Transcriptional activation of the human estrogen receptor by DDT isomers and metabolites in yeast and MCF-7 cells

Biochemical Pharmacology

Volumn 53, Issue 8, 1997, Pages 1161-1172

  Chen, Clarice W ^a   Hurd, Cliff ^b   Vorojeikina, Daria P ^a   Amold, Steven F ^c   Notides, Angelo C ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b OAKLAND UNIVERSITY   (United States)

^c TULANE UNIVERSITY   (United States)

Author keywords

competitive binding; DDT isomers and metabolites; human estrogen receptor; MCF 7 cells; transcriptional activation; yeast

Indexed keywords

3,4' [1,1 DICHLORO 2 (4 CHLOROPHENYL) 2 (3 CHLOROPHENYL)ETHANE]; 3,4' [1,1 DICHLORO 2 (4 CHLOROPHENYL) 2 (3 CHLOROPHENYL)ETHYLENE]; 3,4' [1,1,1,TRICHLORO 2(4 CHLOROPHENYL) 2 (3 CHLOROPHENYL)ETHANE]; 4,4' [1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHANE]; 4,4' [1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE]; 4,4' [1,1,1 TRICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHANE]; 4,4' [2,2 BIS(4 CHLOROPHENYL)ACETIC ACID]; CHLORPHENOTANE; DRUG METABOLITE; ESTRADIOL; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; GENETIC TRANSCRIPTION; HORMONE RESPONSE; HUMAN; HUMAN CELL; ISOMER; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; TRANSACTIVATION; YEAST;

ANIMALS; CELL LINE; DDT; HUMANS; ISOMERISM; PLASMIDS; RATS; RECEPTORS, ESTROGEN; TRANSCRIPTION, GENETIC; YEASTS;

EID: 0030907094     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00097-X     Document Type: Article

References (43)

1. ATSDR, Toxicological Profile for p,p′-DDT, p,p′-DDE, and p,p′-DDD. U.S. Public Health Service, Atlanta, GA, 1989.
2. Hansen LG and Shane BS, Basic Environmental Toxicology. CRC Press, Boca Raton, FL, 1994.
3. Morgan DP and Roan CC, Liver function in workers having high tissue stores of chlorinated hydrocarbon pesticides. Arch Environ Health 29: 14-17, 1974.
4. Sasaki K, Ishizaka S, Suzuki T, Takeda M and Uchiyama M, Accumulation levels of organochlorine pesticides in human adipose tissue and blood. Bull Environ Contam Toxicol 46: 662-669, 1991.
5. Mussalo-Rauhamaa H, Partitioning and levels of neutral organochlorine compounds in human serum, blood cells, adipose, and liver tissue. Sci Total Environ 103: 159-175, 1991.
6. Kupfer D and Bulger WH, Estrogenic properties of DDT and its analogs. In: Estrogens in the Environment (Ed. McLachlan J), pp. 239-263. Elservier/North-Holland, New York, 1980.
7. Bitman J, Cecil HC, Harris SJ and Fries GF, Estrogenic activity of o,p′-DDT in the mammalian uterus and avian oviduct. Science 162: 371-372, 1968.
8. 3H]estradiol binding to rat uterine receptor. Biochem Pharmacol 23: 447-451, 1974.
9. Scribner JD and Mottet NK, DDT acceleration of mammary gland tumors induced in the male Sprague-Dawley rat by 2-acetamidophenanthrene. Carcinogenesis 2: 1235-1239, 1981.
10. Robison AK, Sirbasku DA and Stancel GM, DDT supports the growth of an estrogen-responsive tumor. Toxicol Lett 27: 109-113, 1985.
11. Soto AM, Chung KL and Sonnenschein C, The pesticides endosulfan, toxaphene, and dieldrin have estrogenic effects on human estrogen-sensitive cells. Environ Health Perspect 102: 380-383, 1994.
12. Metzger D, White JH and Chambon P, The human oestrogen receptor functions in yeast. Nature 334: 31-36, 1988.
13. Pierrat B, Heery DM, Chambon P and Losson R, A highly conserved region in the hormone-binding domain of the human estrogen receptor functions as an efficient transactivation domain in yeast. Gene 143: 193-200, 1994.
14. McDonnell DP, Nawaz Z, Densmore C, Weigel NL, Pham TA, Clark JH and O'Malley BW, High level expression of biologically active estrogen receptor in Saccharomyces cerevisiae. J Steroid Biochem Mole Biol 39: 291-297, 1991.
15. Pham TA, Hwung YP, Santiso-Mere D, McDonnell DP and O'Malley BW, Ligand-dependent and -independent function of the transactivation regions of the human estrogen receptor in yeast. Mol Endocrinol 6: 1043-1050, 1992.
16. Katzenetlenbogen BS and Norman MJ, Multihormonal regulation of the progesterone receptor in MCF-7 human breast cancer cells: Interrelationships among insulin/insulin-like growth factor-I, serum, and estrogen [published erratum appears in Endocrinology 126: 3217, 1990]. Endocrinology 126: 891-898, 1990.
17. Borras M, Hardy L, Lempereur F, el Khissiin AH, Legros N, Gol-Winkler R and Leclercq G, Estradiol-induced down-regulation of estrogen receptor. Effect of various modulators of protein synthesis and expression. J Steroid Biochem Mol Biol 48: 325-336, 1994.
18. Shyamala G, Schneider W and Guiot MC, Estrogen dependent regulation of estrogen receptor gene expression in normal mammary gland and its relationship to estrogenic sensitivity. Receptor 2: 121-128, 1992.
19. Obourn JD, Koszewski NJ and Notides AC, Hormone-and DNA-binding mechanisms of the recombinant human estrogen receptor. Biochemistry 32: 6229-6236, 1993.
20. Sung P, Prakash L, Weber S and Prakash S, The RAD3 gene of Saccharomyces cerevisiae encodes a DNA-dependent ATPase. Proc Nat Acad Sci USA 84: 6045-6049, 1987.
21. Jones EW, Three proteolytic systems in the yeast Saccharomyces cerevisiae. J Biol Chem 266: 7963-7966, 1991.
22. Chen DC, Yang BC and Kuo TT, One-step transformation of yeast in stationary phase. Curr Genet 21: 83-84, 1992.
23. Kaiser C, Michaelis S and Mitchell A, Methods in Yeast Genetics. Cold Spring Harbor Laboratory Press, Plainview, NY, 1994.
24. Kuo J and Fox E, Curve fitting examples. Transforms & Curve Fitting, pp. 10-1-10-26. Jandel Scientific, San Rafael, CA, 1992.
25. Eckert RL and Katzenellenbogen BS, Effects of estrogens and antiestrogens on estrogen receptor dynamics and the induction of progesterone receptor in MCF-7 human breast cancer cells. Cancer Res 42: 139-144, 1982.
26. Ludwicki JK and Goralczyk K, Organochlorine pesticides and PCBs in human adipose tissues in Poland. Bull Environ Contam Toxicol 52: 400-403, 1994.
27. Stone R, Environmental estrogens stir debate. Science 265: 308-310, 1994.
28. Davis DL, Bradlow HL, Wolff M, Woodruff T, Hoel DG and Anton-Culver H, Medical hypothesis: Xenoestrogens as preventable causes of breast cancer. Environ Health Perspect 101: 372-377, 1993.
29. Colborn T, vom Saal FS and Soto AM, Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ Health Perspect 101: 378-384, 1993.
30. Nelson JA, Struck RF and James R, Estrogenic activities of chlorinated hydrocarbons. J Toxicol Environ Health 4: 325-339, 1978.
31. Welch RM, Levin W and Conney AH, Estrogenic action of DDT and its analogs. Toxicol Appl Pharmacol 14: 358-367, 1969.
32. Bitman J and Cecil HC, Estrogenic activity of DDT analogs and polychlorinated biphenyls. J Agric Food Chem 18: 1108-1112, 1970.
33. Kelce WR, Stone CR, Laws SC, Gray LE, Kemppalinen JA and Wilson EM, Persistent DDT metabolite p,p′-DDE is a potent androgen receptor antagonist. Nature 375: 581-585, 1995.
34. Katzenellenbogen BS, Bhardwaj B, Fang H, Ince BA, Pakdel F, Reese JC, Schodin D and Wrenn CK, Hormone binding and transcription activation by estrogen receptors: Analyses using mammalian and yeast systems. J Steroid Biochem Mol Biol 47: 39-48, 1993.
35. Weaver CA, Springer PA and Katzenellenbogen BS, Regulation of pS2 gene expression by affinity labeling and reversibly binding estrogens and antiestrogens: Comparison of effects on the native gene and on pS2-chloramphenicol acetyltransferase fusion genes transfected into MCF-7 human breast cancer cells. Mol Endocrinol 2: 936-945, 1988.
36. Arnold SF, Robinson MK, Notides AC, Guillette LJ Jr and McLachlan JA, A yeast estrogen screen for examining the relative exposure of cells to natural and xenoestrogens. Environ Health Perspect 104: 544-548, 1996.
37. Arnold SF, Klotz DM, Collins BM, Vonier PM, Guillette LJ Jr and McLachlan JA, Synergistic activation of estrogen receptor with combinations of environmental chemicals. Science 272: 1489-1492, 1996.
38. Zysk JR, Johnson B, Ozenberger BA, Bingham B and Gorski J, Selective uptake of estrogenic compounds by Saccharomyces cerevisiae: A mechanism for antiestrogen resistance in yeast expressing the mammalian estrogen receptor. Endocrinology 136: 1323-1326, 1995.
39. Burshell A, Stathis PA, Do Y, Miller SC and Feldman D, Characterization of an estrogen-binding protein in the yeast Soccharomyces cerevisiae. J Biol Chem 259: 3450-3456, 1984.
40. Wakeling AE and Bowler J, Steroidal pure antioestrogen, J Endocrinol 112: R7-R10, 1987.
41. Wakeling AE and Bowler J, Novel antiestrogens without partial agonist activity. J Steroid Biochem 31: 645-653, 1988.
42. Lyttle CR, Damian-Matsumura P, Juul H and Butt TR, Human estrogen receptor regulation in a yeast model system and studies on receptor agonists and antagonists. J Steroid Biochem Mol Biol 42: 677-685, 1992.
43. Kohno H, Gandini O, Curtis SW and Korach KS, Antiestrogen activity in the yeast transcription system: Estrogen receptor mediated agonist response. Steroids 59: 572-578, 1994.