-
1
-
-
79953151458
-
Cancer immunoediting: Integrating immunity's roles in cancer suppression and promotion
-
Schreiber, R. D., Old, L. J. & Smyth, M. J. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science 331, 1565-1570 (2011)
-
(2011)
Science
, vol.331
, pp. 1565-1570
-
-
Schreiber, R.D.1
Old, L.J.2
Smyth, M.J.3
-
2
-
-
33748987908
-
Cancer despite immunosurveillance: Immunoselection and immunosubversion
-
Zitvogel, L., Tesniere, A. & Kroemer, G. Cancer despite immunosurveillance: immunoselection and immunosubversion. Nat. Rev. Immunol. 6, 715-727 (2006)
-
(2006)
Nat. Rev. Immunol
, vol.6
, pp. 715-727
-
-
Zitvogel, L.1
Tesniere, A.2
Kroemer, G.3
-
3
-
-
63049104211
-
Microenvironmental regulation of metastasis
-
Joyce, J. A. & Pollard, J. W. Microenvironmental regulation of metastasis. Nat. Rev. Cancer 9, 239-252 (2009)
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 239-252
-
-
Joyce, J.A.1
Pollard, J.W.2
-
4
-
-
84857702419
-
Molecular pathways: Hypoxia response in immune cells fighting or promoting cancer
-
Palazon, A., Aragones, J., Morales-Kastresana, A., de Landazuri, M. O. & Melero, I. Molecular pathways: hypoxia response in immune cells fighting or promoting cancer. Clin. Cancer Res. 18, 1207-1213 (2012)
-
(2012)
Clin. Cancer Res
, vol.18
, pp. 1207-1213
-
-
Palazon, A.1
Aragones, J.2
Morales-Kastresana, A.3
De Landazuri, M.O.4
Melero, I.5
-
5
-
-
82755186508
-
Microenvironmental hypoxia orchestrating the cell stroma cross talk, tumor progression and antitumor response
-
Noman, M. Z. et al. Microenvironmental hypoxia orchestrating the cell stroma cross talk, tumor progression and antitumor response. Crit. Rev. Immunol. 31, 357-377 (2011)
-
(2011)
Crit. Rev. Immunol
, vol.31
, pp. 357-377
-
-
Noman, M.Z.1
-
6
-
-
24044461733
-
Macrophage responses to hypoxia: Implications for tumor progression and anti-cancer therapies
-
Lewis, C. & Murdoch, C. Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies. Am. J. Pathol. 167, 627-635 (2005)
-
(2005)
Am. J. Pathol
, vol.167
, pp. 627-635
-
-
Lewis, C.1
Murdoch, C.2
-
7
-
-
78149330949
-
HIF-1 regulates function and differentiation of myeloidderived suppressor cells in the tumor microenvironment
-
Corzo, C. A. et al. HIF-1 regulates function and differentiation of myeloidderived suppressor cells in the tumor microenvironment. J. Exp. Med. 207, 2439-2453 (2010)
-
(2010)
J. Exp. Med
, vol.207
, pp. 2439-2453
-
-
Corzo, C.A.1
-
8
-
-
84942943894
-
Tumor-promoting effects of myeloid-derived suppressor cells are potentiated by hypoxia-induced expression of MIR-210
-
Noman, M. Z. et al. Tumor-promoting effects of myeloid-derived suppressor cells are potentiated by hypoxia-induced expression of miR-210. Cancer Res. 75, 3771-3787 (2015)
-
(2015)
Cancer Res
, vol.75
, pp. 3771-3787
-
-
Noman, M.Z.1
-
9
-
-
79960393113
-
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells
-
Facciabene, A. et al. Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells. Nature 475, 226-230 (2011)
-
(2011)
Nature
, vol.475
, pp. 226-230
-
-
Facciabene, A.1
-
10
-
-
58249088751
-
MicroRNAs: Target recognition and regulatory functions
-
Bartel, D. P. MicroRNAs: target recognition and regulatory functions. Cell 136, 215-233 (2009)
-
(2009)
Cell
, vol.136
, pp. 215-233
-
-
Bartel, D.P.1
-
11
-
-
75649139134
-
Physiological and pathological roles for microRNAs in the immune system
-
O'Connell, R. M., Rao, D. S., Chaudhuri, A. A. & Baltimore, D. Physiological and pathological roles for microRNAs in the immune system. Nat. Rev. Immunol. 10, 111-122 (2010)
-
(2010)
Nat. Rev. Immunol
, vol.10
, pp. 111-122
-
-
O'Connell, R.M.1
Rao, D.S.2
Chaudhuri, A.A.3
Baltimore, D.4
-
12
-
-
33645294070
-
Oncomirs-microRNAs with a role in cancer
-
Esquela-Kerscher, A. & Slack, F. J. Oncomirs-microRNAs with a role in cancer. Nat. Rev. Cancer 6, 259-269 (2006)
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 259-269
-
-
Esquela-Kerscher, A.1
Slack, F.J.2
-
13
-
-
84878108145
-
EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2
-
Shen, J. et al. EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2. Nature 497, 383-387 (2013)
-
(2013)
Nature
, vol.497
, pp. 383-387
-
-
Shen, J.1
-
14
-
-
40949122258
-
A microRNA component of the hypoxic response
-
Kulshreshtha, R., Davuluri, R. V., Calin, G. A. & Ivan, M. A microRNA component of the hypoxic response. Cell Death Differ. 15, 667-671 (2008)
-
(2008)
Cell Death Differ
, vol.15
, pp. 667-671
-
-
Kulshreshtha, R.1
Davuluri, R.V.2
Calin, G.A.3
Ivan, M.4
-
15
-
-
65449154326
-
The cooperative induction of hypoxia-inducible factor-1 alpha and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTLmediated cell lysis
-
Noman, M. Z. et al. The cooperative induction of hypoxia-inducible factor-1 alpha and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTLmediated cell lysis. J. Immunol. 182, 3510-3521 (2009)
-
(2009)
J. Immunol
, vol.182
, pp. 3510-3521
-
-
Noman, M.Z.1
-
16
-
-
79953059789
-
Natural innate and adaptive immunity to cancer
-
Vesely, M. D., Kershaw, M. H., Schreiber, R. D. & Smyth, M. J. Natural innate and adaptive immunity to cancer. Annu. Rev. Immunol. 29, 235-271 (2011)
-
(2011)
Annu. Rev. Immunol
, vol.29
, pp. 235-271
-
-
Vesely, M.D.1
Kershaw, M.H.2
Schreiber, R.D.3
Smyth, M.J.4
-
17
-
-
40249113328
-
Direct regulation of TWIST by HIF-1 promotes metastasis
-
Yang, M. H. et al. Direct regulation of TWIST by HIF-1 promotes metastasis. Nat. Cell Biol. 10, 295-305 (2008)
-
(2008)
Nat. Cell Biol
, vol.10
, pp. 295-305
-
-
Yang, M.H.1
-
18
-
-
84867381718
-
Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
-
Clambey, E. T. et al. Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc. Natl Acad. Sci. USA 109, E2784-E2793 (2012)
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. E2784-E2793
-
-
Clambey, E.T.1
-
19
-
-
84942937379
-
Hypoxia drives breast tumor malignancy through a TET-TNF-p38-MAPK signaling axis
-
Wu, M. Z. et al. Hypoxia drives breast tumor malignancy through a TET-TNF-p38-MAPK signaling axis. Cancer Res. 75, 3912-3924 (2015)
-
(2015)
Cancer Res
, vol.75
, pp. 3912-3924
-
-
Wu, M.Z.1
-
20
-
-
54249158400
-
Emerging role of MIR-106b-25/MIR-17-92 clusters in the control of transforming growth factor beta signaling
-
Petrocca, F., Vecchione, A. & Croce, C. M. Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling. Cancer Res. 68, 8191-8194 (2008)
-
(2008)
Cancer Res
, vol.68
, pp. 8191-8194
-
-
Petrocca, F.1
Vecchione, A.2
Croce, C.M.3
-
21
-
-
84923289688
-
Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER
-
van den Beucken, T. et al. Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER. Nat. Commun. 5, 5203 (2014)
-
(2014)
Nat. Commun
, vol.5
, pp. 5203
-
-
Van Den Beucken, T.1
-
22
-
-
84902345994
-
TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma
-
Mariani, C. J. et al. TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma. Cell Rep. 7, 1343-1352 (2014)
-
(2014)
Cell Rep
, vol.7
, pp. 1343-1352
-
-
Mariani, C.J.1
-
23
-
-
84882896267
-
Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses
-
Gao, D. et al. Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science 341, 903-906 (2013)
-
(2013)
Science
, vol.341
, pp. 903-906
-
-
Gao, D.1
-
24
-
-
84873711885
-
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type i interferon pathway
-
Sun, L., Wu, J., Du, F., Chen, X. & Chen, Z. J. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339, 786-791 (2013)
-
(2013)
Science
, vol.339
, pp. 786-791
-
-
Sun, L.1
Wu, J.2
Du, F.3
Chen, X.4
Chen, Z.J.5
-
25
-
-
0037066427
-
The danger model: A renewed sense of self
-
Matzinger, P. The danger model: a renewed sense of self. Science 296, 301-305 (2002)
-
(2002)
Science
, vol.296
, pp. 301-305
-
-
Matzinger, P.1
-
26
-
-
84931562356
-
Hypoxia induced HMGB1 and mitochondrial DNA interactions mediate tumor growth in hepatocellular carcinoma through Toll-like receptor 9
-
Liu, Y. et al. Hypoxia induced HMGB1 and mitochondrial DNA interactions mediate tumor growth in hepatocellular carcinoma through Toll-like receptor 9. J. Hepatol. 63, 114-121 (2015)
-
(2015)
J. Hepatol
, vol.63
, pp. 114-121
-
-
Liu, Y.1
-
27
-
-
84919898250
-
Apoptotic caspases prevent the induction of type i interferons by mitochondrial DNA
-
Rongvaux, A. et al. Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA. Cell 159, 1563-1577 (2014)
-
(2014)
Cell
, vol.159
, pp. 1563-1577
-
-
Rongvaux, A.1
-
28
-
-
84919884654
-
Apoptotic caspases suppress mtDNA-induced STING-mediated type i IFN production
-
White, M. J. et al. Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production. Cell 159, 1549-1562 (2014)
-
(2014)
Cell
, vol.159
, pp. 1549-1562
-
-
White, M.J.1
-
29
-
-
84862789618
-
Mitochondrial outer-membrane protein FUNDC1 mediates hypoxiainduced mitophagy in mammalian cells
-
Liu, L. et al. Mitochondrial outer-membrane protein FUNDC1 mediates hypoxiainduced mitophagy in mammalian cells. Nat. Cell Biol. 14, 177-185 (2012)
-
(2012)
Nat. Cell Biol
, vol.14
, pp. 177-185
-
-
Liu, L.1
-
30
-
-
81355133169
-
Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia
-
Kim, H. et al. Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia. Mol. Cell 44, 532-544 (2011)
-
(2011)
Mol. Cell
, vol.44
, pp. 532-544
-
-
Kim, H.1
-
31
-
-
84912128872
-
STING-dependent cytosolic DNA sensing promotes radiation-induced type i interferon-dependent antitumor immunity in immunogenic tumors
-
Deng, L. et al. STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors. Immunity 41, 843-852 (2014)
-
(2014)
Immunity
, vol.41
, pp. 843-852
-
-
Deng, L.1
-
32
-
-
33845314007
-
Steroid receptor coactivator-3 and activator protein-1 coordinately regulate the transcription of components of the insulin-like growth factor/AKT signaling pathway
-
Yan, J. et al. Steroid receptor coactivator-3 and activator protein-1 coordinately regulate the transcription of components of the insulin-like growth factor/AKT signaling pathway. Cancer Res. 66, 11039-11046 (2006)
-
(2006)
Cancer Res
, vol.66
, pp. 11039-11046
-
-
Yan, J.1
-
33
-
-
0030740253
-
Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300
-
Chen, H. et al. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90, 569-580 (1997)
-
(1997)
Cell
, vol.90
, pp. 569-580
-
-
Chen, H.1
-
34
-
-
84867728827
-
Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming
-
Percharde, M. et al. Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming. Genes Dev. 26, 2286-2298 (2012)
-
(2012)
Genes Dev
, vol.26
, pp. 2286-2298
-
-
Percharde, M.1
-
35
-
-
33847234988
-
A microRNA signature of hypoxia
-
Kulshreshtha, R. et al. A microRNA signature of hypoxia. Mol. Cell. Biol. 27, 1859-1867 (2007)
-
(2007)
Mol. Cell. Biol
, vol.27
, pp. 1859-1867
-
-
Kulshreshtha, R.1
-
36
-
-
84876968940
-
MicroRNA-93 controls perfusion recovery after hindlimb ischemia by modulating expression of multiple genes in the cell cycle pathway
-
Hazarika, S. et al. MicroRNA-93 controls perfusion recovery after hindlimb ischemia by modulating expression of multiple genes in the cell cycle pathway. Circulation 127, 1818-1828 (2013)
-
(2013)
Circulation
, vol.127
, pp. 1818-1828
-
-
Hazarika, S.1
-
37
-
-
84955573535
-
MIR-215 is induced post-transcriptionally via HIF-Drosha complex and mediates glioma-initiating cell adaptation to hypoxia by targeting KDM1B
-
Hu, J. et al. MiR-215 is induced post-transcriptionally via HIF-Drosha complex and mediates glioma-initiating cell adaptation to hypoxia by targeting KDM1B. Cancer Cell 29, 49-60 (2016)
-
(2016)
Cancer Cell
, vol.29
, pp. 49-60
-
-
Hu, J.1
-
38
-
-
84921746958
-
Differential regulation of MCM7 and its intronic MIRNA cluster MIR-106b-25 during megakaryopoiesis induced polyploidy
-
Haldar, S., Roy, A. & Banerjee, S. Differential regulation of MCM7 and its intronic miRNA cluster miR-106b-25 during megakaryopoiesis induced polyploidy. RNA Biol. 11, 1137-1147 (2014)
-
(2014)
RNA Biol
, vol.11
, pp. 1137-1147
-
-
Haldar, S.1
Roy, A.2
Banerjee, S.3
-
39
-
-
84890696135
-
Biogenesis of intronic miRNAs located in clusters by independent transcription and alternative splicing
-
Ramalingam, P. et al. Biogenesis of intronic miRNAs located in clusters by independent transcription and alternative splicing. RNA 20, 76-87 (2014)
-
(2014)
RNA
, vol.20
, pp. 76-87
-
-
Ramalingam, P.1
-
40
-
-
84893667824
-
Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia
-
Camps, C. et al. Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia. Mol. Cancer 13, 28 (2014)
-
(2014)
Mol. Cancer
, vol.13
, pp. 28
-
-
Camps, C.1
-
41
-
-
39849095077
-
E2F1-regulated microRNAs impair TGF-dependent cell-cycle arrest and apoptosis in gastric cancer
-
Petrocca, F. et al. E2F1-regulated microRNAs impair TGF-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell 13, 272-286 (2008)
-
(2008)
Cancer Cell
, vol.13
, pp. 272-286
-
-
Petrocca, F.1
-
42
-
-
84947217032
-
Molecular pathways: Targeting the stimulator of interferon genes (STING) in the immunotherapy of cancer
-
Corrales, L. & Gajewski, T. F. Molecular pathways: targeting the stimulator of interferon genes (STING) in the immunotherapy of cancer. Clin. Cancer Res. 21, 4774-4779 (2015)
-
(2015)
Clin. Cancer Res
, vol.21
, pp. 4774-4779
-
-
Corrales, L.1
Gajewski, T.F.2
-
43
-
-
0028201732
-
Tolerance, danger, and the extended family
-
Matzinger, P. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12, 991-1045 (1994)
-
(1994)
Annu. Rev. Immunol
, vol.12
, pp. 991-1045
-
-
Matzinger, P.1
-
44
-
-
77950275298
-
Circulating mitochondrial DAMPs cause inflammatory responses to injury
-
Zhang, Q. et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 464, 104-107 (2010)
-
(2010)
Nature
, vol.464
, pp. 104-107
-
-
Zhang, Q.1
-
45
-
-
80052221592
-
Interplay between HDAC3 and WDR5 is essential for hypoxia-induced epithelial-mesenchymal transition
-
Wu, M. Z. et al. Interplay between HDAC3 and WDR5 is essential for hypoxia-induced epithelial-mesenchymal transition. Mol. Cell 43, 811-822 (2011)
-
(2011)
Mol. Cell
, vol.43
, pp. 811-822
-
-
Wu, M.Z.1
-
46
-
-
77956632634
-
Function of MIR-146a in controlling Treg cell-mediated regulation of Th1 responses
-
Lu, L. F. et al. Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell 142, 914-929 (2010).
-
(2010)
Cell
, vol.142
, pp. 914-929
-
-
Lu, L.F.1
|