Association between exposure to p,p′-DDT and its metabolite p,p′-DDE with obesity: Integrated systematic review and meta-analysis

Environmental Health Perspectives

Volumn 125, Issue 9, 2017, Pages

  Cano Sancho, German ^a   Salmon, Andrew G ^b   La Merrill, Michele A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; ADIPOCYTOKINE; ADIPONECTIN; CHLORPHENOTANE; CHOLESTEROL; LIPID; PROTEIN; TRIACYLGLYCEROL; POLLUTANT;

ALCOHOL CONSUMPTION; BIRTH WEIGHT; BODY MASS; COMORBIDITY; DYSLIPIDEMIA; ENERGY BALANCE; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION; HUMAN; LIPOGENESIS; METABOLISM; METABOLITE; MRNA EXPRESSION ASSAY; NONHUMAN; OBESITY; OUTCOME ASSESSMENT; PHYSICAL ACTIVITY; PRIORITY JOURNAL; REVIEW; THERMOGENESIS; META ANALYSIS; POLLUTANT; STATISTICS AND NUMERICAL DATA;

DDT; DICHLORODIPHENYL DICHLOROETHYLENE; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; HUMANS; OBESITY;

EID: 85031819754     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/EHP527     Document Type: Review

References (89)

1. Agay-Shay K, Martinez D, Valvi D, Garcia-Esteban R, Basagaña X, Robinson O, et al. 2015. Exposure to endocrine-disrupting chemicals during pregnancy and weight at 7 years of age: a multi-pollutant approach. Environ Health Perspect 123:1030–1037, PMID: 25956007, https://doi.org/10.1289/ehp.1409049.
2. Ahdaya SM, Shah PV, Guthrie FE. 1976. Thermoregulation in mice treated with parathion, carbaryl, or DDT. Toxicol Appl Pharmacol 35:575–580, PMID: 817420.
3. Allison DB, Downey M, Atkinson RL, Billington CJ, Bray GA, Eckel RH, et al. 2008. Obesity as a disease: a white paper on evidence and arguments commissioned by the Council of the Obesity Society. Obesity (Silver Spring) 16:1161–1177, https://doi.org/10.1038/oby.2008.231.
4. Appleton BS, Shriver CN, Arnrich L, Hathcock JN. 1981. Effects of 3-methylcholan-threne and DDT on cholesterol 7 alpha-hydroxylase in rats. Durg-Nutr Interact 1(1):15–21, PMID: 6926812.
5. Arnold M, Pandeya N, Byrnes G, Renehan AG, Stevens GA, Ezzati M, et al. 2015. Global burden of cancer attributable to high body-mass index in 2012: a population-based study. Lancet Oncol 16:36–46, PMID: 25467404, https://doi.org/10. 1016/S1470-2045(14)71123-4.
6. ATSDR (Agency for Toxic Substances and Disease Registry). 2002. Toxicological profile for DDT, DDE, and DDD. Atlanta, GA:ATSDR.
7. Attina TM, Hauser R, Sathyanarayana S, Hunt PA, Bourguignon JP, Myers JP, et al. 2016. Exposure to endocrine-disrupting chemicals in the USA: a population-based disease burden and cost analysis. Lancet Diabetes Endocrinol 4(12):996–1003, PMID: 27765541, https://doi.org/10.1016/S2213-8587(16)30275-3.
8. Barker DJ. 1990. The fetal and infant origins of adult disease. BMJ 301:1111, PMID: 2252919, https://doi.org/10.1136/bmj.301.6761.1111.
9. Bays HE, Toth PP, Kris-Etherton PM, Abate N, Aronne LJ, Brown WV, et al. 2013. Obesity, adiposity, and dyslipidemia: a consensus statement from the National Lipid Association. J Clin Lipidol 7:304–383, PMID: 23890517, https://doi.org/10.1016/j.jacl.2013.04.001.
10. Benton MJ, Nimrod AC, Benson WH. 1994. Evaluation of growth and energy storage as biological markers of DDT exposure in sailfin mollies. Ecotoxicol Environ Saf 29:1–12, PMID: 7529156.
11. Cal/EPA-OEHHA (California Environmental Protection Agency–Office of Environmental Health Hazard Assessment, Safe Drinking Water and Toxic Enforcement Act of 1986). 2016. Chemicals Known to the State to Cause Cancer or Reproductive Toxicity.
12. Chapados NA, Casimiro C, Batal M, Blais JM, Haman F, Robidoux MA, et al. 2011. Increased proliferative effect of organochlorine compounds on human preadipocytes [Abstract]. Can J Diabetes 35:213, https://doi.org/10.1016/S1499-2671 (11)52271-3.
13. Chen CW, Hurd C, Vorojeikina DP, Arnold SF, Notides AC. 1997. Transcriptional activation of the human estrogen receptor by DDT isomers and metabolites in yeast and MCF-7 cells. Biochem Pharmacol 53:1161–1172, PMID: 9175721.
14. Conis E. 2010. Debating the health effects of DDT: Thomas Jukes, Charles Wurster, and the fate of an environmental pollutant. Public Health Rep 125(2):337–342, PMID: 20297762, https://doi.org/10.1177/003335491012500224.
15. Cupul-Uicab LA, Hernández-Avila M, Terrazas-Medina EA, Pennell ML, Longnecker MP. 2010. Prenatal exposure to the major DDT metabolite 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and growth in boys from Mexico. Environ Res 110:595–603, PMID: 20566194, https://doi.org/10.1016/j. envres.2010.06.001.
16. Darsie J, Gosha SK, Holman RT. 1976. Induction of abnormal fatty acid metabolism and essential fatty acid deficiency in rats by dietary DDT. Arch Biochem Biophys 175(1):262–269, PMID: 952519.
17. Delvaux I, Van Cauwenberghe J, Den Hond E, Schoeters G, Govarts E, Nelen V, et al. 2014. Prenatal exposure to environmental contaminants and body composition at age 7–9 years. Environ Res 132:24–32, PMID: 24742724, https://doi.org/10.1016/j.envres.2014.03.019.
18. DerSimonian R, Laird N. 1986. Meta-analysis in clinical trials. Control Clin Trials 7:177–188, PMID: 3802833.
19. Donkin I, Versteyhe S, Ingerslev LR, Qian K, Mechta M, Nordkap L, et al. 2016. Obesity and bariatric surgery drive epigenetic variation of spermatozoa in humans. Cell Metab 23:369–378, PMID: 26669700, https://doi.org/10.1016/j.cmet. 2015.11.004.
20. Drenowatz C. 2015. Reciprocal compensation to changes in dietary intake and energy expenditure within the concept of energy balance. Adv Nutr 6:592–599, https://doi.org/10.3945/an.115.008615.
21. Fu Y, Luo N, Klein RL, Garvey WT. 2005. Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation. J Lipid Res 46(7):1369–1379, PMID: 15834118, https://doi.org/10.1194/jlr.M400373-JLR200.
22. Gaskins AJ, Schisterman EF. 2009. The effect of lipid adjustment on the analysis of environmental contaminants and the outcome of human health risks. Methods Mol Biol 580:371–381, PMID: 19784610, https://doi.org/10.1007/978-1-60761-325-1_20.
23. Gore AC, Chappell VA, Fenton SE, Flaws JA, Nadal A, Prins GS, et al. 2015. EDC-2: the Endocrine Society’s Second Scientific Statement on Endocrine-Disrupting Chemicals. Endocr Rev 36:E1–E150, PMID: 26544531, https://doi.org/10.1210/er. 2015-1010.
24. Grün F, Blumberg B. 2006. Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling. Endocrinology 147(6 suppl):S50–S55, PMID: 16690801, https://doi.org/10.1210/en.2005-1129.
25. Guyatt GH, Oxman AD, Schünemann HJ, Tugwell P, Knottnerus A. 2011a. GRADE guidelines: a new series of articles in the Journal of Clinical Epidemiology. J Clin Epidemiol 64:380–382, PMID: 21185693, https://doi.org/10.1016/j.jclinepi. 2010.09.011.
26. Guyatt GH, Oxman AD, Sultan S, Glasziou P, Akl EA, Alonso-Coello P, et al. 2011b. GRADE guidelines: 9. Rating up the quality of evidence. J Clin Epidemiol 64:1311–1316, PMID: 21802902, https://doi.org/10.1016/j.jclinepi.2011.06.004.
27. Harbord RM, Egger M, Sterne JA. 2006. A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints. Stat Med 25:3443– 3457, PMID: 16345038, https://doi.org/10.1002/sim.2380.
28. Heindel JJ, vom Saal FS, Blumberg B, Bovolin P, Calamandrei G, Ceresini G, et al. 2015. Parma consensus statement on metabolic disruptors. Environ Health 14:54, https://doi.org/10.1186/s12940-015-0042-7.
29. Higgins JPT, Green S. 2011. Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0. http://handbook.cochrane.org/[accessed 15 August 2015].
30. Howell G III, Mangum L. 2011. Exposure to bioaccumulative organochlorine compounds alters adipogenesis, fatty acid uptake, and adipokine production in NIH3T3-L1 cells. Toxicol In Vitro 25:394–402, https://doi.org/10.1016/j.tiv.2010.10. 015.
31. Howell GE III, Meek E, Kilic J, Mohns M, Mulligan C, Chambers JE. 2014. Exposure to p,p′ -dichlorodiphenyldichloroethylene (DDE) induces fasting hyperglycemia without insulin resistance in male C57BL/6H mice. Toxicology 320:6–14, https://doi.org/10.1016/j.tox.2014.02.004.
32. Howell GE III, Mulligan C, Meek E, Chambers JE. 2015. Effect of chronic p,p′ -dichlorodiphenyldichloroethylene (DDE) exposure on high fat diet-induced alterations in glucose and lipid metabolism in male C57BL/6H mice. Toxicology 328:112–122, PMID: 25541407, https://doi.org/10.1016/j.tox.2014.12.017.
33. Høyer BB, Ramlau-Hansen CH, Henriksen TB, Pedersen HS, Góralczyk K, Zviezdai V, et al. 2014. Body mass index in young school-age children in relation to organochlorine compounds in early life: a prospective study. Int J Obes (Lond) 38:919–925, PMID: 24718355, https://doi.org/10.1038/ijo.2014.58.
34. I’Allemand D, Wiegand S, Reinehr T, Müller J, Wabitsch M, Widhalm K, et al. 2008. Cardiovascular risk in 26,008 European overweight children as established by a multicenter database. Obesity (Silver Spring) 16(7):1672–1679, PMID: 18451769, https://doi.org/10.1038/oby.2008.259.
35. Ibrahim MM, Fjære E, Lock EJ, Naville D, Amlund H, Meugnier E, et al. 2011. Chronic consumption of farmed salmon containing persistent organic pollutants causes insulin resistance and obesity in mice. PloS One 6:e25170, PMID: 21966444, https://doi.org/10.1371/journal.pone.0025170.
36. Ishikawa T, Graham JL, Stanhope KL, Havel PJ, La Merrill MA. 2015. Effect of DDT exposure on lipids and energy balance in obese Sprague-Dawley rats before and after weight loss. Toxicol Rep 2:990–995, https://doi.org/10.1016/j.toxrep. 2015.07.005.
37. Johnson PI, Sutton P, Atchley DS, Koustas E, Lam J, Sen S, et al. 2014. The Navigation Guide—evidence-based medicine meets environmental health: systematic review of human evidence for PFOA effects on fetal growth. Environ Health Perspect 122:1028–1039, PMID: 24968388, https://doi.org/10. 1289/ehp.1307893.
38. Jokinen E. 2015. Obesity and cardiovascular disease. Minerva Pediatr 67:25–32, PMID: 25387321.
39. Kelce WR, Stone CR, Laws SC, Gray LE, Kemppainen JA, Wilson EM. 1995. Persistent DDT metabolite p,p′ -DDE is a potent androgen receptor antagonist. Nature 375:581–585, PMID: 7791873, https://doi.org/10.1038/375581a0.
40. Klimentidis YC, Beasley TM, Lin HY, Murati G, Glass GE, Guyton M, et al. 2011. Canaries in the coal mine: a cross-species analysis of the plurality of obesity epidemics. Proc Biol Sci 278:1626–1632, https://doi.org/10.1098/rspb.2010.1890.
41. Klop B, Elte JW, Cabezas MC. 2013. Dyslipidemia in obesity: mechanisms and potential targets. Nutrients 5:1218–1240, PMID: 23584084, https://doi.org/10. 3390/nu5041218.
42. Koustas E, Lam J, Sutton P, Johnson PI, Atchley DS, Sen S, et al. 2014. The Navigation Guide—evidence-based medicine meets environmental health: systematic review of nonhuman evidence for PFOA effects on fetal growth. Environ Health Perspect 122:1015–1027, PMID: 24968374, https://doi.org/10.1289/ehp.1307177.
43. La Merrill M, Birnbaum LS. 2011. Childhood obesity and environmental chemicals. Mt Sinai J Med 78:22–48, PMID: 21259261, https://doi.org/10.1002/msj.20229.
44. La Merrill M, Emond C, Kim MJ, Antignac JP, Le Bizec B, Clément K, et al. 2013. Toxicological function of adipose tissue: focus on persistent organic pollutants. Environ Health Perspect 121:162–169, PMID: 23221922, https://doi.org/10. 1289/ehp.1205485.
45. La Merrill M, Karey E, Moshier E, Lindtner C, La Frano MR, Newman JW, et al. 2014. Perinatal exposure of mice to the pesticide DDT impairs energy expenditure and metabolism in adult female offspring. PloS One 9:e103337, PMID: 25076055, https://doi.org/10.1371/journal.pone.0103337.
46. Lam J, Koustas E, Sutton P, Johnson PI, Atchley DS, Sen S, et al. 2014. The Navigation Guide—evidence-based medicine meets environmental health: integration of animal and human evidence for PFOA effects on fetal growth. Environ Health Perspect 122:1040–1051, PMID: 24968389, https://doi.org/10. 1289/ehp.1307923.
47. Landsberg L. 2012. Core temperature: a forgotten variable in energy expenditure and obesity? Obes Rev 13 (suppl 2):97–104, https://doi.org/10.1111/j.1467-789X. 2012.01040.x.
48. Lee DH, Porta M, Jacobs DR Jr, Vandenberg LN. 2014. Chlorinated persistent organic pollutants, obesity, and type 2 diabetes. Endocr Rev 35:557–601, https://doi.org/10.1210/er.2013-1084.
49. Li D, Longnecker MP, Dunson DB. 2013. Lipid adjustment for chemical exposures: accounting for concomitant variables. Epidemiology 24:921–928, PMID: 24051893, https://doi.org/10.1097/EDE.0b013e3182a671e4.
50. Longnecker MP, Klebanoff MA, Gladen BC, Berendes HW. 1999. Serial levels of serum organochlorines during pregnancy and postpartum. Arch Environ Health 54:110–114, PMID: 10094288, https://doi.org/10.1080/00039899909602244.
51. Loomis D, Guyton K, Grosse Y, El Ghissasi F, Bouvard V, Benbrahim-Tallaa L, et al. 2015. Carcinogenicity of lindane, DDT, and 2,4-dichlorophenoxyacetic acid. Lancet Oncol 16:891–892, PMID: 26111929, https://doi.org/10.1016/S1470-2045(15)00081-9.
52. Mangum LH, Howell GE III, Chambers JE. 2015. Exposure to p,p′ -dde enhances differentiation of 3T3-L1 preadipocytes in a model of sub-optimal differentiation. Toxicol Lett 238:65–71, https://doi.org/10.1016/j.toxlet.2015.07.009.
53. Martinez JA. 2000. Body-weight regulation: causes of obesity. Proc Nutr Soc 59:337–345, PMID: 10997649.
54. Moreno-Aliaga MJ, Matsumura F. 2002. Effects of 1,1,1-trichloro-2,2-bis(p-chloro-phenyl)-ethane (p,p′ -DDT) on 3T3-L1 and 3T3-F442A adipocyte differentiation. Biochem Pharmacol 63:997–1007, PMID: 11911853.
55. Morgan RL, Thayer KA, Bero L, Bruce N, Falck-Ytter Y, Ghersi D, et al. 2016. GRADE: assessing the quality of evidence in environmental and occupational health. Environ Int 92-93:611–616, PMID: 26827182, https://doi.org/10.1016/j. envint.2016.01.004.
56. Narayan S, Dani HM, Misra UK. 1990. Changes in lipid profiles of liver microsomes of rats following intratracheal administration of DDT or endosulfan. J Environ Sci Health Part B Pestic Food Contam Agric Wastes 25(2):243–257, PMID: 2380487, https://doi.org/10.1080/10934529009375554.
57. Nascimento AF, Sugizaki MM, Leopoldo AS, Lima-Leopoldo AP, Nogueira CR, Novelli EL, et al. 2008. Misclassification probability as obese or lean in hypercaloric and normocaloric diet. Biol Res 41:253–259, PMID: 19399338, https://doi.org/10.4067//S0716-97602008000300002.
58. 3H)estradiol binding to rat uterine receptor. Biochem Pharmacol 23:447–451, PMID: 4360348.
59. Ogden CL, Carroll MD, Kit BK, Flegal KM. 2014. Prevalence of childhood and adult obesity in the United States, 2011–2012. JAMA 311:806–814, PMID: 24570244, https://doi.org/10.1001/jama.2014.732.
60. OHAT (Office of Health Assessment and Translation). 2015a. Handbook for Conducting a Literature-Based Health Assessment Using OHAT Approach for Systematic Review and Evidence Integration. Washington, DC:National Toxicology Program.
61. OHAT. 2015b. OHAT Risk of Bias Rating Tool for Human and Animal Studies. Washington, DC:National Toxicology Program.
62. Okazaki Y, Katayama T. 2003. Effects of dietary carbohydrate and myo-inositol on metabolic changes in rats fed 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane (DDT). J Nutr Biochem 14(2):81–89, PMID: 12667599.
63. Okazaki Y, Katayama T. 2008. Dietary inositol hexakisphosphate, but not myo-inositol, clearly improves hypercholesterolemia in rats fed casein-type amino acid mixtures and 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane. Nutr Res 28(10):714–721, PMID: 19083479, https://doi.org/10.1016/j.nutres.2008.07.003.
64. Patel CJ, Cullen MR, Ioannidis JP, Butte AJ. 2012. Systematic evaluation of environmental factors: persistent pollutants and nutrients correlated with serum lipid levels. Int J Epidemiol 41:828–843, PMID: 22421054, https://doi.org/10.1093/ije/dys003.
65. Platt DS, Cockrill BL. 1967. Liver enlargement and hepatoxicity: an investigation into the effects of several agents on rat liver enzyme activities. Biochem Pharmacol 16(12):2257–2270, PMID: 4294662.
66. Platt DS, Cockrill BL. 1969. Biochemical changes in rat liver in response to treatment with drugs and other agents. II. Effects of halothane, DDT, other chlorinated hydrocarbons, thioacetamide, dimethylnitrosamine and ethionine. Biochem Pharmacol 18(2):445–457, PMID: 4305095.
67. Rao TN, Sanyal S, Agarwal N, Subrahmanyam D. 1981. Effect of a single oral dose of DDT on lipid metabolism in rat. Toxicol Lett 7(3):263–266, PMID: 7222101.
68. Rodríguez-Alcalá LM, Sá C, Pimentel LL, Pestana D, Teixeira D, Faria A, et al. 2015. Endocrine disruptor DDE associated with a high-fat diet enhances the impairment of liver fatty acid composition in rats. J Agric Food Chem 63:9341–9348, PMID: 26449595, https://doi.org/10.1021/acs.jafc.5b03274.
69. Rogan WJ, Chen A. 2005. Health risks and benefits of bis(4-chlorophenyl)-1,1,1-tri-chloroethane (DDT). Lancet 366:763–773, PMID: 16125595, https://doi.org/10.1016/S0140-6736(05)67182-6.
70. Rooney AA, Boyles AL, Wolfe MS, Bucher JR, Thayer KA. 2014. Systematic review and evidence integration for literature-based environmental health science assessments. Environ Health Perspect 122:711–718, PMID: 24755067, https://doi.org/10.1289/ehp.1307972.
71. Rooney AA, Cooper GS, Jahnke GD, Lam J, Morgan RL, Boyles AL, et al. 2016. How credible are the study results? Evaluating and applying internal validity tools to literature-based assessments of environmental health hazards. Environ Int 92– 93:617–629, PMID: 26857180, https://doi.org/10.1016/j.envint.2016.01.005.
72. Schisterman EF, Whitcomb BW, Buck Louis GM, Louis TA. 2005. Lipid adjustment in the analysis of environmental contaminants and human health risks. Environ Health Perspect 113:853–857, PMID: 16002372, https://doi.org/10.1289/ehp.7640.
73. Sheehan MC, Lam J. 2015. Use of systematic review and meta-analysis in environmental health epidemiology: a systematic review and comparison with guidelines. Curr Environ Health Rep 2:272–283, PMID: 26231504, https://doi.org/10. 1007/s40572-015-0062-z.
74. Skinner MK, Manikkam M, Tracey R, Guerrero-Bosagna C, Haque M, Nilsson EE. 2013. Ancestral dichlorodiphenyltrichloroethane (DDT) exposure promotes epigenetic transgenerational inheritance of obesity. BMC Med 11:228, https://doi.org/10. 1186/1741-7015-11-228.
75. Smith D. 1999. Worldwide trends in DDT levels in human breast milk. Int J Epidemiol 28:179–188, PMID: 10342677.
76. Speakman JR, O’Rahilly S. 2012. Fat: an evolving issue. Dis Model Mech 5:569–573, PMID: 22915015, https://doi.org/10.1242/dmm.010553.
77. Stern JH, Rutkowski JM, Scherer PE. 2016. Adiponectin, leptin, and fatty acids in the maintenance of metabolic homeostasis through adipose tissue crosstalk. Cell Metab 23:770–784, PMID: 27166942, https://doi.org/10.1016/j.cmet.2016.04.011.
78. Strong AL, Shi Z, Strong MJ, Miller DF, Rusch DB, Buechlein AM, et al. 2015. Effects of the endocrine-disrupting chemical DDT on self-renewal and differentiation of human mesenchymal stem cells. Environ Health Perspect 123:42– 48, PMID: 25014179, https://doi.org/10.1289/ehp.1408188.
79. Tang-Péronard JL, Jensen TK, Andersen HR, Ried-Larsen M, Grøntved A, Andersen LB, et al. 2015. Associations between exposure to persistent organic pollutants in childhood and overweight up to 12 years later in a low exposed Danish population. Obes Facts 8:282–292, https://doi.org/10.1159/000438834.
80. Taxvig C, Dreisig K, Boberg J, Nellemann C, Schelde AB, Pedersen D, et al. 2012. Differential effects of environmental chemicals and food contaminants on adipogenesis, biomarker release and PPARγ activation. Mol Cell Endocrinol 361:106–115, PMID: 22526026, https://doi.org/10.1016/j.mce.2012.03.021.
81. Taylor KW, Novak RF, Anderson HA, Birnbaum LS, Blystone C, Devito M, et al. 2013. Evaluation of the association between persistent organic pollutants (POPs) and diabetes in epidemiological studies: a National Toxicology Program workshop review. Environ Health Perspect 121:774–783, https://doi.org/10.1289/ehp.1205502.
82. Thayer KA, Heindel JJ, Bucher JR, Gallo MA. 2012. Role of environmental chemicals in diabetes and obesity: a National Toxicology Program workshop review. Environ Health Perspect 120:779–789, PMID: 22296744, https://doi.org/10.1289/ehp.1104597.
83. UNEP (United Nations Environment Programme). 2010. Report of the Expert Group on the Assessment of the Production and Use of DDT and Its Alternatives for Disease Vector Control. Third Meeting. UNEP/POPS/COP.3/24. Geneva, Switzerland:United Nations.
84. Vafeiadi M, Georgiou V, Chalkiadaki G, Rantakokko P, Kiviranta H, Karachaliou M, et al. 2015. Association of prenatal exposure to persistent organic pollutants with obesity and cardiometabolic traits in early childhood: the Rhea mother– child cohort (Crete, Greece). Environ Health Perspect 123:1015–1021, https://doi.org/10.1289/ehp.1409062.
85. Warner M, Wesselink A, Harley KG, Bradman A, Kogut K, Eskenazi B. 2014. Prenatal exposure to dichlorodiphenyltrichloroethane and obesity at 9 years of age in the CHAMACOS study cohort. Am J Epidemiol 179:1312–1322, PMID: 24722999, https://doi.org/10.1093/aje/kwu046.
86. Westlake GE, Bunyan PJ, Stanley PI, Walker CH. 1979. The effects of 1,1-di(p-chlorophenyl)-2-chloroethylene on plasma enzymes and blood constituents in the Japanese quail. Chem Biol Interact 25:197–210, PMID: 466732.
87. WHO (World Health Organization). 2014. Global Status Report on Noncommunicable Diseases 2014. Geneva, Switzerland:WHO.
88. Woodruff TJ, Sutton P. 2014. The Navigation Guide systematic review methodology: a rigorous and transparent method for translating environmental health science into better health outcomes. Environ Health Perspect 122:1007–1014, PMID: 24968373, https://doi.org/10.1289/ehp.1307175.
89. Woods SC, Seeley RJ, Rushing PA, D’Alessio D, Tso P. 2003. A controlled high-fat diet induces an obese syndrome in rats. J Nutr 133:1081–1087, PMID: 12672923.