Association of prenatal exposure to persistent organic pollutants with obesity and cardiometabolic traits in early childhood: The rhea mother–child cohort (Crete, Greece)

Environmental Health Perspectives

Volumn 123, Issue 10, 2015, Pages 1015-1021

  Vafeiadi, Marina ^a   Georgiou, Vaggelis ^a   Chalkiadaki, Georgia ^a   Rantakokko, Panu ^b   Kiviranta, Hannu ^b   Karachaliou, Marianna ^a   Fthenou, Eleni ^a   Venihaki, Maria ^c   Sarri, Katerina ^a   Vassilaki, Maria ^a   Kyrtopoulos, Soterios A ^d   Oken, Emily ^e   Kogevinas, Manolis ^f,g,h,i   Chatzi, Leda ^a  

^a UNIVERSITY OF CRETE   (Greece)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^c UNIVERSITY OF CRETE   (Greece)

^d INSTITUTE OF BIOLOGY   (Greece)

^e HARVARD MEDICAL SCHOOL   (United States)

^f CENTRE FOR RESEARCH IN ENVIRONMENTAL EPIDEMIOLOGY CREAL   (Spain)

^g HOSPITAL DEL MAR   (Spain)

^h CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

ⁱ NATIONAL SCHOOL OF PUBLIC HEALTH   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

POLYCHLORINATED BIPHENYL DERIVATIVE; VINYLIDENE CHLORIDE; 1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; ENDOCRINE DISRUPTOR; HEXACHLOROBENZENE; POLLUTANT; POLYCHLORINATED BIPHENYL;

ANTHROPOMETRY; ARTICLE; BODY WEIGHT; CARDIOMETABOLIC RISK; CLINICAL EVALUATION; DEMOGRAPHY; EARLY CHILDHOOD INTERVENTION; ENVIRONMENTAL HEALTH; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MOTHER CHILD RELATION; OBESITY; ORGANIC POLLUTION; PREGNANCY; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PUBLIC HEALTH PROBLEM; RISK ASSESSMENT; STATISTICAL ANALYSIS; ADOLESCENT; ADULT; BLOOD ANALYSIS; BLOOD PRESSURE; CHEMICALLY INDUCED; ENVIRONMENTAL EXPOSURE; GREECE; LONGITUDINAL STUDY; MALE; MIDDLE AGED; PEDIATRIC OBESITY; POLLUTANT; PRESCHOOL CHILD; RISK FACTOR; TOXICITY; YOUNG ADULT;

ADOLESCENT; ADULT; ANTHROPOMETRY; BLOOD CHEMICAL ANALYSIS; BLOOD PRESSURE; CHILD, PRESCHOOL; DICHLORODIPHENYL DICHLOROETHYLENE; ENDOCRINE DISRUPTORS; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; FEMALE; GREECE; HEXACHLOROBENZENE; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; PEDIATRIC OBESITY; POLYCHLORINATED BIPHENYLS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RISK FACTORS; YOUNG ADULT;

EID: 84943329492     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1409062     Document Type: Article

References (54)

1. Aminov Z, Haase RF, Pavuk M, Carpenter DO, Anniston Environmental Health Research Consortium. 2013. Analysis of the effects of exposure to polychlorinated biphenyls and chlorinated pesticides on serum lipid levels in residents of Anniston, Alabama. Environ Health 12:108; doi:10.1186/1476-069X-12-108.
2. Arnold DL, Moodie CA, Collins BT, Zawidzka ZZ, Krewski DR. 1986. Two-generation chronic toxicity study with hexachlorobenzene in the rat. IARC Sci Publ 77:405-410.
3. Baillie-Hamilton PF. 2002. Chemical toxins: a hypothesis to explain the global obesity epidemic. J Altern Complement Med 8(2):185-192.
4. Chapados NA, Casimiro C, Robidoux MA, Haman F, Batal M, Blais JM, et al. 2012. Increased proliferative effect of organochlorine compounds on human preadipocytes. Mol Cell Biochem 365(1-2):275-278.
5. Chatzi L, Plana E, Daraki V, Karakosta P, Alegkakis D, Tsatsanis C, et al. 2009. Metabolic syndrome in early pregnancy and risk of preterm birth. Am J Epidemiol 170(7):829-836.
6. Cole TJ, Lobstein T. 2012. Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity. Pediatr Obes 7(4):284-294.
7. Cupul-Uicab LA, Hernández-Avila M, TerrazasMedina EA, Pennell ML, Longnecker MP. 2010. Prenatal exposure to the major DDT metabolite 1,1-dichloro-2,2-bis(p-chloro phenyl)ethylene (DDE) and growth in boys from Mexico. Environ Res 110(6):595-603.
8. Cupul-Uicab LA, Klebanoff MA, Brock JW, Longnecker MP. 2013. Prenatal exposure to persistent organochlorines and childhood obesity in the U.S. Collaborative Perinatal Project. Environ Health Perspect 121:1103-1109; doi:10.1289/ehp.1205901.
9. Delvaux I, Van Cauwenberghe J, Den Hond E, Schoeters G, Govarts E, Nelen V, et al. 2014. Prenatal exposure to environmental contaminants and body composition at age 7-9 years. Environ Res 132:24-32.
10. Diamanti-Kandarakis E, Bourguignon JP, Giudice LC, Hauser R, Prins GS, Soto AM, et al. 2009. Endocrinedisrupting chemicals: an Endocrine Society scientific statement. Endocr Rev 30(4):293-342.
11. Ford ES, Ajani UA, Mokdad AH, National Health and Nutrition Examination. 2005. The metabolic syndrome and concentrations of C-reactive protein among U.S. youth. Diabetes Care 28(4):878-881.
12. Garced S, Torres-Sánchez L, Cebrián ME, Claudio L, López-Carrillo L. 2012. Prenatal dichlorodiphenyldichloroethylene (DDE) exposure and child growth during the first year of life. Environ Res 113:58-62.
13. Gillman MW, Cook NR. 1995. Blood pressure measurement in childhood epidemiological studies. Circulation 92(4):1049-1057.
14. Goncharov A, Pavuk M, Foushee HR, Carpenter DO, Anniston Environmental Health Reseach Consortium. 2011. Blood pressure in relation to concentrations of PCB congeners and chlorinated pesticides. Environ Health Perspect 119:319-325; doi:10.1289/ehp.1002830.
15. Grün F, Blumberg B. 2006. Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling. Endocrinology 147(6 suppl):S50-S55.
16. Grün F, Blumberg B. 2009. Endocrine disrupters as obesogens. Mol Cell Endocrinol 304(1-2):19-29.
17. Guxens M, Ballester F, Espada M, Fernández MF, Grimalt JO, Ibarluzea J, et al. 2012. Cohort profile: the INMA-INfancia y Medio Ambiente- (Environment and Childhood) Project. Int J Epidemiol 41(4):930-940.
18. Heine PA, Taylor JA, Iwamoto GA, Lubahn DB, Cooke PS. 2000. Increased adipose tissue in male and female estrogen receptor-α knockout mice. Proc Natl Acad Sci USA 97(23):12729-12734.
19. Howell G III, Mangum L. 2011. Exposure to bioaccumulative organochlorine compounds alters adipogenesis, fatty acid uptake, and adipokine production in NIH3T3-L1 cells. Toxicol In Vitro 25(1):394-402.
20. Jaddoe VW, van Duijn CM, Franco OH, van der Heijden AJ, van Iizendoorn MH, de Jongste JC, et al. 2012. The Generation R Study: design and cohort update 2012. Eur J Epidemiol 27(9):739-756.
21. Kopf PG, Huwe JK, Walker MK. 2008. Hypertension, cardiac hypertrophy, and impaired vascular relaxation induced by 2,3,7,8-tetrachlorodibenzo-pdioxin are associated with increased superoxide. Cardiovasc Toxicol 8(4):181-193.
22. Koponen J, Rantakokko P, Airaksinen R, Kiviranta H. 2013. Determination of selected perfluorinated alkyl acids and persistent organic pollutants from a small volume human serum sample relevant for epidemiological studies. J Chromatogr A 1309:48-55.
23. La Merrill M, Birnbaum LS. 2011. Childhood obesity and environmental chemicals. Mt Sinai J Med 78(1):22-48.
24. La Merrill M, Cirillo PM, Terry MB, Krigbaum NY, Flom JD, Cohn BA. 2013. Prenatal exposure to the pesticide DDT and hypertension diagnosed in women before age 50: a longitudinal birth cohort study. Environ Health Perspect 121:594-599; doi:10.1289/ehp.1205921.
25. Lamb MR, Taylor S, Liu X, Wolff MS, Borrell L, Matte TD, et al. 2006. Prenatal exposure to polychlorinated biphenyls and postnatal growth: a structural analysis. Environ Health Perspect 114:779-785; doi:10.1289/ehp.8488.
26. Li J, Li N, Ma M, Giesy JP, Wang Z. 2008. In vitro profiling of the endocrine disrupting potency of organochlorine pesticides. Toxicol Lett 183(1-3):65-71.
27. Li S, Chen W, Srinivasan SR, Bond MG, Tang R, Urbina EM, et al. 2003. Childhood cardiovascular risk factors and carotid vascular changes in adulthood: the Bogalusa Heart Study. JAMA 290(17):2271-2276.
28. Linardakis M, Sarri K, Bertsias G, Papadaki A, Kafatos A. 2010. Waist circumference and waistto-height percentiles for the youth of Crete, Greece. Int J Child Health Hum Dev 3:81-93.
29. Lind PM, Orberg J, Edlund UB, Sjöblom L, Lind L. 2004. The dioxin-like pollutant PCB 126 (3,3´,4,4´,5-pentachlorobiphenyl) affects risk factors for cardiovascular disease in female rats. Toxicol Lett 150(3):293-299.
30. Lind PM, Penell J, Salihovic S, van Bavel B, Lind L. 2014. Circulating levels of p,p´-DDE are related to prevalent hypertension in the elderly. Environ Res 129:27-31.
31. Mendez MA, Garcia-Esteban R, Guxens M, Vrijheid M, Kogevinas M, Goñi F, et al. 2011. Prenatal organochlorine compound exposure, rapid weight gain, and overweight in infancy. Environ Health Perspect 119:272-278; doi:10.1289/ehp.1002169.
32. Monteiro PO, Victora CG. 2005. Rapid growth in infancy and childhood and obesity in later life-a systematic review. Obes Rev 6(2):143-154.
33. Moreno-Aliaga MJ, Matsumura F. 2002. Effects of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane (p,p´-DDT) on 3T3-L1 and 3T3-F442A adipocyte differentiation. Biochem Pharmacol 63(5):997-1007.
34. Murata Y, Robertson KM, Jones ME, Simpson ER. 2002. Effect of estrogen deficiency in the male: the ArKO mouse model. Mol Cell Endocrinol 193(1-2):7-12.
35. Needham LL, Grandjean P, Heinzow B, Jorgensen PJ, Nielsen F, Patterson DG Jr, et al. 2011. Partition of environmental chemicals between maternal and fetal blood and tissues. Environ Sci Technol 45(3):1121-1126.
36. Patel CJ, Cullen MR, Ioannidis JP, Butte AJ. 2012. Systematic evaluation of environmental factors: persistent pollutants and nutrients correlated with serum lipid levels. Int J Epidemiol 41(3):828-843.
37. Peters JL, Fabian MP, Levy JI. 2014. Combined impact of lead, cadmium, polychlorinated biphenyls and non-chemical risk factors on blood pressure in NHANES. Environ Res 132:93-99.
38. Porta M, Puigdomènech E, Ballester F, Selva J, RibasFitó N, Llop S, et al. 2008. Monitoring concentrations of persistent organic pollutants in the general population: the international experience. Environ Int 34(4):546-561.
39. Raitakari OT, Juonala M, Kähönen M, Taittonen L, Laitinen T, Mäki-Torkko N, et al. 2003. Cardiovascular risk factors in childhood and carotid artery intimamedia thickness in adulthood: the Cardiovascular Risk in Young Finns Study. JAMA 290(17):2277-2283.
40. Rasmussen KM, Yaktine AL, eds. 2009. Weight Gain during Pregnancy: Reexamining the Guidelines. Washington, DC:National Academies Press.
41. Schisterman EF, Whitcomb BW, Louis GM, Louis TA. 2005. Lipid adjustment in the analysis of environmental contaminants and human health risks. Environ Health Perspect 113:853-857; doi:10.1289/ehp.7640.
42. Smink A, Ribas-Fito N, Garcia R, Torrent M, Mendez MA, Grimalt JO, et al. 2008. Exposure to hexachlorobenzene during pregnancy increases the risk of overweight in children aged 6 years. Acta Paediatr 97(10):1465-1469.
43. Stockholm Convention on Persistent Organic Pollutants. 2009. Available: http://chm.pops. int/TheConvention/POPsReviewCommittee/ ReportsandDecisions/tabid/3309/Default.aspx [accessed 10 November 2014].
44. Tang-Péronard JL, Andersen HR, Jensen TK, Heitmann BL. 2011. Endocrine-disrupting chemicals and obesity development in humans: a review. Obes Rev 12(8):622-636.
45. Tang-Péronard JL, Heitmann BL, Andersen HR, Steuerwald U, Grandjean P, Weihe P, et al. 2014. Association between prenatal polychlorinated biphenyl exposure and obesity development at ages 5 and 7 y: a prospective cohort study of 656 children from the Faroe Islands. Am J Clin Nutr 99(1):5-13.
46. Valvi D, Mendez MA, Garcia-Esteban R, Ballester F, Ibarluzea J, Goñi F, et al. 2014. Prenatal exposure to persistent organic pollutants and rapid weight gain and overweight in infancy. Obesity (Silver Spring) 22(2):488-496.
47. Valvi D, Mendez MA, Martinez D, Grimalt JO, Torrent M, Sunyer J, et al. 2012. Prenatal concentrations of polychlorinated biphenyls, DDE, and DDT and overweight in children: a prospective birth cohort study. Environ Health Perspect 120:451-457; doi:10.1289/ehp.1103862.
48. Vandenberg LN, Colborn T, Hayes TB, Heindel JJ, Jacobs DR Jr, Lee DH, et al. 2012. Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses. Endocr Rev 33(3):378-455.
49. Verhulst SL, Nelen V, Den Hond E, Koppen G, Beunckens C, Vael C, et al. 2009. Intrauterine exposure to environmental pollutants and body mass index during the first 3 years of life. Environ Health Perspect 117:122-126; doi:10.1289/ehp.0800003.
50. Warner M, Aguilar Schall R, Harley KG, Bradman A, Barr D, Eskenazi B. 2013. In uteroDDT and DDE exposure and obesity status of 7-year-old MexicanAmerican children in the CHAMACOS cohort. Environ Health Perspect 121:631-636; doi:10.1289/ ehp.1205656.
51. Warner M, Wesselink A, Harley KG, Bradman A, Kogut K, Eskenazi B. 2014. Prenatal exposure to dichlorodiphenyltrichloroethane and obesity at 9 years of age in the CHAMACOS study cohort. Am J Epidemiol 179(11):1312-1322.
52. WHO (World Health Organization). 2010. Persistent Organic Pollutants: Impact on Child Health. Available: http://www.who.int/ceh/publications/ persistent_organic_pollutant/en/index.html [accessed 4 June 2014].
53. Yu WH, Kimura M, Walczewska A, Karanth S, McCann SM. 1997. Role of leptin in hypothalamic- pituitary function. Proc Natl Acad Sci USA 94(3):1023-1028.
54. Zou G. 2004. A modified Poisson regression approach to prospective studies with binary data. Am J Epidemiol 159(7):702-706.