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Volumn 433, Issue 2, 2013, Pages 227-234

Mutation-based detection and monitoring of cell-free tumor DNA in peripheral blood of cancer patients

Author keywords

BEAMing; Cancer; Capillary electrophoresis; cfDNA; COLD PCR; Digital PCR; Mutations

Indexed keywords

BLOOD; BLOOD VESSELS; CAPILLARY ELECTROPHORESIS; COMPUTERIZED TOMOGRAPHY; DIAGNOSIS; DISEASE CONTROL; DISEASES; DNA; EMULSIFICATION; TUMORS; ULTRASONIC APPLICATIONS;

EID: 84871630944     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2012.06.018     Document Type: Review
Times cited : (87)

References (96)
  • 2
    • 0036179998 scopus 로고    scopus 로고
    • A population-based community estimate of total colon examination: The impact on compliance with screening for colorectal cancer
    • R.E. Schoen, J.L. Weissfeld, J.M. Trauth, B.S. Ling, and M. Hayran A population-based community estimate of total colon examination: the impact on compliance with screening for colorectal cancer Am. J. Gastroenterol. 97 2002 446 451
    • (2002) Am. J. Gastroenterol. , vol.97 , pp. 446-451
    • Schoen, R.E.1    Weissfeld, J.L.2    Trauth, J.M.3    Ling, B.S.4    Hayran, M.5
  • 3
    • 0032869146 scopus 로고    scopus 로고
    • Influence of stage at diagnosis on survival differences for rectal cancer in three European populations
    • E. Monnet, J. Faivre, L. Raymond, and I. Garau Influence of stage at diagnosis on survival differences for rectal cancer in three European populations Br. J. Cancer 81 1999 463 468
    • (1999) Br. J. Cancer , vol.81 , pp. 463-468
    • Monnet, E.1    Faivre, J.2    Raymond, L.3    Garau, I.4
  • 4
    • 74949140527 scopus 로고    scopus 로고
    • Caution is required before recommending routine carcinoembryonic antigen and imaging follow-up for patients with early-stage colon cancer
    • M. Chao, and P. Gibbs Caution is required before recommending routine carcinoembryonic antigen and imaging follow-up for patients with early-stage colon cancer J. Clin. Oncol. 27 2009 e279 e280
    • (2009) J. Clin. Oncol. , vol.27
    • Chao, M.1    Gibbs, P.2
  • 5
    • 49249105380 scopus 로고    scopus 로고
    • The role of imaging in the pre-operative staging and post-operative follow-up of rectal cancer
    • G. Low, L.M. Tho, E. Leen, E. Wiebe, S. Kakumanu, A.C. McDonald, and F.W. Poon The role of imaging in the pre-operative staging and post-operative follow-up of rectal cancer Surgeon 6 2008 222 231
    • (2008) Surgeon , vol.6 , pp. 222-231
    • Low, G.1    Tho, L.M.2    Leen, E.3    Wiebe, E.4    Kakumanu, S.5    McDonald, A.C.6    Poon, F.W.7
  • 6
    • 34250716337 scopus 로고    scopus 로고
    • A small rise in CEA is sensitive for recurrence after surgery for colorectal cancer
    • T. Irvine, M. Scott, and C.I. Clark A small rise in CEA is sensitive for recurrence after surgery for colorectal cancer Colorectal Dis. 9 2007 527 531
    • (2007) Colorectal Dis. , vol.9 , pp. 527-531
    • Irvine, T.1    Scott, M.2    Clark, C.I.3
  • 7
    • 24744451447 scopus 로고    scopus 로고
    • Carcinoembryonic antigen in the staging and follow-up of patients with colorectal cancer
    • M.J. Goldstein, and E.P. Mitchell Carcinoembryonic antigen in the staging and follow-up of patients with colorectal cancer Cancer Invest. 23 2005 338 351
    • (2005) Cancer Invest. , vol.23 , pp. 338-351
    • Goldstein, M.J.1    Mitchell, E.P.2
  • 8
    • 84957852098 scopus 로고
    • Les acides nucleiques du plasma sanguin chezl'homme
    • P. Mandel, and P. Metais Les acides nucleiques du plasma sanguin chezl'homme C.R. Acad. Sci. Paris 142 1948 241 243
    • (1948) C.R. Acad. Sci. Paris , vol.142 , pp. 241-243
    • Mandel, P.1    Metais, P.2
  • 9
    • 37049234402 scopus 로고
    • Circulating DNA as a possible factor in oncogenesis
    • A. Bendich, T. Wilczok, and E. Borenfreund Circulating DNA as a possible factor in oncogenesis Science 148 1965 374 376
    • (1965) Science , vol.148 , pp. 374-376
    • Bendich, A.1    Wilczok, T.2    Borenfreund, E.3
  • 10
    • 0015535196 scopus 로고
    • The occurrence of single-stranded DNA in the serum of patients with systemic lupus erythematosus and other diseases
    • D. Koffler, V. Agnello, R. Winchester, and H.G. Kunkel The occurrence of single-stranded DNA in the serum of patients with systemic lupus erythematosus and other diseases J. Clin. Invest. 52 1973 198 204
    • (1973) J. Clin. Invest. , vol.52 , pp. 198-204
    • Koffler, D.1    Agnello, V.2    Winchester, R.3    Kunkel, H.G.4
  • 11
    • 0017360626 scopus 로고
    • Free DNA in the serum of cancer patients and the effect of therapy
    • S.A. Leon, B. Shapiro, D.M. Sklaroff, and M.J. Yaros Free DNA in the serum of cancer patients and the effect of therapy Cancer Res. 37 1977 646 650
    • (1977) Cancer Res. , vol.37 , pp. 646-650
    • Leon, S.A.1    Shapiro, B.2    Sklaroff, D.M.3    Yaros, M.J.4
  • 12
    • 0020581141 scopus 로고
    • Determination of circulating DNA levels in patients with benign or malignant gastrointestinal disease
    • B. Shapiro, M. Chakrabarty, E.M. Cohn, and S.A. Leon Determination of circulating DNA levels in patients with benign or malignant gastrointestinal disease Cancer 51 1983 2116 2120
    • (1983) Cancer , vol.51 , pp. 2116-2120
    • Shapiro, B.1    Chakrabarty, M.2    Cohn, E.M.3    Leon, S.A.4
  • 16
    • 0034750635 scopus 로고    scopus 로고
    • Circulating nucleic acids in plasma and serum: An overview
    • Y.M. Lo Circulating nucleic acids in plasma and serum: An overview Ann. NY. Acad. Sci. 945 2001 1 7
    • (2001) Ann. NY. Acad. Sci. , vol.945 , pp. 1-7
    • Lo, Y.M.1
  • 17
    • 3242878227 scopus 로고    scopus 로고
    • Circulating nucleic acids in plasma and serum: Past, present, and future
    • B. Taback, and D.S. Hoon Circulating nucleic acids in plasma and serum: past, present, and future Curr. Opin. Mol. Ther. 6 2004 273 278
    • (2004) Curr. Opin. Mol. Ther. , vol.6 , pp. 273-278
    • Taback, B.1    Hoon, D.S.2
  • 18
    • 28544443522 scopus 로고    scopus 로고
    • Diagnostic developments involving cell-free (circulating) nucleic acids
    • Y.K. Tong, and Y.M. Lo Diagnostic developments involving cell-free (circulating) nucleic acids Clin. Chim. Acta 363 2006 187 196
    • (2006) Clin. Chim. Acta , vol.363 , pp. 187-196
    • Tong, Y.K.1    Lo, Y.M.2
  • 19
    • 77951088557 scopus 로고    scopus 로고
    • Circulating nucleic acids as a potential source for cancer biomarkers
    • V.V. Vlassov, P.P. Laktionov, and E.Y. Rykova Circulating nucleic acids as a potential source for cancer biomarkers Curr. Mol. Med. 10 2010 142 165
    • (2010) Curr. Mol. Med. , vol.10 , pp. 142-165
    • Vlassov, V.V.1    Laktionov, P.P.2    Rykova, E.Y.3
  • 20
    • 0035866393 scopus 로고    scopus 로고
    • DNA fragments in the blood plasma of cancer patients: Quantitations and evidence for their origin from apoptotic and necrotic cells
    • S. Jahr, H. Hentze, S. Englisch, D. Hardt, F.O. Fackelmayer, R.D. Hesch, and R. Knippers DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells Cancer Res. 61 2001 1659 1665
    • (2001) Cancer Res. , vol.61 , pp. 1659-1665
    • Jahr, S.1    Hentze, H.2    Englisch, S.3    Hardt, D.4    Fackelmayer, F.O.5    Hesch, R.D.6    Knippers, R.7
  • 23
    • 17844374889 scopus 로고    scopus 로고
    • The role of macrophages in the in vitro generation of extracellular DNA from apoptotic and necrotic cells
    • J.J. Choi, C.F. Reich III, and D.S. Pisetsky The role of macrophages in the in vitro generation of extracellular DNA from apoptotic and necrotic cells Immunology 115 2005 55 62
    • (2005) Immunology , vol.115 , pp. 55-62
    • Choi, J.J.1    Reich III, C.F.2    Pisetsky, D.S.3
  • 24
    • 84966192535 scopus 로고
    • The histological structure of some human lung cancers and the possible implications for radiotherapy
    • R.H. Thomlinson, and L.H. Gray The histological structure of some human lung cancers and the possible implications for radiotherapy Br. J. Cancer 9 1955 539 549
    • (1955) Br. J. Cancer , vol.9 , pp. 539-549
    • Thomlinson, R.H.1    Gray, L.H.2
  • 25
    • 0033067163 scopus 로고    scopus 로고
    • Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast
    • R.D. Leek, R.J. Landers, A.L. Harris, and C.E. Lewis Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast Br. J. Cancer 79 1999 991 995
    • (1999) Br. J. Cancer , vol.79 , pp. 991-995
    • Leek, R.D.1    Landers, R.J.2    Harris, A.L.3    Lewis, C.E.4
  • 26
    • 33749573192 scopus 로고    scopus 로고
    • Higher amount of free circulating DNA in serum than in plasma is not mainly caused by contaminated extraneous DNA during separation
    • N. Umetani, S. Hiramatsu, and D.S. Hoon Higher amount of free circulating DNA in serum than in plasma is not mainly caused by contaminated extraneous DNA during separation Ann. N.Y. Acad. Sci. 1075 2006 299 307
    • (2006) Ann. N.Y. Acad. Sci. , vol.1075 , pp. 299-307
    • Umetani, N.1    Hiramatsu, S.2    Hoon, D.S.3
  • 27
    • 52249107130 scopus 로고    scopus 로고
    • Detection of mutated K-ras DNA in urine, plasma, and serum of patients with colorectal carcinoma or adenomatous polyps
    • Y.H. Su, M. Wang, D.E. Brenner, P.A. Norton, and T.M. Block Detection of mutated K-ras DNA in urine, plasma, and serum of patients with colorectal carcinoma or adenomatous polyps Ann. N.Y. Acad. Sci. 1137 2008 197 206
    • (2008) Ann. N.Y. Acad. Sci. , vol.1137 , pp. 197-206
    • Su, Y.H.1    Wang, M.2    Brenner, D.E.3    Norton, P.A.4    Block, T.M.5
  • 30
    • 52249117895 scopus 로고    scopus 로고
    • Circulating nucleic acids in plasma and serum: Recent developments
    • P.B. Gahan, and R. Swaminathan Circulating nucleic acids in plasma and serum: recent developments Ann. N.Y. Acad. Sci. 1137 2008 1 6
    • (2008) Ann. N.Y. Acad. Sci. , vol.1137 , pp. 1-6
    • Gahan, P.B.1    Swaminathan, R.2
  • 31
    • 33646935703 scopus 로고    scopus 로고
    • Increased integrity of free circulating DNA in sera of patients with colorectal or periampullary cancer: Direct quantitative PCR for ALU repeats
    • N. Umetani, J. Kim, S. Hiramatsu, H.A. Reber, O.J. Hines, A.J. Bilchik, and D.S. Hoon Increased integrity of free circulating DNA in sera of patients with colorectal or periampullary cancer: direct quantitative PCR for ALU repeats Clin. Chem. 52 2006 1062 1069
    • (2006) Clin. Chem. , vol.52 , pp. 1062-1069
    • Umetani, N.1    Kim, J.2    Hiramatsu, S.3    Reber, H.A.4    Hines, O.J.5    Bilchik, A.J.6    Hoon, D.S.7
  • 33
    • 52249087562 scopus 로고    scopus 로고
    • An improved method for the isolation of free-circulating plasma DNA and cell-free DNA from other body fluids
    • C. Kirsch, S. Weickmann, B. Schmidt, and M. Fleischhacker An improved method for the isolation of free-circulating plasma DNA and cell-free DNA from other body fluids Ann. N.Y. Acad. Sci. 1137 2008 135 139
    • (2008) Ann. N.Y. Acad. Sci. , vol.1137 , pp. 135-139
    • Kirsch, C.1    Weickmann, S.2    Schmidt, B.3    Fleischhacker, M.4
  • 35
    • 72649092170 scopus 로고    scopus 로고
    • Is the role of circulating DNA as a biomarker of cancer being prematurely overrated?
    • M. van der Vaart, and P.J. Pretorius Is the role of circulating DNA as a biomarker of cancer being prematurely overrated? Clin. Biochem. 43 2010 26 36
    • (2010) Clin. Biochem. , vol.43 , pp. 26-36
    • Van Der Vaart, M.1    Pretorius, P.J.2
  • 36
    • 33749576333 scopus 로고    scopus 로고
    • Comparison of genetic alterations detected in circulating microsatellite DNA in blood plasma samples of patients with prostate cancer and benign prostatic hyperplasia
    • I. Muller, K. Urban, K. Pantel, and H. Schwarzenbach Comparison of genetic alterations detected in circulating microsatellite DNA in blood plasma samples of patients with prostate cancer and benign prostatic hyperplasia Ann. N.Y. Acad. Sci. 1075 2006 222 229
    • (2006) Ann. N.Y. Acad. Sci. , vol.1075 , pp. 222-229
    • Muller, I.1    Urban, K.2    Pantel, K.3    Schwarzenbach, H.4
  • 38
    • 1842583637 scopus 로고    scopus 로고
    • Quantitative plasma hypermethylated DNA markers of undifferentiated nasopharyngeal carcinoma
    • T.S. Wong, D.L. Kwong, J.S. Sham, W.I. Wei, Y.L. Kwong, and A.P. Yuen Quantitative plasma hypermethylated DNA markers of undifferentiated nasopharyngeal carcinoma Clin. Cancer Res. 10 2004 2401 2406
    • (2004) Clin. Cancer Res. , vol.10 , pp. 2401-2406
    • Wong, T.S.1    Kwong, D.L.2    Sham, J.S.3    Wei, W.I.4    Kwong, Y.L.5    Yuen, A.P.6
  • 40
    • 0242317395 scopus 로고    scopus 로고
    • Frequent copresence of methylated DNA and fragmented nucleosomal DNA in plasma of lymphoma patients
    • U. Deligezer, F. Yaman, N. Erten, and N. Dalay Frequent copresence of methylated DNA and fragmented nucleosomal DNA in plasma of lymphoma patients Clin. Chim. Acta 335 2003 89 94
    • (2003) Clin. Chim. Acta , vol.335 , pp. 89-94
    • Deligezer, U.1    Yaman, F.2    Erten, N.3    Dalay, N.4
  • 41
    • 36248930484 scopus 로고    scopus 로고
    • Metastatic suppressor genes inactivated by aberrant methylation in gastric cancer
    • J.F. Wang, and D.Q. Dai Metastatic suppressor genes inactivated by aberrant methylation in gastric cancer World J. Gastroenterol. 13 2007 5692 5698
    • (2007) World J. Gastroenterol. , vol.13 , pp. 5692-5698
    • Wang, J.F.1    Dai, D.Q.2
  • 43
    • 33845476677 scopus 로고    scopus 로고
    • Circulating nucleic acids (CNAs) and cancer - A survey
    • M. Fleischhacker, and B. Schmidt Circulating nucleic acids (CNAs) and cancer - a survey Biochim. Biophys. Acta 1775 2007 181 232
    • (2007) Biochim. Biophys. Acta , vol.1775 , pp. 181-232
    • Fleischhacker, M.1    Schmidt, B.2
  • 44
    • 0034114254 scopus 로고    scopus 로고
    • Oncogenic base substitution mutations in circulating leukocytes of normal individuals
    • V.L. Wilson, X. Yin, B. Thompson, K.R. Wade, J.P. Watkins, Q. Wei, and W.R. Lee Oncogenic base substitution mutations in circulating leukocytes of normal individuals Cancer Res. 60 2000 1830 1834
    • (2000) Cancer Res. , vol.60 , pp. 1830-1834
    • Wilson, V.L.1    Yin, X.2    Thompson, B.3    Wade, K.R.4    Watkins, J.P.5    Wei, Q.6    Lee, W.R.7
  • 45
    • 0035552215 scopus 로고    scopus 로고
    • Detecting rare mutations associated with cancer risk
    • V.L. Wilson Detecting rare mutations associated with cancer risk Am. J. Pharmacogenomics 1 2001 283 293
    • (2001) Am. J. Pharmacogenomics , vol.1 , pp. 283-293
    • Wilson, V.L.1
  • 46
    • 0001430252 scopus 로고
    • DNA fragments differing by single base-pair substitutions are separated in denaturing gradient gels: Correspondence with melting theory
    • S.G. Fischer, and L.S. Lerman DNA fragments differing by single base-pair substitutions are separated in denaturing gradient gels: correspondence with melting theory Proc. Natl. Acad. Sci. USA 80 1983 1579 1583
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 1579-1583
    • Fischer, S.G.1    Lerman, L.S.2
  • 47
    • 0028275083 scopus 로고
    • Constant denaturant capillary electrophoresis (CDCE): A high resolution approach to mutational analysis
    • K. Khrapko, J.S. Hanekamp, W.G. Thilly, A. Belenkii, F. Foret, and B.L. Karger Constant denaturant capillary electrophoresis (CDCE): a high resolution approach to mutational analysis Nucleic Acids Res. 22 1994 364 369
    • (1994) Nucleic Acids Res. , vol.22 , pp. 364-369
    • Khrapko, K.1    Hanekamp, J.S.2    Thilly, W.G.3    Belenkii, A.4    Foret, F.5    Karger, B.L.6
  • 48
    • 0032745174 scopus 로고    scopus 로고
    • Detection of point mutations by capillary electrophoresis with temporal temperature gradients
    • J. Schell, M. Wulfert, and D. Riesner Detection of point mutations by capillary electrophoresis with temporal temperature gradients Electrophoresis 20 1999 2864 2869
    • (1999) Electrophoresis , vol.20 , pp. 2864-2869
    • Schell, J.1    Wulfert, M.2    Riesner, D.3
  • 49
    • 0034777533 scopus 로고    scopus 로고
    • Spatial temperature gradient capillary electrophoresis for DNA mutation detection
    • L. Zhu, H.K. Lee, B. Lin, and E.S. Yeung Spatial temperature gradient capillary electrophoresis for DNA mutation detection Electrophoresis 22 2001 3683 3687
    • (2001) Electrophoresis , vol.22 , pp. 3683-3687
    • Zhu, L.1    Lee, H.K.2    Lin, B.3    Yeung, E.S.4
  • 50
    • 0042470319 scopus 로고    scopus 로고
    • Cycling gradient capillary electrophoresis: A low-cost tool for high-throughput analysis of genetic variations
    • M. Minarik, L. Minarikova, J. Bjorheim, and P.O. Ekstrom Cycling gradient capillary electrophoresis: a low-cost tool for high-throughput analysis of genetic variations Electrophoresis 24 2003 1716 1722
    • (2003) Electrophoresis , vol.24 , pp. 1716-1722
    • Minarik, M.1    Minarikova, L.2    Bjorheim, J.3    Ekstrom, P.O.4
  • 51
    • 35649026772 scopus 로고    scopus 로고
    • Technology to accelerate pangenomic scanning for unknown point mutations in exonic sequences: Cycling temperature capillary electrophoresis (CTCE)
    • P.O. Ekstrom, J. Bjorheim, and W.G. Thilly Technology to accelerate pangenomic scanning for unknown point mutations in exonic sequences: cycling temperature capillary electrophoresis (CTCE) BMC Genet. 8 2007 54
    • (2007) BMC Genet. , vol.8 , pp. 54
    • Ekstrom, P.O.1    Bjorheim, J.2    Thilly, W.G.3
  • 53
    • 34249717959 scopus 로고    scopus 로고
    • Diagnostic accuracy of methods for the detection of BRCA1 and BRCA2 mutations: A systematic review
    • A. Gerhardus, H. Schleberger, B. Schlegelberger, and D. Gadzicki Diagnostic accuracy of methods for the detection of BRCA1 and BRCA2 mutations: a systematic review Eur. J. Hum. Genet. 15 2007 619 627
    • (2007) Eur. J. Hum. Genet. , vol.15 , pp. 619-627
    • Gerhardus, A.1    Schleberger, H.2    Schlegelberger, B.3    Gadzicki, D.4
  • 54
    • 0041692872 scopus 로고    scopus 로고
    • Evaluation of denaturing conditions in analysis of DNA variants applied to multi-capillary electrophoresis instruments
    • J. Bjorheim, M. Minarik, G. Gaudernack, and P.O. Ekstrom Evaluation of denaturing conditions in analysis of DNA variants applied to multi-capillary electrophoresis instruments J. Sep. Sci. 26 2003 1163 1168
    • (2003) J. Sep. Sci. , vol.26 , pp. 1163-1168
    • Bjorheim, J.1    Minarik, M.2    Gaudernack, G.3    Ekstrom, P.O.4
  • 55
    • 2342537778 scopus 로고    scopus 로고
    • Application of cycling gradient capillary electrophoresis to detection of APC, K-ras, and DCC point mutations in patients with sporadic colorectal tumors
    • M. Minarik, L. Minarikova, M. Hrabikova, P. Minarikova, P. Hrabal, and M. Zavoal Application of cycling gradient capillary electrophoresis to detection of APC, K-ras, and DCC point mutations in patients with sporadic colorectal tumors Electrophoresis 25 2004 1016 1021
    • (2004) Electrophoresis , vol.25 , pp. 1016-1021
    • Minarik, M.1    Minarikova, L.2    Hrabikova, M.3    Minarikova, P.4    Hrabal, P.5    Zavoal, M.6
  • 56
    • 77955411557 scopus 로고    scopus 로고
    • Denaturing capillary electrophoresis for automated detection of L858R mutation in exon 21 of the epidermal growth factor receptor gene in prediction of the outcome of lung cancer therapy
    • L. Benesova, M. Pesek, B. Belsanova, P. Sekerka, and M. Minarik Denaturing capillary electrophoresis for automated detection of L858R mutation in exon 21 of the epidermal growth factor receptor gene in prediction of the outcome of lung cancer therapy J. Sep. Sci. 33 2010 2349 2355
    • (2010) J. Sep. Sci. , vol.33 , pp. 2349-2355
    • Benesova, L.1    Pesek, M.2    Belsanova, B.3    Sekerka, P.4    Minarik, M.5
  • 57
    • 0034181115 scopus 로고    scopus 로고
    • A sensitive scanning technology for low frequency nuclear point mutations in human genomic DNA
    • X.C. Li-Sucholeiki, and W.G. Thilly A sensitive scanning technology for low frequency nuclear point mutations in human genomic DNA Nucleic Acids Res. 28 2000 e44
    • (2000) Nucleic Acids Res. , vol.28 , pp. 44
    • Li-Sucholeiki, X.C.1    Thilly, W.G.2
  • 60
    • 84871634350 scopus 로고    scopus 로고
    • Circulating free tumor DNA in patient plasma is a near-perfect marker for metastatic spread of colorectal cancer: A study on 165 patients undergoing surgical treatment
    • M. Minarik, B. Belsanova, P. Minarikova, L. Lipska, L. Levy, G. Veprekova, V. Visokai, M. Zavoral, and L. Benesova Circulating free tumor DNA in patient plasma is a near-perfect marker for metastatic spread of colorectal cancer: a study on 165 patients undergoing surgical treatment Gastroenterology 140 2011 S343
    • (2011) Gastroenterology , vol.140 , pp. 343
    • Minarik, M.1    Belsanova, B.2    Minarikova, P.3    Lipska, L.4    Levy, L.5    Veprekova, G.6    Visokai, V.7    Zavoral, M.8    Benesova, L.9
  • 64
  • 66
    • 43249116705 scopus 로고    scopus 로고
    • Replacing PCR with COLD-PCR enriches variant DNA sequences and redefines the sensitivity of genetic testing
    • J. Li, L. Wang, H. Mamon, M.H. Kulke, R. Berbeco, and G.M. Makrigiorgos Replacing PCR with COLD-PCR enriches variant DNA sequences and redefines the sensitivity of genetic testing Nat. Med. 14 2008 579 584
    • (2008) Nat. Med. , vol.14 , pp. 579-584
    • Li, J.1    Wang, L.2    Mamon, H.3    Kulke, M.H.4    Berbeco, R.5    Makrigiorgos, G.M.6
  • 67
    • 77956792325 scopus 로고    scopus 로고
    • The use of COLD-PCR and high-resolution melting analysis improves the limit of detection of KRAS and BRAF mutations in colorectal cancer
    • I. Mancini, C. Santucci, R. Sestini, L. Simi, N. Pratesi, F. Cianchi, R. Valanzano, P. Pinzani, and C. Orlando The use of COLD-PCR and high-resolution melting analysis improves the limit of detection of KRAS and BRAF mutations in colorectal cancer J. Mol. Diagn. 12 2010 705 711
    • (2010) J. Mol. Diagn. , vol.12 , pp. 705-711
    • Mancini, I.1    Santucci, C.2    Sestini, R.3    Simi, L.4    Pratesi, N.5    Cianchi, F.6    Valanzano, R.7    Pinzani, P.8    Orlando, C.9
  • 72
    • 67649958254 scopus 로고    scopus 로고
    • Non-invasive prenatal diagnosis by single molecule counting technologies
    • R.W. Chiu, C.R. Cantor, and Y.M. Lo Non-invasive prenatal diagnosis by single molecule counting technologies Trends Genet. 25 2009 324 331
    • (2009) Trends Genet. , vol.25 , pp. 324-331
    • Chiu, R.W.1    Cantor, C.R.2    Lo, Y.M.3
  • 75
    • 54049132561 scopus 로고    scopus 로고
    • Microfluidics digital PCR reveals a higher than expected fraction of fetal DNA in maternal plasma
    • F.M. Lun, R.W. Chiu, K.C.A. Chan, L.T. Yeung, L.T. Kin, and Y.M.D. Lo Microfluidics digital PCR reveals a higher than expected fraction of fetal DNA in maternal plasma Clin. Chem. 54 2008 1664 1672
    • (2008) Clin. Chem. , vol.54 , pp. 1664-1672
    • Lun, F.M.1    Chiu, R.W.2    Chan, K.C.A.3    Yeung, L.T.4    Kin, L.T.5    Lo, Y.M.D.6
  • 76
    • 33845342557 scopus 로고    scopus 로고
    • Microfluidic digital PCR enables multigene analysis of individual environmental bacteria
    • E.A. Ottesen, J.W. Hong, S.R. Quake, and J.R. Leadbetter Microfluidic digital PCR enables multigene analysis of individual environmental bacteria Science 314 2006 1464 1467
    • (2006) Science , vol.314 , pp. 1464-1467
    • Ottesen, E.A.1    Hong, J.W.2    Quake, S.R.3    Leadbetter, J.R.4
  • 80
    • 0347762809 scopus 로고    scopus 로고
    • Principle and applications of digital PCR
    • G. Pohl, and I. Shih Principle and applications of digital PCR Expert Rev. Mol. Diagn. 4 2004 41 47
    • (2004) Expert Rev. Mol. Diagn. , vol.4 , pp. 41-47
    • Pohl, G.1    Shih, I.2
  • 84
    • 0012762889 scopus 로고
    • Imaging of single uncoated DNA molecules by scanning tunneling microscopy
    • D. Keller, C. Bustamante, and R.W. Keller Imaging of single uncoated DNA molecules by scanning tunneling microscopy Proc. Natl. Acad. Sci. USA 86 1989 5356 5360
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 5356-5360
    • Keller, D.1    Bustamante, C.2    Keller, R.W.3
  • 86
    • 33751414735 scopus 로고    scopus 로고
    • Sequencing single molecules of DNA
    • H. Bayley Sequencing single molecules of DNA Curr. Opin. Chem. Biol. 10 2006 628 637
    • (2006) Curr. Opin. Chem. Biol. , vol.10 , pp. 628-637
    • Bayley, H.1
  • 88
    • 0037009084 scopus 로고    scopus 로고
    • A further step towards single-molecule sequencing: Escherichia coli exonuclease III degrades DNA that is fluorescently labeled at each base pair
    • S. Brakmann, and S. Lobermann A further step towards single-molecule sequencing: Escherichia coli exonuclease III degrades DNA that is fluorescently labeled at each base pair Angew. Chem. Int. Ed. Engl. 41 2002 3215 3217
    • (2002) Angew. Chem. Int. Ed. Engl. , vol.41 , pp. 3215-3217
    • Brakmann, S.1    Lobermann, S.2
  • 89
    • 76649128993 scopus 로고    scopus 로고
    • Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype
    • S.Y. Park, M. Gonen, H.J. Kim, F. Michor, and K. Polyak Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype J. Clin. Invest. 120 2010 636 644
    • (2010) J. Clin. Invest. , vol.120 , pp. 636-644
    • Park, S.Y.1    Gonen, M.2    Kim, H.J.3    Michor, F.4    Polyak, K.5
  • 93
    • 64049118136 scopus 로고    scopus 로고
    • From cancer genomes to cancer models: Bridging the gaps
    • A. Baudot, F.X. Real, J.M. Izarzugaza, and A. Valencia From cancer genomes to cancer models: bridging the gaps EMBO Rep. 10 2009 359 366
    • (2009) EMBO Rep. , vol.10 , pp. 359-366
    • Baudot, A.1    Real, F.X.2    Izarzugaza, J.M.3    Valencia, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.