL NEOPLASMS; DIAGNOSIS, DIFFERENTIAL; FEMALE; HEALTH; HUMANS; MALE; MIDDLE AGED; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 79960266530     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2011.230     Document Type: Article

References (70)

1. Allen JI (1995) Molecular biology of colon polyps and colon cancer. Semin Surg Oncol 11: 399-405
2. Board RE, Williams VS, Knight L, Shaw J, Greystoke A, Ranson M, Dive C, Blackhall FH, Hughes A (2008) Isolation and extraction of circulating tumor DNA from patients with small cell lung cancer. Ann NY Acad Sci 1137: 98-107
3. Boni L, Cassinotti E, Canziani M, Dionigi G, Rovera F, Dionigi R (2007) Free circulating DNA as possible tumour marker in colorectal cancer. Surg Oncol 16(Suppl 1): S29-S31
4. Cancer Research UK (2011) Cancer Stats. http://info.cancerresearchuk.org/ cancerstats/
5. Catarino R, Ferreira MM, Rodrigues H, Coelho A, Nogal A, Sousa A, Medeiros R (2008) Quantification of free circulating tumor DNA as a diagnostic marker for breast cancer. DNA Cell Biol 27: 415-421
6. Chang HW, Lee SM, Goodman SN, Singer G, Cho SK, Sokoll LJ, Montz FJ, Roden R, Zhang Z, Chan DW, Kurman RJ, Shih Ie M (2002) Assessment of plasma DNA levels, allelic imbalance, and CA 125 as diagnostic tests for cancer. J Natl Cancer Inst 94: 1697-1703 (Pubitemid 35446838)
7. Chiu RW, Poon LL, Lau TK, Leung TN, Wong EM, Lo YM (2001) Effects of blood-processing protocols on fetal and total DNA quantification in maternal plasma. Clin Chem 47: 1607-1613 (Pubitemid 32781573)
8. Church TR, Wandell M, Lofton-Day C, Mongin S, Blumenstein BA, Allen JI, Roesch T, Snover D, Day R, Ransohoff DF (2010) Prospective clinical validation of an assay for methylated SEPT9 DNA in human plasma as a colorectal cancer screening tool in average risk men and women X50 years. Gastroenterology 139(1): e18
9. deVos T, Tetzner R, Model F, Weiss G, Schuster M, Distler J, Steiger KV, Grutzmann R, Pilarsky C, Habermann JK, Fleshner PR, Oubre BM, Day R, Sledziewski AZ, Lofton-Day C (2009) Circulating methylated SEPT9 DNA in plasma is a biomarker for colorectal cancer. Clin Chem 55: 1337-1346
10. Diehl F, Li M, Dressman D, He Y, Shen D, Szabo S, Diaz Jr LA, Goodman SN, David KA, Juhl H, Kinzler KW, Vogelstein B (2005) Detection and quantification of mutations in the plasma of patients with colorectal tumors. Proc Natl Acad Sci USA 102: 16368-16373 (Pubitemid 41688920)
11. Diehl F, Schmidt K, Choti MA, Romans K, Goodman S, Li M, Thornton K, Agrawal N, Sokoll L, Szabo SA, Kinzler KW, Vogelstein B, Diaz Jr LA (2008) Circulating mutant DNA to assess tumor dynamics. Nat Med 14: 985-990
12. Dobrzycka B, Terlikowski SJ, Mazurek A, Kowalczuk O, Niklinska W, Chyczewski L, Kulikowski M (2010) Circulating free DNA, p53 antibody and mutations of KRAS gene in endometrial cancer. Int J Cancer 127: 612-621
13. Drew WL (2007) Laboratory diagnosis of cytomegalovirus infection and disease in immunocompromised patients. Curr Opin Infect Dis 20: 408-411 (Pubitemid 47026239)
14. Ellinger J, Albers P, Muller SC, von Ruecker A, Bastian PJ (2009a) Circulating mitochondrial DNA in the serum of patients with testicular germ cell cancer as a novel noninvasive diagnostic biomarker. BJU Int 104: 48-52
15. Ellinger J, Bastian PJ, Haan KI, Heukamp LC, Buettner R, Fimmers R, Mueller SC, von Ruecker A (2008) Noncancerous PTGS2 DNA fragments of apoptotic origin in sera of prostate cancer patients qualify as diagnostic and prognostic indicators. Int J Cancer 122: 138-143 (Pubitemid 350209988)
16. Ellinger J, Muller SC, Stadler TC, Jung A, von Ruecker A, Bastian PJ (2009b) The role of cell-free circulating DNA in the diagnosis and prognosis of prostate cancer. Urol Oncol 29(2): 124-129
17. Federici A, Giorgi Rossi P, Borgia P, Bartolozzi F, Farchi S, Gausticchi G (2005) The immunochemical faecal occult blood test leads to higher compliance than the guaiac for colorectal cancer screening programmes: a cluster randomized controlled trial. J Med Screen 12: 83-88 (Pubitemid 40835139)
18. Fenocchi E, Martinez L, Tolve J, Montano D, Rondan M, Parra-Blanco A, Eishi Y (2006) Screening for colorectal cancer in Uruguay with an immunochemical faecal occult blood test. Eur J Cancer Prev 15: 384-390 (Pubitemid 44252909)
19. Flamini E, Mercatali L, Nanni O, Calistri D, Nunziatini R, Zoli W, Rosetti P, Gardini N, Lattuneddu A, Verdecchia GM, Amadori D (2006) Free DNA and carcinoembryonic antigen serum levels: an important combination for diagnosis of colorectal cancer. Clin Cancer Res 12: 6985-6988 (Pubitemid 44974493)
20. Gauthier VJ, Tyler LN, Mannik M (1996) Blood clearance kinetics and liver uptake of mononucleosomes in mice. J Immunol 156: 1151-1156 (Pubitemid 26048111)
21. Harbeck RJ, Hoffmann AA, Carr RI (1975) Studies on the nature of circulating DNA in systemic lupus erythematosus (SLE). J Rheumatol 2: 194-203
22. Holdenrieder S, Stieber P, Bodenmuller H, Busch M, Fertig G, Furst H, Schalhorn A, Schmeller N, Untch M, Seidel D (2001) Nucleosomes in serum of patients with benign and malignant diseases. Int J Cancer 95: 114-120 (Pubitemid 32187083)
23. Holten-Andersen MN, Christensen IJ, Nielsen HJ, Stephens RW, Jensen V, Nielsen OH, Sorensen S, Overgaard J, Lilja H, Harris A, Murphy G, Brunner N (2002) Total levels of tissue inhibitor of metalloproteinases 1 in plasma yield high diagnostic sensitivity and specificity in patients with colon cancer. Clin Cancer Res 8: 156-164 (Pubitemid 34101472)
24. Hosgood III HD, Liu CS, Rothman N, Weinstein SJ, Bonner MR, Shen M, Lim U, Virtamo J, Cheng WL, Albanes D, Lan Q (2010) Mitochondrial DNA copy number and lung cancer risk in a prospective cohort study. Carcinogenesis 31: 847-849
25. http://www.cancerscreening.nhs.uk/bowel (2010) Report to the English Bowel Cancer Screening Working Group, September 2004. Online
26. Huang P, Zhang YX, Zhao T (2009) [The relationship between copy number and microsatellite instability of mitochondrial DNA in colorectal cancer]. Zhonghua Nei Ke Za Zhi 48: 837-840
27. Jung M, Klotzek S, Lewandowski M, Fleischhacker M, Jung K (2003) Changes in concentration of DNA in serum and plasma during storage of blood samples. Clin Chem 49: 1028-1029 (Pubitemid 36623507)
28. Kirsch C, Weickmann S, Schmidt B, Fleischhacker M (2008) An improved method for the isolation of free-circulating plasma DNA and cell-free DNA from other body fluids. Ann NY Acad Sci 1137: 135-139
29. Kolesnikova EV, Tamkovich SN, Bryzgunova OE, Shelestyuk PI, Permya-kova VI, Vlassov VV, Tuzikov AS, Laktionov PP, Rykova EY (2008) Circulating DNA in the blood of gastric cancer patients. Ann NY Acad Sci 1137: 226-231
30. Kopreski MS, Benko FA, Kwee C, Leitzel KE, Eskander E, Lipton A, Gocke CD (1997) Detection of mutant K-ras DNA in plasma or serum of patients with colorectal cancer. Br J Cancer 76: 1293-1299 (Pubitemid 27474970)
31. Lam NY, Rainer TH, Chan LY, Joynt GM, Lo YM (2003) Time course of early and late changes in plasma DNA in trauma patients. Clin Chem 49: 1286-1291 (Pubitemid 36900614)
32. Lam NY, Rainer TH, Chiu RW, Joynt GM, Lo YM (2004) Plasma mitochondrial DNA concentrations after trauma. Clin Chem 50: 213-216 (Pubitemid 38125724)
33. Lee TH, Montalvo L, Chrebtow V, Busch MP (2001) Quantitation of genomic DNA in plasma and serum samples: higher concentrations of genomic DNA found in serum than in plasma. Transfusion 41: 276-282 (Pubitemid 32220522)
34. Leman ES, Schoen RE, Magheli A, Sokoll LJ, Chan DW, Getzenberg RH (2008) Evaluation of colon cancer-specific antigen 2 as a potential serum marker for colorectal cancer. Clin Cancer Res 14: 1349-1354 (Pubitemid 351413914)
35. Liggett T, Melnikov A, Yi QL, Replogle C, Brand R, Kaul K, Talamonti M, Abrams RA, Levenson V (2010) Differential methylation of cell-free circulating DNA among patients with pancreatic cancer versus chronic pancreatitis. Cancer 116: 1674-1680
36. Lin CS, Wang LS, Tsai CM, Wei YH (2008) Low copy number and low oxidative damage of mitochondrial DNA are associated with tumor progression in lung cancer tissues after neoadjuvant chemotherapy. Interact Cardiovasc Thorac Surg 7: 954-958
37. Locker GY, Hamilton S, Harris J, Jessup JM, Kemeny N, Macdonald JS, Somerfield MR, Hayes DF, Bast Jr RC (2006) ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer. J Clin Oncol 24: 5313-5327 (Pubitemid 46631379)
38. Lui YY, Dennis YM (2002) Circulating DNA in plasma and serum: biology, preanalytical issues and diagnostic applications. Clin Chem Lab Med 40: 962-968 (Pubitemid 35356012)
39. Margraf S, Logters T, Reipen J, Altrichter J, Scholz M, Windolf J (2008) Neutrophil-derived circulating free DNA (cf-DNA/NETs): a potential prognostic marker for posttraumatic development of inflammatory second hit and sepsis. Shock 30: 352-358
40. Moreira VG, Prieto B, Rodriguez JS, Alvarez FV (2010) Usefulness of cell-free plasma DNA, procalcitonin and C-reactive protein as markers of infection in febrile patients. Ann Clin Biochem 47: 253-258
41. Muller I, Beeger C, Alix-Panabieres C, Rebillard X, Pantel K, Schwarzen-bach H (2008) Identification of loss of heterozygosity on circulating free DNA in peripheral blood of prostate cancer patients: potential and technical improvements. Clin Chem 54: 688-696 (Pubitemid 351573708)
42. Ore L, Hagoel L, Lavi I, Rennert G (2001) Screening with faecal occult blood test (FOBT) for colorectal cancer: assessment of two methods that attempt to improve compliance. Eur J Cancer Prev 10: 251-256 (Pubitemid 32530369)
43. Parente F, Marino B, DeVecchi N, Moretti R, Ucci G, Tricomi P, Armellino A, Redaelli L, Bargiggia S, Cristofori E, Masala E, Tortorella F, Gattinoni A, Odinolfi F, Pirola ME (2009) Faecal occult blood test-based screening programme with high compliance for colonoscopy has a strong clinical impact on colorectal cancer. Br J Surg 96: 533-540
44. Perego RA, Corizzato M, Brambilla P, Ferrero S, Bianchi C, Fasoli E, Signorini S, Torsello B, Invernizzi L, Bombelli S, Angeloni V, Pitto M, Battaglia C, Proserpio V, Magni F, Galasso G, Mocarelli P (2008) Concentration and microsatellite status of plasma DNA for monitoring patients with renal carcinoma. Eur J Cancer 44: 1039-1047
45. Polcher M, Ellinger J, Willems S, El-Maarri O, Holler T, Amann C, Wolfgarten M, Rudlowski C, Kuhn W, Braun M (2010) Impact of the menstrual cycle on circulating cell-free DNA. Anticancer Res 30: 2235-2240
46. Rago C, Huso DL, Diehl F, Karim B, Liu G, Papadopoulos N, Samuels Y, Velculescu VE, Vogelstein B, Kinzler KW, Diaz Jr LA (2007) Serial assessment of human tumor burdens in mice by the analysis of circulating DNA. Cancer Res 67: 9364-9370 (Pubitemid 47535926)
47. Richards MA (2009) The size of the prize for earlier diagnosis of cancer in England. Br J Cancer 101(Suppl 2): S125-S129
48. Stroun M, Lyautey J, Lederrey C, Olson-Sand A, Anker P (2001) About the possible origin and mechanism of circulating DNA apoptosis and active DNA release. Clin Chim Acta 313: 139-142 (Pubitemid 33016703)
49. Sunami E, Shinozaki M, Higano CS, Wollman R, Dorff TB, Tucker SJ, Martinez SR, Mizuno R, Singer FR, Hoon DS (2009) Multimarker circulating DNA assay for assessing blood of prostate cancer patients. Clin Chem 55: 559-567
50. Sunami E, Vu AT, Nguyen SL, Giuliano AE, Hoon DS (2008) Quantification of LINE1 in circulating DNA as a molecular biomarker of breast cancer. Ann NY Acad Sci 1137: 171-174
51. Taback B, O'Day SJ, Hoon DS (2004) Quantification of circulating DNA in the plasma and serum of cancer patients. Ann NY Acad Sci 1022: 17-24 (Pubitemid 38951576)
52. Taback B, Saha S, Hoon DS (2006) Comparative analysis of mesenteric and peripheral blood circulating tumor DNA in colorectal cancer patients. Ann NY Acad Sci 1075: 197-203 (Pubitemid 44532785)
53. Thierry AR, Mouliere F, Gongora C, Ollier J, Robert B, Ychou M, Del Rio M, Molina F (2010) Origin and quantification of circulating DNA in mice with human colorectal cancer xenografts. Nucleic Acids Res 38(18): 6159-6175
54. Tomita H, Ichikawa D, Sai S, Morimura R, Murayama Y, Komatsu S, Ikoma D, Tani N, Ikoma H, Fujiwara H, Kikuchi S, Okamoto K, Ochiai T, Kokuba Y, Sakakura C, Sonoyama T, Hagiwara A, Otsuji E (2007) Quantification of circulating plasma DNA fragments as tumor markers in patients with esophageal and gastric cancer. Gan To Kagaku Ryoho 34: 1908-1910
55. Toth K, Galamb O, Spisak S, Wichmann B, Sipos F, Leiszter K, Molnar J, Molnar B, Tulassay Z (2009) [Free circulating DNA based colorectal cancer screening from peripheral blood: the possibility of the methylated septin 9 gene marker]. Orv Hetil 150: 969-977
56. Tuaeva NO, Abramova ZI, Sofronov VV (2008) The origin of elevated levels of circulating DNA in blood plasma of premature neonates. Ann NY Acad Sci 1137: 27-30
57. Umetani N, Giuliano AE, Hiramatsu SH, Amersi F, Nakagawa T, Martino S, Hoon DS (2006a) Prediction of breast tumor progression by integrity of free circulating DNA in serum. J Clin Oncol 24: 4270-4276 (Pubitemid 46630784)
58. Umetani N, Hiramatsu S, Hoon DS (2006b) Higher amount of free circulating DNA in serum than in plasma is not mainly caused by contaminated extraneous DNA during separation. Ann NY Acad Sci 1075: 299-307 (Pubitemid 44532797)
59. Umetani N, Kim J, Hiramatsu S, Reber HA, Hines OJ, Bilchik AJ, Hoon DS (2006c) Increased integrity of free circulating DNA in sera of patients with colorectal or periampullary cancer: direct quantitative PCR for ALU repeats. Clin Chem 52: 1062-1069 (Pubitemid 43794418)
60. van Dam L, Hol L, de Bekker-Grob EW, Steyerberg EW, Kuipers EJ, Habbema JD, Essink-Bot ML, van Leerdam ME (2010) What determines individuals' preferences for colorectal cancer screening programmeS A discrete choice experiment. Eur J Cancer 46: 150-159
61. van der Drift MA, Hol BE, Klaassen CH, Prinsen CF, van Aarssen YA, Donders R, van der Stappen JW, Dekhuijzen PN, van der Heijden HF, Thunnissen FB (2010) Circulating DNA is a non-invasive prognostic factor for survival in non-small cell lung cancer. Lung Cancer 68: 283-287
62. van der Vaart M, Pretorius PJ (2010) Is the role of circulating DNA as a biomarker of cancer being prematurely overrated? Clin Biochem 43: 26-36
63. Vernon SW (1997) Participation in colorectal cancer screening: a review. J Natl Cancer Inst 89: 1406-1422 (Pubitemid 27419204)
64. Vogelstein B, Kinzler KW (2004) Cancer genes and the pathways they control. Nat Med 10: 789-799 (Pubitemid 39070849)
65. Wang BG, Huang HY, Chen YC, Bristow RE, Kassauei K, Cheng CC, Roden R, Sokoll LJ, Chan DW, Shih Ie M (2003) Increased plasma DNA integrity in cancer patients. Cancer Res 63: 3966-3968 (Pubitemid 36917913)
66. Wang M, Block TM, Steel L, Brenner DE, Su YH (2004) Preferential isolation of fragmented DNA enhances the detection of circulating mutated k-ras DNA. Clin Chem 50: 211-213 (Pubitemid 38125723)
67. Xia P, An HX, Dang CX, Radpour R, Kohler C, Fokas E, Engenhart-Cabillic R, Holzgreve W, Zhong XY (2009) Decreased mitochondrial DNA content in blood samples of patients with stage I breast cancer. BMC Cancer 9: 454
68. Xue X, Teare MD, Holen I, Zhu YM, Woll PJ (2009) Optimizing the yield and utility of circulating cell-free DNA from plasma and serum. Clin Chim Acta 404: 100-104
69. Yoon KA, Park S, Lee SH, Kim JH, Lee JS (2009) Comparison of circulating plasma DNA levels between lung cancer patients and healthy controls. J Mol Diagn 11: 182-185
70. Zhong XY, von Muhlenen I, Li Y, Kang A, Gupta AK, Tyndall A, Holzgreve W, Hahn S, Hasler P (2007) Increased concentrations of antibody-bound circulatory cell-free DNA in rheumatoid arthritis. Clin Chem 53: 1609-1614 (Pubitemid 47340056)