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Volumn 18, Issue 11, 2017, Pages 1207-1217

De novo induction of intratumoral lymphoid structures and vessel normalization enhances immunotherapy in resistant tumors

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; IMMUNOLOGIC AGENT; LIGHT VASCULAR TARGETING PEPTIDE; UNCLASSIFIED DRUG; CANCER VACCINE; HERPESVIRUS ENTRY MEDIATOR LIGAND; PEPTIDE; TNFSF14 PROTEIN, MOUSE;

EID: 85031770796     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3836     Document Type: Article
Times cited : (214)

References (51)
  • 1
    • 84855225492 scopus 로고    scopus 로고
    • The immune score as a new possible approach for the classification of cancer
    • Galon, J. et al. The immune score as a new possible approach for the classification of cancer. J. Transl. Med. 10, 1 (2012).
    • (2012) J. Transl. Med. , vol.10 , pp. 1
    • Galon, J.1
  • 2
    • 84877072174 scopus 로고    scopus 로고
    • Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment
    • Gajewski, T. F. et al. Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment. Curr. Opin. Immunol. 25, 268-276 (2013).
    • (2013) Curr. Opin. Immunol. , vol.25 , pp. 268-276
    • Gajewski, T.F.1
  • 3
    • 84945451852 scopus 로고    scopus 로고
    • Immunological hallmarks of stromal cells in the tumour microenvironment
    • Turley, S. J., Cremasco, V. & Astarita, J. L. Immunological hallmarks of stromal cells in the tumour microenvironment. Nat. Rev. Immunol. 15, 669-682 (2015).
    • (2015) Nat. Rev. Immunol. , vol.15 , pp. 669-682
    • Turley, S.J.1    Cremasco, V.2    Astarita, J.L.3
  • 4
    • 84958913785 scopus 로고    scopus 로고
    • More than a scaffold: Stromal modulation of tumor immunity
    • Johansson, A., Hamzah, J. & Ganss, R. More than a scaffold: Stromal modulation of tumor immunity. Biochim. Biophys. Acta 1865, 3-13 (2016).
    • (2016) Biochim. Biophys. Acta , vol.1865 , pp. 3-13
    • Johansson, A.1    Hamzah, J.2    Ganss, R.3
  • 5
    • 84912096468 scopus 로고    scopus 로고
    • Antiangiogenesis strategies revisited: From starving tumors to alleviating hypoxia
    • Jain, R. K. Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. Cancer Cell 26, 605-622 (2014).
    • (2014) Cancer Cell , vol.26 , pp. 605-622
    • Jain, R.K.1
  • 6
    • 0037699015 scopus 로고    scopus 로고
    • Tumor angiogenesis modulates leukocyte-vessel wall interactions in vivo by reducing endothelial adhesion molecule expression
    • Dirkx, A. E. et al. Tumor angiogenesis modulates leukocyte-vessel wall interactions in vivo by reducing endothelial adhesion molecule expression. Cancer Res. 63, 2322-2329 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 2322-2329
    • Dirkx, A.E.1
  • 7
    • 43749112760 scopus 로고    scopus 로고
    • Vascular normalization in Rgs5-deficient tumours promotes immune destruction
    • Hamzah, J. et al. Vascular normalization in Rgs5-deficient tumours promotes immune destruction. Nature 453, 410-414 (2008).
    • (2008) Nature , vol.453 , pp. 410-414
    • Hamzah, J.1
  • 8
    • 43049147611 scopus 로고    scopus 로고
    • Vascular targeting of anti-CD40 antibodies and IL-2 into autochthonous tumors enhances immunotherapy in mice
    • Hamzah, J. et al. Vascular targeting of anti-CD40 antibodies and IL-2 into autochthonous tumors enhances immunotherapy in mice. J. Clin. Invest. 118, 1691-1699 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 1691-1699
    • Hamzah, J.1
  • 9
    • 84861215805 scopus 로고    scopus 로고
    • Tumor-targeted TNFstabilizes tumor vessels and enhances active immunotherapy
    • Johansson, A., Hamzah, J., Payne, C. J. & Ganss, R. Tumor-targeted TNFstabilizes tumor vessels and enhances active immunotherapy. Proc. Natl. Acad. Sci. USA 109, 7841-7846 (2012).
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 7841-7846
    • Johansson, A.1    Hamzah, J.2    Payne, C.J.3    Ganss, R.4
  • 10
    • 77955406159 scopus 로고    scopus 로고
    • Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer
    • Shrimali, R. K. et al. Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer. Cancer Res. 70, 6171-6180 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 6171-6180
    • Shrimali, R.K.1
  • 11
    • 33646231504 scopus 로고    scopus 로고
    • Anti-angiogenesis therapy can overcome endothelial cell anergy and promote leukocyte-endothelium interactions and infiltration in tumors
    • Dirkx, A. E. et al. Anti-angiogenesis therapy can overcome endothelial cell anergy and promote leukocyte-endothelium interactions and infiltration in tumors. FASEB J. 20, 621-630 (2006).
    • (2006) FASEB J. , vol.20 , pp. 621-630
    • Dirkx, A.E.1
  • 12
    • 84960395521 scopus 로고    scopus 로고
    • Intratumoral LIGHT restores pericyte contractile properties and vessel integrity
    • Johansson-Percival, A. et al. Intratumoral LIGHT restores pericyte contractile properties and vessel integrity. Cell Rep. 13, 2687-2698 (2015).
    • (2015) Cell Rep. , vol.13 , pp. 2687-2698
    • Johansson-Percival, A.1
  • 13
    • 84895537712 scopus 로고    scopus 로고
    • Role of the lymphotoxin/LIGHT system in the development and maintenance of reticular networks and vasculature in lymphoid tissues
    • Lu, T. T. & Browning, J. L. Role of the lymphotoxin/LIGHT system in the development and maintenance of reticular networks and vasculature in lymphoid tissues. Front. Immunol. 5, 47 (2014).
    • (2014) Front. Immunol. , vol.5 , pp. 47
    • Lu, T.T.1    Browning, J.L.2
  • 14
    • 27744573075 scopus 로고    scopus 로고
    • Lymphotoxin-receptor signaling is required for the homeostatic control of HEV differentiation and function
    • Browning, J. L. et al. Lymphotoxin-receptor signaling is required for the homeostatic control of HEV differentiation and function. Immunity 23, 539-550 (2005).
    • (2005) Immunity , vol.23 , pp. 539-550
    • Browning, J.L.1
  • 15
    • 0033214348 scopus 로고    scopus 로고
    • CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
    • Förster, R. et al. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 99, 23-33 (1999).
    • (1999) Cell , vol.99 , pp. 23-33
    • Förster, R.1
  • 16
    • 84963542411 scopus 로고    scopus 로고
    • Tertiary lymphoid structures, drivers of the anti-tumor responses in human cancers
    • Dieu-Nosjean, M. C. et al. Tertiary lymphoid structures, drivers of the anti-tumor responses in human cancers. Immunol. Rev. 271, 260-275 (2016).
    • (2016) Immunol. Rev. , vol.271 , pp. 260-275
    • Dieu-Nosjean, M.C.1
  • 17
    • 0035893749 scopus 로고    scopus 로고
    • The dynamics of the T-cell antitumor response: Chemokine-secreting dendritic cells can prime tumor-reactive T cells extranodally
    • Kirk, C. J., Hartigan-O'Connor, D. & Mulé, J. J. The dynamics of the T-cell antitumor response: chemokine-secreting dendritic cells can prime tumor-reactive T cells extranodally. Cancer Res. 61, 8794-8802 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 8794-8802
    • Kirk, C.J.1    Hartigan-O'Connor, D.2    Mulé, J.J.3
  • 18
    • 77955389719 scopus 로고    scopus 로고
    • Tumor masses support naive T cell infiltration, activation, and differentiation into effectors
    • Thompson, E. D., Enriquez, H. L., Fu, Y. X. & Engelhard, V. H. Tumor masses support naive T cell infiltration, activation, and differentiation into effectors. J. Exp. Med. 207, 1791-1804 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 1791-1804
    • Thompson, E.D.1    Enriquez, H.L.2    Fu, Y.X.3    Engelhard, V.H.4
  • 19
    • 77952231121 scopus 로고    scopus 로고
    • Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL21
    • Shields, J. D., Kourtis, I. C., Tomei, A. A., Roberts, J. M. & Swartz, M. A. Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL21. Science 328, 749-752 (2010).
    • (2010) Science , vol.328 , pp. 749-752
    • Shields, J.D.1    Kourtis, I.C.2    Tomei, A.A.3    Roberts, J.M.4    Swartz, M.A.5
  • 20
    • 84941628879 scopus 로고    scopus 로고
    • Regulatory T cells in tumor-associated tertiary lymphoid structures suppress anti-tumor T cell responses
    • Joshi, N. S. et al. Regulatory T cells in tumor-associated tertiary lymphoid structures suppress anti-tumor T cell responses. Immunity 43, 579-590 (2015).
    • (2015) Immunity , vol.43 , pp. 579-590
    • Joshi, N.S.1
  • 21
    • 84962921798 scopus 로고    scopus 로고
    • Facilitating T cell infiltration in tumor microenvironment overcomes resistance to PD-L1 blockade
    • Tang, H. et al. Facilitating T cell infiltration in tumor microenvironment overcomes resistance to PD-L1 blockade. Cancer Cell 29, 285-296 (2016).
    • (2016) Cancer Cell , vol.29 , pp. 285-296
    • Tang, H.1
  • 22
    • 85017526619 scopus 로고    scopus 로고
    • Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation
    • Allen, E. et al. Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation. Sci. Transl. Med. 9, eaak96 (2017).
    • (2017) Sci. Transl. Med. , vol.9 , pp. eaak96
    • Allen, E.1
  • 23
    • 85017547813 scopus 로고    scopus 로고
    • Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade
    • Schmittnaegel, M. et al. Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade. Sci. Transl. Med. 9, eaak9670 (2017).
    • (2017) Sci. Transl. Med. , vol.9 , pp. eaak9670
    • Schmittnaegel, M.1
  • 24
    • 10744227434 scopus 로고    scopus 로고
    • Priming of naive T cells inside tumors leads to eradication of established tumors
    • Yu, P. et al. Priming of naive T cells inside tumors leads to eradication of established tumors. Nat. Immunol. 5, 141-149 (2004).
    • (2004) Nat. Immunol. , vol.5 , pp. 141-149
    • Yu, P.1
  • 25
    • 21244497570 scopus 로고    scopus 로고
    • Proinflammatory effects of LIGHT through HVEM and LTbetaR interactions in cultured human umbilical vein endothelial cells
    • Chang, Y. H., Hsieh, S. L., Chao, Y., Chou, Y. C. & Lin, W. W. Proinflammatory effects of LIGHT through HVEM and LTbetaR interactions in cultured human umbilical vein endothelial cells. J. Biomed. Sci. 12, 363-375 (2005).
    • (2005) J. Biomed. Sci. , vol.12 , pp. 363-375
    • Chang, Y.H.1    Hsieh, S.L.2    Chao, Y.3    Chou, Y.C.4    Lin, W.W.5
  • 26
    • 77949762340 scopus 로고    scopus 로고
    • Targeting of drugs and nanoparticles to tumors
    • Ruoslahti, E., Bhatia, S. N. & Sailor, M. J. Targeting of drugs and nanoparticles to tumors. J. Cell Biol. 188, 759-768 (2010).
    • (2010) J. Cell Biol. , vol.188 , pp. 759-768
    • Ruoslahti, E.1    Bhatia, S.N.2    Sailor, M.J.3
  • 27
    • 84891373820 scopus 로고    scopus 로고
    • License for destruction: Tumor-specific cytokine targeting
    • Johansson, A., Hamzah, J. & Ganss, R. License for destruction: Tumor-specific cytokine targeting. Trends Mol. Med. 20, 16-24 (2014).
    • (2014) Trends Mol. Med. , vol.20 , pp. 16-24
    • Johansson, A.1    Hamzah, J.2    Ganss, R.3
  • 28
    • 59649117924 scopus 로고    scopus 로고
    • Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
    • Mazzone, M. et al. Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell 136, 839-851 (2009).
    • (2009) Cell , vol.136 , pp. 839-851
    • Mazzone, M.1
  • 29
    • 85004144063 scopus 로고    scopus 로고
    • Inhibition of the glycolytic activator PFKFB3 in Endothelium induces tumor vessel normalization, impairs metastasis, and improves chemotherapy
    • Cantelmo, A. R. et al. Inhibition of the glycolytic activator PFKFB3 in Endothelium induces tumor vessel normalization, impairs metastasis, and improves chemotherapy. Cancer Cell 30, 968-985 (2016).
    • (2016) Cancer Cell , vol.30 , pp. 968-985
    • Cantelmo, A.R.1
  • 30
    • 84868277668 scopus 로고    scopus 로고
    • 12-Chemokine gene signature identifies lymph node-like structures in melanoma: Potential for patient selection for immunotherapy
    • Messina, J. L. et al. 12-Chemokine gene signature identifies lymph node-like structures in melanoma: potential for patient selection for immunotherapy Sci. Rep. 2, 765 (2012).
    • (2012) Sci. Rep , vol.2 , pp. 765
    • Messina, J.L.1
  • 31
    • 84877586473 scopus 로고    scopus 로고
    • Endothelial cell-specific lymphotoxin-receptor signaling is critical for lymph node and high endothelial venule formation
    • Onder, L. et al. Endothelial cell-specific lymphotoxin-receptor signaling is critical for lymph node and high endothelial venule formation. J. Exp. Med. 210, 465-473 (2013).
    • (2013) J. Exp. Med. , vol.210 , pp. 465-473
    • Onder, L.1
  • 32
    • 0034655276 scopus 로고    scopus 로고
    • Cutting edge: Ectopic expression of the chemokine TCA4/SLC is sufficient to trigger lymphoid neogenesis
    • Fan, L., Reilly, C. R., Luo, Y., Dorf, M. E. & Lo, D. Cutting edge: ectopic expression of the chemokine TCA4/SLC is sufficient to trigger lymphoid neogenesis. J. Immunol. 164, 3955-3959 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 3955-3959
    • Fan, L.1    Reilly, C.R.2    Luo, Y.3    Dorf, M.E.4    Lo, D.5
  • 33
    • 0029060005 scopus 로고
    • Limited capacity for tolerization of CD4+ T cells specific for a pancreatic beta cell neo-antigen
    • Förster, I., Hirose, R., Arbeit, J. M., Clausen, B. E. & Hanahan, D. Limited capacity for tolerization of CD4+ T cells specific for a pancreatic beta cell neo-antigen. Immunity 2, 573-585 (1995).
    • (1995) Immunity , vol.2 , pp. 573-585
    • Förster, I.1    Hirose, R.2    Arbeit, J.M.3    Clausen, B.E.4    Hanahan, D.5
  • 34
    • 2442452552 scopus 로고    scopus 로고
    • CpG motifs as proinflammatory factors render autochthonous tumors permissive for infiltration and destruction
    • Garbi, N., Arnold, B., Gordon, S., Hämmerling, G. J. & Ganss, R. CpG motifs as proinflammatory factors render autochthonous tumors permissive for infiltration and destruction. J. Immunol. 172, 5861-5869 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 5861-5869
    • Garbi, N.1    Arnold, B.2    Gordon, S.3    Hämmerling, G.J.4    Ganss, R.5
  • 35
    • 77749279776 scopus 로고    scopus 로고
    • PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
    • Curran, M. A., Montalvo, W., Yagita, H. & Allison, J. P. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc. Natl. Acad. Sci. USA 107, 4275-4280 (2010).
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 4275-4280
    • Curran, M.A.1    Montalvo, W.2    Yagita, H.3    Allison, J.P.4
  • 37
    • 0036494443 scopus 로고    scopus 로고
    • Combination of T-cell therapy and trigger of inflammation induces remodeling of the vasculature and tumor eradication
    • Ganss, R., Ryschich, E., Klar, E., Arnold, B. & Hämmerling, G. J. Combination of T-cell therapy and trigger of inflammation induces remodeling of the vasculature and tumor eradication. Cancer Res. 62, 1462-1470 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 1462-1470
    • Ganss, R.1    Ryschich, E.2    Klar, E.3    Arnold, B.4    Hämmerling, G.J.5
  • 38
    • 84887561907 scopus 로고    scopus 로고
    • Low-dose irradiation programs macrophage differentiation to an iNOS/M1 phenotype that orchestrates effective T cell immunotherapy
    • Klug, F. et al. Low-dose irradiation programs macrophage differentiation to an iNOS/M1 phenotype that orchestrates effective T cell immunotherapy. Cancer Cell 24, 589-602 (2013).
    • (2013) Cancer Cell , vol.24 , pp. 589-602
    • Klug, F.1
  • 39
    • 84898973055 scopus 로고    scopus 로고
    • Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab
    • Topalian, S. L. et al. Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. J. Clin. Oncol. 32, 1020-1030 (2014).
    • (2014) J. Clin. Oncol. , vol.32 , pp. 1020-1030
    • Topalian, S.L.1
  • 40
    • 84930042269 scopus 로고    scopus 로고
    • Intratumoral tertiary lymphoid organ is a favourable prognosticator in patients with pancreatic cancer
    • Hiraoka, N. et al. Intratumoral tertiary lymphoid organ is a favourable prognosticator in patients with pancreatic cancer. Br. J. Cancer 112, 1782-1790 (2015).
    • (2015) Br. J. Cancer , vol.112 , pp. 1782-1790
    • Hiraoka, N.1
  • 41
    • 84954518640 scopus 로고    scopus 로고
    • High endothelial venules are rare in colorectal cancers but accumulate in extra-tumoral areas with disease progression
    • Bento, D. C. et al. High endothelial venules are rare in colorectal cancers but accumulate in extra-tumoral areas with disease progression. OncoImmunology 4, e974374 (2015).
    • (2015) OncoImmunology , vol.4 , pp. e974374
    • Bento, D.C.1
  • 42
    • 80053429941 scopus 로고    scopus 로고
    • IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells
    • Fisher, D. T. et al. IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells. J. Clin. Invest. 121, 3846-3859 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 3846-3859
    • Fisher, D.T.1
  • 43
    • 84929379918 scopus 로고    scopus 로고
    • Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity
    • Peske, J. D. et al. Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity. Nat. Commun. 6, 7114 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 7114
    • Peske, J.D.1
  • 44
    • 84894522129 scopus 로고    scopus 로고
    • M1 macrophages act as LTR-independent lymphoid tissue inducer cells during atherosclerosis-related lymphoid neogenesis
    • Guedj, K. et al. M1 macrophages act as LTR-independent lymphoid tissue inducer cells during atherosclerosis-related lymphoid neogenesis. Cardiovasc. Res. 101, 434-443 (2014).
    • (2014) Cardiovasc. Res. , vol.101 , pp. 434-443
    • Guedj, K.1
  • 45
    • 84992315668 scopus 로고    scopus 로고
    • Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses
    • Moynihan, K. D. et al. Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses. Nat. Med. 22, 1402-1410 (2016).
    • (2016) Nat. Med. , vol.22 , pp. 1402-1410
    • Moynihan, K.D.1
  • 46
    • 0032532318 scopus 로고    scopus 로고
    • Tumor microenvironment can restrict the effectiveness of activated antitumor lymphocytes
    • Ganss, R. & Hanahan, D. Tumor microenvironment can restrict the effectiveness of activated antitumor lymphocytes. Cancer Res. 58, 4673-4681 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 4673-4681
    • Ganss, R.1    Hanahan, D.2
  • 47
    • 0035102225 scopus 로고    scopus 로고
    • Targeting of lymphotoxin-to the tumor elicits an efficient immune response associated with induction of peripheral lymphoid-like tissue
    • Schrama, D. et al. Targeting of lymphotoxin-to the tumor elicits an efficient immune response associated with induction of peripheral lymphoid-like tissue. Immunity 14, 111-121 (2001).
    • (2001) Immunity , vol.14 , pp. 111-121
    • Schrama, D.1
  • 48
    • 84893856633 scopus 로고    scopus 로고
    • Intramuscular therapeutic vaccination targeting HPV16 induces T cell responses that localize in mucosal lesions
    • Maldonado, L. et al. Intramuscular therapeutic vaccination targeting HPV16 induces T cell responses that localize in mucosal lesions. Sci. Transl. Med. 6, 221ra13 (2014).
    • (2014) Sci. Transl. Med. , vol.6 , pp. 221ra13
    • Maldonado, L.1
  • 49
    • 84964314430 scopus 로고    scopus 로고
    • Immunotherapy converts nonimmunogenic pancreatic tumors into immunogenic foci of immune regulation
    • Lutz, E. R. et al. Immunotherapy converts nonimmunogenic pancreatic tumors into immunogenic foci of immune regulation. Cancer Immunol. Res. 2, 616-631 (2014).
    • (2014) Cancer Immunol. Res. , vol.2 , pp. 616-631
    • Lutz, E.R.1
  • 50
    • 0344185348 scopus 로고    scopus 로고
    • Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesis
    • Joyce, J. A. et al. Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesis. Cancer Cell 4, 393-403 (2003).
    • (2003) Cancer Cell , vol.4 , pp. 393-403
    • Joyce, J.A.1
  • 51
    • 80054795004 scopus 로고    scopus 로고
    • Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma
    • Agemy, L. et al. Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma. Proc. Natl. Acad. Sci. USA 108, 17450-17455 (2011).
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 17450-17455
    • Agemy, L.1


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